ATE71528T1 - Loesliches phosphoryliertes glukan. - Google Patents

Loesliches phosphoryliertes glukan.

Info

Publication number
ATE71528T1
ATE71528T1 AT86905497T AT86905497T ATE71528T1 AT E71528 T1 ATE71528 T1 AT E71528T1 AT 86905497 T AT86905497 T AT 86905497T AT 86905497 T AT86905497 T AT 86905497T AT E71528 T1 ATE71528 T1 AT E71528T1
Authority
AT
Austria
Prior art keywords
soluble phosphorylated
useful
glucans
soluble
phosphorylated glucan
Prior art date
Application number
AT86905497T
Other languages
English (en)
Inventor
Nicholas R Diluzio
Original Assignee
Univ Tulane
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Tulane filed Critical Univ Tulane
Application granted granted Critical
Publication of ATE71528T1 publication Critical patent/ATE71528T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0024—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid beta-D-Glucans; (beta-1,3)-D-Glucans, e.g. paramylon, coriolan, sclerotan, pachyman, callose, scleroglucan, schizophyllan, laminaran, lentinan or curdlan; (beta-1,6)-D-Glucans, e.g. pustulan; (beta-1,4)-D-Glucans; (beta-1,3)(beta-1,4)-D-Glucans, e.g. lichenan; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/06—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Materials Engineering (AREA)
  • Polymers & Plastics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AT86905497T 1985-08-19 1986-08-13 Loesliches phosphoryliertes glukan. ATE71528T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US06/767,388 US4739046A (en) 1985-08-19 1985-08-19 Soluble phosphorylated glucan
EP86905497A EP0232405B1 (de) 1985-08-19 1986-08-13 Lösliches phosphoryliertes glukan
PCT/US1986/001646 WO1987001037A1 (en) 1985-08-19 1986-08-13 Soluble phosphorylated glucan

Publications (1)

Publication Number Publication Date
ATE71528T1 true ATE71528T1 (de) 1992-02-15

Family

ID=25079320

Family Applications (1)

Application Number Title Priority Date Filing Date
AT86905497T ATE71528T1 (de) 1985-08-19 1986-08-13 Loesliches phosphoryliertes glukan.

Country Status (12)

Country Link
US (5) US4739046A (de)
EP (1) EP0232405B1 (de)
JP (1) JP2550332B2 (de)
KR (1) KR900008442B1 (de)
AT (1) ATE71528T1 (de)
AU (1) AU599045B2 (de)
CA (1) CA1337408C (de)
DE (1) DE3683479D1 (de)
DK (1) DK198587A (de)
FI (1) FI88109C (de)
NO (1) NO170586C (de)
WO (1) WO1987001037A1 (de)

