AU2002230524A1 - Apparatus and methods for conducting assays and high throughput screening - Google Patents
Apparatus and methods for conducting assays and high throughput screeningInfo
- Publication number
- AU2002230524A1 AU2002230524A1 AU2002230524A AU3052402A AU2002230524A1 AU 2002230524 A1 AU2002230524 A1 AU 2002230524A1 AU 2002230524 A AU2002230524 A AU 2002230524A AU 3052402 A AU3052402 A AU 3052402A AU 2002230524 A1 AU2002230524 A1 AU 2002230524A1
- Authority
- AU
- Australia
- Prior art keywords
- methods
- high throughput
- throughput screening
- conducting assays
- assays
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 238000003556 assay Methods 0.000 title 1
- 238000013537 high throughput screening Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
Classifications
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
- F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
- F04B43/00—Machines, pumps, or pumping installations having flexible working members
- F04B43/12—Machines, pumps, or pumping installations having flexible working members having peristaltic action
- F04B43/14—Machines, pumps, or pumping installations having flexible working members having peristaltic action having plate-like flexible members
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D57/00—Separation, other than separation of solids, not fully covered by a single other group or subclass, e.g. B03C
- B01D57/02—Separation, other than separation of solids, not fully covered by a single other group or subclass, e.g. B03C by electrophoresis
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- B—PERFORMING OPERATIONS; TRANSPORTING
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- B01D61/14—Ultrafiltration; Microfiltration
- B01D61/18—Apparatus therefor
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- B—PERFORMING OPERATIONS; TRANSPORTING
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- B01D61/24—Dialysis ; Membrane extraction
- B01D61/28—Apparatus therefor
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- B—PERFORMING OPERATIONS; TRANSPORTING
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- B01D63/08—Flat membrane modules
- B01D63/081—Manufacturing thereof
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- B01D63/088—Microfluidic devices comprising semi-permeable flat membranes
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- B01F25/42—Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
- B01F25/43—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction
- B01F25/433—Mixing tubes wherein the shape of the tube influences the mixing, e.g. mixing tubes with varying cross-section or provided with inwardly extending profiles
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- B01F25/43—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction
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- C—CHEMISTRY; METALLURGY
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- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
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- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
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PCT/US2001/044869 WO2002040874A1 (fr) | 2000-11-16 | 2001-11-16 | Appareil et procedes pour effectuer des dosages et des criblages a haut rendement |
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Families Citing this family (310)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6221654B1 (en) | 1996-09-25 | 2001-04-24 | California Institute Of Technology | Method and apparatus for analysis and sorting of polynucleotides based on size |
US6833242B2 (en) * | 1997-09-23 | 2004-12-21 | California Institute Of Technology | Methods for detecting and sorting polynucleotides based on size |
US7144616B1 (en) | 1999-06-28 | 2006-12-05 | California Institute Of Technology | Microfabricated elastomeric valve and pump systems |
US7459022B2 (en) | 2001-04-06 | 2008-12-02 | California Institute Of Technology | Microfluidic protein crystallography |
US8709153B2 (en) | 1999-06-28 | 2014-04-29 | California Institute Of Technology | Microfludic protein crystallography techniques |
US7217321B2 (en) | 2001-04-06 | 2007-05-15 | California Institute Of Technology | Microfluidic protein crystallography techniques |
US7306672B2 (en) | 2001-04-06 | 2007-12-11 | California Institute Of Technology | Microfluidic free interface diffusion techniques |
US8052792B2 (en) | 2001-04-06 | 2011-11-08 | California Institute Of Technology | Microfluidic protein crystallography techniques |
US7244402B2 (en) * | 2001-04-06 | 2007-07-17 | California Institute Of Technology | Microfluidic protein crystallography |
CA2721172C (fr) * | 1999-06-28 | 2012-04-10 | California Institute Of Technology | Obturateur elastomere micro-usine et systemes de pompe |
AU2001240040A1 (en) * | 2000-03-03 | 2001-09-17 | California Institute Of Technology | Combinatorial array for nucleic acid analysis |
US7867763B2 (en) | 2004-01-25 | 2011-01-11 | Fluidigm Corporation | Integrated chip carriers with thermocycler interfaces and methods of using the same |
US20050118073A1 (en) | 2003-11-26 | 2005-06-02 | Fluidigm Corporation | Devices and methods for holding microfluidic devices |
US7351376B1 (en) | 2000-06-05 | 2008-04-01 | California Institute Of Technology | Integrated active flux microfluidic devices and methods |
AU2001290879A1 (en) | 2000-09-15 | 2002-03-26 | California Institute Of Technology | Microfabricated crossflow devices and methods |
WO2002040874A1 (fr) | 2000-11-16 | 2002-05-23 | California Institute Of Technology | Appareil et procedes pour effectuer des dosages et des criblages a haut rendement |
US20020108860A1 (en) * | 2001-01-15 | 2002-08-15 | Staats Sau Lan Tang | Fabrication of polymeric microfluidic devices |
US20050196785A1 (en) * | 2001-03-05 | 2005-09-08 | California Institute Of Technology | Combinational array for nucleic acid analysis |
EP1384022A4 (fr) | 2001-04-06 | 2004-08-04 | California Inst Of Techn | Amplification d'acide nucleique au moyen de dispositifs microfluidiques |
US7060227B2 (en) * | 2001-08-06 | 2006-06-13 | Sau Lan Tang Staats | Microfluidic devices with raised walls |
US7090003B2 (en) * | 2001-10-19 | 2006-08-15 | Wisconsin Alumni Research Foundation | Method and apparatus for temperature control of a microfluidic device |
US7691333B2 (en) | 2001-11-30 | 2010-04-06 | Fluidigm Corporation | Microfluidic device and methods of using same |
WO2003048295A1 (fr) * | 2001-11-30 | 2003-06-12 | Fluidigm Corporation | Dispositif microfluidique et procedes d'utilisation de ce dernier |
US7312085B2 (en) * | 2002-04-01 | 2007-12-25 | Fluidigm Corporation | Microfluidic particle-analysis systems |
WO2003085379A2 (fr) * | 2002-04-01 | 2003-10-16 | Fluidigm Corporation | Systemes d'analyse de particules microfluidiques |
JP3970226B2 (ja) | 2002-09-10 | 2007-09-05 | キヤノン株式会社 | 液体微細搬送装置 |
US6806543B2 (en) | 2002-09-12 | 2004-10-19 | Intel Corporation | Microfluidic apparatus with integrated porous-substrate/sensor for real-time (bio)chemical molecule detection |
US8220494B2 (en) | 2002-09-25 | 2012-07-17 | California Institute Of Technology | Microfluidic large scale integration |
AU2003282875A1 (en) | 2002-09-25 | 2004-04-19 | California Institute Of Technology | Microfluidic large scale integration |
WO2004040001A2 (fr) | 2002-10-02 | 2004-05-13 | California Institute Of Technology | Analyse microfluidique d'acides nucleiques |
JP4346893B2 (ja) * | 2002-11-01 | 2009-10-21 | 株式会社日立製作所 | 化学反応装置 |
US7419638B2 (en) * | 2003-01-14 | 2008-09-02 | Micronics, Inc. | Microfluidic devices for fluid manipulation and analysis |
US20100022414A1 (en) | 2008-07-18 | 2010-01-28 | Raindance Technologies, Inc. | Droplet Libraries |
WO2004086055A1 (fr) * | 2003-03-24 | 2004-10-07 | Sony Corporation | Microplaquette, trousse d'extraction d'acide nucleique et procede d'extraction d'acide nucleique |
GB0307428D0 (en) | 2003-03-31 | 2003-05-07 | Medical Res Council | Compartmentalised combinatorial chemistry |
GB0307403D0 (en) * | 2003-03-31 | 2003-05-07 | Medical Res Council | Selection by compartmentalised screening |
US20060078893A1 (en) | 2004-10-12 | 2006-04-13 | Medical Research Council | Compartmentalised combinatorial chemistry by microfluidic control |
US20050145496A1 (en) * | 2003-04-03 | 2005-07-07 | Federico Goodsaid | Thermal reaction device and method for using the same |
US8828663B2 (en) | 2005-03-18 | 2014-09-09 | Fluidigm Corporation | Thermal reaction device and method for using the same |
US7604965B2 (en) | 2003-04-03 | 2009-10-20 | Fluidigm Corporation | Thermal reaction device and method for using the same |
US7476363B2 (en) | 2003-04-03 | 2009-01-13 | Fluidigm Corporation | Microfluidic devices and methods of using same |
WO2004089810A2 (fr) * | 2003-04-03 | 2004-10-21 | Fluidigm Corp. | Dispositifs microfluidiques et leurs procedes d'utilisation |
CA2526368A1 (fr) | 2003-05-20 | 2004-12-02 | Fluidigm Corporation | Procede et systeme pour dispositif microfluidique et son imagerie |
US7413712B2 (en) * | 2003-08-11 | 2008-08-19 | California Institute Of Technology | Microfluidic rotary flow reactor matrix |
SG145784A1 (en) * | 2003-08-11 | 2008-09-29 | California Inst Of Techn | Microfluidic large scale integration |
US9597644B2 (en) | 2003-09-05 | 2017-03-21 | Stokes Bio Limited | Methods for culturing and analyzing cells |
WO2005023427A1 (fr) | 2003-09-05 | 2005-03-17 | Stokes Bio Limited | Systeme d'analyse microfluide |
JP4455032B2 (ja) * | 2003-12-08 | 2010-04-21 | キヤノン株式会社 | 濃度測定装置および濃度測定方法 |
US20050148064A1 (en) * | 2003-12-29 | 2005-07-07 | Intel Corporation | Microfluid molecular-flow fractionator and bioreactor with integrated active/passive diffusion barrier |
US7407799B2 (en) | 2004-01-16 | 2008-08-05 | California Institute Of Technology | Microfluidic chemostat |
US20050221339A1 (en) | 2004-03-31 | 2005-10-06 | Medical Research Council Harvard University | Compartmentalised screening by microfluidic control |
WO2005121864A2 (fr) | 2004-06-07 | 2005-12-22 | Fluidigm Corporation | Systeme de lentilles optiques et procedes pour dispositifs microfluidiques |
US20050272144A1 (en) * | 2004-06-08 | 2005-12-08 | Konica Minolta Medical & Graphic, Inc. | Micro-reactor for improving efficiency of liquid mixing and reaction |
