KR100815042B1 - 이형접합성 가족성 고콜레스테롤혈증 치료에 있어서로수바스타틴(ｚｄ－４５２２)의 용도 - Google Patents

이형접합성 가족성 고콜레스테롤혈증 치료에 있어서로수바스타틴(ｚｄ－４５２２)의 용도 Download PDF

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Publication number
KR100815042B1
KR100815042B1 KR1020037006791A KR20037006791A KR100815042B1 KR 100815042 B1 KR100815042 B1 KR 100815042B1 KR 1020037006791 A KR1020037006791 A KR 1020037006791A KR 20037006791 A KR20037006791 A KR 20037006791A KR 100815042 B1 KR100815042 B1 KR 100815042B1
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ldl
pharmaceutical composition
delete delete
dihydroxyhept
methylsulfonyl
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Korean (ko)
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KR20030048479A (ko
Inventor
라자알리
허친슨하워드제라드
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아스트라제네카 아베
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
KR1020037006791A 2000-11-22 2001-11-16 이형접합성 가족성 고콜레스테롤혈증 치료에 있어서로수바스타틴(ｚｄ－４５２２)의 용도 Ceased KR100815042B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0028429.9A GB0028429D0 (en) 2000-11-22 2000-11-22 Therapy
GB0028429.9 2000-11-22
PCT/GB2001/005041 WO2002041895A1 (en) 2000-11-22 2001-11-16 Use of rosuvastatin (zd-4522) in the treatment of heterozygous familial hypercholesterolemia

Publications (2)

Publication Number Publication Date
KR20030048479A KR20030048479A (ko) 2003-06-19
KR100815042B1 true KR100815042B1 (ko) 2008-03-18

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KR1020037006791A Ceased KR100815042B1 (ko) 2000-11-22 2001-11-16 이형접합성 가족성 고콜레스테롤혈증 치료에 있어서로수바스타틴(ｚｄ－４５２２)의 용도

Country Status (34)

Country Link
US (1) US6858618B2 (enExample)
EP (1) EP1339409B1 (enExample)
JP (2) JP5062940B2 (enExample)
KR (1) KR100815042B1 (enExample)
CN (1) CN1268339C (enExample)
AR (1) AR031766A1 (enExample)
AT (1) ATE394103T1 (enExample)
AU (2) AU2002214165B9 (enExample)
BG (1) BG66009B1 (enExample)
BR (1) BR0115511A (enExample)
CA (1) CA2429263C (enExample)
CY (1) CY1110428T1 (enExample)
CZ (1) CZ301583B6 (enExample)
DE (1) DE60133921D1 (enExample)
DK (1) DK1339409T3 (enExample)
EE (1) EE05507B1 (enExample)
ES (1) ES2305118T3 (enExample)
GB (1) GB0028429D0 (enExample)
HU (1) HUP0301380A3 (enExample)
IL (2) IL155919A0 (enExample)
IS (1) IS6819A (enExample)
MX (1) MXPA03004336A (enExample)
MY (1) MY134902A (enExample)
NO (1) NO326245B1 (enExample)
NZ (1) NZ525754A (enExample)
PL (1) PL365386A1 (enExample)
PT (1) PT1339409E (enExample)
RU (1) RU2294744C2 (enExample)
SI (1) SI1339409T1 (enExample)
SK (1) SK6212003A3 (enExample)
TW (1) TWI238720B (enExample)
UA (1) UA75614C2 (enExample)
WO (1) WO2002041895A1 (enExample)
ZA (1) ZA200303636B (enExample)

