WO2023169554A8 - 甲硫氨酸腺苷转移酶抑制剂、其制备方法及应用 - Google Patents

甲硫氨酸腺苷转移酶抑制剂、其制备方法及应用 Download PDF

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Publication number
WO2023169554A8
WO2023169554A8 PCT/CN2023/080740 CN2023080740W WO2023169554A8 WO 2023169554 A8 WO2023169554 A8 WO 2023169554A8 CN 2023080740 W CN2023080740 W CN 2023080740W WO 2023169554 A8 WO2023169554 A8 WO 2023169554A8
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WO
WIPO (PCT)
Prior art keywords
inhibitor
preparation
methionine adenosyltransferase
present application
method therefor
Prior art date
Application number
PCT/CN2023/080740
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English (en)
French (fr)
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WO2023169554A1 (zh
Inventor
董理进
易韬
胡凯
田林
张毅
唐元清
张晓东
唐军
Original Assignee
赛诺哈勃药业（成都）有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by 赛诺哈勃药业（成都）有限公司 filed Critical 赛诺哈勃药业（成都）有限公司
Priority to CN202380023352.6A priority Critical patent/CN118742550A/zh
Publication of WO2023169554A1 publication Critical patent/WO2023169554A1/zh
Publication of WO2023169554A8 publication Critical patent/WO2023169554A8/zh

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

本申请提供了一种甲硫氨酸腺苷转移酶抑制剂、包含其的药物组合物及应用。本申请的化合物具有优异的MAT2a酶抑制活性，同时对癌症细胞的生长具有优异的抑制作用，因此本申请的化合物可在MAT2a相关的癌症或肿瘤疾病中具有优异的治疗效果。
PCT/CN2023/080740 2022-03-11 2023-03-10 甲硫氨酸腺苷转移酶抑制剂、其制备方法及应用 WO2023169554A1 (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202380023352.6A CN118742550A (zh) 2022-03-11 2023-03-10 甲硫氨酸腺苷转移酶抑制剂、其制备方法及应用

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
CN202210236154 2022-03-11
CN202210236154.5 2022-03-11
CN202211172965.X 2022-09-26
CN202211172965 2022-09-26
CN202211445963.3 2022-11-18
CN202211445963 2022-11-18

Publications (2)

Publication Number Publication Date
WO2023169554A1 WO2023169554A1 (zh) 2023-09-14
WO2023169554A8 true WO2023169554A8 (zh) 2023-11-09

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ID=87936151

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PCT/CN2023/080740 WO2023169554A1 (zh) 2022-03-11 2023-03-10 甲硫氨酸腺苷转移酶抑制剂、其制备方法及应用

Country Status (3)

Country Link
CN (1) CN118742550A (zh)
TW (1) TW202342024A (zh)
WO (1) WO2023169554A1 (zh)

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2019243289B2 (en) * 2018-03-30 2023-01-12 Les Laboratoires Servier Heterobicyclic inhibitors of MAT2A and methods of use for treating cancer
CN113474347A (zh) * 2018-12-27 2021-10-01 法国施维雅药厂 Mat2a的aza杂双环抑制剂和用于治疗癌症的方法
AR117544A1 (es) * 2018-12-27 2021-08-11 Agios Pharmaceuticals Inc Heterocíclicos inhibidores de mat2a y métodos de uso para el tratamiento del cáncer
JOP20210317A1 (ar) * 2019-05-31 2023-01-30 Servier Lab مثبطات غير متجانسة ثنائية الحلقة لـ mat2a وطرق استخدامها لعلاج السرطان
WO2021139775A1 (zh) * 2020-01-10 2021-07-15 江苏先声药业有限公司 吡啶酮化合物及应用
CN115960098A (zh) * 2020-09-11 2023-04-14 上海凌达生物医药有限公司 一类含氮稠环类化合物的制备方法和用途

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CN118742550A (zh) 2024-10-01
TW202342024A (zh) 2023-11-01
WO2023169554A1 (zh) 2023-09-14

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