ATE135928T1 - Elektrolytische zuführung von polypeptiden durch die haut - Google Patents

Elektrolytische zuführung von polypeptiden durch die haut

Info

Publication number
ATE135928T1
ATE135928T1 AT88101857T AT88101857T ATE135928T1 AT E135928 T1 ATE135928 T1 AT E135928T1 AT 88101857 T AT88101857 T AT 88101857T AT 88101857 T AT88101857 T AT 88101857T AT E135928 T1 ATE135928 T1 AT E135928T1
Authority
AT
Austria
Prior art keywords
polypeptide
aqueous
skin
patient
suspension
Prior art date
Application number
AT88101857T
Other languages
English (en)
Inventor
Dan Sibalis
Sanford Rosen
Original Assignee
Drug Delivery Systems Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Drug Delivery Systems Inc filed Critical Drug Delivery Systems Inc
Application granted granted Critical
Publication of ATE135928T1 publication Critical patent/ATE135928T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Electrotherapy Devices (AREA)
  • Peptides Or Proteins (AREA)
AT88101857T 1987-02-10 1988-02-09 Elektrolytische zuführung von polypeptiden durch die haut ATE135928T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/012,889 US4878892A (en) 1987-02-10 1987-02-10 Electrolytic transdermal delivery of polypeptides

Publications (1)

Publication Number Publication Date
ATE135928T1 true ATE135928T1 (de) 1996-04-15

Family

ID=21757240

Family Applications (1)

Application Number Title Priority Date Filing Date
AT88101857T ATE135928T1 (de) 1987-02-10 1988-02-09 Elektrolytische zuführung von polypeptiden durch die haut

Country Status (9)