US7575681B2 (en) * | 2004-07-06 | 2009-08-18 | Schlumberger Technology Corporation | Microfluidic separator |
US8262909B2 (en) * | 2004-07-06 | 2012-09-11 | Schlumberger Technology Corporation | Methods and devices for minimizing membrane fouling for microfluidic separators |
US20060073035A1 (en) * | 2004-09-30 | 2006-04-06 | Narayan Sundararajan | Deformable polymer membranes |
US7955504B1 (en) * | 2004-10-06 | 2011-06-07 | State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon State University | Microfluidic devices, particularly filtration devices comprising polymeric membranes, and method for their manufacture and use |
US7968287B2 (en) | 2004-10-08 | 2011-06-28 | Medical Research Council Harvard University | In vitro evolution in microfluidic systems |
US7585664B2 (en) * | 2004-10-14 | 2009-09-08 | The Hong Kong University Of Science And Technology | Integrated circuit optical detector for biological detection |
EP1652911A1 (fr) * | 2004-10-26 | 2006-05-03 | Konica Minolta Medical & Graphic, Inc. | Microréacteur pour l'inspection de matériau biologique et dispositif pour l' inspection de matériau biologique |
JPWO2006046433A1 (ja) * | 2004-10-27 | 2008-05-22 | コニカミノルタエムジー株式会社 | 遺伝子検査用マイクロリアクタ |
JP2008522795A (ja) * | 2004-12-03 | 2008-07-03 | カリフォルニア インスティチュート オブ テクノロジー | 化学反応回路を有するマイクロ流体装置 |
US20080264863A1 (en) | 2004-12-03 | 2008-10-30 | California Institute Of Technology | Microfluidic Sieve Valves |
US8985547B2 (en) | 2005-01-31 | 2015-03-24 | President And Fellows Of Harvard College | Valves and reservoirs for microfluidic systems |
ATE538213T1 (de) * | 2005-02-18 | 2012-01-15 | Canon Us Life Sciences Inc | Vorrichtung und verfahren zum identifizieren genomischer dna von organismen |
JP4548174B2 (ja) * | 2005-03-24 | 2010-09-22 | コニカミノルタエムジー株式会社 | 検査用マイクロチップおよびそれを用いた検査装置 |
DE102005018337A1 (de) * | 2005-04-20 | 2006-11-02 | Micronas Gmbh | Mikrooptisches Detektionssystem und Verfahren zur Bestimmung temperaturabhängiger Parameter von Analyten |
WO2006127191A2 (fr) | 2005-04-20 | 2006-11-30 | Fluidigm Corporation | Moteur d'analyse et base de donnees permettant de manipuler des parametres destines a des systemes fluidiques sur une puce |
EP2477029A1 (fr) * | 2005-06-02 | 2012-07-18 | Fluidigm Corporation | Analyse utilisant des dispositifs de partage microfluidique |
US7320338B2 (en) * | 2005-06-03 | 2008-01-22 | Honeywell International Inc. | Microvalve package assembly |
US20090129980A1 (en) * | 2005-08-04 | 2009-05-21 | Helicos Biosciences Corporation | Multi-Channel Flow Cells |
US20070054293A1 (en) * | 2005-08-30 | 2007-03-08 | California Institute Of Technology | Microfluidic chaotic mixing systems and methods |
EP1938101A2 (fr) * | 2005-09-13 | 2008-07-02 | Fluidigm Corporation | Dispositifs et procedes de dosage microfluidique |
JP2007121275A (ja) * | 2005-09-27 | 2007-05-17 | Fujifilm Corp | マイクロチップ、このマイクロチップを用いた液体の混合方法及び血液検査方法 |
US7790028B1 (en) | 2005-09-28 | 2010-09-07 | The Charles Stark Draper Laboratory, Inc. | Systems, methods, and devices relating to a cellularized nephron unit |
ES2379921T3 (es) | 2005-09-29 | 2012-05-07 | Siemens Medical Solutions Usa, Inc. | Chip microfluídico que puede sintetizar moléculas marcadas radiactivamente en una escala adecuada para la obtención de imágenes en seres humanos con tomografía por emisión de positrones |
EP1941256B1 (fr) * | 2005-10-06 | 2011-11-23 | Rhodia Opérations | Evaporateurs microfluidiques et procede pour determiner des proprietes physiques et/ou chimiques de composes chimiques ou de melanges de composes chimiques |
WO2007044856A1 (fr) * | 2005-10-11 | 2007-04-19 | The Johns Hopkins University | Appareil et méthode pour stimulation à haut débit, immunocoloration et visualisation de cellules individuelles |
US8449837B2 (en) * | 2005-10-11 | 2013-05-28 | The Johns Hopkins University | Microfluidic device for high-throughput cellular gradient and dose response studies |
US9206396B2 (en) * | 2005-11-16 | 2015-12-08 | Wisconsin Alumni Research Foundation | Methods and devices for quantitative viral assays |
US7763453B2 (en) | 2005-11-30 | 2010-07-27 | Micronics, Inc. | Microfluidic mixing and analytic apparatus |
US9056291B2 (en) | 2005-11-30 | 2015-06-16 | Micronics, Inc. | Microfluidic reactor system |
EP3913375A1 (fr) | 2006-01-11 | 2021-11-24 | Bio-Rad Laboratories, Inc. | Dispositifs microfluidiques et procédés d'utilisation dans la formation et contrôle de nanoréacteurs |
EP2298438A1 (fr) | 2006-02-07 | 2011-03-23 | Stokes Bio Limited | Réseau de mise en file d'attente de gouttelettes microfluidiques |
US7815868B1 (en) | 2006-02-28 | 2010-10-19 | Fluidigm Corporation | Microfluidic reaction apparatus for high throughput screening |
JP4569711B2 (ja) * | 2006-04-14 | 2010-10-27 | 和光純薬工業株式会社 | 複数溶液導入構造、該構造を有する微小流体装置及び溶液導入法 |
US8828661B2 (en) | 2006-04-24 | 2014-09-09 | Fluidigm Corporation | Methods for detection and quantification of nucleic acid or protein targets in a sample |
ATE496300T1 (de) * | 2006-04-25 | 2011-02-15 | Panasonic Corp | Immuntestverfahren und -chip |
US9562837B2 (en) | 2006-05-11 | 2017-02-07 | Raindance Technologies, Inc. | Systems for handling microfludic droplets |
EP3335782B1 (fr) * | 2006-05-11 | 2020-09-09 | Bio-Rad Laboratories, Inc. | Dispositifs microfluidiques |
JP2007301534A (ja) * | 2006-05-15 | 2007-11-22 | Ebara Corp | 微細化装置 |
US7629124B2 (en) * | 2006-06-30 | 2009-12-08 | Canon U.S. Life Sciences, Inc. | Real-time PCR in micro-channels |
EP3536396B1 (fr) | 2006-08-07 | 2022-03-30 | The President and Fellows of Harvard College | Tensioactifs fluorocarbonés stabilisateurs d'émulsions |
US8055034B2 (en) | 2006-09-13 | 2011-11-08 | Fluidigm Corporation | Methods and systems for image processing of microfluidic devices |
US10753927B2 (en) | 2006-09-22 | 2020-08-25 | ALERE TECHNOLOGIES GmbH | Methods for detecting an analyte |
FR2907228B1 (fr) * | 2006-10-13 | 2009-07-24 | Rhodia Recherches & Tech | Dispositif d'ecoulement fluidique,ensemble de determination d'au moins une caracteristique d'un systeme physico-chimique comprenant un tel dispositif,procede de determination et procede de criblage correspondants |
US8473216B2 (en) * | 2006-11-30 | 2013-06-25 | Fluidigm Corporation | Method and program for performing baseline correction of amplification curves in a PCR experiment |
WO2008089493A2 (fr) * | 2007-01-19 | 2008-07-24 | Fluidigm Corporation | Dispositifs microfluidiques d'efficacité élevée et de précision élevée et procédés |
US7829032B2 (en) | 2007-01-23 | 2010-11-09 | Siemens Medical Solutions Usa, Inc. | Fully-automated microfluidic system for the synthesis of radiolabeled biomarkers for positron emission tomography |
US8772046B2 (en) | 2007-02-06 | 2014-07-08 | Brandeis University | Manipulation of fluids and reactions in microfluidic systems |
US20100151465A1 (en) | 2008-03-27 | 2010-06-17 | Jingyue Ju | Selective Capture and Release of Analytes |
US8071035B2 (en) | 2007-04-12 | 2011-12-06 | Siemens Medical Solutions Usa, Inc. | Microfluidic radiosynthesis system for positron emission tomography biomarkers |
US8592221B2 (en) | 2007-04-19 | 2013-11-26 | Brandeis University | Manipulation of fluids, fluid components and reactions in microfluidic systems |
EP2543440B1 (fr) * | 2007-05-03 | 2020-03-25 | Alere Technologies GmbH | Machine de fonctionnement pour une cartouche et procédé de détection de particules |
WO2009023153A1 (fr) * | 2007-08-10 | 2009-02-19 | Carnegie Institution Of Washington | Procédés d'utilisation de nanocapteurs ret |
ATE541946T1 (de) * | 2007-09-07 | 2012-02-15 | Fluidigm Corp | Verfahren und system zur bestimmung von genkopiezahlvarianten |
WO2009039433A1 (fr) * | 2007-09-20 | 2009-03-26 | Incept Biosystems Inc. | Système de culture analytique microfluidique |
WO2009039640A1 (fr) * | 2007-09-28 | 2009-04-02 | University Of Toronto | Système, appareil et procédé permettant d'appliquer une force mécanique à un matériau |
US9267918B2 (en) | 2007-10-16 | 2016-02-23 | Cambridge Enterprise Limited | Microfluidic systems |
GB0720202D0 (en) | 2007-10-16 | 2007-11-28 | Cambridge Entpr Ltd | Microfluidic systems |
JP2009133818A (ja) * | 2007-11-05 | 2009-06-18 | Sony Corp | 基板流路内における液体の送液方法及び液体送液装置 |
US20090117664A1 (en) * | 2007-11-05 | 2009-05-07 | Masataka Shinoda | Liquid sending method of liquid in substrate channel and liquid sending apparatus |
US20100279309A1 (en) * | 2007-11-19 | 2010-11-04 | Florida Atlantic University | Microfluidic chips and systems for analyzing protein expression, and methods of use thereof |
JP2011512125A (ja) * | 2008-02-01 | 2011-04-21 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | マイクロ流体画像サイトメトリ |
US9157116B2 (en) | 2008-02-08 | 2015-10-13 | Fluidigm Corporation | Combinatorial amplification and detection of nucleic acids |
US8173080B2 (en) * | 2008-02-14 | 2012-05-08 | Illumina, Inc. | Flow cells and manifolds having an electroosmotic pump |
US20090211977A1 (en) * | 2008-02-27 | 2009-08-27 | Oregon State University | Through-plate microchannel transfer devices |
EP2268401B1 (fr) * | 2008-03-14 | 2018-08-08 | Clondiag GmbH | essais et dispositif |
CN102056838B (zh) | 2008-04-11 | 2013-07-03 | 弗卢丁公司 | 微流体装置和方法 |
FR2931141B1 (fr) | 2008-05-13 | 2011-07-01 | Commissariat Energie Atomique | Systeme microfluidique et procede pour le tri d'amas de cellules et de preference pour leur encapsulation en continu suite a leur tri |
EP2297333B1 (fr) * | 2008-05-30 | 2015-01-28 | Massachusetts Institute of Technology | Procédé pour une séparation spatiale et un criblage de cellules |
KR20160129919A (ko) | 2008-06-05 | 2016-11-09 | 더 어드미니스트레이터즈 오브 더 튜래인 어듀케이셔널 훤드 | 중합체 기능성 진화를 합성 동안 모니터하기 위한 방법 및 장치 |
WO2010011852A1 (fr) | 2008-07-25 | 2010-01-28 | Fluidigm Corporation | Procédé et système de fabrication de puces fluidiques intégrées |
WO2010017210A1 (fr) | 2008-08-07 | 2010-02-11 | Fluidigm Corporation | Systèmes microfluidique de mélange et de réaction pour un tamisage à efficacité élevée |
JP4722977B2 (ja) * | 2008-08-27 | 2011-07-13 | シャープ株式会社 | 検出器具、分析装置、検出方法および検出器具の制御方法 |
US9540686B2 (en) * | 2008-09-18 | 2017-01-10 | Canon U.S. Life Sciences, Inc. | Systems and methods for the amplification of DNA |
DE102008048064A1 (de) * | 2008-09-19 | 2010-04-08 | Jobst Technologies Gmbh | Mikrofluidisches Ventil, mikrofluidische Pumpe, mikrofluidisches System und ein Herstellungsverfahren |
