ATE79036T1 - Transdermale, elektrolytische zufuehrung von proteinen. - Google Patents
Transdermale, elektrolytische zufuehrung von proteinen.Info
- Publication number
- ATE79036T1 ATE79036T1 AT88101856T AT88101856T ATE79036T1 AT E79036 T1 ATE79036 T1 AT E79036T1 AT 88101856 T AT88101856 T AT 88101856T AT 88101856 T AT88101856 T AT 88101856T AT E79036 T1 ATE79036 T1 AT E79036T1
- Authority
- AT
- Austria
- Prior art keywords
- electrolytic
- patient
- composition
- protein
- skin
- Prior art date
Links
- 102000004169 proteins and genes Human genes 0.000 title abstract 4
- 108090000623 proteins and genes Proteins 0.000 title abstract 4
- 239000000203 mixture Substances 0.000 abstract 3
- NLKNQRATVPKPDG-UHFFFAOYSA-M potassium iodide Chemical compound [K+].[I-] NLKNQRATVPKPDG-UHFFFAOYSA-M 0.000 abstract 3
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 2
- 102000055006 Calcitonin Human genes 0.000 abstract 1
- 108060001064 Calcitonin Proteins 0.000 abstract 1
- 102400000739 Corticotropin Human genes 0.000 abstract 1
- 101800000414 Corticotropin Proteins 0.000 abstract 1
- 102400000321 Glucagon Human genes 0.000 abstract 1
- 108060003199 Glucagon Proteins 0.000 abstract 1
- 102000004877 Insulin Human genes 0.000 abstract 1
- 108090001061 Insulin Proteins 0.000 abstract 1
- 102000007327 Protamines Human genes 0.000 abstract 1
- 108010007568 Protamines Proteins 0.000 abstract 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 abstract 1
- 239000000853 adhesive Substances 0.000 abstract 1
- 230000001070 adhesive effect Effects 0.000 abstract 1
- 230000004888 barrier function Effects 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- BBBFJLBPOGFECG-VJVYQDLKSA-N calcitonin Chemical compound N([C@H](C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(N)=O)C(C)C)C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1 BBBFJLBPOGFECG-VJVYQDLKSA-N 0.000 abstract 1
- 229960004015 calcitonin Drugs 0.000 abstract 1
- 239000004202 carbamide Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- IDLFZVILOHSSID-OVLDLUHVSA-N corticotropin Chemical compound C([C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)NC(=O)[C@@H](N)CO)C1=CC=C(O)C=C1 IDLFZVILOHSSID-OVLDLUHVSA-N 0.000 abstract 1
- 229960000258 corticotropin Drugs 0.000 abstract 1
- 239000006184 cosolvent Substances 0.000 abstract 1
- MASNOZXLGMXCHN-ZLPAWPGGSA-N glucagon Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 MASNOZXLGMXCHN-ZLPAWPGGSA-N 0.000 abstract 1
- 229960004666 glucagon Drugs 0.000 abstract 1
- 229960000789 guanidine hydrochloride Drugs 0.000 abstract 1
- PJJJBBJSCAKJQF-UHFFFAOYSA-N guanidinium chloride Chemical compound [Cl-].NC(N)=[NH2+] PJJJBBJSCAKJQF-UHFFFAOYSA-N 0.000 abstract 1
- 229940125396 insulin Drugs 0.000 abstract 1
- 239000012528 membrane Substances 0.000 abstract 1
- ZQZJKHIIQFPZCS-UHFFFAOYSA-N propylurea Chemical compound CCCNC(N)=O ZQZJKHIIQFPZCS-UHFFFAOYSA-N 0.000 abstract 1
- 229950008679 protamine sulfate Drugs 0.000 abstract 1
- BAZAXWOYCMUHIX-UHFFFAOYSA-M sodium perchlorate Chemical compound [Na+].[O-]Cl(=O)(=O)=O BAZAXWOYCMUHIX-UHFFFAOYSA-M 0.000 abstract 1
- 229910001488 sodium perchlorate Inorganic materials 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0408—Use-related aspects
- A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/44—Applying ionised fluids
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Radiology & Medical Imaging (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Electrotherapy Devices (AREA)
- Media Introduction/Drainage Providing Device (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1289887A | 1987-02-10 | 1987-02-10 | |