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GB0003305D0 (en) * 2000-02-15 2000-04-05 Zeneca Ltd Pyrimidine derivatives
US7407965B2 (en) * 2003-04-25 2008-08-05 Gilead Sciences, Inc. Phosphonate analogs for treating metabolic diseases
US20050261237A1 (en) * 2003-04-25 2005-11-24 Boojamra Constantine G Nucleoside phosphonate analogs
US7452901B2 (en) * 2003-04-25 2008-11-18 Gilead Sciences, Inc. Anti-cancer phosphonate analogs
EP1628685B1 (en) 2003-04-25 2010-12-08 Gilead Sciences, Inc. Antiviral phosphonate analogs
US7470724B2 (en) * 2003-04-25 2008-12-30 Gilead Sciences, Inc. Phosphonate compounds having immuno-modulatory activity
US20090247488A1 (en) * 2003-04-25 2009-10-01 Carina Cannizzaro Anti-inflammatory phosphonate compounds
MXPA05011296A (es) * 2003-04-25 2006-01-24 Gilead Sciences Inc Conjugados de fosfonato inhibidores de la cinasa.
WO2005023778A2 (en) * 2003-08-28 2005-03-17 Teva Pharmaceutical Industries Ltd. Process for preparation of rosuvastatin calcium
GB0322552D0 (en) 2003-09-26 2003-10-29 Astrazeneca Uk Ltd Therapeutic treatment
US7432273B2 (en) * 2003-10-24 2008-10-07 Gilead Sciences, Inc. Phosphonate analogs of antimetabolites
US7777034B2 (en) 2003-11-24 2010-08-17 Teva Pharmaceutical Industries Ltd. Crystalline ammonium salts of rosuvastatin
EP1689723B1 (en) * 2003-12-02 2011-04-27 Teva Pharmaceutical Industries, Ltd. Reference standard for characterization of rosuvastatin
US20070179166A1 (en) * 2003-12-24 2007-08-02 Valerie Niddam-Hildesheim Process for preparation of statins with high syn to anti ratio
US7851624B2 (en) * 2003-12-24 2010-12-14 Teva Pharamaceutical Industries Ltd. Triol form of rosuvastatin and synthesis of rosuvastatin
US20060013861A1 (en) * 2004-05-26 2006-01-19 Kgk Synergize Inc. Functional foods comprising flavonoids and tocotrienols and methods thereof
EP1673351A1 (en) * 2004-07-13 2006-06-28 Teva Pharmaceutical Industries Ltd. A process for the preparation of rosuvastatin involving a tempo-mediated oxidation step
WO2006110157A2 (en) 2004-07-27 2006-10-19 Gilead Sciences, Inc. Nucleoside phosphonate conjugates as anti hiv agents
CA2591439C (en) * 2005-02-22 2013-03-26 Teva Pharmaceutical Industries Ltd. Rosuvastatin and salts thereof free of rosuvastatin alkylether and a process for the preparation thereof
US20070037979A1 (en) * 2005-02-22 2007-02-15 Valerie Niddam-Hildesheim Preparation of rosuvastatin
US20070167625A1 (en) * 2005-02-22 2007-07-19 Anna Balanov Preparation of rosuvastatin
MX2007004427A (es) * 2005-08-16 2007-06-14 Teva Pharma Intermedio de rosuvastatina cristalina.
US8383614B2 (en) * 2008-01-31 2013-02-26 The Trustees Of The University Of Pennsylvania Hypercholestrolemia and tendinous injuries
US9427437B2 (en) 2008-01-31 2016-08-30 The Trustees Of The University Of Pennsylvania Hypercholesterolemia and tendinous injuries
WO2009143776A1 (zh) 2008-05-27 2009-12-03 常州制药厂有限公司 瑞舒伐他汀钙盐的制备方法及其中间体
HRP20120700T1 (hr) 2008-07-08 2012-09-30 Gilead Sciences SOLI SPOJEVA INHIBITORA HIV-a
AR092872A1 (es) 2012-09-17 2015-05-06 Madrigal Pharmaceuticals Inc Metodo para sintetizar analogos de la hormona tiroidea y polimorfos de los mismos
US9132117B2 (en) 2013-06-17 2015-09-15 Kgk Synergize, Inc Compositions and methods for glycemic control of subjects with impaired fasting glucose
US10600502B2 (en) 2016-12-20 2020-03-24 Astrazeneca Uk Ltd. Systems and methods for dispensing a statin medication over the counter
ES2892402T3 (es) 2017-08-01 2022-02-04 Gilead Sciences Inc Formas cristalinas de ((S)-((((2R,5R)-5-(6-amino-9H-purin-9-il)-4-fluoro-2,5-dihidrofuran-2-il)oxi)metil)(fenoxi)fosforil)-L-alaninato de etilo para tratar infecciones virales
PE20220164A1 (es) 2019-05-27 2022-01-28 Immatics Us Inc Vectores viricos y uso de los mismos en terapias celulares adoptivas
DE102020111571A1 (de) 2020-03-11 2021-09-16 Immatics US, Inc. Wpre-mutantenkonstrukte, zusammensetzungen und zugehörige verfahren
US20220008519A1 (en) 2020-07-09 2022-01-13 Costa Rican Social Security Fund / Caja Costarricense de Seguro Social (CCSS) Treatment of severe acute respiratory syndrome-related coronavirus infection with klotho
WO2022040631A1 (en) 2020-08-21 2022-02-24 Immatics US, Inc. Methods for isolating cd8+ selected t cells
JP2024506848A (ja) * 2021-02-01 2024-02-15 マドリガル ファーマシューティカルズ インコーポレイテッド 肝障害又は脂質障害の治療のためのロスバスタチンとレスメチロムの治療的組み合わせ
US12377104B1 (en) 2024-02-06 2025-08-05 Madrigal Pharmaceuticals, Inc. Methods for treating a fatty liver disease

