KR880009633A - 단백질의 전해식 경피투여 - Google Patents

단백질의 전해식 경피투여 Download PDF

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Publication number
KR880009633A
KR880009633A KR1019880001245A KR880001245A KR880009633A KR 880009633 A KR880009633 A KR 880009633A KR 1019880001245 A KR1019880001245 A KR 1019880001245A KR 880001245 A KR880001245 A KR 880001245A KR 880009633 A KR880009633 A KR 880009633A
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South Korea
Prior art keywords
chemical composition
protein
composition
water
patient
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KR1019880001245A
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English (en)
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KR970000232B1 (ko
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시발스 단
로센 샌포드
Original Assignee
단 시발스. 샌포드 로센
드러그 델리버리 시스템 인코포레이티드
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Application filed by 단 시발스. 샌포드 로센, 드러그 델리버리 시스템 인코포레이티드 filed Critical 단 시발스. 샌포드 로센
Publication of KR880009633A publication Critical patent/KR880009633A/ko
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Publication of KR970000232B1 publication Critical patent/KR970000232B1/ko

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/44—Applying ionised fluids

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Electrotherapy Devices (AREA)
  • Media Introduction/Drainage Providing Device (AREA)

Abstract

내용 없음.

Description

단백질의 전해식 경피투여
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (15)

  1. 단백질, 물 그리고 부의 Setschenow 상수를 가지는 해리제를 포함하는 전해식 수단에 의해서 1 내지 40볼트의 상태에서 0.5μA/㎠ 내지 10mA/㎠의 전류밀도로,그리고 0.001ml/㎠/hr 내지 0.01ml/㎠/hr 의 유주하는 물의 용적의 값으로 환자의 피부가 자극되거나 홍반이 없이, 환자의 혈액 스트림에 경피식 이동을 시키기 위한 화학조성물.
  2. 제1항에 있어서, 전류밀도가 5μA/㎠ 내지 1mA/㎠ 범위이고, 전압이 3 내지 10볼트의 범위이고 그리고 유주하는 물의 용적이 0.002 내지 0.005ml 범위인 화학조성물.
  3. 제1항에 있어서, 해리제를 요소, 요소의 알킬유도체, 구아니딘염, 부탄올, 2-부탄올, 3이상의 탄소원자를 가진 수용성 아미드, 부의 Setschenow 상수를 가진 어떤 수용성 염 및 이들의 혼합물로 구성된 그룹으로 부터 선택하는 화학조성물.
  4. 제3항에 있어서, 해리제를 요소, 프로필우레아 및 구아니딘 하이드로클로라이드로 구성된 그룹에서 선택하는 화학조성물.
  5. 제1항에 있어서, 단백질을 글루카곤, 프로타민, 아드레날 코르텍스 단백질성 호르몬, 칼시토닌, 알부민, 글로블린, 인슐린 및 이들의 혼합물로 구성된 그룹에서 선택하는 화학조성물.
  6. 제5항에 있어서, 단백질이 인슐린인 화학조성물.
  7. 제1항에 있어서, 단백질이 약 20폴리펩티드 단위이상을 가지는 많은 폴리펩티드인 화학조성물.
  8. 제1항에 있어서, 이조성물을 포함하는 친수성 저장기를 추가로 포함하는 화학조성물.
  9. 제8항에 있어서, 저장기가 약 0.01ml 내지약 15ml 의 이 조성물을 가지는 화학조성물.
  10. 제8항에 있어서, 하나의 전지와 두개의 연장된 접촉을 추가로 포함하는 화학조성물.
  11. 제10항에 있어서, 저장기의 피부측에 반투과성막을 추가로 포함하는 화학조성물.
  12. 제1항에 있어서, 킬레이트제를 추가로 포함하는 화학조성물.
  13. 제1항에 있어서, 완충제를 추가로 포함하는 화학조성물.
  14. 제1항에 있어서, 조성물을 방부하는 살균제를 추가로 포함하는 화학조성물.
  15. a) 전지, 양극, 음극, 단백질약물 저장기 그리고 전극 사이에 장벽수단을 포함하는 전해식 수단, 그리고 b) 단백질, 물 그리고 부의 Setschenow 상수를 가진 해리제를 포함하여 경피식 이동을 위한 화학 조성물을 병용으로 포함하며, 약 0.5μA/㎠ 내지 약 10mA/㎠의 전류밀도에서 첩제가 작동하게 되고, 환자의 혈액스트림에 최소한 하나의 단백질 약물을 투여하기 위한 경피식첩제.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019880001245A 1987-02-10 1988-02-10 단백질의 전해식 경피투여 KR970000232B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1289887A 1987-02-10 1987-02-10
US012,898 1987-02-10

Publications (2)

Publication Number Publication Date
KR880009633A true KR880009633A (ko) 1988-10-04
KR970000232B1 KR970000232B1 (ko) 1997-01-08

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KR1019880001245A KR970000232B1 (ko) 1987-02-10 1988-02-10 단백질의 전해식 경피투여

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EP (1) EP0278473B1 (ko)
JP (1) JP2670794B2 (ko)
KR (1) KR970000232B1 (ko)
AT (1) ATE79036T1 (ko)
AU (1) AU609769B2 (ko)
CA (1) CA1319608C (ko)
DE (1) DE3873366T2 (ko)
ES (1) ES2033349T3 (ko)
MX (1) MX168981B (ko)

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JP2907342B2 (ja) * 1988-01-29 1999-06-21 ザ リージェンツ オブ ザ ユニバーシティー オブ カリフォルニア イオン滲透非侵襲的サンプリングまたは送出装置
US5362307A (en) 1989-01-24 1994-11-08 The Regents Of The University Of California Method for the iontophoretic non-invasive-determination of the in vivo concentration level of an inorganic or organic substance
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DE69133328T2 (de) * 1990-03-30 2004-07-29 Alza Corp., Palo Alto Vorrichtung zur iontophoretischen verabreichung
CA2087087C (en) * 1992-01-22 2000-07-18 Burton H. Sage, Jr. Molecules for iontophoretic delivery
CA2153243A1 (en) * 1993-01-27 1994-08-18 Harold E. Selick Compositions and methods for transdermal drug delivery
US5533971A (en) * 1993-09-03 1996-07-09 Alza Corporation Reduction of skin irritation during electrotransport
US5505715A (en) * 1994-02-25 1996-04-09 Bristol-Myers Squibb Company Iontophoretic transdermal delivery of deoxyspergualin compounds
DE69532503T2 (de) * 1994-06-17 2004-11-04 Hisamitsu Pharmaceutical Co., Inc., Tosu Elektrode für iontophorese und vorrichtung dafür
EP0818995A1 (de) * 1995-04-07 1998-01-21 Novartis AG Transdermales system mit elektroden als initialisierungssystem
US5624415A (en) * 1995-04-24 1997-04-29 Alza Corporation Reduction of skin irritation and resistance during electrotransport
US5990179A (en) * 1995-04-28 1999-11-23 Alza Corporation Composition and method of enhancing electrotransport agent delivery
IT1285405B1 (it) 1995-06-06 1998-06-03 Alza Corp Modificazione di farmaci polipeptidici per accrescere il flusso per elettrotrasporto.
US5747453A (en) * 1995-06-06 1998-05-05 Alza Corporation Method for increasing the electrotransport flux of polypeptides
US6333189B1 (en) 1996-06-06 2001-12-25 Alza Corporation Method of making an electrotransport device
US6119036A (en) 1997-03-26 2000-09-12 The Board Of Regents Of The University Of Oklahoma Iontophoretic transdermal delivery device
IL159273A0 (en) * 2003-12-09 2004-06-01 Transpharma Medical Ltd Transdermal delivery system for sustained release of polypeptides
KR20070090166A (ko) * 2004-11-30 2007-09-05 트랜스큐 테크놀로지스 가부시키가이샤 이온토포레시스 장치
JPWO2007032446A1 (ja) 2005-09-15 2009-03-19 Ｔｔｉ・エルビュー株式会社 ロッド型イオントフォレーシス装置
FR2950802B1 (fr) 2009-10-02 2012-02-03 Sartorius Stedim Biotech Sa Elaboration et/ou conservation d'un produit biopharmaceutique.
CA2889165A1 (en) * 2012-12-19 2014-06-26 Wockhardt Limited A stable aqueous composition comprising human insulin or an analogue or derivative thereof
CN113087787B (zh) * 2021-05-19 2023-03-21 广西医科大学第二附属医院(广西医科大学第二临床医学院) 一种蚯蚓血红蛋白分离及纯化方法

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Also Published As

Publication number Publication date
DE3873366T2 (de) 1992-12-10
EP0278473A1 (en) 1988-08-17
ATE79036T1 (de) 1992-08-15
CA1319608C (en) 1993-06-29
AU1098688A (en) 1988-08-11
AU609769B2 (en) 1991-05-09
MX168981B (es) 1993-06-16
DE3873366D1 (de) 1992-09-10
EP0278473B1 (en) 1992-08-05
JPS63200774A (ja) 1988-08-19
KR970000232B1 (ko) 1997-01-08
ES2033349T3 (es) 1993-03-16
JP2670794B2 (ja) 1997-10-29

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