US8318439B2 (en) | 2008-10-03 | 2012-11-27 | Micronics, Inc. | Microfluidic apparatus and methods for performing blood typing and crossmatching |
US8217478B2 (en) * | 2008-10-10 | 2012-07-10 | Seagate Technology Llc | Magnetic stack with oxide to reduce switching current |
US8309306B2 (en) * | 2008-11-12 | 2012-11-13 | Nodality, Inc. | Detection composition |
CA2740222C (fr) | 2008-11-26 | 2015-11-17 | Jonathan Posner | Pompe electroosmotique avec gestion de gaz amelioree |
US8628923B2 (en) * | 2009-01-13 | 2014-01-14 | Fluidigm Corporation | Single cell nucleic acid analysis |
US8058630B2 (en) * | 2009-01-16 | 2011-11-15 | Fluidigm Corporation | Microfluidic devices and methods |
TWI400446B (zh) * | 2009-03-20 | 2013-07-01 | Univ Nat Cheng Kung | 免疫分析晶片 |
US8528589B2 (en) | 2009-03-23 | 2013-09-10 | Raindance Technologies, Inc. | Manipulation of microfluidic droplets |
EP2789694A1 (fr) | 2009-04-02 | 2014-10-15 | Fluidigm Corporation | Dispositif microfluidique avec système de récupération de produit de réaction |
US9090663B2 (en) * | 2009-04-21 | 2015-07-28 | The Trustees Of Columbia University In The City Of New York | Systems and methods for the capture and separation of microparticles |
ES2635219T3 (es) * | 2009-06-24 | 2017-10-02 | Oregon State University | Dispositivos microfluídicos para diálisis |
US8801922B2 (en) | 2009-06-24 | 2014-08-12 | State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon State University | Dialysis system |
CN101614655B (zh) * | 2009-07-16 | 2010-11-10 | 江西科技师范学院 | 一种基于光声技术的微流控芯片检测方法及其装置 |
WO2011011669A1 (fr) * | 2009-07-23 | 2011-01-27 | University Of Wyoming | Procédés et compositions pour la détection de matériaux biologiques à l'aide de dispositifs microfluidiques |
US8551787B2 (en) * | 2009-07-23 | 2013-10-08 | Fluidigm Corporation | Microfluidic devices and methods for binary mixing |
EP2292329B1 (fr) * | 2009-09-08 | 2014-11-12 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Substrat polymère doté d'une structure fluorescente, son procédé de fabrication et son utilisation |
SG169918A1 (en) | 2009-10-02 | 2011-04-29 | Fluidigm Corp | Microfluidic devices with removable cover and methods of fabrication and application |
EP2486409A1 (fr) | 2009-10-09 | 2012-08-15 | Universite De Strasbourg | Nanomatériau marqué à base de silice à propriétés améliorées et ses utilisations |
WO2011059786A1 (fr) * | 2009-10-29 | 2011-05-19 | The Charles Stark Draper Laboratory, Inc. | Dispositif microfluidique pour la dialyse du sang |
US20110143378A1 (en) * | 2009-11-12 | 2011-06-16 | CyVek LLC. | Microfluidic method and apparatus for high performance biological assays |
DE102009055023B4 (de) * | 2009-11-19 | 2011-09-22 | Vereta Gmbh | Vorrichtung zur Messung der Massenkonzentration von im Abgas von Feststoffverbrennungsvorrichtungen vorhandenem Feinstaub |
EP2504701B1 (fr) | 2009-11-23 | 2017-09-13 | Cyvek, Inc. | Procédé et appareil destiné à réaliser des dosages |
US9700889B2 (en) | 2009-11-23 | 2017-07-11 | Cyvek, Inc. | Methods and systems for manufacture of microarray assay systems, conducting microfluidic assays, and monitoring and scanning to obtain microfluidic assay results |
US9651568B2 (en) | 2009-11-23 | 2017-05-16 | Cyvek, Inc. | Methods and systems for epi-fluorescent monitoring and scanning for microfluidic assays |
US10065403B2 (en) | 2009-11-23 | 2018-09-04 | Cyvek, Inc. | Microfluidic assay assemblies and methods of manufacture |
US9500645B2 (en) | 2009-11-23 | 2016-11-22 | Cyvek, Inc. | Micro-tube particles for microfluidic assays and methods of manufacture |
US9855735B2 (en) | 2009-11-23 | 2018-01-02 | Cyvek, Inc. | Portable microfluidic assay devices and methods of manufacture and use |
US9759718B2 (en) | 2009-11-23 | 2017-09-12 | Cyvek, Inc. | PDMS membrane-confined nucleic acid and antibody/antigen-functionalized microlength tube capture elements, and systems employing them, and methods of their use |
CA2782181A1 (fr) | 2009-11-30 | 2011-06-03 | Fluidigm Corporation | Regeneration d'un dispositif microfluidique |
US20110189048A1 (en) * | 2009-12-05 | 2011-08-04 | Curtis James R | Modular dialysis system |
US8753515B2 (en) | 2009-12-05 | 2014-06-17 | Home Dialysis Plus, Ltd. | Dialysis system with ultrafiltration control |
WO2011079176A2 (fr) | 2009-12-23 | 2011-06-30 | Raindance Technologies, Inc. | Systèmes microfluidiques et procédés pour réduire l'échange de molécules entre des gouttelettes |
US9399797B2 (en) | 2010-02-12 | 2016-07-26 | Raindance Technologies, Inc. | Digital analyte analysis |
US9366632B2 (en) | 2010-02-12 | 2016-06-14 | Raindance Technologies, Inc. | Digital analyte analysis |
US10351905B2 (en) | 2010-02-12 | 2019-07-16 | Bio-Rad Laboratories, Inc. | Digital analyte analysis |
CA2789425C (fr) | 2010-02-12 | 2020-04-28 | Raindance Technologies, Inc. | Analyse numerique d'analyte comportant la correction d'erreur de polymerase |
US10787701B2 (en) | 2010-04-05 | 2020-09-29 | Prognosys Biosciences, Inc. | Spatially encoded biological assays |
US20190300945A1 (en) | 2010-04-05 | 2019-10-03 | Prognosys Biosciences, Inc. | Spatially Encoded Biological Assays |
EP3239717B1 (fr) * | 2010-04-15 | 2020-05-27 | Accellix Ltd | Dispositif et procédé de détermination d'un état médical |
US8867803B2 (en) | 2010-04-20 | 2014-10-21 | Eric J. Seibel | Optical projection tomography microscopy (OPTM) for large specimen sizes |
US9101573B2 (en) | 2010-05-04 | 2015-08-11 | Virginia Tech Intellectual Properties, Inc. | Lanthionine synthetase component C-like proteins as molecular targets for preventing and treating diseases and disorders |
US8580161B2 (en) | 2010-05-04 | 2013-11-12 | State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon State University | Fluidic devices comprising photocontrollable units |
US8475738B2 (en) * | 2010-05-04 | 2013-07-02 | Electronics And Telecommunications Research Institute | Photocatalytic apparatus and method for injecting microfluidic volumes |
US8501009B2 (en) | 2010-06-07 | 2013-08-06 | State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon State University | Fluid purification system |
US20110311409A1 (en) * | 2010-06-17 | 2011-12-22 | Geneasys Pty Ltd. | Reagent dispensing apparatus with automatic collection and storage of reagent data |
GB2481425A (en) | 2010-06-23 | 2011-12-28 | Iti Scotland Ltd | Method and device for assembling polynucleic acid sequences |
EP2589652A4 (fr) * | 2010-07-01 | 2017-04-05 | Kaneka Corporation | Ensemble jetable de culture de cellules, dispositif de culture de cellules et procédé de préparation de cellules |
US9365816B2 (en) | 2010-09-13 | 2016-06-14 | California Institute Of Technology | Handheld low pressure mechanical cell lysis device with single cell resolution |
US8277659B2 (en) * | 2010-09-23 | 2012-10-02 | Battelle Memorial Institute | Microchip capillary electrophoresis absent electrokinetic injection |
US20140291155A1 (en) * | 2010-09-23 | 2014-10-02 | Battelle Memorial Institute | Microfluidic Sample Injectors Absent Electrokinetic Injection |
US20160084805A1 (en) * | 2010-09-23 | 2016-03-24 | Battelle Memorial Institute | System and method of preconcentrating analytes in a microfluidic device |
US9562897B2 (en) | 2010-09-30 | 2017-02-07 | Raindance Technologies, Inc. | Sandwich assays in droplets |
WO2012054933A2 (fr) | 2010-10-22 | 2012-04-26 | Fluidigm Corporation | Méthodes de dosage par sondes universelles |
KR101776215B1 (ko) * | 2010-10-29 | 2017-09-08 | 삼성전자 주식회사 | 세포 파쇄용 마이크로 디바이스 및 이를 이용한 세포 파쇄 방법 |
US8871500B2 (en) * | 2011-01-21 | 2014-10-28 | Innovative Micro Technology | MEMS particle sorting actuator and method of manufacturing |
WO2012106385A2 (fr) | 2011-01-31 | 2012-08-09 | Apprise Bio, Inc. | Procédés d'identification de multiples épitopes dans des cellules |
WO2012109600A2 (fr) | 2011-02-11 | 2012-08-16 | Raindance Technologies, Inc. | Procédés de formation de gouttelettes mélangées |
EP2675819B1 (fr) | 2011-02-18 | 2020-04-08 | Bio-Rad Laboratories, Inc. | Compositions et méthodes de marquage moléculaire |
CN103649759B (zh) | 2011-03-22 | 2016-08-31 | 西维克公司 | 微流体装置以及制造方法和用途 |
US9168531B2 (en) | 2011-03-24 | 2015-10-27 | Fluidigm Corporation | Method for thermal cycling of microfluidic samples |
GB201106254D0 (en) | 2011-04-13 | 2011-05-25 | Frisen Jonas | Method and product |
WO2012154876A1 (fr) | 2011-05-09 | 2012-11-15 | Fluidigm Corporation | Détection d'acide nucléique à l'aide d'une sonde |
US9644231B2 (en) | 2011-05-09 | 2017-05-09 | Fluidigm Corporation | Nucleic acid detection using probes |
US8841071B2 (en) | 2011-06-02 | 2014-09-23 | Raindance Technologies, Inc. | Sample multiplexing |
EP3216872B1 (fr) | 2011-06-02 | 2020-04-01 | Bio-Rad Laboratories, Inc. | Quantification d'enzyme |
JP6041872B2 (ja) | 2011-06-15 | 2016-12-14 | ザ チャールズ スターク ドレイパー ラボラトリー インク | バイオ人工腎臓 |
US8658430B2 (en) | 2011-07-20 | 2014-02-25 | Raindance Technologies, Inc. | Manipulating droplet size |
WO2013019714A1 (fr) | 2011-07-29 | 2013-02-07 | The Trustees Of Columbia University In The City Of New York | Capteur d'affinité mems pour surveillance ininterrompue de substances à analyser |
US9328969B2 (en) | 2011-10-07 | 2016-05-03 | Outset Medical, Inc. | Heat exchange fluid purification for dialysis system |
GB2495536A (en) * | 2011-10-14 | 2013-04-17 | J R Biomedical Ltd | Bioanalytical device with mixing device |
JP6178335B2 (ja) * | 2011-12-21 | 2017-08-09 | ベクトン・ディキンソン・アンド・カンパニーBecton, Dickinson And Company | 磁気標識サンプル成分の無菌分離のためのフローサイトメトリーシステム |
TW201326814A (zh) * | 2011-12-21 | 2013-07-01 | Nat Univ Tsing Hua | 篩選細胞適合體之微流體晶片裝置及其方法 |
KR101244285B1 (ko) * | 2011-12-21 | 2013-03-18 | 충남대학교산학협력단 | 액적 발생용 마이크로 유체칩, 액적 반응용 마이크로 유체칩 및 다중 액적반응 분석장치 |
DE102012201018B4 (de) * | 2012-01-24 | 2016-03-31 | Ifm Electronic Gmbh | Messgerät mit am Gehäuse vorgesehenem Luftdurchgang |
US9952126B2 (en) | 2012-02-29 | 2018-04-24 | Fluidigm Corporation | Methods for multiple single-cell capturing and processing using micro fluidics |
EP2822689B1 (fr) | 2012-03-08 | 2023-07-26 | Cyvek, Inc. | Particules micro-tubulaires pour analyses microfluidiques et procédés de fabrication |
JP6159391B2 (ja) | 2012-04-03 | 2017-07-05 | イラミーナ インコーポレーテッド | 核酸シークエンシングに有用な統合化した読取りヘッド及び流体カートリッジ |
JP5651787B2 (ja) * | 2012-04-06 | 2015-01-14 | 株式会社フジクラ | 流体制御デバイス、及び流体混合器 |
WO2013177206A2 (fr) | 2012-05-21 | 2013-11-28 | Fluidigm Corporation | Analyse de particules uniques de populations de particules |
CN105264088B (zh) | 2012-08-08 | 2018-12-28 | 豪夫迈·罗氏有限公司 | 提高鉴定细胞中的多个表位的动态范围 |
US9580679B2 (en) | 2012-09-21 | 2017-02-28 | California Institute Of Technology | Methods and devices for sample lysis |
US9518914B2 (en) | 2012-09-24 | 2016-12-13 | Brigham And Women's Hospital, Inc. | Portal and method for management of dialysis therapy |
US9518977B2 (en) | 2012-10-19 | 2016-12-13 | University Of Washington Through Its Center For Commercialization | Microfluidic assay apparatus and methods of use |
US9233225B2 (en) | 2012-11-10 | 2016-01-12 | Curvo Medical, Inc. | Coaxial bi-directional catheter |
US9549666B2 (en) | 2012-11-10 | 2017-01-24 | Curvo Medical, Inc. | Coaxial micro-endoscope |
WO2014085655A1 (fr) * | 2012-11-29 | 2014-06-05 | Indiana University Research And Technology Corporation | Dispositif de mesure d'électrolyte diélectrique |
US20140170678A1 (en) | 2012-12-17 | 2014-06-19 | Leukodx Ltd. | Kits, compositions and methods for detecting a biological condition |
EP3462172B1 (fr) | 2012-12-17 | 2023-09-06 | Accellix Ltd | Systèmes et procédés de détection d'une condition biologique |
US10610861B2 (en) | 2012-12-17 | 2020-04-07 | Accellix Ltd. | Systems, compositions and methods for detecting a biological condition |
EP2970849B1 (fr) | 2013-03-15 | 2019-08-21 | Fluidigm Corporation | Procédés et dispositifs pour l'analyse de combinaisons multicellulaires définies |
EP3462174B1 (fr) | 2013-03-15 | 2021-12-29 | Arizona Board of Regents on behalf of Arizona State University | Compositions et procédés de microréseaux de biocapteurs |
EP2799137A1 (fr) | 2013-04-30 | 2014-11-05 | Koninklijke Philips N.V. | Système fluidique pour traiter un échantillon de fluide |
US20140326400A1 (en) * | 2013-05-01 | 2014-11-06 | Ismail Emre ARACI | Robust monolithic micromechanical valves for high density microfluidic very large scale integration |
US10386377B2 (en) | 2013-05-07 | 2019-08-20 | Micronics, Inc. | Microfluidic devices and methods for performing serum separation and blood cross-matching |
ITTO20130447A1 (it) * | 2013-05-31 | 2014-12-01 | St Microelectronics Srl | Valvola microfluidica a membrana e procedimento per fabbricare una valvola microfluidica a membrana |
LT3013984T (lt) | 2013-06-25 | 2023-06-12 | Prognosys Biosciences, Inc. | Biologinių taikinių erdvinių modelių mėginyje nustatymo būdai |
US9855554B2 (en) | 2013-07-22 | 2018-01-02 | President And Fellows Of Harvard College | Microfluidic cartridge assembly |
US9618450B2 (en) * | 2013-09-27 | 2017-04-11 | Ecolab USA, Inc. | Multi-channel fluorometric sensor and method of using same |
US11901041B2 (en) | 2013-10-04 | 2024-02-13 | Bio-Rad Laboratories, Inc. | Digital analysis of nucleic acid modification |
CA2866542A1 (fr) * | 2013-10-08 | 2015-04-08 | Ponnambalam Selvaganapathy | Pretraitement d'echantillons de reactifs integre pour diagnostics moleculaires utilisant un dispositif microfluidique a membrane nanoporeuse |
DK3060912T3 (da) * | 2013-10-22 | 2020-09-28 | Berkeley Lights Inc | Fremgangsmåde og mikrofluidanordning til analyse af biologisk aktivitet |
US9889445B2 (en) | 2013-10-22 | 2018-02-13 | Berkeley Lights, Inc. | Micro-fluidic devices for assaying biological activity |
CN110560187B (zh) | 2013-11-18 | 2022-01-11 | 尹特根埃克斯有限公司 | 用于样本分析的卡盒和仪器 |
US9944977B2 (en) | 2013-12-12 | 2018-04-17 | Raindance Technologies, Inc. | Distinguishing rare variations in a nucleic acid sequence from a sample |
US11193176B2 (en) | 2013-12-31 | 2021-12-07 | Bio-Rad Laboratories, Inc. | Method for detecting and quantifying latent retroviral RNA species |
WO2015168280A1 (fr) | 2014-04-29 | 2015-11-05 | Outset Medical, Inc. | Système et procédés de dialyse |
GB2544198B (en) | 2014-05-21 | 2021-01-13 | Integenx Inc | Fluidic cartridge with valve mechanism |
KR102195769B1 (ko) * | 2014-07-10 | 2020-12-30 | 주식회사 미코바이오메드 | 미세유체 칩, 이의 제조 방법 및 이를 이용한 분석 장치 |
WO2016022696A1 (fr) | 2014-08-05 | 2016-02-11 | The Trustees Of Columbia University In The City Of New York | Procédé d'isolement d'aptamères pour détecter une maladie résiduelle minimale |
US10266397B2 (en) * | 2014-08-13 | 2019-04-23 | University Of South Carolina | III-V nitride resonate structure based photoacoustic sensor |
CA3001555C (fr) | 2014-10-13 | 2023-09-05 | Administrators Of The Tulane Educational Fund | Dispositif et procede de changement de conditions de solution dans un ecoulement en serie |
FR3028038B1 (fr) * | 2014-10-31 | 2018-01-12 | Commissariat A L'energie Atomique Et Aux Energies Alternatives | Procede et systeme d'estimation d'une concentration d'une espece dans un milieu de culture par imagerie sans lentille |
WO2016145050A1 (fr) | 2015-03-10 | 2016-09-15 | Carbon3D, Inc. | Dispositifs microfluidiques comportant des éléments flexibles et leurs procédés de fabrication |
ES2955488T3 (es) | 2015-04-10 | 2023-12-01 | Spatial Transcriptomics Ab | Análisis multiplex de especímenes biológicos de ácidos nucleicos espacialmente distinguidos |
US10751715B1 (en) * | 2015-04-22 | 2020-08-25 | Berkeley Lights, Inc. | Microfluidic reporter cell assay methods and kits thereof |
US10233491B2 (en) | 2015-06-19 | 2019-03-19 | IntegenX, Inc. | Valved cartridge and system |
US10647981B1 (en) | 2015-09-08 | 2020-05-12 | Bio-Rad Laboratories, Inc. | Nucleic acid library generation methods and compositions |
US11235320B2 (en) * | 2015-10-08 | 2022-02-01 | International Business Machines Corporation | Self-tuning system for manipulating complex fluids using electrokinectics |
JP6806374B2 (ja) * | 2015-10-23 | 2021-01-06 | 国立研究開発法人科学技術振興機構 | ナノ流体デバイス及び化学分析装置 |
WO2017091601A1 (fr) | 2015-11-23 | 2017-06-01 | Berkeley Lights, Inc. | Structures d'isolation microfluidiques produites in situ, kits et procédés d'utilisation de celles-ci |
US10228367B2 (en) | 2015-12-01 | 2019-03-12 | ProteinSimple | Segmented multi-use automated assay cartridge |
WO2017100347A1 (fr) | 2015-12-08 | 2017-06-15 | Berkeley Lights, Inc. | Dispositifs et trousses microfluidiques et leurs procédés d'utilisation |
US10444184B2 (en) | 2015-12-28 | 2019-10-15 | International Business Machines Corporation | Operation of diagnostic devices involving microchannels and electrodes |
EP3427037A4 (fr) | 2016-03-09 | 2019-11-27 | The Regents of the University of California | Procédé de spectroscopie électronique moléculaire à induction transitoire pour l'étude d'interactions moléculaires |
CA3019167A1 (fr) | 2016-04-15 | 2017-10-19 | Becton, Dickinson And Company | Trieur de gouttelettes ferme et procedes d'utilisation associes |
ES2908601T3 (es) | 2016-08-19 | 2022-05-03 | Outset Medical Inc | Sistema y métodos de diálisis peritoneal |
WO2018051242A1 (fr) | 2016-09-14 | 2018-03-22 | Ecole Polytechnique Federale De Lausanne (Epfl) | Dispositif destiné à des études à haut débit de cellules uniques |
US10816456B2 (en) | 2016-10-19 | 2020-10-27 | International Business Machines Corporation | Systems and methods for reconfigurable point-of-care diagnostics |
US11226278B2 (en) | 2016-11-08 | 2022-01-18 | Kennesaw State University Research And Service Foundation, Inc. | Leukocyte quantitation microfluidic method and device |
US11660571B2 (en) * | 2016-11-18 | 2023-05-30 | The Regents Of The University Of California | Microscale device and method for purification of radiopharmaceuticals |
MX2019007653A (es) * | 2016-12-23 | 2020-07-29 | Selux Diagnostics Inc | Métodos para la optimización de ensayos rápidos de susceptibilidad antimicrobiana. |
CN106770376B (zh) * | 2017-02-15 | 2023-04-07 | 河南师范大学 | 基于射频技术的生物传感器 |
CN110913988B (zh) * | 2017-03-28 | 2022-03-01 | 紫荆实验室公司 | 使用致动的表面附接柱来处理细胞的系统、流体盒及方法 |
CN109012768B (zh) * | 2017-06-09 | 2021-11-19 | 国家纳米科学中心 | 微流控液体单向流动控制结构、芯片及方法 |
US11634676B2 (en) * | 2017-07-18 | 2023-04-25 | President And Fellows Of Harvard College | Intracellular delivery using microfluidics-assisted cell screening (MACS) |
KR102387367B1 (ko) * | 2017-09-01 | 2022-04-14 | 엠쥐아이 테크 컴퍼니 엘티디. | 실리콘 기반 센서와 통합된 사출 성형된 미세유체/유체 카트리지 |
US10344929B1 (en) | 2017-09-01 | 2019-07-09 | Heathco, Llc | Battery backup for lighting system |
US11185830B2 (en) | 2017-09-06 | 2021-11-30 | Waters Technologies Corporation | Fluid mixer |
KR20190035241A (ko) * | 2017-09-26 | 2019-04-03 | 삼성전자주식회사 | 화학 기계적 연마 공정의 온도 제어 방법, 이를 수행하기 위한 온도 제어 유닛, 및 이러한 온도 제어 유닛을 포함하는 화학 기계적 연마 장치 |
US11402376B2 (en) | 2018-03-23 | 2022-08-02 | University Of Wyoming | Methods and devices for detection of biological materials using electric field assisted rapid analyte capture |
US20210031201A1 (en) * | 2018-04-15 | 2021-02-04 | Optofluidic Bioassay, Llc | Differential pressure assisted drainage system |
WO2019209776A1 (fr) | 2018-04-27 | 2019-10-31 | Corning Incorporated | Dispositifs microfluidiques et procédés de fabrication de dispositifs microfluidiques |
JP7374124B2 (ja) | 2018-04-27 | 2023-11-06 | ベクトン・ディキンソン・アンド・カンパニー | フローサイトメトリで選別された試料のための収集システムおよびそれを使用する方法 |
EP3785015B1 (fr) | 2018-04-27 | 2024-06-26 | Becton, Dickinson and Company | Cytomètres en flux comportant des trieurs de gouttelettes incorporés avec teneur d'aérosol contrôlée et procédés d'utilisation de ceux-ci |
WO2019241794A1 (fr) * | 2018-06-16 | 2019-12-19 | Hacker Kevin Jay | Identification et caractérisation de micro-organismes |
CN112805548A (zh) | 2018-10-30 | 2021-05-14 | 贝克顿·迪金森公司 | 具有对准窗口的颗粒分选模块、系统及其使用方法 |
US12007345B2 (en) | 2018-11-20 | 2024-06-11 | Xatek, Inc. | Dielectric spectroscopy sensing apparatus and method of use |
EP3894588A1 (fr) | 2018-12-10 | 2021-10-20 | 10X Genomics, Inc. | Résolution de réseaux spatiaux à l'aide d'une déconvolution |
US11926867B2 (en) | 2019-01-06 | 2024-03-12 | 10X Genomics, Inc. | Generating capture probes for spatial analysis |
US11649485B2 (en) | 2019-01-06 | 2023-05-16 | 10X Genomics, Inc. | Generating capture probes for spatial analysis |
CN110007069B (zh) * | 2019-03-05 | 2022-11-11 | 深圳迎凯生物科技有限公司 | 荧光免疫测试仪 |
GB2582619A (en) * | 2019-03-28 | 2020-09-30 | Sumitomo Chemical Co | Enzyme linked assay methods and apparatuses |
US20220187285A1 (en) * | 2019-05-17 | 2022-06-16 | Hitachi High-Tech Corporation | Automatic Analyzer |
CN110308674A (zh) * | 2019-05-28 | 2019-10-08 | 云南农业大学 | 一种山原红壤中水分渗透规律的测量方法 |
EP3976820A1 (fr) | 2019-05-30 | 2022-04-06 | 10X Genomics, Inc. | Procédés de détection de l'hétérogénéité spatiale d'un échantillon biologique |
US11555805B2 (en) | 2019-08-12 | 2023-01-17 | Waters Technologies Corporation | Mixer for chromatography system |
US11959057B2 (en) | 2019-10-17 | 2024-04-16 | New Jersey Institute Of Technology | Automated addressable microfluidic technology for minimally disruptive manipulation of cells and fluids within living cultures |
EP4025711A2 (fr) | 2019-11-08 | 2022-07-13 | 10X Genomics, Inc. | Amélioration de la spécificité de la liaison d'un analyte |
CN114885610A (zh) | 2019-12-23 | 2022-08-09 | 10X基因组学有限公司 | 使用rna模板化连接进行空间分析的方法 |
US11732299B2 (en) | 2020-01-21 | 2023-08-22 | 10X Genomics, Inc. | Spatial assays with perturbed cells |
US11702693B2 (en) | 2020-01-21 | 2023-07-18 | 10X Genomics, Inc. | Methods for printing cells and generating arrays of barcoded cells |
US11898205B2 (en) | 2020-02-03 | 2024-02-13 | 10X Genomics, Inc. | Increasing capture efficiency of spatial assays |
US11732300B2 (en) | 2020-02-05 | 2023-08-22 | 10X Genomics, Inc. | Increasing efficiency of spatial analysis in a biological sample |
EP4139485B1 (fr) | 2020-04-22 | 2023-09-06 | 10X Genomics, Inc. | Procédés d'analyse spatiale utilisant un appauvrissement d'arn ciblée |
AU2021275906A1 (en) | 2020-05-22 | 2022-12-22 | 10X Genomics, Inc. | Spatial analysis to detect sequence variants |
WO2021236929A1 (fr) | 2020-05-22 | 2021-11-25 | 10X Genomics, Inc. | Mesure spatio-temporelle simultanée de l'expression génique et de l'activité cellulaire |
US12031177B1 (en) | 2020-06-04 | 2024-07-09 | 10X Genomics, Inc. | Methods of enhancing spatial resolution of transcripts |
EP4162074B1 (fr) | 2020-06-08 | 2024-04-24 | 10X Genomics, Inc. | Méthodes de détermination de marge chirurgicale et méthodes d'utilisation associées |
AU2021294334A1 (en) | 2020-06-25 | 2023-02-02 | 10X Genomics, Inc. | Spatial analysis of DNA methylation |
US11981960B1 (en) | 2020-07-06 | 2024-05-14 | 10X Genomics, Inc. | Spatial analysis utilizing degradable hydrogels |
US11761038B1 (en) | 2020-07-06 | 2023-09-19 | 10X Genomics, Inc. | Methods for identifying a location of an RNA in a biological sample |
CN115812146A (zh) | 2020-07-07 | 2023-03-17 | 沃特世科技公司 | 用于流体色谱法降噪的组合式混合器装置 |
EP4179310A1 (fr) | 2020-07-07 | 2023-05-17 | Waters Technologies Corporation | Mélangeur pour chromatographie en phase liquide |
US11981958B1 (en) | 2020-08-20 | 2024-05-14 | 10X Genomics, Inc. | Methods for spatial analysis using DNA capture |
KR20230062842A (ko) | 2020-09-08 | 2023-05-09 | 썬플라워 테라퓨틱스, 피비씨 | 유체 이송 및 분배 매니폴드 |
WO2022066752A1 (fr) | 2020-09-22 | 2022-03-31 | Waters Technologies Corporation | Mélangeur à écoulement continu |
US11926822B1 (en) | 2020-09-23 | 2024-03-12 | 10X Genomics, Inc. | Three-dimensional spatial analysis |
US11872357B2 (en) | 2020-11-09 | 2024-01-16 | Agile Devices, Inc. | Devices for steering catheters |
US11827935B1 (en) | 2020-11-19 | 2023-11-28 | 10X Genomics, Inc. | Methods for spatial analysis using rolling circle amplification and detection probes |
EP4121555A1 (fr) | 2020-12-21 | 2023-01-25 | 10X Genomics, Inc. | Procédés, compositions et systèmes pour capturer des sondes et/ou des codes à barres |
WO2023034489A1 (fr) | 2021-09-01 | 2023-03-09 | 10X Genomics, Inc. | Procédés, compositions et kits pour bloquer une sonde de capture sur un réseau spatial |
DE102022111381A1 (de) | 2022-03-09 | 2023-09-14 | Hnp Mikrosysteme Gmbh | Fluidisches Element, fluidisches System und Verfahren zum Betreiben eines fluidischen Systems |
CN115445680B (zh) * | 2022-11-11 | 2023-03-24 | 杭州毫厘科技有限公司 | 微流控阀门及微流控装置 |
Family Cites Families (279)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL6711928A (fr) † | 1967-08-30 | 1969-03-04 | ||
US3570515A (en) | 1969-06-19 | 1971-03-16 | Foxboro Co | Aminar stream cross-flow fluid diffusion logic gate |
NL7102074A (fr) | 1971-02-17 | 1972-08-21 | ||
US4022876A (en) | 1973-06-21 | 1977-05-10 | Stanford Research Institute | Mass spectrometric immunoassay |
FR2287606A1 (fr) | 1974-10-08 | 1976-05-07 | Pegourie Jean Pierre | Circuits logiques pneumatiques et leurs circuits integres |
JPS5941169B2 (ja) | 1975-12-25 | 1984-10-05 | シチズン時計株式会社 | エラストマ−ヒヨウジソウチ |
US4119120A (en) † | 1976-11-29 | 1978-10-10 | Beckman Instruments, Inc. | Fluid switch |
US4153855A (en) | 1977-12-16 | 1979-05-08 | The United States Of America As Represented By The Secretary Of The Army | Method of making a plate having a pattern of microchannels |
US4245673A (en) | 1978-03-01 | 1981-01-20 | La Telemechanique Electrique | Pneumatic logic circuit |
US4344064A (en) | 1979-12-06 | 1982-08-10 | Western Electric Co., Inc. | Article carrying a distinctive mark |
US4434704A (en) | 1980-04-14 | 1984-03-06 | Halliburton Company | Hydraulic digital stepper actuator |
FR2504010B1 (fr) | 1981-04-15 | 1985-10-25 | Sanofi Sa | Medicaments anticancereux contenant la chaine a de la ricine associee a un anticorps antimelanome et procede pour leur preparation |
US4454233A (en) | 1981-10-21 | 1984-06-12 | Wang Associates | Method of tagged immunoassay |
US4671958A (en) | 1982-03-09 | 1987-06-09 | Cytogen Corporation | Antibody conjugates for the delivery of compounds to target sites |
US4589071A (en) | 1982-04-19 | 1986-05-13 | Nissan Motor Co., Ltd. | Method and apparatus for controlling reduction ratio of continuously variable transmission with acceleration compensation |
IL68507A (en) * | 1982-05-10 | 1986-01-31 | Univ Bar Ilan | System and methods for cell selection |
US4707237A (en) | 1982-09-09 | 1987-11-17 | Ciba Corning Diagnostics Corp. | System for identification of cells by electrophoresis |
US4479762A (en) † | 1982-12-28 | 1984-10-30 | Baxter Travenol Laboratories, Inc. | Prepackaged fluid processing module having pump and valve elements operable in response to applied pressures |
US4568649A (en) | 1983-02-22 | 1986-02-04 | Immunex Corporation | Immediate ligand detection assay |
US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
US4581624A (en) | 1984-03-01 | 1986-04-08 | Allied Corporation | Microminiature semiconductor valve |
US4542225A (en) | 1984-08-29 | 1985-09-17 | Dana-Farber Cancer Institute, Inc. | Acid-cleavable compound |
US4659839A (en) | 1984-10-10 | 1987-04-21 | Mallinckrodt, Inc. | Coupling agents for radiolabeled antibody fragments |
EP0188256B1 (fr) | 1985-01-14 | 1991-08-21 | NeoRx | Protéines marquées par un radionuclide d'un métal pour diagnostic et thérapie |
US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
US4680338A (en) | 1985-10-17 | 1987-07-14 | Immunomedics, Inc. | Bifunctional linker |
US4669784A (en) | 1986-02-24 | 1987-06-02 | Palmer Grasse | Oscillated head and connecting element, with bearing support, for floor stripping machine |
US5088515A (en) | 1989-05-01 | 1992-02-18 | Kamen Dean L | Valve system with removable fluid interface |
US4948564A (en) * | 1986-10-28 | 1990-08-14 | Costar Corporation | Multi-well filter strip and composite assemblies |
EP0314469B1 (fr) | 1987-10-27 | 1993-06-23 | Fujitsu Limited | Procédé et appareil de préparation d'un monocrystal de biopolymères |
US5032720A (en) | 1988-04-21 | 1991-07-16 | White John G | Confocal imaging system |
EP0424465B1 (fr) | 1988-07-08 | 1997-10-29 | Jbl Scientific, Inc. | Preparation et utilisation de derives de benzothiazole fluorescents |
DE68929553T2 (de) | 1988-07-13 | 2009-01-29 | Optiscan Pty. Ltd., Toorak | Konfokales Rastermikroskop |
US4898582A (en) | 1988-08-09 | 1990-02-06 | Pharmetrix Corporation | Portable infusion device assembly |
SE462408B (sv) † | 1988-11-10 | 1990-06-18 | Pharmacia Ab | Optiskt biosensorsystem utnyttjande ytplasmonresonans foer detektering av en specific biomolekyl, saett att kalibrera sensoranordningen samt saett att korrigera foer baslinjedrift i systemet |
US5004744A (en) * | 1988-12-13 | 1991-04-02 | Bayer Aktiengesellschaft | Pyridazinones as pesticides |
US5856092A (en) | 1989-02-13 | 1999-01-05 | Geneco Pty Ltd | Detection of a nucleic acid sequence or a change therein |
US5162946A (en) | 1989-03-07 | 1992-11-10 | Ricoh Company, Ltd. | Zoom viewfinder |
US4992312A (en) | 1989-03-13 | 1991-02-12 | Dow Corning Wright Corporation | Methods of forming permeation-resistant, silicone elastomer-containing composite laminates and devices produced thereby |
CH679555A5 (fr) | 1989-04-11 | 1992-03-13 | Westonbridge Int Ltd | |
US5143854A (en) | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
US5007309A (en) * | 1989-06-08 | 1991-04-16 | Rockwell International Corporation | Automatic transmission control system and method of operation |
JPH04501449A (ja) | 1989-06-14 | 1992-03-12 | ウエストンブリッジ インターナショナル リミティド | マイクロポンプ |
KR910012538A (ko) | 1989-12-27 | 1991-08-08 | 야마무라 가쯔미 | 마이크로 펌프 및 그 제조 방법 |
US5091652A (en) | 1990-01-12 | 1992-02-25 | The Regents Of The University Of California | Laser excited confocal microscope fluorescence scanner and method |
US6013431A (en) | 1990-02-16 | 2000-01-11 | Molecular Tool, Inc. | Method for determining specific nucleotide variations by primer extension in the presence of mixture of labeled nucleotides and terminators |
DE4006152A1 (de) | 1990-02-27 | 1991-08-29 | Fraunhofer Ges Forschung | Mikrominiaturisierte pumpe |
US5770029A (en) | 1996-07-30 | 1998-06-23 | Soane Biosciences | Integrated electrophoretic microdevices |
US5096388A (en) | 1990-03-22 | 1992-03-17 | The Charles Stark Draper Laboratory, Inc. | Microfabricated pump |
US5530100A (en) * | 1990-05-07 | 1996-06-25 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Methods for purification of recombinantly produced proteins |
SE470347B (sv) | 1990-05-10 | 1994-01-31 | Pharmacia Lkb Biotech | Mikrostruktur för vätskeflödessystem och förfarande för tillverkning av ett sådant system |
EP0465229B1 (fr) | 1990-07-02 | 1994-12-28 | Seiko Epson Corporation | Micropompe et son procédé de fabrication |
GB2276169A (en) | 1990-07-05 | 1994-09-21 | Celltech Ltd | Antibodies specific for carcinoembryonic antigen |
GB9015793D0 (en) | 1990-07-18 | 1990-09-05 | Medical Res Council | Confocal scanning optical microscope |
US5401629A (en) | 1990-08-07 | 1995-03-28 | The Salk Institute Biotechnology/Industrial Associates, Inc. | Assay methods and compositions useful for measuring the transduction of an intracellular signal |
US5846710A (en) | 1990-11-02 | 1998-12-08 | St. Louis University | Method for the detection of genetic diseases and gene sequence variations by single nucleotide primer extension |
US6004744A (en) | 1991-03-05 | 1999-12-21 | Molecular Tool, Inc. | Method for determining nucleotide identity through extension of immobilized primer |
US5888819A (en) | 1991-03-05 | 1999-03-30 | Molecular Tool, Inc. | Method for determining nucleotide identity through primer extension |
WO1992016657A1 (fr) | 1991-03-13 | 1992-10-01 | E.I. Du Pont De Nemours And Company | Procede d'identification d'un nucleotide present dans un acide nucleique en une position definie |
US5260578A (en) | 1991-04-10 | 1993-11-09 | Mayo Foundation For Medical Education And Research | Confocal imaging system for visible and ultraviolet light |
US5164558A (en) | 1991-07-05 | 1992-11-17 | Massachusetts Institute Of Technology | Micromachined threshold pressure switch and method of manufacture |
JP3328300B2 (ja) | 1991-07-18 | 2002-09-24 | アイシン精機株式会社 | 流体制御装置 |
CA2113716A1 (fr) | 1991-07-19 | 1993-02-04 | Robert E. Wagner, Jr. | Methode de detection de mutations |
US5162941A (en) | 1991-07-23 | 1992-11-10 | The Board Of Governors Of Wayne State University | Confocal microscope |
US5168946A (en) | 1991-09-09 | 1992-12-08 | General Electric Company | Track-laying vehicle electric drive system |
DE4135655A1 (de) | 1991-09-11 | 1993-03-18 | Fraunhofer Ges Forschung | Mikrominiaturisierte, elektrostatisch betriebene membranpumpe |
US5265327A (en) | 1991-09-13 | 1993-11-30 | Faris Sadeg M | Microchannel plate technology |
DE69217497T2 (de) | 1991-09-18 | 1997-06-12 | Affymax Tech Nv | Verfahren zur synthese der verschiedenen sammlungen von oligomeren |
FR2684162B1 (fr) † | 1991-11-27 | 1994-04-15 | Ysebaert | Clapet a membrane elastique. |
IT1255014B (it) † | 1992-03-27 | 1995-10-13 | Instrumentation Lab Spa | Dispositivi di movimentazione ed intercettazione di fluidi |
US5726026A (en) | 1992-05-01 | 1998-03-10 | Trustees Of The University Of Pennsylvania | Mesoscale sample preparation device and systems for determination and processing of analytes |
US5304487A (en) | 1992-05-01 | 1994-04-19 | Trustees Of The University Of Pennsylvania | Fluid handling in mesoscale analytical devices |
US5981176A (en) | 1992-06-17 | 1999-11-09 | City Of Hope | Method of detecting and discriminating between nucleic acid sequences |
DE4220077A1 (de) | 1992-06-19 | 1993-12-23 | Bosch Gmbh Robert | Mikropumpe |
US5710028A (en) | 1992-07-02 | 1998-01-20 | Eyal; Nurit | Method of quick screening and identification of specific DNA sequences by single nucleotide primer extension and kits therefor |
US5284568A (en) | 1992-07-17 | 1994-02-08 | E. I. Du Pont De Nemours And Company | Disposable cartridge for ion selective electrode sensors |
US5639423A (en) | 1992-08-31 | 1997-06-17 | The Regents Of The University Of Calfornia | Microfabricated reactor |
US5364742A (en) | 1992-09-21 | 1994-11-15 | International Business Machines Corporation | Micro-miniature structures and method of fabrication thereof |
CA2143848C (fr) | 1992-10-01 | 2007-09-11 | W. Clark Still | Chimie combinatoire complexe, avec encodage a l'aide de descripteurs |
JP2812629B2 (ja) | 1992-11-25 | 1998-10-22 | 宇宙開発事業団 | 結晶成長セル |
US5290240A (en) | 1993-02-03 | 1994-03-01 | Pharmetrix Corporation | Electrochemical controlled dispensing assembly and method for selective and controlled delivery of a dispensing fluid |
WO1994026413A1 (fr) * | 1993-05-17 | 1994-11-24 | Amersham International Plc | Dispositifs et procedes permettant de mesurer des processus cellulaires biochimiques |
US5400741A (en) | 1993-05-21 | 1995-03-28 | Medical Foundation Of Buffalo, Inc. | Device for growing crystals |
DE59403742D1 (de) | 1993-05-27 | 1997-09-18 | Fraunhofer Ges Forschung | Mikroventil |
SE501713C2 (sv) | 1993-09-06 | 1995-05-02 | Pharmacia Biosensor Ab | Ventil av membrantyp, speciellt för vätskehanteringsblock med mikroflödeskanaler |
US5642015A (en) | 1993-07-14 | 1997-06-24 | The University Of British Columbia | Elastomeric micro electro mechanical systems |
US5565215A (en) | 1993-07-23 | 1996-10-15 | Massachusettes Institute Of Technology | Biodegradable injectable particles for imaging |
US5543158A (en) | 1993-07-23 | 1996-08-06 | Massachusetts Institute Of Technology | Biodegradable injectable nanoparticles |
US5659171A (en) | 1993-09-22 | 1997-08-19 | Northrop Grumman Corporation | Micro-miniature diaphragm pump for the low pressure pumping of gases |
JPH09508353A (ja) | 1993-11-02 | 1997-08-26 | アフィマックス テクノロジーズ ナムローゼ フェンノートシャップ | 分子多様性の合成及びスクリーニング |
CH689836A5 (fr) | 1994-01-14 | 1999-12-15 | Westonbridge Int Ltd | Micropompe. |
US5525490A (en) | 1994-03-29 | 1996-06-11 | Onyx Pharmaceuticals, Inc. | Reverse two-hybrid method |
US5547861A (en) | 1994-04-18 | 1996-08-20 | Becton, Dickinson And Company | Detection of nucleic acid amplification |
EP0758313A4 (fr) | 1994-05-06 | 1999-09-15 | Pharmacopeia Inc | Bibliotheque combinatoire de dihydrobenzopyranes |
US5663046A (en) | 1994-06-22 | 1997-09-02 | Pharmacopeia, Inc. | Synthesis of combinatorial libraries |
ATE193294T1 (de) | 1994-07-25 | 2000-06-15 | Roche Diagnostics Gmbh | Metallkomplexe mit geladenem linker |
US6001229A (en) | 1994-08-01 | 1999-12-14 | Lockheed Martin Energy Systems, Inc. | Apparatus and method for performing microfluidic manipulations for chemical analysis |
DE4433894A1 (de) | 1994-09-22 | 1996-03-28 | Fraunhofer Ges Forschung | Verfahren und Vorrichtung zur Ansteuerung einer Mikropumpe |
DE69531430T2 (de) | 1994-10-07 | 2004-07-01 | Bayer Corp. | Entlastungsventil |
US5695934A (en) | 1994-10-13 | 1997-12-09 | Lynx Therapeutics, Inc. | Massively parallel sequencing of sorted polynucleotides |
US5788468A (en) | 1994-11-03 | 1998-08-04 | Memstek Products, Llc | Microfabricated fluidic devices |
JP3398749B2 (ja) | 1994-11-10 | 2003-04-21 | オーキッド バイオ サイエンシズ, インコーポレイテッド | 液体分配システム |
US5593290A (en) † | 1994-12-22 | 1997-01-14 | Eastman Kodak Company | Micro dispensing positive displacement pump |
WO1996027025A1 (fr) | 1995-02-27 | 1996-09-06 | Ely Michael Rabani | Dispositif, composes, algorithmes, et procedes de caracterisation et manipulation avec parallelisme moleculaire |
JP3094880B2 (ja) | 1995-03-01 | 2000-10-03 | 住友金属工業株式会社 | 有機化合物の結晶化制御方法およびそれに用いる結晶化制御用固体素子 |
US5775371A (en) | 1995-03-08 | 1998-07-07 | Abbott Laboratories | Valve control |
US5876187A (en) | 1995-03-09 | 1999-03-02 | University Of Washington | Micropumps with fixed valves |
US6227809B1 (en) | 1995-03-09 | 2001-05-08 | University Of Washington | Method for making micropumps |
US5757482A (en) † | 1995-04-20 | 1998-05-26 | Perseptive Biosystems, Inc. | Module for optical detection in microscale fluidic analyses |
US5976822A (en) | 1995-05-18 | 1999-11-02 | Coulter International Corp. | Method and reagent for monitoring apoptosis and distinguishing apoptosis from necrosis |
US5856174A (en) | 1995-06-29 | 1999-01-05 | Affymetrix, Inc. | Integrated nucleic acid diagnostic device |
CA2183478C (fr) | 1995-08-17 | 2004-02-24 | Stephen A. Carter | Systeme numerique de gazometrie a l'aide de solenoides bistables et tristables |
US6130098A (en) | 1995-09-15 | 2000-10-10 | The Regents Of The University Of Michigan | Moving microdroplets |
US6132580A (en) | 1995-09-28 | 2000-10-17 | The Regents Of The University Of California | Miniature reaction chamber and devices incorporating same |
US5958344A (en) | 1995-11-09 | 1999-09-28 | Sarnoff Corporation | System for liquid distribution |
US5705018A (en) | 1995-12-13 | 1998-01-06 | Hartley; Frank T. | Micromachined peristaltic pump |
KR100207410B1 (ko) | 1995-12-19 | 1999-07-15 | 전주범 | 광로 조절 장치의 제조방법 |
US5863502A (en) * | 1996-01-24 | 1999-01-26 | Sarnoff Corporation | Parallel reaction cassette and associated devices |
US6803188B1 (en) | 1996-01-31 | 2004-10-12 | The Regents Of The University Of California | Tandem fluorescent protein constructs |
US5660370A (en) | 1996-03-07 | 1997-08-26 | Integrated Fludics, Inc. | Valve with flexible sheet member and two port non-flexing backer member |
US5942443A (en) | 1996-06-28 | 1999-08-24 | Caliper Technologies Corporation | High throughput screening assay systems in microscale fluidic devices |
US5867266A (en) | 1996-04-17 | 1999-02-02 | Cornell Research Foundation, Inc. | Multiple optical channels for chemical analysis |
US6177266B1 (en) | 1996-04-29 | 2001-01-23 | The United States Of America As Represented By The Secretary Of The Army | Rapid identification of bacteria by mass spectrometry |
FR2749663B1 (fr) | 1996-06-07 | 1998-07-31 | Bio Merieux | Carte d'analyse a usage unique comprenant un conduit d'ecoul ement de liquides |
WO1998000231A1 (fr) | 1996-06-28 | 1998-01-08 | Caliper Technologies Corporation | Systeme de dosage de criblage a fort rendement dans des dispositifs microscopiques de transfert de fluides |
WO1998002601A1 (fr) | 1996-07-15 | 1998-01-22 | Sumitomo Metal Industries, Ltd. | Equipement de croissance de cristaux et procede pour la croissance de cristaux utilisant cet equipement |
EP0956364A1 (fr) | 1996-07-26 | 1999-11-17 | Genzyme Corporation | Dosage cellulaire total |
WO1998005060A1 (fr) | 1996-07-31 | 1998-02-05 | The Board Of Trustees Of The Leland Stanford Junior University | Module multizone a cycles thermiques de cuisson/refroidissement brusque |
US6136212A (en) | 1996-08-12 | 2000-10-24 | The Regents Of The University Of Michigan | Polymer-based micromachining for microfluidic devices |
US6124128A (en) | 1996-08-16 | 2000-09-26 | The Regents Of The University Of California | Long wavelength engineered fluorescent proteins |
US5832165A (en) | 1996-08-28 | 1998-11-03 | University Of Utah Research Foundation | Composite waveguide for solid phase binding assays |
US5738799A (en) | 1996-09-12 | 1998-04-14 | Xerox Corporation | Method and materials for fabricating an ink-jet printhead |
US6221654B1 (en) | 1996-09-25 | 2001-04-24 | California Institute Of Technology | Method and apparatus for analysis and sorting of polynucleotides based on size |
US5971355A (en) | 1996-11-27 | 1999-10-26 | Xerox Corporation | Microdevice valve structures to fluid control |
EP1009802B1 (fr) | 1997-02-12 | 2004-08-11 | Eugene Y. Chan | PROCEDES d ANALYSE DES POLYMERES |
JP2001521622A (ja) | 1997-04-04 | 2001-11-06 | カリパー テクノロジーズ コーポレイション | 閉ループ生化学分析器 |
US6235471B1 (en) * | 1997-04-04 | 2001-05-22 | Caliper Technologies Corp. | Closed-loop biochemical analyzers |
US5910287A (en) * | 1997-06-03 | 1999-06-08 | Aurora Biosciences Corporation | Low background multi-well plates with greater than 864 wells for fluorescence measurements of biological and biochemical samples |