Citations (1)

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Publication number Priority date Publication date Assignee Title
EP0521471A1 (en) * 1991-07-01 1993-01-07 Shionogi Seiyaku Kabushiki Kaisha Pyrimidine derivatives as HMG-CoA reductase inhibitors

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RU2051907C1 (ru) * 1989-05-22 1996-01-10 Сандос АГ Способ получения 7-замещенной гептен-6-овой кислоты
US5631365A (en) * 1993-09-21 1997-05-20 Schering Corporation Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents
US6369103B1 (en) * 1994-01-18 2002-04-09 Bristol-Myers Squibb Company Method for preventing or reducing risk of onset of cardiovascular events employing an HMG CoA reductase inhibitor
GB0001621D0 (en) * 2000-01-26 2000-03-15 Astrazeneca Ab Pharmaceutical compositions
AU6294501A (en) * 2000-09-20 2002-04-02 Rtp Pharma Inc Spray drying process and compositions of fenofibrate

Patent Citations (1)

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Publication number Priority date Publication date Assignee Title
EP0521471A1 (en) * 1991-07-01 1993-01-07 Shionogi Seiyaku Kabushiki Kaisha Pyrimidine derivatives as HMG-CoA reductase inhibitors

Also Published As

Publication number Publication date
AR031766A1 (es) 2003-10-01
ZA200303636B (en) 2004-08-12
BG107811A (bg) 2004-03-31
ATE394103T1 (de) 2008-05-15
EP1339409A1 (en) 2003-09-03
PT1339409E (pt) 2008-07-07
BG66009B1 (bg) 2010-10-29
NZ525754A (en) 2004-10-29
CY1110428T1 (el) 2015-04-29
NO20032292D0 (no) 2003-05-21
HUP0301380A3 (en) 2007-03-28
DE60133921D1 (de) 2008-06-19
DK1339409T3 (da) 2008-09-08
HK1056691A1 (en) 2004-02-27
EE05507B1 (et) 2012-02-15
CN1630520A (zh) 2005-06-22
SK6212003A3 (en) 2003-11-04
CZ301583B6 (cs) 2010-04-21
IL155919A0 (en) 2003-12-23
CZ20031406A3 (cs) 2003-09-17
WO2002041895A1 (en) 2002-05-30
JP5062940B2 (ja) 2012-10-31
IS6819A (is) 2003-05-19
NO20032292L (no) 2003-07-17
GB0028429D0 (en) 2001-01-10
MY134902A (en) 2007-12-31
AU1416502A (en) 2002-06-03
AU2002214165B9 (en) 2013-07-04
EP1339409B1 (en) 2008-05-07
MXPA03004336A (es) 2003-08-19
UA75614C2 (uk) 2006-05-15
US6858618B2 (en) 2005-02-22
TWI238720B (en) 2005-09-01
JP2010031047A (ja) 2010-02-12
US20040072852A1 (en) 2004-04-15
HUP0301380A2 (hu) 2003-10-28
EE200300239A (et) 2003-08-15
BR0115511A (pt) 2003-12-30
KR20030048479A (ko) 2003-06-19
PL365386A1 (en) 2005-01-10
CN1268339C (zh) 2006-08-09
RU2294744C2 (ru) 2007-03-10
SI1339409T1 (sl) 2008-08-31
IL155919A (en) 2009-09-01
CA2429263C (en) 2009-03-17
ES2305118T3 (es) 2008-11-01
JP2004522714A (ja) 2004-07-29
AU2002214165B2 (en) 2006-12-14
NO326245B1 (no) 2008-10-27
CA2429263A1 (en) 2002-05-30

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Decision date: 20150227

Appeal identifier: 2013100002933

Appeal kind category: Invalidation

Request date: 20130801

Decision date: 20150227

Appeal identifier: 2013100002053

Appeal kind category: Invalidation

Request date: 20130702

Decision date: 20150227

Appeal identifier: 2013100001746

Patent event code: PJ13011S05D

Patent event date: 20150227

Comment text: Trial Decision on Invalidation (Patent, Utility Model, Industrial Design)

Appeal kind category: Invalidation

Request date: 20130524

Decision date: 20150227

Appeal identifier: 2013100001360

PC2102 Extinguishment

Termination category: Others

Termination date: 20150616

Termination category: Others

Termination date: 20150514

PG1701 Publication of correction

Publication date: 20151104

J301 Trial decision

Free format text: TRIAL DECISION FOR INVALIDATION REQUESTED 20141027

Effective date: 20150612

Free format text: TRIAL DECISION FOR INVALIDATION REQUESTED 20140926

Effective date: 20150612

PJ1301 Trial decision

Appeal kind category: Invalidation

Request date: 20141222

Decision date: 20150612

Appeal identifier: 2014100003291

Appeal kind category: Invalidation

Request date: 20141027

Decision date: 20150612

Appeal identifier: 2014100002671

Appeal kind category: Invalidation

Request date: 20141027

Decision date: 20150612

Appeal identifier: 2014100002670

Appeal kind category: Invalidation

Request date: 20141027

Decision date: 20150612

Appeal identifier: 2014100002669

Appeal kind category: Invalidation

Request date: 20141027

Decision date: 20150612

Appeal identifier: 2014100002668

Appeal kind category: Invalidation

Request date: 20141027

Decision date: 20150612

Appeal identifier: 2014100002667

Appeal kind category: Invalidation

Request date: 20141027

Decision date: 20150612

Appeal identifier: 2014100002666

Appeal kind category: Invalidation

Request date: 20141027

Decision date: 20150612

Appeal identifier: 2014100002665

Appeal kind category: Invalidation

Request date: 20141027

Decision date: 20150612

Appeal identifier: 2014100002664

Appeal kind category: Invalidation

Request date: 20141027

Decision date: 20150612

Appeal identifier: 2014100002663

Appeal kind category: Invalidation

Request date: 20140926

Decision date: 20150612

Appeal identifier: 2014100002411

Appeal kind category: Invalidation

Request date: 20140926

Decision date: 20150612

Appeal identifier: 2014100002409

Appeal kind category: Invalidation

Request date: 20140926

Decision date: 20150612

Appeal identifier: 2014100002407

Appeal kind category: Invalidation

Request date: 20140926

Decision date: 20150612

Appeal identifier: 2014100002405

Patent event code: PJ13011S05D

Patent event date: 20150612

Comment text: Trial Decision on Invalidation (Patent, Utility Model, Industrial Design)

Appeal kind category: Invalidation

Request date: 20140926

Decision date: 20150612

Appeal identifier: 2014100002403

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PG1701 Publication of correction

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PG1701 Publication of correction

Publication date: 20151104