KR880009632A - 폴리펩티드의 전해식 경피투여 - Google Patents

폴리펩티드의 전해식 경피투여 Download PDF

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Publication number
KR880009632A
KR880009632A KR1019880000989A KR880000989A KR880009632A KR 880009632 A KR880009632 A KR 880009632A KR 1019880000989 A KR1019880000989 A KR 1019880000989A KR 880000989 A KR880000989 A KR 880000989A KR 880009632 A KR880009632 A KR 880009632A
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South Korea
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polypeptide
transdermal
transdermal patch
patch
patient
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KR1019880000989A
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KR970004037B1 (ko
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시발스 단
로센 샌포드
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단 시발스· 샌포드 로센
드러그 델리버리 시스템 인코포레이티드
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Electrotherapy Devices (AREA)
  • Peptides Or Proteins (AREA)

Abstract

내용 없음.

Description

폴리펩티드의 전해식 경피투여
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 환자에게 폴리펩티드를 경피식으로 투여하기 위한 전자식/전해식 장치의 한형태의 횡단면도.

Claims (14)

  1. 환자의 혈액 스트림에 최소한 하나의 약물을 직접투여하기 위한 경피식 첩제에 있어서: a) 약 3내지 약 20펩티드 단위를 가지는 최소한 하나의 폴리펩티드, 그리고 b) 약 0.5μ a/㎠ 내지 약 1μ a/㎠의 전류밀도를 특징으로 하는 폴리펩티드의 경피식 운반을 위한 전해식(electrolytic)수단을 병용으로 포함하고, 이때 환자의 피부는 자극되지 않고 홍반으로 되지 않게 되도록된 평피식 첩제(transdermal patch).
  2. 제1항에 있어서, 폴리펩티드를 바조프레신(vasopressin), 리프레신 (lypressin), 아트리오펩틴(atriopeptin), 옥시토신(oxytocin), 데스모프레신 (desmopressin), 디노르핀(dynorphin), 로이프로리드(leuprolide), 앙기오텐신 (angiotensin),및 이들의 혼합물을 포함하는 그룹에서 선택하는 경피식 첩제.
  3. 제2항에 있어서, 폴리펩티드가 바조프레신을 포함하는 경피식 첩제.
  4. 제2항에 있어서, 폴리펩티드가 리프레신을 포함하는 경피식 첩제.
  5. 제2항에 있어서, 폴리펩티드가 아트리오펩틴을 포함하는 경피식 첩제.
  6. 제1항에 있어서, 전해식 수단이 전지, 양극, 음극, 약물저장기 및 전극 사이에 있는 장벽수단을 포함하는 경피식 첩제.
  7. 제1항에 있어서, 폴리펩티드를 위한 수용액 용매를 추가로 포함하는 경피식 첩제.
  8. 제7항에 있어서, 해리용 공용매를 추가로 포함하는 경피식 첩제.
  9. 제8항에 있어서, 해리용 공용매를 요소, 요소의 알킬유도체, 구아니딘 염, 부탄올, 2-부탄올, 3이상의 탄소원자를 가지는 수용성 아미드, 옥화나트륨 및 칼륨, 과염소산나트륨, 낙산나트륨, 그리고 부의 Setschenow 상수를 가지는 다른 염을 포함하는 그룹에서 선택하는 경피식 첩제.
  10. 제1항에 있어서, 환충제, 킬레이트제, 산화방지제, 방부제 및 살균제를 포함하는 그룹에서 선택된 최소한 하나의 화합물을 추가로 포함하는 경피식 첩제.
  11. 제6항에 있어서, 약물 저장기의 피부측에 반투과성막을 포함하는 경피식 첩제.
  12. 제1항에 있어서, 최소한 하나의 폴리펩티드가 테스토테론을 추가로 포함하는 LH-RH 유사체인 경피식 접체.
  13. 제1항에 있어서, 최소한 하나의 폴리펩티드가 플루타미드를 추가로 포함하는 LH-RH 유사체인 경피식 접체.
  14. 제1항에 있어서, 전류밀도가 약 0.5ua/㎠ 내지 약 10ua/㎠인 경피식 접체.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019880000989A 1987-02-10 1988-02-03 폴리펩티드의 전해식 경피투여 KR970004037B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US012,889 1987-02-10
US07/012,889 US4878892A (en) 1987-02-10 1987-02-10 Electrolytic transdermal delivery of polypeptides

Publications (2)

Publication Number Publication Date
KR880009632A true KR880009632A (ko) 1988-10-04
KR970004037B1 KR970004037B1 (ko) 1997-03-24

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Country Link
US (1) US4878892A (ko)
EP (1) EP0278474B1 (ko)
JP (1) JPH0647016B2 (ko)
KR (1) KR970004037B1 (ko)
AT (1) ATE135928T1 (ko)
AU (1) AU608278B2 (ko)
CA (1) CA1317879C (ko)
DE (1) DE3855143T2 (ko)
MX (1) MX165338B (ko)

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Also Published As

Publication number Publication date
MX165338B (es) 1992-11-05
AU608278B2 (en) 1991-03-28
US4878892A (en) 1989-11-07
AU1098488A (en) 1988-08-11
EP0278474B1 (en) 1996-03-27
ATE135928T1 (de) 1996-04-15
JPH0647016B2 (ja) 1994-06-22
JPS63200775A (ja) 1988-08-19
DE3855143T2 (de) 1996-10-31
EP0278474A1 (en) 1988-08-17
DE3855143D1 (de) 1996-05-02
CA1317879C (en) 1993-05-18
KR970004037B1 (ko) 1997-03-24

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