DE3784852D1 - - Google Patents

Info

Publication number
DE3784852D1
DE3784852D1 DE87310138T DE3784852T DE3784852D1 DE 3784852 D1 DE3784852 D1 DE 3784852D1 DE 87310138 T DE87310138 T DE 87310138T DE 3784852 T DE3784852 T DE 3784852T DE 3784852 D1 DE3784852 D1 DE 3784852D1
Authority
DE
Germany
Prior art keywords
cobalamin
folate
disorders
indicative
warm
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE87310138T
Other languages
English (en)
Other versions
DE3784852T2 (de
Inventor
Robert H. Englewood Colorado 80110 Us Allen
Sally P. Denver Colorado 80206 Us Stabler
John New York New York 10023 Us Lindenbaum
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Competitive Technologies Inc
Original Assignee
University Patents Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25464166&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE3784852(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by University Patents Inc filed Critical University Patents Inc
Publication of DE3784852D1 publication Critical patent/DE3784852D1/de
Application granted granted Critical
Publication of DE3784852T2 publication Critical patent/DE3784852T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6806—Determination of free amino acids
    • G01N33/6812—Assays for specific amino acids
    • G01N33/6815—Assays for specific amino acids containing sulfur, e.g. cysteine, cystine, methionine, homocysteine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/82—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving vitamins or their receptors
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/825—Pretreatment for removal of interfering factors from sample
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/18—Sulfur containing
    • Y10T436/182—Organic or sulfhydryl containing [e.g., mercaptan, hydrogen, sulfide, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Obesity (AREA)
  • Nutrition Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Veterinary Medicine (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
  • Sampling And Sample Adjustment (AREA)
DE8787310138T 1986-11-20 1987-11-17 Test fuer sulfhydrylaminosaeure und verfahren zum nachweis und zur unterscheidung von cobalamin und folsaeure. Expired - Fee Related DE3784852T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/933,553 US4940658A (en) 1986-11-20 1986-11-20 Assay for sulfhydryl amino acids and methods for detecting and distinguishing cobalamin and folic acid deficency

Publications (2)

Publication Number Publication Date
DE3784852D1 true DE3784852D1 (de) 1993-04-22
DE3784852T2 DE3784852T2 (de) 1993-06-24

Family

ID=25464166

Family Applications (2)

Application Number Title Priority Date Filing Date
DE3751840T Expired - Fee Related DE3751840T2 (de) 1986-11-20 1987-11-17 Verfahren zum Nachweis eines Cobalamin- und Folsäuredefizits
DE8787310138T Expired - Fee Related DE3784852T2 (de) 1986-11-20 1987-11-17 Test fuer sulfhydrylaminosaeure und verfahren zum nachweis und zur unterscheidung von cobalamin und folsaeure.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE3751840T Expired - Fee Related DE3751840T2 (de) 1986-11-20 1987-11-17 Verfahren zum Nachweis eines Cobalamin- und Folsäuredefizits

Country Status (7)

Country Link
US (1) US4940658A (de)
EP (2) EP0486118B1 (de)
JP (3) JP2574339B2 (de)
AT (2) ATE139344T1 (de)
CA (1) CA1298536C (de)
DE (2) DE3751840T2 (de)
HK (1) HK1007799A1 (de)