Families Citing this family (113)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5028703A (en) * 1988-03-11 1991-07-02 Massachusetts Institute Of Technology Glucan composition and process for preparation thereof
US4992540A (en) * 1984-11-28 1991-02-12 Massachusetts Institute Of Technology Glucan composition and process for preparation thereof
US5082936A (en) * 1984-11-28 1992-01-21 Massachusetts Institute Of Technology Glucan composition and process for preparation thereof
US4975421A (en) * 1985-08-19 1990-12-04 Bioglucan, Lp. Soluble phosphorylated glucan: methods and compositions for wound healing
US4900722A (en) * 1985-08-19 1990-02-13 Bioglucans, L.P. Methods and compositions for prophylactic and therapeutic treatment of infections
US4739046A (en) * 1985-08-19 1988-04-19 Luzio Nicholas R Di Soluble phosphorylated glucan
SG47515A1 (en) * 1987-02-26 1998-04-17 Bio Polymers Pty Ltd Plant gum material and use thereof in food products
DE3855525T2 (de) * 1987-06-18 1997-04-10 Kureha Chemical Ind Co Ltd Verwendung eines Protein gebundenen Polysaccharid Zur Herstellung eines Arzneimittels für die Behandlung von AIDS.
US4904768A (en) * 1987-08-04 1990-02-27 Bristol-Myers Company Epipodophyllotoxin glucoside 4'-phosphate derivatives
AU624331B2 (en) * 1988-05-26 1992-06-11 Nika Health Products Ltd. A composition having as its active ingredient lysozyme or ribonuclease dimer in a pharmaceutically acceptable carrier
DE68926746T2 (de) * 1988-08-19 1996-11-28 Univ Australian Auf phosphozucker basierende antientzündliche und/oder immunitätsunterdrückende arzneimittel
US5506210A (en) * 1988-08-19 1996-04-09 The Australian National University Phosphosugar-based anti-inflammatory and/or immunosuppressive drugs
US5986061A (en) 1988-10-28 1999-11-16 Pbl Biomedical Laboratories Phosphorylated fusion proteins
IL92124A (en) 1988-10-28 1996-10-31 Sidney Pestka Recombinant proteins modified to contain post-phosphorylation that do not occur in nature
US6747131B1 (en) 1988-10-28 2004-06-08 Pestka Biomedical Laboratories, Inc. Phosphorylated fusion proteins
US5135920A (en) * 1988-11-16 1992-08-04 Takeda Chemical Industries, Ltd. Angiostatic agents
EP0466813A4 (en) * 1989-04-05 1992-07-15 Peter Y. S Fung Active specific immunotherapy of adenocarcinomas producing immunosuppressive mucins
US4946450A (en) * 1989-04-18 1990-08-07 Biosource Genetics Corporation Glucan/collagen therapeutic eye shields
US5032401A (en) * 1989-06-15 1991-07-16 Alpha Beta Technology Glucan drug delivery system and adjuvant
FR2648350B1 (fr) * 1989-06-20 1994-07-01 Roussel Uclaf Utilisation de lipopolysaccharides extraits de bacteries gram(-) pour la fabrication d'un medicament facilitant la cicatrisation de la peau
US5622939A (en) * 1992-08-21 1997-04-22 Alpha-Beta Technology, Inc. Glucan preparation
WO1991003248A2 (en) * 1989-09-08 1991-03-21 Alpha Beta Technology, Inc. Method for immune system activation
JPH05503952A (ja) * 1989-09-08 1993-06-24 アルファ　ベータ　テクノロジー，インコーポレイティッド 可溶性グルカン類の製造方法
US5811542A (en) * 1989-09-08 1998-09-22 Alpha-Beta Technology, Inc. Method for producing soluble glucans
US5488040A (en) * 1989-09-08 1996-01-30 Alpha-Beta Technology, Inc. Use of neutral soluble glucan preparations to stimulate platelet production
US5223491A (en) * 1989-11-09 1993-06-29 Donzis Byron A Method for revitalizing skin by applying topically water insoluble glucan
FR2655267B1 (fr) * 1989-12-04 1992-04-03 Roussel Uclaf Nouveau derive sulfate du galactanne extrait de klebsiella, procede de preparation, application a titre de medicaments et compositions pharmaceutiques le renfermant.
US5242806A (en) * 1990-05-07 1993-09-07 Baxter Diagnostics Inc. Method for conducting the cytotoxicity assays on tumor cells
CA2040374C (en) * 1990-07-06 1998-06-16 Gunnar Rorstad Process for enhancing the resistance of aquatic animals to disease
ES2027528A6 (es) * 1990-12-17 1992-06-01 Andromaco Lab Procedimiento para la obtencion de polimeros con actividad antiviral.
DE4101910A1 (de) * 1991-01-23 1992-07-30 Laevosan Gmbh & Co Kg Verfahren zur herstellung eines pyrogenfreien gut wasserloeslichen fructans sowie ein nierendiagnostikum, das ein solches fructan enthaelt
AU1455292A (en) * 1991-02-01 1992-09-07 Bioglucans, L.P. Soluble glucans
US5466680A (en) * 1992-03-26 1995-11-14 Cytologics, Inc. Method and compositions for enhancing white blood cell functioning on a mucosal or cutaneous surface
PL173978B1 (pl) * 1992-07-13 1998-05-29 Nika Health Products Ltd Sposób oddziaływania na wydzielanie cytokin w hodowli limfocytów krwi obwodowej
ZA935649B (en) * 1992-08-05 1994-03-07 Bioglucans L P Method for preparing soluble glucans
EP0595209A3 (en) * 1992-10-23 1996-07-17 R I T A Corp An Illinois Corp Cosmetic composition
US5519009A (en) * 1993-10-01 1996-05-21 Donzis; Byron A. Solubilized yeast glucan