| EP88101856A EP0278473B1 (de) | 1987-02-10 | 1988-02-09 | Transdermale, elektrolytische Zuführung von Proteinen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE79036T1 true ATE79036T1 (de) | 1992-08-15 |
Family
ID=21757276
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT88101856T ATE79036T1 (de) | 1987-02-10 | 1988-02-09 | Transdermale, elektrolytische zufuehrung von proteinen. |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP0278473B1 (de) |
| JP (1) | JP2670794B2 (de) |
| KR (1) | KR970000232B1 (de) |
| AT (1) | ATE79036T1 (de) |
| AU (1) | AU609769B2 (de) |
| CA (1) | CA1319608C (de) |
| DE (1) | DE3873366T2 (de) |
| ES (1) | ES2033349T3 (de) |
| MX (1) | MX168981B (de) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5362307A (en) * | 1989-01-24 | 1994-11-08 | The Regents Of The University Of California | Method for the iontophoretic non-invasive-determination of the in vivo concentration level of an inorganic or organic substance |
| KR970011449B1 (ko) * | 1988-01-29 | 1997-07-11 | 더 리전트 오브 디 유니버시티 오브 캘리포니아 | 이온전기 영동형 비침입 검체 채취 또는 이송 장치 및 방법 |
| IE64891B1 (en) | 1990-03-15 | 1995-09-20 | Becton Dickinson Co | Composition for increased skin concentration of active agents by iontophoresis |
| AU647103B2 (en) * | 1990-03-30 | 1994-03-17 | Alza Corporation | Iontophoretic delivery device |
| CA2087087C (en) * | 1992-01-22 | 2000-07-18 | Burton H. Sage, Jr. | Molecules for iontophoretic delivery |
| EP0683668A4 (de) * | 1993-01-27 | 1997-12-29 | Affymax Tech Nv | Präparate und verfahren für eine transdermale arzneistoffverabreichung. |
| US5533971A (en) * | 1993-09-03 | 1996-07-09 | Alza Corporation | Reduction of skin irritation during electrotransport |
| US5505715A (en) * | 1994-02-25 | 1996-04-09 | Bristol-Myers Squibb Company | Iontophoretic transdermal delivery of deoxyspergualin compounds |
| JP3119486B2 (ja) * | 1994-06-17 | 2000-12-18 | 久光製薬株式会社 | イオントフォレーシス用電極及びそれを用いたデバイス |
| WO1996031200A1 (de) * | 1995-04-07 | 1996-10-10 | Novartis Ag | Transdermales system mit elektroden als initialisierungssystem |
| US5624415A (en) * | 1995-04-24 | 1997-04-29 | Alza Corporation | Reduction of skin irritation and resistance during electrotransport |
| US5990179A (en) * | 1995-04-28 | 1999-11-23 | Alza Corporation | Composition and method of enhancing electrotransport agent delivery |
| IT1285405B1 (it) | 1995-06-06 | 1998-06-03 | Alza Corp | Modificazione di farmaci polipeptidici per accrescere il flusso per elettrotrasporto. |
| US5747453A (en) | 1995-06-06 | 1998-05-05 | Alza Corporation | Method for increasing the electrotransport flux of polypeptides |
| US6333189B1 (en) | 1996-06-06 | 2001-12-25 | Alza Corporation | Method of making an electrotransport device |
| US6119036A (en) * | 1997-03-26 | 2000-09-12 | The Board Of Regents Of The University Of Oklahoma | Iontophoretic transdermal delivery device |
| IL159273A0 (en) * | 2003-12-09 | 2004-06-01 | Transpharma Medical Ltd | Transdermal delivery system for sustained release of polypeptides |
| CA2587657A1 (en) * | 2004-11-30 | 2006-06-08 | Transcutaneous Technologies Inc. | Iontophoresis device |
| EP1925336A4 (de) | 2005-09-15 | 2011-01-19 | Tti Ellebeau Inc | Stabartiges iontophoresegerät |
| FR2950802B1 (fr) | 2009-10-02 | 2012-02-03 | Sartorius Stedim Biotech Sa | Elaboration et/ou conservation d'un produit biopharmaceutique. |
| US9707275B2 (en) * | 2012-12-19 | 2017-07-18 | Wockhardt Limited | Stable aqueous composition comprising human insulin or an analogue or derivative thereof |