Country Link
US (1) US4878892A (de)
EP (1) EP0278474B1 (de)
JP (1) JPH0647016B2 (de)
KR (1) KR970004037B1 (de)
AT (1) ATE135928T1 (de)
AU (1) AU608278B2 (de)
CA (1) CA1317879C (de)
DE (1) DE3855143T2 (de)
MX (1) MX165338B (de)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5032109A (en) * 1987-02-10 1991-07-16 Drug Delivery Systems Inc. Electrolytic transdermal delivery of polypeptides
US4940456A (en) * 1987-02-10 1990-07-10 Dan Sibalis Electrolytic transdermal delivery of proteins
US5080646A (en) * 1988-10-03 1992-01-14 Alza Corporation Membrane for electrotransport transdermal drug delivery
US5362307A (en) 1989-01-24 1994-11-08 The Regents Of The University Of California Method for the iontophoretic non-invasive-determination of the in vivo concentration level of an inorganic or organic substance
KR970011449B1 (ko) * 1988-01-29 1997-07-11 더 리전트 오브 디 유니버시티 오브 캘리포니아 이온전기 영동형 비침입 검체 채취 또는 이송 장치 및 방법
US5169382A (en) * 1988-10-03 1992-12-08 Alza Corporation Membrane for electrotransport transdermal drug delivery
US5496266A (en) * 1990-04-30 1996-03-05 Alza Corporation Device and method of iontophoretic drug delivery
US5374241A (en) * 1989-07-21 1994-12-20 Iomed, Inc. Electrodes for iontophoresis
EP0429842B1 (de) * 1989-10-27 1996-08-28 Korea Research Institute Of Chemical Technology Vorrichtung zur transdermalen Applikation von Protein- oder Peptid-Medikamenten
US5167616A (en) * 1989-12-14 1992-12-01 Alza Corporation Iontophoretic delivery method
US5087241A (en) * 1990-07-24 1992-02-11 Empi, Inc. Iontophoresis electrode with reservoir and injection site
US5158537A (en) * 1990-10-29 1992-10-27 Alza Corporation Iontophoretic delivery device and method of hydrating same
US5464387A (en) * 1991-07-24 1995-11-07 Alza Corporation Transdermal delivery device
US5356632A (en) * 1991-09-12 1994-10-18 S.I. Scientific Innovations Ltd. Transdermal drug delivery device
US5215520A (en) * 1991-09-17 1993-06-01 Centre Internationale De Recherches Dermatologiques Galderma (C.I.R.D. Galderma) Method for delivering an active substance topically or percutaneously
CA2087087C (en) * 1992-01-22 2000-07-18 Burton H. Sage, Jr. Molecules for iontophoretic delivery
US5443441A (en) * 1993-03-05 1995-08-22 De Claviere; Anne Marie Apparatus and method for transdermal delivery of cosmetic compositions
US5503632A (en) * 1994-04-08 1996-04-02 Alza Corporation Electrotransport device having improved cathodic electrode assembly
IE960312A1 (en) * 1995-06-02 1996-12-11 Alza Corp An electrotransport delivery device with voltage boosting¹circuit
ZA964320B (en) * 1995-06-05 1997-01-13 Alza Corp Device for transdermal electrotransport delivery of fentanyl and sufentanil
US6425892B2 (en) 1995-06-05 2002-07-30 Alza Corporation Device for transdermal electrotransport delivery of fentanyl and sufentanil
US6216033B1 (en) 1996-05-22 2001-04-10 Alza Corporation Device for transdermal electrotransport delivery of fentanyl and sufentanil
BR9609358A (pt) * 1995-06-05 1999-05-18 Alza Corp Dispositivo para distribuição transdérmica por eletrotransporte fentanil e sufentanil
US7572252B1 (en) * 1995-06-07 2009-08-11 Alza Corporation Electrotransport agent delivery method and apparatus
US5983130A (en) * 1995-06-07 1999-11-09 Alza Corporation Electrotransport agent delivery method and apparatus
US5779661A (en) * 1995-12-11 1998-07-14 Physion, S.R.L. Method of treating dysfunctional bladder syndromes by electromotive drug administration
US6718201B1 (en) * 1996-06-07 2004-04-06 Alza Corporation Electrotransport agent delivery method and apparatus
US7153845B2 (en) * 1998-08-25 2006-12-26 Columbia Laboratories, Inc. Bioadhesive progressive hydration tablets
US8765177B2 (en) * 1997-09-12 2014-07-01 Columbia Laboratories, Inc. Bioadhesive progressive hydration tablets
ES2202910T3 (es) * 1997-11-12 2004-04-01 Alza Corporation Composiciones de farmacos regulados para la administracion transdermica por electrotranporte.
KR100247558B1 (ko) 1997-11-24 2000-05-01 김충섭 사이클로덱스트린을 이용한 이온토포레시스 개선방법
US6163720A (en) * 1997-12-18 2000-12-19 Alza Corporation Layered rate controlling membranes for use in an electrotransport device
US6374136B1 (en) 1997-12-22 2002-04-16 Alza Corporation Anhydrous drug reservoir for electrolytic transdermal delivery device
US6475514B1 (en) 1998-12-03 2002-11-05 Andrew Blitzer Athletic patch
US6275728B1 (en) 1998-12-22 2001-08-14 Alza Corporation Thin polymer film drug reservoirs
JP2004518455A (ja) * 2000-08-24 2004-06-24 エンキャプシュレーション システムズ インコーポレイテッド 超音波強化物質送達方法
EP2085109A3 (de) 2000-10-26 2009-09-02 Alza Corporation Transdermale Arzneimittelverabreichungsvorrichtungen mit beschichteten Mikrovorsprüngen
US20110005507A9 (en) * 2001-01-23 2011-01-13 Rick Bagwell Real-time control of exhaust flow
US6908448B2 (en) * 2001-08-24 2005-06-21 Dermisonics, Inc. Substance delivery device
GB0210397D0 (en) * 2002-05-07 2002-06-12 Ferring Bv Pharmaceutical formulations
DE10228680A1 (de) * 2002-06-27 2004-01-22 Holden Development Limited, Tortola Grundlage für transdermale Formulierungen (PTF)
JP2006518640A (ja) * 2003-02-19 2006-08-17 セカンド ステージ ベンチャーズ インコーポレイテッド 経皮的薬物送達方法及び装置
CA2545798A1 (en) * 2003-02-19 2004-09-02 Dermisonics, Inc. Ultrasonically enhanced saline treatment for burn damaged skin
CA2828718C (en) 2004-07-23 2016-05-03 Oy Halton Group Ltd. Improvements for control of exhaust systems
US8197844B2 (en) 2007-06-08 2012-06-12 Activatek, Inc. Active electrode for transdermal medicament administration
AU2008283929B2 (en) 2007-08-06 2013-10-10 Serenity Pharmaceuticals, Llc Methods and devices for desmopressin drug delivery
US8862223B2 (en) 2008-01-18 2014-10-14 Activatek, Inc. Active transdermal medicament patch and circuit board for same
US20100286045A1 (en) 2008-05-21 2010-11-11 Bjarke Mirner Klein Methods comprising desmopressin
US11963995B2 (en) 2008-05-21 2024-04-23 Ferring B.V. Methods comprising desmopressin
EP2712622B1 (de) 2008-05-21 2016-07-13 Ferring B.V. Orodispersibles Desmopressin zur Erhöhung der nicht durch Nykturie gestörten Anfangsschlafperiode
US7883487B2 (en) 2008-06-16 2011-02-08 Shantha Totada R Transdermal local anesthetic patch with injection port
PT2442821T (pt) 2009-06-18 2017-09-29 Allergan Inc Administração segura de desmopressina
US8428709B1 (en) 2012-06-11 2013-04-23 Incline Therapeutics, Inc. Current control for electrotransport drug delivery
US8781571B2 (en) 2011-03-31 2014-07-15 Incline Therapeutics, Inc. Switch validation circuit and method
US9731121B2 (en) 2011-03-31 2017-08-15 Incline Therapeutics, Inc. Switch validation circuit and method
US8428708B1 (en) 2012-05-21 2013-04-23 Incline Therapeutics, Inc. Self-test for analgesic product
US9928115B2 (en) 2015-09-03 2018-03-27 Apple Inc. Hardware migration between dissimilar cores

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3163166A (en) * 1961-04-28 1964-12-29 Colgate Palmolive Co Iontophoresis apparatus
DK140801B (da) * 1975-01-15 1979-11-19 Nordisk Insulinlab Fremgangsmåde til fremstilling af et stabilt langtidsvirkende insulinpræparat.
US4141359A (en) * 1976-08-16 1979-02-27 University Of Utah Epidermal iontophoresis device
US4218255A (en) * 1976-08-30 1980-08-19 University Of Dayton Porous ceramic carriers for controlled release of proteins, polypeptide hormones, and other substances within human and/or other mamillian species and method
US4250878A (en) * 1978-11-22 1981-02-17 Motion Control, Inc. Non-invasive chemical species delivery apparatus and method
US4291015A (en) * 1979-08-14 1981-09-22 Key Pharmaceuticals, Inc. Polymeric diffusion matrix containing a vasodilator
JPS5810066A (ja) * 1981-07-10 1983-01-20 株式会社アドバンス イオントフオレ−ゼ用プラスタ−構造体
US4459226A (en) * 1982-02-26 1984-07-10 Eli Lilly And Company Process for recovering insulin
US4475916A (en) * 1982-03-18 1984-10-09 Merck & Co., Inc. Osmotic drug delivery system
EP0092015A1 (de) * 1982-04-16 1983-10-26 Roland Brodard Ionisierungsvorrichtung
US4639244A (en) * 1983-05-03 1987-01-27 Nabil I. Rizk Implantable electrophoretic pump for ionic drugs and associated methods
US4710497A (en) * 1983-05-20 1987-12-01 Nitto Electric Industrial Co., Ltd. Method for percutaneously administering physiologically active agents
US4622031A (en) * 1983-08-18 1986-11-11 Drug Delivery Systems Inc. Indicator for electrophoretic transcutaneous drug delivery device
US4557723A (en) * 1983-08-18 1985-12-10 Drug Delivery Systems Inc. Applicator for the non-invasive transcutaneous delivery of medicament
US4640689A (en) * 1983-08-18 1987-02-03 Drug Delivery Systems Inc. Transdermal drug applicator and electrodes therefor
US4704282A (en) * 1984-06-29 1987-11-03 Alza Corporation Transdermal therapeutic system having improved delivery characteristics
US4725439A (en) * 1984-06-29 1988-02-16 Alza Corporation Transdermal drug delivery device
US4624665A (en) * 1984-10-01 1986-11-25 Biotek, Inc. Method of transdermal drug delivery
US4702732A (en) * 1984-12-24 1987-10-27 Trustees Of Boston University Electrodes, electrode assemblies, methods, and systems for tissue stimulation and transdermal delivery of pharmacologically active ligands
US4713244A (en) * 1985-08-16 1987-12-15 Bausch & Lomb Incorporated Sustained-release formulation containing an amino acid polymer with a lower alkyl (C1 -C4) polar solvent
US4752285B1 (en) * 1986-03-19 1995-08-22 Univ Utah Res Found Methods and apparatus for iontophoresis application of medicaments
IE60941B1 (en) * 1986-07-10 1994-09-07 Elan Transdermal Ltd Transdermal drug delivery device

Also Published As

Publication number Publication date
DE3855143D1 (de) 1996-05-02
DE3855143T2 (de) 1996-10-31
US4878892A (en) 1989-11-07
JPS63200775A (ja) 1988-08-19
AU1098488A (en) 1988-08-11
AU608278B2 (en) 1991-03-28
EP0278474A1 (de) 1988-08-17
JPH0647016B2 (ja) 1994-06-22
KR880009632A (ko) 1988-10-04
MX165338B (es) 1992-11-05
CA1317879C (en) 1993-05-18
KR970004037B1 (ko) 1997-03-24
EP0278474B1 (de) 1996-03-27

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee