AU2002214165B9 - Use of rosuvastatin (ZD-4522) in the treatment of heterozygous familial hypercholesterolemia - Google Patents

Use of rosuvastatin (ZD-4522) in the treatment of heterozygous familial hypercholesterolemia Download PDF

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Publication number
AU2002214165B9
AU2002214165B9 AU2002214165A AU2002214165A AU2002214165B9 AU 2002214165 B9 AU2002214165 B9 AU 2002214165B9 AU 2002214165 A AU2002214165 A AU 2002214165A AU 2002214165 A AU2002214165 A AU 2002214165A AU 2002214165 B9 AU2002214165 B9 AU 2002214165B9
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AU
Australia
Prior art keywords
astrazeneca
cross
apotex
dihydroxyhept
pty
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Revoked
Application number
AU2002214165A
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English (en)
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AU2002214165A1 (en
AU2002214165B2 (en
Inventor
Howard Gerard Hutchinson
Ali Raza
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AstraZeneca AB
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AstraZeneca AB
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Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9903629&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AU2002214165(B9) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by AstraZeneca AB filed Critical AstraZeneca AB
Publication of AU2002214165A1 publication Critical patent/AU2002214165A1/en
Application granted granted Critical
Publication of AU2002214165B2 publication Critical patent/AU2002214165B2/en
Publication of AU2002214165B9 publication Critical patent/AU2002214165B9/en
Anticipated expiration legal-status Critical
Revoked legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AU2002214165A 2000-11-22 2001-11-16 Use of rosuvastatin (ZD-4522) in the treatment of heterozygous familial hypercholesterolemia Revoked AU2002214165B9 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0028429.9A GB0028429D0 (en) 2000-11-22 2000-11-22 Therapy
GB0028429.9 2000-11-22
PCT/GB2001/005041 WO2002041895A1 (en) 2000-11-22 2001-11-16 Use of rosuvastatin (zd-4522) in the treatment of heterozygous familial hypercholesterolemia

Publications (3)

Publication Number Publication Date
AU2002214165A1 AU2002214165A1 (en) 2002-08-08
AU2002214165B2 AU2002214165B2 (en) 2006-12-14
AU2002214165B9 true AU2002214165B9 (en) 2013-07-04

Family

ID=9903629

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2002214165A Revoked AU2002214165B9 (en) 2000-11-22 2001-11-16 Use of rosuvastatin (ZD-4522) in the treatment of heterozygous familial hypercholesterolemia
AU1416502A Pending AU1416502A (en) 2000-11-22 2001-11-16 Use of rosuvastatin (zd-4522) in the treatment of heterozygous familial hypercholesterolemia

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU1416502A Pending AU1416502A (en) 2000-11-22 2001-11-16 Use of rosuvastatin (zd-4522) in the treatment of heterozygous familial hypercholesterolemia

Country Status (34)

Country Link
US (1) US6858618B2 (enExample)
EP (1) EP1339409B1 (enExample)
JP (2) JP5062940B2 (enExample)
KR (1) KR100815042B1 (enExample)
CN (1) CN1268339C (enExample)
AR (1) AR031766A1 (enExample)
AT (1) ATE394103T1 (enExample)
AU (2) AU2002214165B9 (enExample)
BG (1) BG66009B1 (enExample)
BR (1) BR0115511A (enExample)
CA (1) CA2429263C (enExample)
CY (1) CY1110428T1 (enExample)
CZ (1) CZ301583B6 (enExample)
DE (1) DE60133921D1 (enExample)
DK (1) DK1339409T3 (enExample)
EE (1) EE05507B1 (enExample)
ES (1) ES2305118T3 (enExample)
GB (1) GB0028429D0 (enExample)
HU (1) HUP0301380A3 (enExample)
IL (2) IL155919A0 (enExample)
IS (1) IS6819A (enExample)
MX (1) MXPA03004336A (enExample)
MY (1) MY134902A (enExample)
NO (1) NO326245B1 (enExample)
NZ (1) NZ525754A (enExample)
PL (1) PL365386A1 (enExample)
PT (1) PT1339409E (enExample)
RU (1) RU2294744C2 (enExample)
SI (1) SI1339409T1 (enExample)
SK (1) SK6212003A3 (enExample)
TW (1) TWI238720B (enExample)
UA (1) UA75614C2 (enExample)
WO (1) WO2002041895A1 (enExample)
ZA (1) ZA200303636B (enExample)

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GB0003305D0 (en) * 2000-02-15 2000-04-05 Zeneca Ltd Pyrimidine derivatives
US7407965B2 (en) * 2003-04-25 2008-08-05 Gilead Sciences, Inc. Phosphonate analogs for treating metabolic diseases
US20050261237A1 (en) * 2003-04-25 2005-11-24 Boojamra Constantine G Nucleoside phosphonate analogs
US7452901B2 (en) * 2003-04-25 2008-11-18 Gilead Sciences, Inc. Anti-cancer phosphonate analogs
EP1628685B1 (en) 2003-04-25 2010-12-08 Gilead Sciences, Inc. Antiviral phosphonate analogs
US7470724B2 (en) * 2003-04-25 2008-12-30 Gilead Sciences, Inc. Phosphonate compounds having immuno-modulatory activity
US20090247488A1 (en) * 2003-04-25 2009-10-01 Carina Cannizzaro Anti-inflammatory phosphonate compounds
MXPA05011296A (es) * 2003-04-25 2006-01-24 Gilead Sciences Inc Conjugados de fosfonato inhibidores de la cinasa.
WO2005023778A2 (en) * 2003-08-28 2005-03-17 Teva Pharmaceutical Industries Ltd. Process for preparation of rosuvastatin calcium
GB0322552D0 (en) 2003-09-26 2003-10-29 Astrazeneca Uk Ltd Therapeutic treatment
US7432273B2 (en) * 2003-10-24 2008-10-07 Gilead Sciences, Inc. Phosphonate analogs of antimetabolites
US7777034B2 (en) 2003-11-24 2010-08-17 Teva Pharmaceutical Industries Ltd. Crystalline ammonium salts of rosuvastatin
EP1689723B1 (en) * 2003-12-02 2011-04-27 Teva Pharmaceutical Industries, Ltd. Reference standard for characterization of rosuvastatin
US20070179166A1 (en) * 2003-12-24 2007-08-02 Valerie Niddam-Hildesheim Process for preparation of statins with high syn to anti ratio
US7851624B2 (en) * 2003-12-24 2010-12-14 Teva Pharamaceutical Industries Ltd. Triol form of rosuvastatin and synthesis of rosuvastatin
US20060013861A1 (en) * 2004-05-26 2006-01-19 Kgk Synergize Inc. Functional foods comprising flavonoids and tocotrienols and methods thereof
EP1673351A1 (en) * 2004-07-13 2006-06-28 Teva Pharmaceutical Industries Ltd. A process for the preparation of rosuvastatin involving a tempo-mediated oxidation step
WO2006110157A2 (en) 2004-07-27 2006-10-19 Gilead Sciences, Inc. Nucleoside phosphonate conjugates as anti hiv agents
CA2591439C (en) * 2005-02-22 2013-03-26 Teva Pharmaceutical Industries Ltd. Rosuvastatin and salts thereof free of rosuvastatin alkylether and a process for the preparation thereof
US20070037979A1 (en) * 2005-02-22 2007-02-15 Valerie Niddam-Hildesheim Preparation of rosuvastatin
US20070167625A1 (en) * 2005-02-22 2007-07-19 Anna Balanov Preparation of rosuvastatin
MX2007004427A (es) * 2005-08-16 2007-06-14 Teva Pharma Intermedio de rosuvastatina cristalina.
US8383614B2 (en) * 2008-01-31 2013-02-26 The Trustees Of The University Of Pennsylvania Hypercholestrolemia and tendinous injuries
US9427437B2 (en) 2008-01-31 2016-08-30 The Trustees Of The University Of Pennsylvania Hypercholesterolemia and tendinous injuries
WO2009143776A1 (zh) 2008-05-27 2009-12-03 常州制药厂有限公司 瑞舒伐他汀钙盐的制备方法及其中间体
HRP20120700T1 (hr) 2008-07-08 2012-09-30 Gilead Sciences SOLI SPOJEVA INHIBITORA HIV-a
AR092872A1 (es) 2012-09-17 2015-05-06 Madrigal Pharmaceuticals Inc Metodo para sintetizar analogos de la hormona tiroidea y polimorfos de los mismos
US9132117B2 (en) 2013-06-17 2015-09-15 Kgk Synergize, Inc Compositions and methods for glycemic control of subjects with impaired fasting glucose
US10600502B2 (en) 2016-12-20 2020-03-24 Astrazeneca Uk Ltd. Systems and methods for dispensing a statin medication over the counter
ES2892402T3 (es) 2017-08-01 2022-02-04 Gilead Sciences Inc Formas cristalinas de ((S)-((((2R,5R)-5-(6-amino-9H-purin-9-il)-4-fluoro-2,5-dihidrofuran-2-il)oxi)metil)(fenoxi)fosforil)-L-alaninato de etilo para tratar infecciones virales
PE20220164A1 (es) 2019-05-27 2022-01-28 Immatics Us Inc Vectores viricos y uso de los mismos en terapias celulares adoptivas
DE102020111571A1 (de) 2020-03-11 2021-09-16 Immatics US, Inc. Wpre-mutantenkonstrukte, zusammensetzungen und zugehörige verfahren
US20220008519A1 (en) 2020-07-09 2022-01-13 Costa Rican Social Security Fund / Caja Costarricense de Seguro Social (CCSS) Treatment of severe acute respiratory syndrome-related coronavirus infection with klotho
WO2022040631A1 (en) 2020-08-21 2022-02-24 Immatics US, Inc. Methods for isolating cd8+ selected t cells
JP2024506848A (ja) * 2021-02-01 2024-02-15 マドリガル ファーマシューティカルズ インコーポレイテッド 肝障害又は脂質障害の治療のためのロスバスタチンとレスメチロムの治療的組み合わせ
US12377104B1 (en) 2024-02-06 2025-08-05 Madrigal Pharmaceuticals, Inc. Methods for treating a fatty liver disease

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0521471A1 (en) * 1991-07-01 1993-01-07 Shionogi Seiyaku Kabushiki Kaisha Pyrimidine derivatives as HMG-CoA reductase inhibitors

Family Cites Families (5)

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RU2051907C1 (ru) * 1989-05-22 1996-01-10 Сандос АГ Способ получения 7-замещенной гептен-6-овой кислоты
US5631365A (en) * 1993-09-21 1997-05-20 Schering Corporation Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents
US6369103B1 (en) * 1994-01-18 2002-04-09 Bristol-Myers Squibb Company Method for preventing or reducing risk of onset of cardiovascular events employing an HMG CoA reductase inhibitor
GB0001621D0 (en) * 2000-01-26 2000-03-15 Astrazeneca Ab Pharmaceutical compositions
AU6294501A (en) * 2000-09-20 2002-04-02 Rtp Pharma Inc Spray drying process and compositions of fenofibrate

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0521471A1 (en) * 1991-07-01 1993-01-07 Shionogi Seiyaku Kabushiki Kaisha Pyrimidine derivatives as HMG-CoA reductase inhibitors

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
American J of Cardiology 76(2) (1995) pp 47A-50A *
Atherosclerosis 100(1) (1993) pp 65-74 *
Bioorganic & Medicinal Chemistry 5(2) (1997) pp 437-444 *
Canadian J of Cardiology 16(Suppl F) (2000) p.196F *
Current Therapeutic Research 57(1) (1996) pp 62-71 *
European Heart Journal 21(Abst Suppl) (2000) p/156 *
J of American Medical Association 281(2) (1999) pp 137-144 *

Also Published As

Publication number Publication date
AR031766A1 (es) 2003-10-01
ZA200303636B (en) 2004-08-12
BG107811A (bg) 2004-03-31
ATE394103T1 (de) 2008-05-15
EP1339409A1 (en) 2003-09-03
PT1339409E (pt) 2008-07-07
BG66009B1 (bg) 2010-10-29
NZ525754A (en) 2004-10-29
CY1110428T1 (el) 2015-04-29
NO20032292D0 (no) 2003-05-21
HUP0301380A3 (en) 2007-03-28
DE60133921D1 (de) 2008-06-19
DK1339409T3 (da) 2008-09-08
HK1056691A1 (en) 2004-02-27
EE05507B1 (et) 2012-02-15
CN1630520A (zh) 2005-06-22
SK6212003A3 (en) 2003-11-04
CZ301583B6 (cs) 2010-04-21
IL155919A0 (en) 2003-12-23
CZ20031406A3 (cs) 2003-09-17
WO2002041895A1 (en) 2002-05-30
JP5062940B2 (ja) 2012-10-31
IS6819A (is) 2003-05-19
NO20032292L (no) 2003-07-17
GB0028429D0 (en) 2001-01-10
KR100815042B1 (ko) 2008-03-18
MY134902A (en) 2007-12-31
AU1416502A (en) 2002-06-03
EP1339409B1 (en) 2008-05-07
MXPA03004336A (es) 2003-08-19
UA75614C2 (uk) 2006-05-15
US6858618B2 (en) 2005-02-22
TWI238720B (en) 2005-09-01
JP2010031047A (ja) 2010-02-12
US20040072852A1 (en) 2004-04-15
HUP0301380A2 (hu) 2003-10-28
EE200300239A (et) 2003-08-15
BR0115511A (pt) 2003-12-30
KR20030048479A (ko) 2003-06-19
PL365386A1 (en) 2005-01-10
CN1268339C (zh) 2006-08-09
RU2294744C2 (ru) 2007-03-10
SI1339409T1 (sl) 2008-08-31
IL155919A (en) 2009-09-01
CA2429263C (en) 2009-03-17
ES2305118T3 (es) 2008-11-01
JP2004522714A (ja) 2004-07-29
AU2002214165B2 (en) 2006-12-14
NO326245B1 (no) 2008-10-27
CA2429263A1 (en) 2002-05-30

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Legal Events

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FGA Letters patent sealed or granted (standard patent)
GD Licence registered

Name of requester: ASTRAZENECA PTY LIMITED

SREP Specification republished
SREP Specification republished