US5919466A (en) * 1993-10-01 1999-07-06 Gerbu Biotechnik Gmbh Method for improving the yield of immunoantibodies in the vaccination of animals and humans
US5622940A (en) * 1994-07-14 1997-04-22 Alpha-Beta Technology Inhibition of infection-stimulated oral tissue destruction by β(1,3)-glucan
JP3240102B2 (ja) 1994-08-11 2001-12-17 江崎グリコ株式会社 リン酸化糖とその製造方法
US5576015A (en) * 1995-03-02 1996-11-19 Donzis; Byron A. Substantially purified beta (1,3) finely ground yeast cell wall glucan composition with dermatological and nutritional uses
AUPN166195A0 (en) * 1995-03-13 1995-04-06 Norvet Research Pty Limited Process for glucan extraction
GB2331014C (en) * 1995-03-13 2005-06-21 Novogen Res Pty Ltd Therapeutic uses of glucan
US5833946A (en) * 1995-06-06 1998-11-10 Bayer Corporation Dissemination of fungal infections: animal model and method of prophylaxis
US6800747B1 (en) 1995-06-07 2004-10-05 Pestka Biomedical Laboratories, Inc. Nucleic acids encoding phosphorylated fusion proteins
US6117850A (en) * 1995-08-28 2000-09-12 The Collaborative Group, Ltd. Mobilization of peripheral blood precursor cells by β(1,3)-glucan
US6083922A (en) * 1996-04-02 2000-07-04 Pathogenesis, Corp. Method and a tobramycin aerosol formulation for treatment prevention and containment of tuberculosis
US5858378A (en) * 1996-05-02 1999-01-12 Galagen, Inc. Pharmaceutical composition comprising cryptosporidium parvum oocysts antigen and whole cell candida species antigen
CA2275889C (en) 1996-12-30 2008-03-18 Battelle Memorial Institute Formulation and method for treating neoplasms by inhalation
US5786343A (en) * 1997-03-05 1998-07-28 Immudyne, Inc. Phagocytosis activator compositions and their use
DE19710368A1 (de) * 1997-03-13 1998-09-17 Henkel Kgaa Verwendung von wasserlöslichen beta-Glucanen als Wirkstoffe zur Herstellung von therapeutischen Mitteln zur Hautbehandlung
US6046323A (en) * 1997-07-29 2000-04-04 The Collaborative Group, Ltd. Conformations of PPG-glucan
KR100680014B1 (ko) * 1997-10-03 2007-02-09 갈레니카 파마슈티칼스 인크. 이민 형성 폴리사카라이드, 이의 제조 방법 및 이것의 아쥬반트 및 면역자극제로서의 용도
US6136794A (en) * 1998-02-02 2000-10-24 Merck & Co., Inc. Platelet aggregation inhibition using low molecular weight heparin in combination with a GP IIb/IIIa antagonist
US6251877B1 (en) * 1998-03-24 2001-06-26 Pacific Corporation Composition for external application containing a β-1,6-branched-β-1,3-glucan
EP1073667A2 (de) 1998-04-28 2001-02-07 Galenica Pharmaceuticals, Inc. Polysaccharid-antigen-konjugate
TW591105B (en) * 1998-04-30 2004-06-11 Korea Inst Sci & Tech Novel immuno-stimulating polysaccharide substance from Phellinus spp. strain and use thereof
US7030101B2 (en) 1998-09-14 2006-04-18 Nabi Biopharmaceuticals Compositions of β-glucans and specific antibodies
ES2321892T3 (es) * 1998-09-14 2009-06-12 Nabi Biopharmaceuticals Composiciones de beta-glucanos e inmunoglobulinas especificas.
US6369216B1 (en) 1998-09-25 2002-04-09 Biopolymer Engineering Pharmaceutical, Inc. Very high molecular weight β-glucans
AU6261999A (en) 1998-09-25 2000-04-17 Collaborative Group, Ltd., The Very high molecular weight beta-glucans
AUPP659198A0 (en) * 1998-10-19 1998-11-12 Novogen Research Pty Ltd Mastitis treatment
US6165994A (en) * 1999-02-08 2000-12-26 Blue Ridge Pharmaceuticals, Inc. Methods for promoting the healing of cutaneous wounds and ulcers using compositions of α-D-glucans
KR100717742B1 (ko) 1999-07-21 2007-05-11 가부시키가이샤 야쿠루트 혼샤 콜레스테롤 저하제，2차 담즙산 생산 억제제 및 음식품
US6541678B2 (en) * 1999-09-27 2003-04-01 Brennen Medical, Inc. Immunostimulating coating for surgical devices
EP1267795A1 (de) * 2000-03-30 2003-01-02 Brennen Medical Inc. Antimikrobielle und immunstimulierende zusammensetzung
US6713459B1 (en) 2000-04-28 2004-03-30 East Tennessee State University Methods for the prophylactic and therapeutic treatment of cardiac tissue damage
JP2001354570A (ja) * 2000-06-15 2001-12-25 Ichimaru Pharcos Co Ltd 免疫賦活剤及びそれを利用した香粧品
AU2002214649A1 (en) * 2000-10-16 2002-04-29 Neopharm, Inc. Liposomal formulation of mitoxantrone
US6436411B1 (en) * 2000-10-23 2002-08-20 The Center For The Improvement Of Human Functioning, Int'l., Inc. Cancer treatment method
ATE290873T1 (de) * 2000-11-22 2005-04-15 Dmg Italia Srl Arzneizubereitung zur intranasalen verabreichung um die immunantwort in der mund- und nasenschleimhaut und im waldeyer-ring zu verstärken
US7507724B2 (en) * 2001-01-16 2009-03-24 Sloan-Kettering Institute For Cancer Research Therapy-enhancing glucan
WO2002058711A1 (en) 2001-01-16 2002-08-01 Sloan-Kettering Institute For Cancer Research Therapy-enhancing glucan
US7906492B2 (en) * 2001-01-16 2011-03-15 Sloan-Kettering Institute For Cancer Research Therapy-enhancing glucan
US20040170598A1 (en) * 2001-04-05 2004-09-02 Emilio Barragan Polysubstituted polycarboxylic phosphoamide biopolymers, methods for their production and uses of compositions derived therefrom