| CN113087787B (zh) * | 2021-05-19 | 2023-03-21 | 广西医科大学第二附属医院(广西医科大学第二临床医学院) | 一种蚯蚓血红蛋白分离及纯化方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK140801B (da) * | 1975-01-15 | 1979-11-19 | Nordisk Insulinlab | Fremgangsmåde til fremstilling af et stabilt langtidsvirkende insulinpræparat. |
| JPS5810066A (ja) * | 1981-07-10 | 1983-01-20 | 株式会社アドバンス | イオントフオレ−ゼ用プラスタ−構造体 |
| EP0092015A1 (de) * | 1982-04-16 | 1983-10-26 | Roland Brodard | Ionisierungsvorrichtung |
| JPS59118167A (ja) * | 1982-12-24 | 1984-07-07 | 株式会社アドバンス | イオントフオレ−ゼ用導子並びに同プラスタ−構造体 |
| US4622031A (en) * | 1983-08-18 | 1986-11-11 | Drug Delivery Systems Inc. | Indicator for electrophoretic transcutaneous drug delivery device |
| US4640689A (en) * | 1983-08-18 | 1987-02-03 | Drug Delivery Systems Inc. | Transdermal drug applicator and electrodes therefor |
| JPS61259679A (ja) * | 1985-05-14 | 1986-11-17 | 日東電工株式会社 | イオントフオレ−ゼ生体電極用基剤組成物 |
-
1988
- 1988-01-29 AU AU10986/88A patent/AU609769B2/en not_active Ceased
- 1988-02-09 EP EP88101856A patent/EP0278473B1/de not_active Expired - Lifetime
- 1988-02-09 JP JP63028617A patent/JP2670794B2/ja not_active Expired - Fee Related
- 1988-02-09 ES ES198888101856T patent/ES2033349T3/es not_active Expired - Lifetime
- 1988-02-09 AT AT88101856T patent/ATE79036T1/de not_active IP Right Cessation
- 1988-02-09 DE DE8888101856T patent/DE3873366T2/de not_active Expired - Lifetime
- 1988-02-10 CA CA000558559A patent/CA1319608C/en not_active Expired - Fee Related
- 1988-02-10 KR KR1019880001245A patent/KR970000232B1/ko not_active Expired - Fee Related
- 1988-02-10 MX MX010366A patent/MX168981B/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU1098688A (en) | 1988-08-11 |
| JPS63200774A (ja) | 1988-08-19 |
| EP0278473A1 (de) | 1988-08-17 |
| MX168981B (es) | 1993-06-16 |
| JP2670794B2 (ja) | 1997-10-29 |
| ES2033349T3 (es) | 1993-03-16 |
| AU609769B2 (en) | 1991-05-09 |
| EP0278473B1 (de) | 1992-08-05 |
| KR970000232B1 (ko) | 1997-01-08 |
| DE3873366T2 (de) | 1992-12-10 |
| DE3873366D1 (de) | 1992-09-10 |
| CA1319608C (en) | 1993-06-29 |
| KR880009633A (ko) | 1988-10-04 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE79036T1 (de) | Transdermale, elektrolytische zufuehrung von proteinen. | |
| KR880009632A (ko) | 폴리펩티드의 전해식 경피투여 | |
| AU644917B2 (en) | Device and method for renewing electrodes during iontophoresis | |
| CA1319578C (en) | Transdermal drug delivery device | |
| US5328454A (en) | Pulsating transdermal drug delivery system | |
| ES8403321A1 (es) | Procedimiento para la produccion de un preparado solido de fibrinogeno. | |
| DK1196430T3 (da) | Rensning og stabilisering af peptider og proteiner i farmaceutiske midler | |
| DE69630918D1 (de) | Matrix für Iontophorese | |
| KR910016318A (ko) | 이온 전기 도입법으로 딜리버리된 활성제의 피부내 농도를 증가시키는 방법 및 여기에 사용되는 조성물 | |
| DE69220808D1 (de) | Vorrichtung zur verabreichung von heilmitteln | |
| ATE67417T1 (de) | Medizinische einrichtung zur pulsatilen transdermalen verabreichung von biologisch aktiven wirkstoffen. | |
| DE3856189D1 (de) | Adhäsionsvarianten | |
| ES2061522T3 (es) | Material de conduccion ionica. | |
| JP2001522793A (ja) | 経皮電気輸送送達用の緩衝処理された薬物処方物 | |
| ATE184206T1 (de) | Vorrichtung zur erhöhung der wirkstoffsverabreichung durch elektrotransport | |
| AU647109B2 (en) | Iontophoresis device and method using a rate-controlling membrane | |
| DE3854631D1 (de) | Pulsierendes transkutanes Arzneimittel-Abgabesystem. | |
| DE69530217D1 (de) | Eine mikrodialysevorrichtung | |
| JPS6483254A (en) | Metal surface treatment agent for adhesion | |
| ATE101510T1 (de) | Transcutane verabreichung von aminen. | |
| JPH08743A (ja) | イオントフォレーシス用電極構造体 | |
| ATE335817T1 (de) | Adhäsionsvarianten | |
| JPH0312173A (ja) | イオントフォレーシス用インタフェース |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |