AU2001251389A1 - Proteins deposited onto sparingly soluble biocompatible particles for controlledprotein release into a biological environment from a polymer matrix - Google Patents
Proteins deposited onto sparingly soluble biocompatible particles for controlledprotein release into a biological environment from a polymer matrixInfo
- Publication number
- AU2001251389A1 AU2001251389A1 AU2001251389A AU5138901A AU2001251389A1 AU 2001251389 A1 AU2001251389 A1 AU 2001251389A1 AU 2001251389 A AU2001251389 A AU 2001251389A AU 5138901 A AU5138901 A AU 5138901A AU 2001251389 A1 AU2001251389 A1 AU 2001251389A1
- Authority
- AU
- Australia
- Prior art keywords
- protein
- particle
- poly
- drug delivery
- delivery system
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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- 108090000623 proteins and genes Proteins 0.000 title claims abstract description 129
- 239000002245 particle Substances 0.000 title claims abstract description 111
- 239000011159 matrix material Substances 0.000 title claims abstract description 47
- 229920000642 polymer Polymers 0.000 title claims description 44
- 108090000765 processed proteins & peptides Proteins 0.000 claims abstract description 67
- 239000000203 mixture Substances 0.000 claims abstract description 36
- 235000018102 proteins Nutrition 0.000 claims description 123
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- 108010000521 Human Growth Hormone Proteins 0.000 claims description 58
- 239000000854 Human Growth Hormone Substances 0.000 claims description 58
- -1 etc.) Proteins 0.000 claims description 57
- 238000012377 drug delivery Methods 0.000 claims description 43
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- 239000011667 zinc carbonate Substances 0.000 claims description 36
- 229910000010 zinc carbonate Inorganic materials 0.000 claims description 36
- FMRLDPWIRHBCCC-UHFFFAOYSA-L Zinc carbonate Chemical compound [Zn+2].[O-]C([O-])=O FMRLDPWIRHBCCC-UHFFFAOYSA-L 0.000 claims description 29
- 235000004416 zinc carbonate Nutrition 0.000 claims description 29
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- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 4
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- XNSAINXGIQZQOO-UHFFFAOYSA-N L-pyroglutamyl-L-histidyl-L-proline amide Natural products NC(=O)C1CCCN1C(=O)C(NC(=O)C1NC(=O)CC1)CC1=CN=CN1 XNSAINXGIQZQOO-UHFFFAOYSA-N 0.000 claims description 4
- 102000007651 Macrophage Colony-Stimulating Factor Human genes 0.000 claims description 4
- 108010046938 Macrophage Colony-Stimulating Factor Proteins 0.000 claims description 4
- 108010025020 Nerve Growth Factor Proteins 0.000 claims description 4
- 102000015336 Nerve Growth Factor Human genes 0.000 claims description 4
- 102000003982 Parathyroid hormone Human genes 0.000 claims description 4
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- 101800004623 Thyrotropin-releasing hormone Proteins 0.000 claims description 4
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- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 claims description 4
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- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 claims description 4
- 235000012245 magnesium oxide Nutrition 0.000 claims description 4
- AXZKOIWUVFPNLO-UHFFFAOYSA-N magnesium;oxygen(2-) Chemical class [O-2].[Mg+2] AXZKOIWUVFPNLO-UHFFFAOYSA-N 0.000 claims description 4
- 229940053128 nerve growth factor Drugs 0.000 claims description 4
- 239000000199 parathyroid hormone Substances 0.000 claims description 4
- 229960001319 parathyroid hormone Drugs 0.000 claims description 4
- 229940065514 poly(lactide) Drugs 0.000 claims description 4
- 239000002745 poly(ortho ester) Substances 0.000 claims description 4
- 229920000058 polyacrylate Polymers 0.000 claims description 4
- XNSAINXGIQZQOO-SRVKXCTJSA-N protirelin Chemical compound NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H]1NC(=O)CC1)CC1=CN=CN1 XNSAINXGIQZQOO-SRVKXCTJSA-N 0.000 claims description 4
- 229940034199 thyrotropin-releasing hormone Drugs 0.000 claims description 4
- 102000003390 tumor necrosis factor Human genes 0.000 claims description 4
- VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 claims description 4
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Classifications
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- A61K9/00—Medicinal preparations characterised by special physical form
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/143—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with inorganic compounds