CN100391439C (zh) * 2001-04-27 2008-06-04 味之素株式会社 免疫增强剂
US20060073197A1 (en) * 2004-05-20 2006-04-06 Ramaekers Joseph C Encapsulated transfer factor compositions and methods of use
US20070128253A1 (en) * 2005-04-13 2007-06-07 Ramaekers Joseph C Encapsulated transfer factor compositions and methods of use
US6506413B1 (en) * 2001-04-30 2003-01-14 Joseph C. Ramaekers Compositions for treating animal diseases and syndromes
JP4561098B2 (ja) * 2001-06-01 2010-10-13 味の素株式会社 糖尿病用薬剤
AU2002320964B2 (en) * 2001-08-14 2008-03-13 Valderm Aps Treatment of hyperproliferative conditions of body surfaces
US7786094B2 (en) * 2001-10-09 2010-08-31 Biopolymer Engineering, Inc. Use of beta-glucans against biological warfare weapons and pathogens including anthrax
US7048932B2 (en) * 2002-05-22 2006-05-23 The Chinese University Of Hong Kong Preparation and standardization of immunomodulatory peptide-linked glucans with verifiable oral absorbability from coriolus versicolor
WO2004014320A2 (en) * 2002-08-13 2004-02-19 Biopolymer Engineering, Inc. Methods of using beta glucan as a radioprotective agent
CA2496508C (en) * 2002-09-04 2014-04-22 University Of Louisville Research Foundation, Inc. Cancer therapy using beta glucan and antibodies
US20060165700A1 (en) * 2002-09-04 2006-07-27 Ostroff Gary R Cancer therapy using whole glucan particles and antibodies
US7018986B2 (en) * 2002-09-20 2006-03-28 Immudyne Use of beta glucans for the treatment of osteoporosis and other diseases of bone resorption
US20050026849A1 (en) * 2003-03-28 2005-02-03 Singh Chandra U. Water soluble formulations of digitalis glycosides for treating cell-proliferative and other diseases
US7197521B2 (en) * 2003-11-21 2007-03-27 Intel Corporation Method and system performing concurrently mark-sweep garbage collection invoking garbage collection thread to track and mark live objects in heap block using bit vector
KR100485056B1 (ko) * 2004-01-19 2005-04-22 (주)네추럴에프앤피 효모의 수용성 글루칸 올리고머를 함유하는 항 h1n2형 조류독감 바이러스제
WO2006121803A1 (en) 2005-05-05 2006-11-16 Sensient Flavors Inc. Production of beta-glucans and mannans
DK1965809T3 (da) 2005-11-21 2010-01-04 Bioatlantis Ltd Præparater til forbedring af sundhedstilstanden i dyrs tarmsystem og dyrs ydeevne omfattende Beta-glucanerne og Alfa-fucaner
US20090053221A1 (en) * 2006-01-17 2009-02-26 Cheung Nai-Kong V Immune response enhancing glucan
US8323644B2 (en) 2006-01-17 2012-12-04 Sloan-Kettering Institute For Cancer Research Therapy-enhancing glucan
FR2899815B1 (fr) * 2006-04-14 2008-07-11 Goemar Lab Sa Nouveaux medicaments pour les traitements contre les retrovirus
US20090053197A1 (en) * 2006-06-14 2009-02-26 Ramaekers Joseph C Transfer Factor Compositions and Methods
US9125874B2 (en) 2007-11-30 2015-09-08 The Ramaekers Family Trust Administration of transfer factor for improving reproductive health
US20090022799A1 (en) * 2006-10-06 2009-01-22 Shikha Pramanik Barman Compositions that contain beta-glucan to be used for the prevention and treatment of disease and methods for their use
US9457047B2 (en) 2006-11-06 2016-10-04 Whitehead Institute Immunomodulating compositions and methods of use thereof
WO2008057501A2 (en) * 2006-11-06 2008-05-15 Whitehead Institute Immunomodulating compositions and methods of use thereof
US20090074751A1 (en) * 2007-09-18 2009-03-19 Ramaekers Nutrition, Inc. Growth factor fraction compositions and methods
WO2009070788A1 (en) * 2007-11-30 2009-06-04 The Ramaekers Family Trust Compositions and methods for enhancing fertility
US7854936B2 (en) * 2008-01-14 2010-12-21 Active Organics, Inc. Anti-inflammatory hydrolysate of C. versicolor
CN101250236B (zh) * 2008-04-11 2010-09-29 武汉大学 茯苓葡聚糖磷酸酯化衍生物及其制备方法和用途
US8617823B2 (en) 2008-04-29 2013-12-31 Immunexcite, Inc. Immunomodulating compositions and methods of use thereof
US20100267661A1 (en) * 2009-03-17 2010-10-21 Immudyne, Inc. Beta glucans and methods of use thereof
US20110129801A1 (en) * 2009-11-27 2011-06-02 Shikha Pramanik Barman Compositions and methods to prevent and treat dry socket post-operatively after tooth extraction surgery
CN107674129B (zh) * 2017-09-04 2020-12-15 珠海伊斯佳科技股份有限公司 裂褶多糖磷酸化衍生物及其制备方法、应用
WO2023002252A1 (en) 2021-07-21 2023-01-26 Bioatlantis Limited Composition comprising beta-glucans and alpha-fucans for improving gut health and animal performance and methods of making the same
US11572420B1 (en) 2021-07-30 2023-02-07 Tissue repair ltd Isolated biological polysaccharide compound, methods of use and methods of manufacture thereof
US11384160B1 (en) 2021-07-30 2022-07-12 Tissue repair ltd Method of making a beta glucan compound
CN114014949B (zh) * 2021-11-15 2022-08-30 戚春建 一种水溶性酵母葡聚糖的制备方法
CN115232845A (zh) * 2022-07-08 2022-10-25 广东先强药业有限公司 一种活化的葡糖氨基葡聚糖及其制备方法和应用

