ATE87104T1 - Test fuer sulfhydrylaminosaeure und verfahren zum nachweis und zur unterscheidung von cobalamin und folsaeure. - Google Patents
Test fuer sulfhydrylaminosaeure und verfahren zum nachweis und zur unterscheidung von cobalamin und folsaeure.Info
- Publication number
- ATE87104T1 ATE87104T1 AT87310138T AT87310138T ATE87104T1 AT E87104 T1 ATE87104 T1 AT E87104T1 AT 87310138 T AT87310138 T AT 87310138T AT 87310138 T AT87310138 T AT 87310138T AT E87104 T1 ATE87104 T1 AT E87104T1
- Authority
- AT
- Austria
- Prior art keywords
- acid
- cobalamin
- sulfhydrylamino
- fols
- distinguishing
- Prior art date
Links
- 239000002253 acid Substances 0.000 title 2
- ASARMUCNOOHMLO-WLORSUFZSA-L cobalt(2+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2s)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+2].[N-]([C@@H]1[C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@H](C)OP([O-])(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O ASARMUCNOOHMLO-WLORSUFZSA-L 0.000 title 1
- FFFHZYDWPBMWHY-VKHMYHEASA-N L-homocysteine Chemical compound OC(=O)[C@@H](N)CCS FFFHZYDWPBMWHY-VKHMYHEASA-N 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- 210000001124 body fluid Anatomy 0.000 abstract 1
- 239000010839 body fluid Substances 0.000 abstract 1
- FDJOLVPMNUYSCM-WZHZPDAFSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+3].N#[C-].N([C@@H]([C@]1(C)[N-]\C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C(\C)/C1=N/C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C\C1=N\C([C@H](C1(C)C)CCC(N)=O)=C/1C)[C@@H]2CC(N)=O)=C\1[C@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]1[C@@H](O)[C@@H](N2C3=CC(C)=C(C)C=C3N=C2)O[C@@H]1CO FDJOLVPMNUYSCM-WZHZPDAFSA-L 0.000 abstract 1
- 230000007812 deficiency Effects 0.000 abstract 1
- 229940014144 folate Drugs 0.000 abstract 1
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 abstract 1
- 235000019152 folic acid Nutrition 0.000 abstract 1
- 239000011724 folic acid Substances 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6806—Determination of free amino acids
- G01N33/6812—Assays for specific amino acids
- G01N33/6815—Assays for specific amino acids containing sulfur, e.g. cysteine, cystine, methionine, homocysteine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/82—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving vitamins or their receptors
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/825—Pretreatment for removal of interfering factors from sample
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/18—Sulfur containing
- Y10T436/182—Organic or sulfhydryl containing [e.g., mercaptan, hydrogen, sulfide, etc.]
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Pathology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Bioinformatics & Computational Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Obesity (AREA)
- Nutrition Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Diabetes (AREA)
- Veterinary Medicine (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
- Measurement Of Radiation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/933,553 US4940658A (en) | 1986-11-20 | 1986-11-20 | Assay for sulfhydryl amino acids and methods for detecting and distinguishing cobalamin and folic acid deficency |
| EP87310138A EP0269352B1 (de) | 1986-11-20 | 1987-11-17 | Test für Sulfhydrylaminosäure und Verfahren zum Nachweis und zur Unterscheidung von Cobalamin und Folsäure |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE87104T1 true ATE87104T1 (de) | 1993-04-15 |
Family
ID=25464166
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT87310138T ATE87104T1 (de) | 1986-11-20 | 1987-11-17 | Test fuer sulfhydrylaminosaeure und verfahren zum nachweis und zur unterscheidung von cobalamin und folsaeure. |
| AT91203329T ATE139344T1 (de) | 1986-11-20 | 1987-11-17 | Verfahren zum nachweis eines cobalamin- und folsäuredefizits |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT91203329T ATE139344T1 (de) | 1986-11-20 | 1987-11-17 | Verfahren zum nachweis eines cobalamin- und folsäuredefizits |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US4940658A (de) |
| EP (2) | EP0486118B1 (de) |
| JP (3) | JP2574339B2 (de) |
| AT (2) | ATE87104T1 (de) |
| CA (1) | CA1298536C (de) |
| DE (2) | DE3784852T2 (de) |
Families Citing this family (84)
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|---|---|---|---|---|
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| US5457055A (en) * | 1986-11-20 | 1995-10-10 | The University Of Colorado Foundation | Diagnostic method for cobalamin deficiency |
| US5374560A (en) * | 1989-04-03 | 1994-12-20 | The University Of Colorado, Inc. | Method for screening and distinguishing between cobalamin and folic acid deficiency based on assay for cystathionine and 2-methylcitric acid |