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- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
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- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Inorganic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
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US19570000P | 2000-04-07 | 2000-04-07 | |
US60195700 | 2000-04-07 | ||
US09827100 | 2001-04-05 | ||
US09/827,100 US6998137B2 (en) | 2000-04-07 | 2001-04-05 | Proteins deposited onto sparingly soluble biocompatible particles for controlled protein release into a biological environment from a polymer matrix |
PCT/US2001/011217 WO2001076558A1 (en) | 2000-04-07 | 2001-04-06 | Proteins deposited onto sparingly soluble biocompatible particles for controlled protein release into a biological environment from a polymer matrix |
Publications (1)
Publication Number | Publication Date |
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AU2001251389A1 true AU2001251389A1 (en) | 2001-10-23 |
Family
ID=26891244
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU2001251389A Abandoned AU2001251389A1 (en) | 2000-04-07 | 2001-04-06 | Proteins deposited onto sparingly soluble biocompatible particles for controlledprotein release into a biological environment from a polymer matrix |
Country Status (19)
Country | Link |
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US (1) | US6998137B2 (pt) |
EP (1) | EP1267838B1 (pt) |
JP (2) | JP4731088B2 (pt) |
KR (1) | KR100923817B1 (pt) |
CN (1) | CN100518814C (pt) |
AT (1) | ATE526947T1 (pt) |
AU (1) | AU2001251389A1 (pt) |
BR (1) | BRPI0110319B1 (pt) |
CA (1) | CA2405030C (pt) |
CY (1) | CY1112294T1 (pt) |
DK (1) | DK1267838T3 (pt) |
ES (1) | ES2374224T3 (pt) |
HK (1) | HK1057705A1 (pt) |
IL (2) | IL152131A0 (pt) |
MX (1) | MXPA02009790A (pt) |
NZ (1) | NZ521994A (pt) |
PT (1) | PT1267838E (pt) |
WO (1) | WO2001076558A1 (pt) |
ZA (1) | ZA200208039B (pt) |
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2001
- 2001-04-05 US US09/827,100 patent/US6998137B2/en not_active Expired - Lifetime
- 2001-04-06 KR KR1020027013405A patent/KR100923817B1/ko not_active IP Right Cessation
- 2001-04-06 CN CNB018099823A patent/CN100518814C/zh not_active Expired - Fee Related
- 2001-04-06 WO PCT/US2001/011217 patent/WO2001076558A1/en active IP Right Grant
- 2001-04-06 MX MXPA02009790A patent/MXPA02009790A/es active IP Right Grant
- 2001-04-06 CA CA2405030A patent/CA2405030C/en not_active Expired - Fee Related
- 2001-04-06 AT AT01924765T patent/ATE526947T1/de active
- 2001-04-06 PT PT01924765T patent/PT1267838E/pt unknown
- 2001-04-06 EP EP01924765A patent/EP1267838B1/en not_active Expired - Lifetime
- 2001-04-06 ES ES01924765T patent/ES2374224T3/es not_active Expired - Lifetime
- 2001-04-06 AU AU2001251389A patent/AU2001251389A1/en not_active Abandoned
- 2001-04-06 DK DK01924765.9T patent/DK1267838T3/da active
- 2001-04-06 JP JP2001574076A patent/JP4731088B2/ja not_active Expired - Fee Related
- 2001-04-06 BR BRPI0110319A patent/BRPI0110319B1/pt not_active IP Right Cessation
- 2001-04-06 NZ NZ521994A patent/NZ521994A/en not_active IP Right Cessation
- 2001-04-06 IL IL15213101A patent/IL152131A0/xx unknown
-
2002
- 2002-10-06 IL IL152131A patent/IL152131A/en not_active IP Right Cessation
- 2002-10-07 ZA ZA200208039A patent/ZA200208039B/en unknown
-
2004
- 2004-01-19 HK HK04100051.2A patent/HK1057705A1/xx not_active IP Right Cessation
-
2010
- 2010-10-01 JP JP2010223933A patent/JP5193262B2/ja not_active Expired - Lifetime
-
2011
- 2011-12-22 CY CY20111101281T patent/CY1112294T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
PT1267838E (pt) | 2012-01-11 |
NZ521994A (en) | 2003-08-29 |
JP2011026336A (ja) | 2011-02-10 |
KR20030009425A (ko) | 2003-01-29 |
IL152131A0 (en) | 2003-05-29 |
EP1267838B1 (en) | 2011-10-05 |
MXPA02009790A (es) | 2003-06-19 |
CY1112294T1 (el) | 2015-12-09 |
BR0110319A (pt) | 2003-07-29 |
BRPI0110319B1 (pt) | 2016-09-27 |
JP4731088B2 (ja) | 2011-07-20 |
CN100518814C (zh) | 2009-07-29 |
KR100923817B1 (ko) | 2009-10-27 |
US20020015737A1 (en) | 2002-02-07 |
US6998137B2 (en) | 2006-02-14 |
EP1267838A4 (en) | 2009-01-14 |
CA2405030A1 (en) | 2001-10-18 |
EP1267838A1 (en) | 2003-01-02 |
CN1430504A (zh) | 2003-07-16 |
ZA200208039B (en) | 2004-02-04 |
JP5193262B2 (ja) | 2013-05-08 |
IL152131A (en) | 2010-11-30 |
WO2001076558A1 (en) | 2001-10-18 |
HK1057705A1 (en) | 2004-04-16 |
ATE526947T1 (de) | 2011-10-15 |
CA2405030C (en) | 2011-01-25 |
JP2004507450A (ja) | 2004-03-11 |
DK1267838T3 (da) | 2012-01-23 |
ES2374224T3 (es) | 2012-02-14 |
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