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* Cited by examiner, † Cited by third party
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US5374560A (en) * 1989-04-03 1994-12-20 The University Of Colorado, Inc. Method for screening and distinguishing between cobalamin and folic acid deficiency based on assay for cystathionine and 2-methylcitric acid
US5457055A (en) * 1986-11-20 1995-10-10 The University Of Colorado Foundation Diagnostic method for cobalamin deficiency
US5438017A (en) * 1989-05-01 1995-08-01 The University Of Colorado Foundation, Inc. Assays for sulfhydryl amino acids and methylmalonic acid and their application to diagnosis of cobalamin deficiency
DK138090D0 (da) * 1990-06-06 1990-06-06 Novo Nordisk As Diagnostisk analysemetode
US6207651B1 (en) 1996-08-02 2001-03-27 Metabolite Laboratories Method for treatment and prevention of deficiencies of vitamins B12, folic acid, and B6
US20030203873A1 (en) * 1992-12-29 2003-10-30 Allen Robert H Method for treatment of neuropsychiatric disorders
US5478729A (en) * 1994-04-28 1995-12-26 Syntex (U.S.A.) Inc. Immunoassay for homocysteine
US5559038A (en) * 1994-05-04 1996-09-24 The Regents Of The University Of Colorado Gas chromatography/mass spectrometry determination of oxidized sulfhydryl amino acids
US5800979A (en) * 1994-12-01 1998-09-01 Kolhouse; J. Fred Gas chromatography/mass spectrometric determination of folic acid coenzymes
US5932624A (en) * 1995-10-17 1999-08-03 Herbert; Victor D. Vitamin supplement composition
US6265391B1 (en) 1995-10-17 2001-07-24 Upsher-Smith Laboratories, Inc. Method for preventing peripheral nerve damage
US5997915A (en) * 1996-01-31 1999-12-07 South Alabama Medical Science Foundation Compositions for human and animal consumption containing reduced folates and methods for making and using same
GB9617683D0 (en) 1996-08-23 1996-10-02 Univ Glasgow Homocysteine desulphurase
AU6765798A (en) 1997-03-20 1998-10-12 Coventry Group, Ltd. Nutritional supplement for cardiovascular health
DE19713088C1 (de) * 1997-03-27 1998-11-26 Reiner Dr Probst Verfahren und Blutabnahmegefäß zur Aufbereitung von Blutproben für die Homocystein- und/oder Folatbestimmung
WO1998049199A1 (en) * 1997-05-01 1998-11-05 Panorama Research, Inc. Cardiovascular disease risk assessment
US5910403A (en) * 1997-05-15 1999-06-08 The Regents Of University Of California Methods for measuring cellular proliferation and destruction rates in vitro and in vivo
AU8153098A (en) * 1997-06-23 1999-01-04 Nexstar Pharmaceuticals, Inc. Homocysteine assay
US6140102A (en) * 1997-07-24 2000-10-31 Anticancer, Inc. High specificity homocysteinases and genes therefor
US6468762B1 (en) 1997-07-24 2002-10-22 Anticancer, Inc. High specificity homocysteinases
US6066467A (en) * 1997-07-24 2000-05-23 Anticancer, Inc. High specificity homocysteine assays for biological samples
US5985540A (en) * 1997-07-24 1999-11-16 Anticancer, Inc. High specificity homocysteine assays for biological samples
US6300136B1 (en) * 1997-09-03 2001-10-09 The Trustees Of The University Of Pennsylvania Methods for diagnosis and treatment of tumors in humans
WO2000000821A1 (en) 1998-06-29 2000-01-06 Ullman Edwin F Assay for homocysteine
US6284219B1 (en) 1998-06-30 2001-09-04 Phenome Sciences Inc. In vivo determination of metabolic function for use in therapy management
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US6174696B1 (en) 1999-11-12 2001-01-16 Genzyme Corporation Method for the determination of homocysteine
AU780804B2 (en) 1999-02-01 2005-04-21 Anticancer, Inc. Homogeneous enzymatic assay for vitamin B6 and improvements in H2S detection
US7696219B2 (en) * 2000-09-27 2010-04-13 Everett Laboratories, Inc. Method and composition for supplementation of nutritional deficiences in renal patients
US6995166B1 (en) 2000-09-27 2006-02-07 Everett Laboratories, Inc. Method and composition for supplementation of nutritional deficiencies in renal patients
CN1537009A (zh) * 2001-04-25 2004-10-13 �ư������������޹�˾ 一种用于治疗或者预防个体功能性维生素b12缺陷的方法以及在该方法中使用的药物组合物
WO2003001182A2 (en) * 2001-06-21 2003-01-03 The Cleveland Clinic Foundation Homocysteinylated transthyretin
US6660293B2 (en) * 2001-06-29 2003-12-09 Everett Laboratories, Inc. Compositions and methods for prophylactic and therapeutic supplementation of nutrition in subjects
US7560123B2 (en) * 2004-08-12 2009-07-14 Everett Laboratories, Inc. Compositions and methods for nutrition supplementation
US7001587B2 (en) * 2001-10-24 2006-02-21 The Regents Of The University Of California Measurement of protein synthesis rates in humans and experimental systems by use of isotopically labeled water
DE60324393D1 (de) * 2002-02-12 2008-12-11 Univ California Nichtinvasive messung der biosynthese- und abbaugeschwindigkeiten biologischer moleküle, die einer direkten probenahme unzugänglich oder nicht leicht zugänglich sind, durch einbau einer markierung in metabolische derivate und katabole produkte
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ATE415486T1 (de) * 2002-09-13 2008-12-15 Univ California Verfahren zur messung der geschwindigkeiten des cholesterinrückwärtstransports in vivo als index für anti-artherogenese
US20070248540A1 (en) * 2002-09-16 2007-10-25 The Regents Of The University Of California Biochemical methods for measuring metabolic fitness of tissues or whole organisms
AU2003275037A1 (en) * 2002-09-16 2004-04-30 The Regents Of The University Of California Biochemical methods for measuring metabolic fitness of tissues or whole organisms
EP1558293A4 (de) * 2002-11-04 2006-10-25 Univ California Deuterierte glucose- oder fetttoleranztests für die messung des stoffwechsels vonzuckern oder fettsüuren im k rper mit hohem durchsatz
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US8617617B2 (en) * 2002-12-10 2013-12-31 Everett Laboratories, Inc. Methods and kits for co-administration of nutritional supplements
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US7262020B2 (en) * 2003-07-03 2007-08-28 The Regents Of The University Of California Methods for comparing relative flux rates of two or more biological molecules in vivo through a single protocol
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US8480797B2 (en) 2005-09-12 2013-07-09 Abela Pharmaceuticals, Inc. Activated carbon systems for facilitating use of dimethyl sulfoxide (DMSO) by removal of same, related compounds, or associated odors
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US8597640B2 (en) * 2007-10-31 2013-12-03 University Of Massachusetts Lowell Over-the-counter vitamin/nutriceutical formulation that provides neuroprotection and maintains or improves cognitive performance in alzheimer's disease and normal aging
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GB2168478A (en) * 1984-11-26 1986-06-18 Scan Limited M Analysis of protein etc using mass spectrometry
JPS62292190A (ja) * 1986-06-11 1987-12-18 日本ユニオンスペシャル株式会社 ミシンのル−パ糸の糸繰り装置
US4940658A (en) * 1986-11-20 1990-07-10 University Patents, Inc. Assay for sulfhydryl amino acids and methods for detecting and distinguishing cobalamin and folic acid deficency

Also Published As

Publication number Publication date
US4940658A (en) 1990-07-10
EP0269352B1 (de) 1993-03-17
JPS63221249A (ja) 1988-09-14
EP0269352A3 (en) 1988-07-06
JPH0749348A (ja) 1995-02-21
JP2574339B2 (ja) 1997-01-22
ATE139344T1 (de) 1996-06-15
EP0486118A1 (de) 1992-05-20
CA1298536C (en) 1992-04-07
JP2577878B2 (ja) 1997-02-05
JP2579434B2 (ja) 1997-02-05
EP0269352A2 (de) 1988-06-01
ATE87104T1 (de) 1993-04-15
DE3751840D1 (de) 1996-07-18
DE3784852T2 (de) 1993-06-24
EP0486118B1 (de) 1996-06-12
JPH0854398A (ja) 1996-02-27
DE3751840T2 (de) 1997-01-09
HK1007799A1 (en) 1999-04-23

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