| US5438017A (en) * | 1989-05-01 | 1995-08-01 | The University Of Colorado Foundation, Inc. | Assays for sulfhydryl amino acids and methylmalonic acid and their application to diagnosis of cobalamin deficiency |
| DK138090D0 (da) * | 1990-06-06 | 1990-06-06 | Novo Nordisk As | Diagnostisk analysemetode |
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| US5478729A (en) * | 1994-04-28 | 1995-12-26 | Syntex (U.S.A.) Inc. | Immunoassay for homocysteine |
| US5559038A (en) * | 1994-05-04 | 1996-09-24 | The Regents Of The University Of Colorado | Gas chromatography/mass spectrometry determination of oxidized sulfhydryl amino acids |
| US5800979A (en) * | 1994-12-01 | 1998-09-01 | Kolhouse; J. Fred | Gas chromatography/mass spectrometric determination of folic acid coenzymes |
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| US9134319B2 (en) | 2013-03-15 | 2015-09-15 | The Regents Of The University Of California | Method for replacing biomarkers of protein kinetics from tissue samples by biomarkers of protein kinetics from body fluids after isotopic labeling in vivo |
| US20160195510A1 (en) * | 2014-12-31 | 2016-07-07 | Castle Medical, LLC | Methods for determination of total homocysteine |
| KR102085946B1 (ko) | 2017-07-24 | 2020-03-06 | 충남대학교 산학협력단 | 무세포 단백질 합성 시스템을 이용한 아미노산의 정량 방법 |
| US20190309271A1 (en) | 2018-03-20 | 2019-10-10 | Rubius Therapeutics, Inc. | Therapeutic cell systems and methods for treating homocystinuria |
| CN116818966A (zh) * | 2023-06-29 | 2023-09-29 | 山东英盛生物技术有限公司 | Lc-ms/ms测定甲基丙二酸、同型半胱氨酸及其相关代谢产物方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3577511A (en) * | 1968-02-21 | 1971-05-04 | Adrian Leonard Luhby | Process and compositions for differential diagnosis of the megaloblastic anemia syndromes |
| JPS5246838B2 (de) * | 1973-10-18 | 1977-11-28 | ||
| US4188189A (en) * | 1978-04-04 | 1980-02-12 | University Patents, Inc. | Quantitative testing for vitamin B12 |
| US4351822A (en) * | 1978-04-04 | 1982-09-28 | University Patents, Inc. | Quantitative testing for vitamin B12 |
| US4279886A (en) * | 1979-01-02 | 1981-07-21 | University Patents, Inc. | Test for pancreatic exocrine function |
| US4447547A (en) * | 1980-04-09 | 1984-05-08 | University Patents, Inc. | Immunoassay for measurement of reticulocytes, and immunoreactive reagents for use therein |
| US4332785A (en) * | 1980-04-09 | 1982-06-01 | University Patents, Inc. | Immunoassay for measurement of reticulocytes, and immunoreactive reagents for use therein |
| US4451571A (en) * | 1981-04-06 | 1984-05-29 | University Patents, Inc. | Preparation of samples for vitamin B12 and/or folate assay and assay |
| US4427780A (en) * | 1981-08-13 | 1984-01-24 | University Patents, Inc. | Method for assaying vitamin-containing compositions for vitamin analogues |
| US4467037A (en) * | 1982-03-01 | 1984-08-21 | The Curators Of The University Of Missouri | Silylation of amino acids |
| GB2168478A (en) * | 1984-11-26 | 1986-06-18 | Scan Limited M | Analysis of protein etc using mass spectrometry |
| JPS62292190A (ja) * | 1986-06-11 | 1987-12-18 | 日本ユニオンスペシャル株式会社 | ミシンのル−パ糸の糸繰り装置 |
| US4940658A (en) * | 1986-11-20 | 1990-07-10 | University Patents, Inc. | Assay for sulfhydryl amino acids and methods for detecting and distinguishing cobalamin and folic acid deficency |
-
1986
- 1986-11-20 US US06/933,553 patent/US4940658A/en not_active Expired - Lifetime
-
1987
- 1987-11-17 AT AT87310138T patent/ATE87104T1/de not_active IP Right Cessation
- 1987-11-17 EP EP91203329A patent/EP0486118B1/de not_active Expired - Lifetime
- 1987-11-17 AT AT91203329T patent/ATE139344T1/de not_active IP Right Cessation
- 1987-11-17 EP EP87310138A patent/EP0269352B1/de not_active Expired - Lifetime
- 1987-11-17 DE DE8787310138T patent/DE3784852T2/de not_active Expired - Fee Related
- 1987-11-17 DE DE3751840T patent/DE3751840T2/de not_active Expired - Fee Related
- 1987-11-19 CA CA000552222A patent/CA1298536C/en not_active Expired - Lifetime
- 1987-11-20 JP JP62292190A patent/JP2574339B2/ja not_active Expired - Lifetime
-
1994
- 1994-04-26 JP JP6088530A patent/JP2579434B2/ja not_active Expired - Fee Related
-
1995
- 1995-07-07 JP JP7171988A patent/JP2577878B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0749348A (ja) | 1995-02-21 |
| JP2577878B2 (ja) | 1997-02-05 |
| JPS63221249A (ja) | 1988-09-14 |
| HK1007799A1 (en) | 1999-04-23 |
| JP2579434B2 (ja) | 1997-02-05 |
| JPH0854398A (ja) | 1996-02-27 |
| DE3751840T2 (de) | 1997-01-09 |
| ATE139344T1 (de) | 1996-06-15 |
| CA1298536C (en) | 1992-04-07 |
| JP2574339B2 (ja) | 1997-01-22 |
| EP0269352A3 (en) | 1988-07-06 |
| US4940658A (en) | 1990-07-10 |
| EP0269352A2 (de) | 1988-06-01 |
| EP0486118B1 (de) | 1996-06-12 |
| DE3784852T2 (de) | 1993-06-24 |
| DE3784852D1 (de) | 1993-04-22 |
| EP0269352B1 (de) | 1993-03-17 |
| DE3751840D1 (de) | 1996-07-18 |
| EP0486118A1 (de) | 1992-05-20 |
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