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1258100B (de) * 1960-11-22 1968-01-04 Wacker Chemie Gmbh Verfahren zum Phosphorylieren hydroxylgruppenhaltiger polymerer Stoffe
US3081226A (en) * 1961-01-07 1963-03-12 Luzio Nicholas R Di Process for reducing exogenous cholesterol levels in animal organisms
US3396082A (en) * 1965-06-09 1968-08-06 Agriculture Usa Glucan production by fermentation of fleshy fungi
DE1518587A1 (de) * 1965-08-23 1969-08-14 Bloecker Dr Dipl Chem Erich Verfahren zur Herstellung von Phosphorsaeureestern von hydroxylgruppenhaltigen Polymeren
US3987166A (en) * 1970-05-13 1976-10-19 Kaken Kagaku Kabushiki Kaisha Treatment of tumors with glucan compositions in mice and rats
US3943247A (en) * 1972-05-22 1976-03-09 Kaken Kagaku Kabushiki Kaisha Treatment of bacterial infections with glucan compositions
DE2646879A1 (de) * 1975-10-21 1977-05-05 Takeda Chemical Industries Ltd Matrix aus einem in wasser unloeslichen beta-1,3-glucangel und verfahren zu ihrer herstellung
US4138479A (en) * 1975-11-07 1979-02-06 Bayer Aktiengesellschaft Process for the preparation of immunopotentiating agents from components of yeast cell wall material
JPS5385000A (en) * 1976-12-31 1978-07-26 Akira Misaki Glucan and its preparation
JPS5461112A (en) * 1977-10-24 1979-05-17 Ono Pharmaceut Co Ltd Oncostatic polysaccharide* its preparation* and oncostatic drugs containing it as an effective component
FR2447193A1 (fr) * 1979-01-25 1980-08-22 Unicler Utilisation de pichia ou d'extraits de pichia, comme medicament.
EP0045338B1 (de) * 1980-08-05 1986-11-05 LABORATOIRES DEBAT Société anonyme dite: Verwendung von Glycosylglukane in der Gastroenterologie, in der Behandlung von Affektionen des Dickdarmes
US4340673A (en) * 1980-11-07 1982-07-20 Merck & Co., Inc. Process of producing modified glucans as anti-caries agent
US4614733A (en) * 1981-12-31 1986-09-30 Kureha Kagaku Kogyo Kabushiki Kaisha Polysaccharides pharmaceutical compositions and the use thereof
US4739046A (en) * 1985-08-19 1988-04-19 Luzio Nicholas R Di Soluble phosphorylated glucan

Also Published As

Publication number Publication date
US4739046A (en) 1988-04-19
WO1987001037A1 (en) 1987-02-26
US4833131A (en) 1989-05-23
KR900008442B1 (ko) 1990-11-22
EP0232405A4 (de) 1989-04-27
AU6229686A (en) 1987-03-10
FI871718A0 (fi) 1987-04-16
NO871603L (no) 1987-06-15
EP0232405A1 (de) 1987-08-19
NO871603D0 (no) 1987-04-15
NO170586B (no) 1992-07-27
US4818752A (en) 1989-04-04
NO170586C (no) 1992-11-04
JPS63500805A (ja) 1988-03-24
JP2550332B2 (ja) 1996-11-06
KR870700355A (ko) 1987-12-28
FI88109C (fi) 1993-04-13
EP0232405B1 (de) 1992-01-15
DK198587A (da) 1987-06-18
US4761402A (en) 1988-08-02
DK198587D0 (da) 1987-04-15
CA1337408C (en) 1995-10-24
US4877777A (en) 1989-10-31
FI88109B (fi) 1992-12-31
FI871718A (fi) 1987-04-16
AU599045B2 (en) 1990-07-12
DE3683479D1 (de) 1992-02-27

Similar Documents

Publication Publication Date Title
ATE71528T1 (de) Loesliches phosphoryliertes glukan.
FI964339A (fi) Glukaanien entsyymikäsittely
AU554443B2 (en) 4-aminosalicylic acid as an anti-inflammatory agent
WO1991017773A3 (de) Neue protein-polykation-konjugate
HRP960508A2 (en) A method of enhancing cellular production of molecular chaperon,hydroxalamine derivatives useful for enhancing the chaperon production and the preparation thereof
UA34419C2 (uk) Ліофілізований препарат для ін'єкцій та спосіб інгібування росту пухлин
IE35177B1 (en) Improvements in or relating to uracil derivatives
FR2455893A1 (fr) Polysaccharides physiologiquement actifs, leur preparation et leurs applications
AU6327086A (en) Novel polyoxygenated labdane derivatives, processes for their preparation and their use as medicaments
HUT58037A (en) Process for producing n-2,3-butadienyl tri- and tetraaminoalkane derivatives
IE801891L (en) 4-alkyl-8-aminoalkylpsoralens
ATE49884T1 (de) Verwendung von saccharomyces-hefen fuer die herstellung eines arzneimittels gegen amoebiasis.
IE39141B1 (en) Production of immunological material
EP0132359A3 (de) Natürliches menschliches Interleukin-2 und seine Herstellung
Zmitrovich et al. Professor Shu-Ting Chang, cancer mycotherapy and Le Chatelier principle
WO2023169554A8 (zh) 甲硫氨酸腺苷转移酶抑制剂、其制备方法及应用
WO2023240143A8 (en) Methods of preparing lymphocytes for cell therapy
IE44318L (en) Fungicidal compositions
IE33322L (en) Vaccine manufacture
JPS57131723A (en) Enzymatic activity inhibiting agent
GB1316006A (en) Pharmaceutically active chemical compound and an antitumourigenic preparation containing same
HUP0001879A2 (hu) Celluláris nátrium/hidrogén-csere inhibitorok alkalmazása a szérumlipid normalizálására alkalmas gyógyszerkészítmények előállítására
AU93783S (en) Container
AU648046B2 (en) Treatment of breast cancer with antigestagens
MY100308A (en) Fungicides containing triazole and oligoether groups and combinations

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee