DE3784852D1 - - Google Patents

Info

Publication number
DE3784852D1
DE3784852D1 DE87310138T DE3784852T DE3784852D1 DE 3784852 D1 DE3784852 D1 DE 3784852D1 DE 87310138 T DE87310138 T DE 87310138T DE 3784852 T DE3784852 T DE 3784852T DE 3784852 D1 DE3784852 D1 DE 3784852D1
Authority
DE
Germany
Prior art keywords
cobalamin
folate
disorders
indicative
warm
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE87310138T
Other languages
English (en)
Other versions
DE3784852T2 (de
Inventor
Robert H. Englewood Colorado 80110 Us Allen
Sally P. Denver Colorado 80206 Us Stabler
John New York New York 10023 Us Lindenbaum
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Competitive Technologies Inc
Original Assignee
University Patents Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25464166&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE3784852(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by University Patents Inc filed Critical University Patents Inc
Publication of DE3784852D1 publication Critical patent/DE3784852D1/de
Application granted granted Critical
Publication of DE3784852T2 publication Critical patent/DE3784852T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6806Determination of free amino acids
    • G01N33/6812Assays for specific amino acids
    • G01N33/6815Assays for specific amino acids containing sulfur, e.g. cysteine, cystine, methionine, homocysteine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/02Nutrients, e.g. vitamins, minerals
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/82Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving vitamins or their receptors
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00Chemistry: analytical and immunological testing
    • Y10S436/825Pretreatment for removal of interfering factors from sample
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/10Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/18Sulfur containing
    • Y10T436/182Organic or sulfhydryl containing [e.g., mercaptan, hydrogen, sulfide, etc.]
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/24Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/25Chemistry: analytical and immunological testing including sample preparation

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Obesity (AREA)
  • Nutrition Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Veterinary Medicine (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
  • Sampling And Sample Adjustment (AREA)
DE8787310138T 1986-11-20 1987-11-17 Test fuer sulfhydrylaminosaeure und verfahren zum nachweis und zur unterscheidung von cobalamin und folsaeure. Expired - Fee Related DE3784852T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/933,553 US4940658A (en) 1986-11-20 1986-11-20 Assay for sulfhydryl amino acids and methods for detecting and distinguishing cobalamin and folic acid deficency

Publications (2)

Publication Number Publication Date
DE3784852D1 true DE3784852D1 (de) 1993-04-22
DE3784852T2 DE3784852T2 (de) 1993-06-24

Family

ID=25464166

Family Applications (2)

Application Number Title Priority Date Filing Date
DE3751840T Expired - Fee Related DE3751840T2 (de) 1986-11-20 1987-11-17 Verfahren zum Nachweis eines Cobalamin- und Folsäuredefizits
DE8787310138T Expired - Fee Related DE3784852T2 (de) 1986-11-20 1987-11-17 Test fuer sulfhydrylaminosaeure und verfahren zum nachweis und zur unterscheidung von cobalamin und folsaeure.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE3751840T Expired - Fee Related DE3751840T2 (de) 1986-11-20 1987-11-17 Verfahren zum Nachweis eines Cobalamin- und Folsäuredefizits

Country Status (7)

Country Link
US (1) US4940658A (de)
EP (2) EP0486118B1 (de)
JP (3) JP2574339B2 (de)
AT (2) ATE139344T1 (de)
CA (1) CA1298536C (de)
DE (2) DE3751840T2 (de)
HK (1) HK1007799A1 (de)

Families Citing this family (84)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5563126A (en) * 1986-11-20 1996-10-08 Metabolite Laboratories Method for treatment and prevention of deficiencies of vitamins B12, folic acid, and B6
US4940658A (en) * 1986-11-20 1990-07-10 University Patents, Inc. Assay for sulfhydryl amino acids and methods for detecting and distinguishing cobalamin and folic acid deficency
US5374560A (en) * 1989-04-03 1994-12-20 The University Of Colorado, Inc. Method for screening and distinguishing between cobalamin and folic acid deficiency based on assay for cystathionine and 2-methylcitric acid
US5457055A (en) * 1986-11-20 1995-10-10 The University Of Colorado Foundation Diagnostic method for cobalamin deficiency
US5438017A (en) * 1989-05-01 1995-08-01 The University Of Colorado Foundation, Inc. Assays for sulfhydryl amino acids and methylmalonic acid and their application to diagnosis of cobalamin deficiency
DK138090D0 (da) * 1990-06-06 1990-06-06 Novo Nordisk As Diagnostisk analysemetode
US6207651B1 (en) 1996-08-02 2001-03-27 Metabolite Laboratories Method for treatment and prevention of deficiencies of vitamins B12, folic acid, and B6
US20030203873A1 (en) * 1992-12-29 2003-10-30 Allen Robert H Method for treatment of neuropsychiatric disorders
US5478729A (en) * 1994-04-28 1995-12-26 Syntex (U.S.A.) Inc. Immunoassay for homocysteine
US5559038A (en) * 1994-05-04 1996-09-24 The Regents Of The University Of Colorado Gas chromatography/mass spectrometry determination of oxidized sulfhydryl amino acids
US5800979A (en) * 1994-12-01 1998-09-01 Kolhouse; J. Fred Gas chromatography/mass spectrometric determination of folic acid coenzymes
US5932624A (en) * 1995-10-17 1999-08-03 Herbert; Victor D. Vitamin supplement composition
US6265391B1 (en) 1995-10-17 2001-07-24 Upsher-Smith Laboratories, Inc. Method for preventing peripheral nerve damage
US5997915A (en) * 1996-01-31 1999-12-07 South Alabama Medical Science Foundation Compositions for human and animal consumption containing reduced folates and methods for making and using same
GB9617683D0 (en) 1996-08-23 1996-10-02 Univ Glasgow Homocysteine desulphurase
AU6765798A (en) 1997-03-20 1998-10-12 Coventry Group, Ltd. Nutritional supplement for cardiovascular health
DE19713088C1 (de) * 1997-03-27 1998-11-26 Reiner Dr Probst Verfahren und Blutabnahmegefäß zur Aufbereitung von Blutproben für die Homocystein- und/oder Folatbestimmung
WO1998049199A1 (en) * 1997-05-01 1998-11-05 Panorama Research, Inc. Cardiovascular disease risk assessment
US5910403A (en) * 1997-05-15 1999-06-08 The Regents Of University Of California Methods for measuring cellular proliferation and destruction rates in vitro and in vivo
AU8153098A (en) * 1997-06-23 1999-01-04 Nexstar Pharmaceuticals, Inc. Homocysteine assay
US6140102A (en) * 1997-07-24 2000-10-31 Anticancer, Inc. High specificity homocysteinases and genes therefor
US6468762B1 (en) 1997-07-24 2002-10-22 Anticancer, Inc. High specificity homocysteinases
US6066467A (en) * 1997-07-24 2000-05-23 Anticancer, Inc. High specificity homocysteine assays for biological samples
US5985540A (en) * 1997-07-24 1999-11-16 Anticancer, Inc. High specificity homocysteine assays for biological samples
US6300136B1 (en) * 1997-09-03 2001-10-09 The Trustees Of The University Of Pennsylvania Methods for diagnosis and treatment of tumors in humans
WO2000000821A1 (en) 1998-06-29 2000-01-06 Ullman Edwin F Assay for homocysteine
US6284219B1 (en) 1998-06-30 2001-09-04 Phenome Sciences Inc. In vivo determination of metabolic function for use in therapy management
US6953666B1 (en) 1998-11-06 2005-10-11 Emory University Biomarkers for oxidative stress
US6174696B1 (en) 1999-11-12 2001-01-16 Genzyme Corporation Method for the determination of homocysteine
AU780804B2 (en) 1999-02-01 2005-04-21 Anticancer, Inc. Homogeneous enzymatic assay for vitamin B6 and improvements in H2S detection
US7696219B2 (en) * 2000-09-27 2010-04-13 Everett Laboratories, Inc. Method and composition for supplementation of nutritional deficiences in renal patients
US6995166B1 (en) 2000-09-27 2006-02-07 Everett Laboratories, Inc. Method and composition for supplementation of nutritional deficiencies in renal patients
CN1537009A (zh) * 2001-04-25 2004-10-13 �ư������������޹�˾ 一种用于治疗或者预防个体功能性维生素b12缺陷的方法以及在该方法中使用的药物组合物
WO2003001182A2 (en) * 2001-06-21 2003-01-03 The Cleveland Clinic Foundation Homocysteinylated transthyretin
US6660293B2 (en) * 2001-06-29 2003-12-09 Everett Laboratories, Inc. Compositions and methods for prophylactic and therapeutic supplementation of nutrition in subjects
US7560123B2 (en) * 2004-08-12 2009-07-14 Everett Laboratories, Inc. Compositions and methods for nutrition supplementation
US7001587B2 (en) * 2001-10-24 2006-02-21 The Regents Of The University Of California Measurement of protein synthesis rates in humans and experimental systems by use of isotopically labeled water
DE60324393D1 (de) * 2002-02-12 2008-12-11 Univ California Nichtinvasive messung der biosynthese- und abbaugeschwindigkeiten biologischer moleküle, die einer direkten probenahme unzugänglich oder nicht leicht zugänglich sind, durch einbau einer markierung in metabolische derivate und katabole produkte
US20030224420A1 (en) * 2002-04-05 2003-12-04 Hellerstein Marc K. Method for isolating and measuring proliferation of long-term label retaining cells and stem cells
WO2004011426A2 (en) 2002-07-30 2004-02-05 The Regents Of The University Of California Method for automated, large-scale measurement of the molecular flux rates of the proteome or the organeome using mass spectrometry
WO2004021863A2 (en) * 2002-09-04 2004-03-18 The Regents Of The University Of California Methods for measuring rates of replication and death of nfectious microbial agents in an infected host organism
ATE415486T1 (de) * 2002-09-13 2008-12-15 Univ California Verfahren zur messung der geschwindigkeiten des cholesterinrückwärtstransports in vivo als index für anti-artherogenese
US20070248540A1 (en) * 2002-09-16 2007-10-25 The Regents Of The University Of California Biochemical methods for measuring metabolic fitness of tissues or whole organisms
AU2003275037A1 (en) * 2002-09-16 2004-04-30 The Regents Of The University Of California Biochemical methods for measuring metabolic fitness of tissues or whole organisms
EP1558293A4 (de) * 2002-11-04 2006-10-25 Univ California Deuterierte glucose- oder fetttoleranztests für die messung des stoffwechsels vonzuckern oder fettsüuren im k rper mit hohem durchsatz
US20050019937A1 (en) * 2002-11-29 2005-01-27 Industrial Technology Research Institute Assay and kit for homocysteine
US8617617B2 (en) * 2002-12-10 2013-12-31 Everett Laboratories, Inc. Methods and kits for co-administration of nutritional supplements
US6814983B2 (en) * 2002-12-10 2004-11-09 Everett Laboratories, Inc. Compositions and methods for nutrition supplementation
US7262020B2 (en) * 2003-07-03 2007-08-28 The Regents Of The University Of California Methods for comparing relative flux rates of two or more biological molecules in vivo through a single protocol
US7097968B2 (en) * 2003-07-10 2006-08-29 General Atomics Methods and compositions for assaying homocysteine
US8476034B2 (en) * 2003-07-10 2013-07-02 General Atomics Methods and compositions for assaying homocysteine
US8173618B2 (en) * 2003-07-25 2012-05-08 University Of Massachusetts Formulations for reducing neuronal degeneration
US20050202406A1 (en) 2003-11-25 2005-09-15 The Regents Of The University Of California Method for high-throughput screening of compounds and combinations of compounds for discovery and quantification of actions, particularly unanticipated therapeutic or toxic actions, in biological systems
TW200538738A (en) 2004-02-20 2005-12-01 Univ California Molecular flux rates through critical pathways measured by stable isotope labeling in vivo, as biomarkers of drug action and disease activity
AU2005222430A1 (en) * 2004-03-11 2005-09-22 The Regents Of University Of California Temporal or spatial characterization of biosynthetic events in living organisms by isotopic fingerprinting under conditions of imposed isotopic gradients
WO2005094327A2 (en) * 2004-03-29 2005-10-13 The Regents Of The University Of California Isolation of epithelial cells or their biochemical contents from excreta after in vivo isotopic labeling
US20080063730A9 (en) * 2004-07-29 2008-03-13 Giordano John A Methods for prophylactic and therapeutic nutritional supplementation
US8101587B2 (en) * 2004-08-12 2012-01-24 Everett Laboratories, Inc. Kits for nutrition supplementation
US20060251576A1 (en) * 2005-05-03 2006-11-09 The Regents Of The University Of California Methods for measuring cholesterol metabolism and transport
TW200711660A (en) 2005-06-10 2007-04-01 Univ California Monitoring two dimensions of diabetes pathogenesis separately or concurrently (insulin sensitivity and beta-cell sufficiency): uses in diagnosis, prognosis, assessment of disease risk, and drug development
US8480797B2 (en) 2005-09-12 2013-07-09 Abela Pharmaceuticals, Inc. Activated carbon systems for facilitating use of dimethyl sulfoxide (DMSO) by removal of same, related compounds, or associated odors
EP1966229B1 (de) 2005-09-12 2015-10-21 Abela Pharmaceuticals, Inc. Systeme zur entfernung von dimethylsulfoxid (dmso) oder verwandten verbindungen, oder damit assoziierten gerüchen
EP1937286B1 (de) * 2005-09-12 2016-03-09 Abela Pharmaceuticals, Inc. Zusammensetzungen aus dimethylsulfoxid (dmso)
US8435224B2 (en) 2005-09-12 2013-05-07 Abela Pharmaceuticals, Inc. Materials for facilitating administration of dimethyl sulfoxide (DMSO) and related compounds
US20070292529A1 (en) * 2006-06-19 2007-12-20 Tabbiner Philip S Strontium compositions and methods of treating osteoporotic conditions
US20070292535A1 (en) * 2006-06-19 2007-12-20 Tabbiner Philip S Strontium compositions and methods of treating arthritic and or osteoporitic conditions
US8257697B2 (en) 2007-10-31 2012-09-04 Allertech Laboratory Inc. Use of platelet activating factor acetylhydrolase as biomarker for anaphylaxis
US8597640B2 (en) * 2007-10-31 2013-12-03 University Of Massachusetts Lowell Over-the-counter vitamin/nutriceutical formulation that provides neuroprotection and maintains or improves cognitive performance in alzheimer's disease and normal aging
US20100285593A1 (en) * 2007-11-26 2010-11-11 Waters Technologies Corporation Internal standards and methods for use in quantitatively measuring analytes in a sample
BRPI0921494A2 (pt) 2008-11-03 2018-10-30 Prad Reasearch And Development Ltd método de planejamento de uma operação de amostragem para uma formação subterrãnea, método de contolar uma operação de amostragem de formação subterrânea, método de controlar uma operação de perfuração para uma formação subterrãnea, e método de realizar uma amostragem durante a operação de perfuração.
CN101509913B (zh) * 2009-04-08 2012-08-22 内蒙古蒙牛乳业(集团)股份有限公司 一种乳及乳制品中氨基酸含量检测的回收实验方法
MX353712B (es) 2009-10-30 2018-01-24 Abela Pharmaceuticals Inc Formulaciones de sulfoxido de dimetilo (dmso) y metilsulfonilmetano (msm) para tratar osteoartritis.
US10837972B2 (en) * 2010-06-09 2020-11-17 Quest Diagnostics Investments Incorporated Mass spectrometric determination of derivatized methylmalonic acid
US8183227B1 (en) 2011-07-07 2012-05-22 Chemo S. A. France Compositions, kits and methods for nutrition supplementation
JP2014526685A (ja) 2011-09-08 2014-10-06 ザ・リージェンツ・オブ・ザ・ユニバーシティ・オブ・カリフォルニア 代謝流量測定、画像化、および顕微鏡法
US8168611B1 (en) 2011-09-29 2012-05-01 Chemo S.A. France Compositions, kits and methods for nutrition supplementation
CA2858368A1 (en) 2011-12-07 2013-06-13 Glaxosmithkline Llc Methods for determining total body skeletal muscle mass
WO2013099949A1 (ja) * 2011-12-28 2013-07-04 扶桑薬品工業株式会社 血漿中の酢酸濃度の測定方法
MX2015001788A (es) * 2012-08-10 2015-09-28 Cedars Sinai Medical Center Metabolitos de metionina predicen la evolución agresiva del cáncer.
US9134319B2 (en) 2013-03-15 2015-09-15 The Regents Of The University Of California Method for replacing biomarkers of protein kinetics from tissue samples by biomarkers of protein kinetics from body fluids after isotopic labeling in vivo
US20160195510A1 (en) * 2014-12-31 2016-07-07 Castle Medical, LLC Methods for determination of total homocysteine
US11519918B2 (en) 2017-07-24 2022-12-06 The Industry & Academic Cooperation In Chungnam National University (Iac) Method for quantification of amino acids using cell-free protein synthesis system
WO2019183294A1 (en) 2018-03-20 2019-09-26 Rubius Therapeutics, Inc. Therapeutic cell systems and methods for treating homocystinuria
CN116818966A (zh) * 2023-06-29 2023-09-29 山东英盛生物技术有限公司 Lc-ms/ms测定甲基丙二酸、同型半胱氨酸及其相关代谢产物方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3577511A (en) * 1968-02-21 1971-05-04 Adrian Leonard Luhby Process and compositions for differential diagnosis of the megaloblastic anemia syndromes
JPS5246838B2 (de) * 1973-10-18 1977-11-28
US4351822A (en) * 1978-04-04 1982-09-28 University Patents, Inc. Quantitative testing for vitamin B12
US4188189A (en) * 1978-04-04 1980-02-12 University Patents, Inc. Quantitative testing for vitamin B12
US4279886A (en) * 1979-01-02 1981-07-21 University Patents, Inc. Test for pancreatic exocrine function
US4447547A (en) * 1980-04-09 1984-05-08 University Patents, Inc. Immunoassay for measurement of reticulocytes, and immunoreactive reagents for use therein
US4332785A (en) * 1980-04-09 1982-06-01 University Patents, Inc. Immunoassay for measurement of reticulocytes, and immunoreactive reagents for use therein
US4451571A (en) * 1981-04-06 1984-05-29 University Patents, Inc. Preparation of samples for vitamin B12 and/or folate assay and assay
US4427780A (en) * 1981-08-13 1984-01-24 University Patents, Inc. Method for assaying vitamin-containing compositions for vitamin analogues
US4467037A (en) * 1982-03-01 1984-08-21 The Curators Of The University Of Missouri Silylation of amino acids
GB2168478A (en) * 1984-11-26 1986-06-18 Scan Limited M Analysis of protein etc using mass spectrometry
JPS62292190A (ja) * 1986-06-11 1987-12-18 日本ユニオンスペシャル株式会社 ミシンのル−パ糸の糸繰り装置
US4940658A (en) * 1986-11-20 1990-07-10 University Patents, Inc. Assay for sulfhydryl amino acids and methods for detecting and distinguishing cobalamin and folic acid deficency

Also Published As

Publication number Publication date
US4940658A (en) 1990-07-10
EP0269352B1 (de) 1993-03-17
JPS63221249A (ja) 1988-09-14
EP0269352A3 (en) 1988-07-06
JPH0749348A (ja) 1995-02-21
JP2574339B2 (ja) 1997-01-22
ATE139344T1 (de) 1996-06-15
EP0486118A1 (de) 1992-05-20
CA1298536C (en) 1992-04-07
JP2577878B2 (ja) 1997-02-05
JP2579434B2 (ja) 1997-02-05
EP0269352A2 (de) 1988-06-01
ATE87104T1 (de) 1993-04-15
DE3751840D1 (de) 1996-07-18
DE3784852T2 (de) 1993-06-24
EP0486118B1 (de) 1996-06-12
JPH0854398A (ja) 1996-02-27
DE3751840T2 (de) 1997-01-09
HK1007799A1 (en) 1999-04-23

Similar Documents

Publication Publication Date Title
DE3784852D1 (de)
FI865151A (fi) Anordning med baerbara, snoerloesa telefonapparater.
FI880174A0 (fi) Tertiaerae hydroxialkylxantiner, foerfarande foer deras framstaellning, dessa innehaollande laekemedel samt deras anvaendning.
DE69014911D1 (de) Füllstandsensor für Fluide.
NO875486L (no) Doerstopper med spor.
NO882176L (no) Borestrengkomponent med hoeyt boeyestyrkeforhold.
DE3689072D1 (de) Hochfeste polyolefine.
DE3685083D1 (de) Gesteinsbohrer mit verschleissbestaendigen einsaetzen.
DE3676613D1 (de) Gleiskoerper.
NO159611C (no) Hjertestykke, spesielt hjertestykkespiss for sporkryss eller -veksler, samt te for dettes fremstilling.
FI864403A0 (fi) Ban- eller slangformig foerpackningsfolie, i synnerhet med spaerrskikt foersett korvskal.
NO157952C (no) Kombinasjonsgevaer med repetermekanisme.
NO883070D0 (no) 4-aminosubstituerte 1,2-dihydroksynaftalin-derivater.
FI862900A0 (fi) Formanpassad saengklaedsartikel.
DE3686758D1 (de) Profilsteuerungsorgan.
DK24687A (da) 3-alkoxyflavonderivater samt antiviralt virksomme terapeutiske midler indeholdende disse
ATE38434T1 (de) Kuvetten.
IT8420775V0 (it) Corpo musicale, nonche' di illuminazione, automatico.
NO875448L (no) Assistert oljeutvikling med hydrofobisk assosierende polymerer.
DE3680815D1 (de) 5,6-dihydroimidazo(2,1-b)thiazol-2-carboxamidderivate und ihre salze.
FI875061A0 (fi) Foerfarande foer att med spraytorkningsabsorption avsvavla en varm roekgasstroem.
FI883361A0 (fi) Myntfoervar med svaengbar botten.
FI855121A0 (fi) Kopplingsanordning foer kommunikationsanlaeggningar, saerskilt telefonanlaeggningar, med till foermedlingsstaellen via ledningsknippen anslutna underfoermedlingsstaellen.
FI882389A (fi) 5-substituerat-10-cyanmetylentieno/ 3,4-b/benzoazepin.
FI852405L (fi) Substituerade 3,4-diamino-1,2,5 -tiadiazoler med antagoniserande inverkan pao histaminets h2-receptorer.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: COMPETITIVE TECHNOLOGIES, INC. (N.D.GES.D. STAATES

8339 Ceased/non-payment of the annual fee