US6229603B1 (en) * | 1997-06-02 | 2001-05-08 | Aurora Biosciences Corporation | Low background multi-well plates with greater than 864 wells for spectroscopic measurements |
US6171780B1 (en) * | 1997-06-02 | 2001-01-09 | Aurora Biosciences Corporation | Low fluorescence assay platforms and related methods for drug discovery |
US5876946A (en) | 1997-06-03 | 1999-03-02 | Pharmacopeia, Inc. | High-throughput assay |
US5922604A (en) | 1997-06-05 | 1999-07-13 | Gene Tec Corporation | Thin reaction chambers for containing and handling liquid microvolumes |
US5869004A (en) | 1997-06-09 | 1999-02-09 | Caliper Technologies Corp. | Methods and apparatus for in situ concentration and/or dilution of materials in microfluidic systems |
US5888778A (en) | 1997-06-16 | 1999-03-30 | Exact Laboratories, Inc. | High-throughput screening method for identification of genetic mutations or disease-causing microorganisms using segmented primers |
AU8275998A (en) | 1997-06-27 | 1999-01-19 | Immunetics, Inc. | Rapid flow-through binding assay apparatus and method |
AU8492998A (en) | 1997-07-16 | 1999-02-10 | Diversified Scientific, Inc. | Method for acquiring, storing and analyzing crystal images |
US5932799A (en) * | 1997-07-21 | 1999-08-03 | Ysi Incorporated | Microfluidic analyzer module |
US6073482A (en) | 1997-07-21 | 2000-06-13 | Ysi Incorporated | Fluid flow module |
US5972639A (en) | 1997-07-24 | 1999-10-26 | Irori | Fluorescence-based assays for measuring cell proliferation |
US5876675A (en) | 1997-08-05 | 1999-03-02 | Caliper Technologies Corp. | Microfluidic devices and systems |
JP2001516573A (ja) | 1997-09-18 | 2001-10-02 | スミスクライン・ビーチャム・コーポレイション | 抗微生物化合物のスクリーニング方法 |
TW352471B (en) | 1997-09-20 | 1999-02-11 | United Microelectronics Corp | Method for preventing B-P-Si glass from subsiding |
US6833242B2 (en) | 1997-09-23 | 2004-12-21 | California Institute Of Technology | Methods for detecting and sorting polynucleotides based on size |
US7214298B2 (en) | 1997-09-23 | 2007-05-08 | California Institute Of Technology | Microfabricated cell sorter |
US6540895B1 (en) * | 1997-09-23 | 2003-04-01 | California Institute Of Technology | Microfabricated cell sorter for chemical and biological materials |
AU9673198A (en) | 1997-10-02 | 1999-04-27 | Aclara Biosciences, Inc. | Capillary assays involving separation of free and bound species |
US5842787A (en) | 1997-10-09 | 1998-12-01 | Caliper Technologies Corporation | Microfluidic systems incorporating varied channel dimensions |
US5836750A (en) | 1997-10-09 | 1998-11-17 | Honeywell Inc. | Electrostatically actuated mesopump having a plurality of elementary cells |
US5958694A (en) | 1997-10-16 | 1999-09-28 | Caliper Technologies Corp. | Apparatus and methods for sequencing nucleic acids in microfluidic systems |
AU1522299A (en) | 1997-11-12 | 1999-05-31 | California Institute Of Technology | Micromachined parylene membrane valve and pump |
US6174675B1 (en) | 1997-11-25 | 2001-01-16 | Caliper Technologies Corp. | Electrical current for controlling fluid parameters in microchannels |
DE69936255T2 (de) | 1998-01-20 | 2008-02-07 | Invensys Systems, Inc., Foxboro | Elektromagnet- vorrichtung mit zwei von drei elektromagneten die immer betätigt sind |
US6167910B1 (en) | 1998-01-20 | 2001-01-02 | Caliper Technologies Corp. | Multi-layer microfluidic devices |
WO1999041015A1 (fr) | 1998-02-11 | 1999-08-19 | Institut für Physikalische Hochtechnologie e.V. | Reacteur a flux miniaturise comportant differentes zones de temperatures |
US6018616A (en) | 1998-02-23 | 2000-01-25 | Applied Materials, Inc. | Thermal cycling module and process using radiant heat |
US6388788B1 (en) * | 1998-03-16 | 2002-05-14 | Praelux, Inc. | Method and apparatus for screening chemical compounds |
AU3491299A (en) | 1998-04-14 | 1999-11-01 | Lumenal Technologies, L.P. | Test cartridge with a single inlet port |
JP2002528699A (ja) | 1998-05-22 | 2002-09-03 | カリフォルニア インスティチュート オブ テクノロジー | 微細製作細胞分類器 |
JPH11352409A (ja) | 1998-06-05 | 1999-12-24 | Olympus Optical Co Ltd | 蛍光検出装置 |
AU747464B2 (en) † | 1998-06-08 | 2002-05-16 | Caliper Technologies Corporation | Microfluidic devices, systems and methods for performing integrated reactions and separations |
WO2000000678A1 (fr) | 1998-06-26 | 2000-01-06 | University Of Washington | Milieux de cristallisation |
US6132685A (en) | 1998-08-10 | 2000-10-17 | Caliper Technologies Corporation | High throughput microfluidic systems and methods |
US6146842A (en) | 1998-09-21 | 2000-11-14 | Mitotix, Inc. | High-throughput screening assays utilizing metal-chelate capture |
DE19843509A1 (de) | 1998-09-23 | 2000-06-21 | Fuhrmann Stephan | Einrichtung zur Menüsteuerung |
US20030044776A1 (en) | 1998-09-25 | 2003-03-06 | James A. Dykens | Compositions and methods for identifying agents that alter mitochondrial permeability transition pores |
US6086740A (en) † | 1998-10-29 | 2000-07-11 | Caliper Technologies Corp. | Multiplexed microfluidic devices and systems |
RU2143343C1 (ru) | 1998-11-03 | 1999-12-27 | Самсунг Электроникс Ко., Лтд. | Микроинжектор и способ изготовления микроинжектора |
US6958865B1 (en) | 1998-11-12 | 2005-10-25 | California Institute Of Technology | Microlicensing particles and applications |
US6062261A (en) | 1998-12-16 | 2000-05-16 | Lockheed Martin Energy Research Corporation | MicrofluIdic circuit designs for performing electrokinetic manipulations that reduce the number of voltage sources and fluid reservoirs |
US6361671B1 (en) * | 1999-01-11 | 2002-03-26 | The Regents Of The University Of California | Microfabricated capillary electrophoresis chip and method for simultaneously detecting multiple redox labels |
US6150119A (en) | 1999-01-19 | 2000-11-21 | Caliper Technologies Corp. | Optimized high-throughput analytical system |
US6171850B1 (en) | 1999-03-08 | 2001-01-09 | Caliper Technologies Corp. | Integrated devices and systems for performing temperature controlled reactions and analyses |
AU2900400A (en) | 1999-03-08 | 2000-09-28 | Merck Frosst Canada & Co. | Intact cell assay for protein tyrosine phosphatases |
AU3769000A (en) * | 1999-03-22 | 2000-10-09 | Pangene Corporation | High-throughput gene cloning and phenotypic screening |
DE60034033T2 (de) | 1999-04-06 | 2007-12-06 | University of Alabama, Birmingham Research Foundation, Birmingham | Vorrichtung zum screening von kristallisierungsbedingungen in lösungen zur kristallzüchtung |
US6346373B1 (en) | 1999-05-05 | 2002-02-12 | Merck Frosst Canada & Co., | Whole cell assay for cathepsin K activity |
GB9911095D0 (en) | 1999-05-13 | 1999-07-14 | Secr Defence | Microbiological test method and reagents |
US6225109B1 (en) | 1999-05-27 | 2001-05-01 | Orchid Biosciences, Inc. | Genetic analysis device |
US6296673B1 (en) | 1999-06-18 | 2001-10-02 | The Regents Of The University Of California | Methods and apparatus for performing array microcrystallizations |
CA2721172C (fr) | 1999-06-28 | 2012-04-10 | California Institute Of Technology | Obturateur elastomere micro-usine et systemes de pompe |
US7144616B1 (en) | 1999-06-28 | 2006-12-05 | California Institute Of Technology | Microfabricated elastomeric valve and pump systems |
US6899137B2 (en) | 1999-06-28 | 2005-05-31 | California Institute Of Technology | Microfabricated elastomeric valve and pump systems |
US7306672B2 (en) | 2001-04-06 | 2007-12-11 | California Institute Of Technology | Microfluidic free interface diffusion techniques |
US7459022B2 (en) | 2001-04-06 | 2008-12-02 | California Institute Of Technology | Microfluidic protein crystallography |
WO2001007061A1 (fr) | 1999-07-27 | 2001-02-01 | Smithkline Beecham Corporation | Dosage de cellules entieres |
US6977145B2 (en) * | 1999-07-28 | 2005-12-20 | Serono Genetics Institute S.A. | Method for carrying out a biochemical protocol in continuous flow in a microreactor |
WO2001009595A2 (fr) | 1999-08-02 | 2001-02-08 | Emerald Biostructures, Inc. | Procede et systeme de creation d'une base de donnees de resultats de cristallisation |
GB9923324D0 (en) | 1999-10-01 | 1999-12-08 | Pyrosequencing Ab | Separation apparatus and method |
DE29917313U1 (de) | 1999-10-01 | 2001-02-15 | Mwg Biotech Ag | Vorrichtung zur Durchführung chemischer oder biologischer Reaktionen |
AU7867600A (en) | 1999-10-08 | 2001-04-23 | General Hospital Corporation, The | Methods and apparatus for cell analysis |
WO2001032930A1 (fr) | 1999-11-04 | 2001-05-10 | California Institute Of Technology | Methodes et dispositifs permettant d'analyser des sequences polynucleotidiques |
AU2001240040A1 (en) | 2000-03-03 | 2001-09-17 | California Institute Of Technology | Combinatorial array for nucleic acid analysis |
EP1285106A2 (fr) * | 2000-03-31 | 2003-02-26 | Micronics, Inc. | Cristallisation de proteines dans des structures microfluidiques |
US20050118073A1 (en) | 2003-11-26 | 2005-06-02 | Fluidigm Corporation | Devices and methods for holding microfluidic devices |
US7867763B2 (en) | 2004-01-25 | 2011-01-11 | Fluidigm Corporation | Integrated chip carriers with thermocycler interfaces and methods of using the same |
AU2001259786A1 (en) * | 2000-05-15 | 2001-11-26 | Tecan Boston | Bidirectional flow centrifugal microfluidic devices |
US7351376B1 (en) * | 2000-06-05 | 2008-04-01 | California Institute Of Technology | Integrated active flux microfluidic devices and methods |
WO2002000343A2 (fr) | 2000-06-27 | 2002-01-03 | Fluidigm Corporation | Procede et systeme d'automatisation de conception de systemes microfluidiques |
US6885982B2 (en) * | 2000-06-27 | 2005-04-26 | Fluidigm Corporation | Object oriented microfluidic design method and system |
US6301055B1 (en) * | 2000-08-16 | 2001-10-09 | California Institute Of Technology | Solid immersion lens structures and methods for producing solid immersion lens structures |
US6902702B1 (en) * | 2000-08-16 | 2005-06-07 | University Health Network | Devices and methods for producing microarrays of biological samples |
AU2001290879A1 (en) | 2000-09-15 | 2002-03-26 | California Institute Of Technology | Microfabricated crossflow devices and methods |
CA2422762A1 (fr) * | 2000-09-18 | 2002-03-21 | President And Fellows Of Harvard College | Traitement differentiel de parties choisies d'une seule cellule comprenant differents composants fluidiques |
WO2002029106A2 (fr) | 2000-10-03 | 2002-04-11 | California Institute Of Technology | Dispositifs microfluidiques et procedes d'utilisation |
US7097809B2 (en) | 2000-10-03 | 2006-08-29 | California Institute Of Technology | Combinatorial synthesis system |
US7678547B2 (en) * | 2000-10-03 | 2010-03-16 | California Institute Of Technology | Velocity independent analyte characterization |
US6827095B2 (en) * | 2000-10-12 | 2004-12-07 | Nanostream, Inc. | Modular microfluidic systems |
WO2002030486A2 (fr) | 2000-10-13 | 2002-04-18 | Fluidigm Corporation | Systeme d'injection d'echantillons utilisant un dispositif microfluidique, pour dispositifs d'analyse |
DE60103924T2 (de) * | 2000-11-06 | 2005-07-14 | Nanostream, Inc., Pasadena | Mikrofluidische durchflussregelvorrichtung |
WO2002065005A1 (fr) | 2000-11-06 | 2002-08-22 | California Institute Of Technology | Valves electrostatiques pour dispositifs microfluidiques |
US6951632B2 (en) | 2000-11-16 | 2005-10-04 | Fluidigm Corporation | Microfluidic devices for introducing and dispensing fluids from microfluidic systems |
WO2002040874A1 (fr) * | 2000-11-16 | 2002-05-23 | California Institute Of Technology | Appareil et procedes pour effectuer des dosages et des criblages a haut rendement |
US7135296B2 (en) | 2000-12-28 | 2006-11-14 | Mds Inc. | Elemental analysis of tagged biologically active materials |
JP2004523243A (ja) | 2001-03-12 | 2004-08-05 | カリフォルニア インスティチュート オブ テクノロジー | 非同期性塩基伸長によってポリヌクレオチド配列を分析するための方法および装置 |
EP1385692B1 (fr) * | 2001-04-06 | 2011-03-02 | Fluidigm Corporation | Modification de surface polymere |
US6802342B2 (en) | 2001-04-06 | 2004-10-12 | Fluidigm Corporation | Microfabricated fluidic circuit elements and applications |
US6752922B2 (en) * | 2001-04-06 | 2004-06-22 | Fluidigm Corporation | Microfluidic chromatography |
EP1384022A4 (fr) | 2001-04-06 | 2004-08-04 | California Inst Of Techn | Amplification d'acide nucleique au moyen de dispositifs microfluidiques |
US7075162B2 (en) | 2001-08-30 | 2006-07-11 | Fluidigm Corporation | Electrostatic/electrostrictive actuation of elastomer structures using compliant electrodes |
US6841096B2 (en) | 2001-10-08 | 2005-01-11 | California Institute Of Technology | Microfabricated lenses, methods of manufacture thereof, and applications therefor |
US7192629B2 (en) * | 2001-10-11 | 2007-03-20 | California Institute Of Technology | Devices utilizing self-assembled gel and method of manufacture |
US7691333B2 (en) * | 2001-11-30 | 2010-04-06 | Fluidigm Corporation | Microfluidic device and methods of using same |
WO2003048295A1 (fr) | 2001-11-30 | 2003-06-12 | Fluidigm Corporation | Dispositif microfluidique et procedes d'utilisation de ce dernier |
WO2003085379A2 (fr) * | 2002-04-01 | 2003-10-16 | Fluidigm Corporation | Systemes d'analyse de particules microfluidiques |
US7059348B2 (en) * | 2002-05-13 | 2006-06-13 | Fluidigm Corporation | Drug delivery system |
US20060086309A1 (en) | 2002-06-24 | 2006-04-27 | Fluiding Corporation | Recirculating fluidic network and methods for using the same |
AU2003282875A1 (en) * | 2002-09-25 | 2004-04-19 | California Institute Of Technology | Microfluidic large scale integration |
WO2004040001A2 (fr) * | 2002-10-02 | 2004-05-13 | California Institute Of Technology | Analyse microfluidique d'acides nucleiques |
GB0302302D0 (en) | 2003-01-31 | 2003-03-05 | Glaxo Group Ltd | Microfluidic apparatus and method |
US8828663B2 (en) | 2005-03-18 | 2014-09-09 | Fluidigm Corporation | Thermal reaction device and method for using the same |
WO2004089810A2 (fr) | 2003-04-03 | 2004-10-21 | Fluidigm Corp. | Dispositifs microfluidiques et leurs procedes d'utilisation |
US20050145496A1 (en) | 2003-04-03 | 2005-07-07 | Federico Goodsaid | Thermal reaction device and method for using the same |
US7476363B2 (en) * | 2003-04-03 | 2009-01-13 | Fluidigm Corporation | Microfluidic devices and methods of using same |
US7604965B2 (en) | 2003-04-03 | 2009-10-20 | Fluidigm Corporation | Thermal reaction device and method for using the same |
WO2004094020A2 (fr) | 2003-04-17 | 2004-11-04 | Fluidigm Corporation | Dispositifs et systemes de cristallogenese et methodes d'utilisation de ceux-ci |
CA2526368A1 (fr) | 2003-05-20 | 2004-12-02 | Fluidigm Corporation | Procede et systeme pour dispositif microfluidique et son imagerie |
US7583853B2 (en) | 2003-07-28 | 2009-09-01 | Fluidigm Corporation | Image processing method and system for microfluidic devices |
US7042649B2 (en) * | 2003-08-11 | 2006-05-09 | California Institute Of Technology | Microfabricated rubber microscope using soft solid immersion lenses |
US7413712B2 (en) * | 2003-08-11 | 2008-08-19 | California Institute Of Technology | Microfluidic rotary flow reactor matrix |
US20060172408A1 (en) | 2003-12-01 | 2006-08-03 | Quake Steven R | Device for immobilizing chemical and biochemical species and methods of using same |
US7407799B2 (en) * | 2004-01-16 | 2008-08-05 | California Institute Of Technology | Microfluidic chemostat |
WO2005121864A2 (fr) | 2004-06-07 | 2005-12-22 | Fluidigm Corporation | Systeme de lentilles optiques et procedes pour dispositifs microfluidiques |
JP2008522795A (ja) | 2004-12-03 | 2008-07-03 | カリフォルニア インスティチュート オブ テクノロジー | 化学反応回路を有するマイクロ流体装置 |
US20080264863A1 (en) | 2004-12-03 | 2008-10-30 | California Institute Of Technology | Microfluidic Sieve Valves |
WO2006127191A2 (fr) | 2005-04-20 | 2006-11-30 | Fluidigm Corporation | Moteur d'analyse et base de donnees permettant de manipuler des parametres destines a des systemes fluidiques sur une puce |
EP2477029A1 (fr) | 2005-06-02 | 2012-07-18 | Fluidigm Corporation | Analyse utilisant des dispositifs de partage microfluidique |
US20070054293A1 (en) | 2005-08-30 | 2007-03-08 | California Institute Of Technology | Microfluidic chaotic mixing systems and methods |
EP1938101A2 (fr) | 2005-09-13 | 2008-07-02 | Fluidigm Corporation | Dispositifs et procedes de dosage microfluidique |
US8206975B2 (en) * | 2005-10-28 | 2012-06-26 | California Institute Of Technology | Method and device for regulating fluid flow in microfluidic devices |
US20070248971A1 (en) | 2006-01-26 | 2007-10-25 | California Institute Of Technology | Programming microfluidic devices with molecular information |
EP1984107A4 (fr) | 2006-01-26 | 2013-12-04 | California Inst Of Techn | Programmation de dispositifs microfluidiques avec une information moleculaire |
US7815868B1 (en) | 2006-02-28 | 2010-10-19 | Fluidigm Corporation | Microfluidic reaction apparatus for high throughput screening |
US8828661B2 (en) * | 2006-04-24 | 2014-09-09 | Fluidigm Corporation | Methods for detection and quantification of nucleic acid or protein targets in a sample |
EP2041662A4 (fr) | 2006-07-05 | 2012-08-08 | Agere Systems Inc | Systèmes et procédés permettant la gestion de la consommation pour un dispositif de stockage sans fil |
US8055034B2 (en) * | 2006-09-13 | 2011-11-08 | Fluidigm Corporation | Methods and systems for image processing of microfluidic devices |
EP2074341A4 (fr) | 2006-10-04 | 2013-04-10 | Fluidigm Corp | Clapets de non-retour microfluidiques |
US8473216B2 (en) * | 2006-11-30 | 2013-06-25 | Fluidigm Corporation | Method and program for performing baseline correction of amplification curves in a PCR experiment |
WO2008089493A2 (fr) | 2007-01-19 | 2008-07-24 | Fluidigm Corporation | Dispositifs microfluidiques d'efficacité élevée et de précision élevée et procédés |
WO2008141183A2 (fr) * | 2007-05-09 | 2008-11-20 | Fluidigm Corporation | Procédé et système de cristallisation et criblage par diffraction de rayons x |
ATE541946T1 (de) * | 2007-09-07 | 2012-02-15 | Fluidigm Corp | Verfahren und system zur bestimmung von genkopiezahlvarianten |
US7700925B2 (en) | 2007-12-28 | 2010-04-20 | Varian Semiconductor Equipment Associates, Inc. | Techniques for providing a multimode ion source |
US9157116B2 (en) | 2008-02-08 | 2015-10-13 | Fluidigm Corporation | Combinatorial amplification and detection of nucleic acids |
US9487822B2 (en) | 2008-03-19 | 2016-11-08 | Fluidigm Corporation | Method and apparatus for determining copy number variation using digital PCR |
WO2010011852A1 (fr) | 2008-07-25 | 2010-01-28 | Fluidigm Corporation | Procédé et système de fabrication de puces fluidiques intégrées |
WO2010017210A1 (fr) | 2008-08-07 | 2010-02-11 | Fluidigm Corporation | Systèmes microfluidique de mélange et de réaction pour un tamisage à efficacité élevée |
SG10201404682WA (en) | 2008-12-08 | 2014-10-30 | Fluidigm Corp | Programmable microfluidic digital array |
US8058630B2 (en) | 2009-01-16 | 2011-11-15 | Fluidigm Corporation | Microfluidic devices and methods |
WO2011053790A2 (fr) | 2009-10-30 | 2011-05-05 | Fluidigm Corporation | Dosage de cibles étroitement liées en diagnostic foetal et dosage de détection de coïncidence pour l'analyse génétique |
-
2001
- 2001-11-16 WO PCT/US2001/044869 patent/WO2002040874A1/fr active Search and Examination
- 2001-11-16 US US10/416,418 patent/US7378280B2/en not_active Expired - Fee Related
- 2001-11-16 AU AU2002230524A patent/AU2002230524A1/en not_active Abandoned
- 2001-11-16 EP EP11161890A patent/EP2381116A1/fr not_active Withdrawn
- 2001-11-16 EP EP01990762.5A patent/EP1343973B2/fr not_active Expired - Lifetime
-
2008
- 2008-05-27 US US12/127,720 patent/US7887753B2/en not_active Expired - Fee Related
-
2011
- 2011-02-14 US US13/026,587 patent/US8273574B2/en not_active Expired - Lifetime
- 2011-02-15 US US13/027,768 patent/US8455258B2/en not_active Expired - Lifetime
-
2012
- 2012-09-04 US US13/603,263 patent/US8673645B2/en not_active Expired - Lifetime
-
2014
- 2014-03-17 US US14/216,740 patent/US9176137B2/en not_active Expired - Fee Related
-
2015
- 2015-10-30 US US14/928,631 patent/US10509018B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US20130140181A1 (en) | 2013-06-06 |
EP2381116A1 (fr) | 2011-10-26 |
EP1343973B1 (fr) | 2017-11-08 |
WO2002040874A1 (fr) | 2002-05-23 |
US8673645B2 (en) | 2014-03-18 |
US20110151498A1 (en) | 2011-06-23 |
US7378280B2 (en) | 2008-05-27 |
US8455258B2 (en) | 2013-06-04 |
US20040115838A1 (en) | 2004-06-17 |
US10509018B2 (en) | 2019-12-17 |
US20080274493A1 (en) | 2008-11-06 |
US7887753B2 (en) | 2011-02-15 |
US20140199713A1 (en) | 2014-07-17 |
US8273574B2 (en) | 2012-09-25 |
EP1343973A4 (fr) | 2004-12-22 |
EP1343973B2 (fr) | 2020-09-16 |
US9176137B2 (en) | 2015-11-03 |
EP1343973A1 (fr) | 2003-09-17 |
US20110151499A1 (en) | 2011-06-23 |
US20160123958A1 (en) | 2016-05-05 |
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