ATE543795T1 - Kondensierte bicyclische carbonsäureamidderivate zur verwendung als cxcr2-inhibitoren bei der behandlung von entzündungen - Google Patents
Kondensierte bicyclische carbonsäureamidderivate zur verwendung als cxcr2-inhibitoren bei der behandlung von entzündungenInfo
- Publication number
- ATE543795T1 ATE543795T1 AT05818685T AT05818685T ATE543795T1 AT E543795 T1 ATE543795 T1 AT E543795T1 AT 05818685 T AT05818685 T AT 05818685T AT 05818685 T AT05818685 T AT 05818685T AT E543795 T1 ATE543795 T1 AT E543795T1
- Authority
- AT
- Austria
- Prior art keywords
- inflammation
- treatment
- amide derivatives
- carboxylic amide
- condensed bicyclic
- Prior art date
Links
- 206010061218 Inflammation Diseases 0.000 title 1
- 102000002791 Interleukin-8B Receptors Human genes 0.000 title 1
- 108010018951 Interleukin-8B Receptors Proteins 0.000 title 1
- 150000001408 amides Chemical class 0.000 title 1
- 230000004054 inflammatory process Effects 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
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- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/68—One oxygen atom attached in position 4
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- C07D333/70—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
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- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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| PCT/EP2005/013624 WO2006069656A1 (en) | 2004-12-30 | 2005-12-17 | Fused bicyclic carboxamide derivatives for use as cxcr2 inhibitors in the treatment of inflammation |
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| ZA200806752B (en) | 2006-01-27 | 2009-10-28 | Fibrogen Inc | Cyanoisoquinoline compounds that stabilize hypoxia inducible factor (HIF) |
| KR101084635B1 (ko) | 2006-04-04 | 2011-11-18 | 피브로겐, 인크. | Hif 조절제로서 피롤로- 및 티아졸로-피리딘 화합물 |
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| AU2007264114A1 (en) | 2006-06-28 | 2008-01-03 | Sanofi-Aventis | New CXCR2 inhibitors |
| JP5232144B2 (ja) * | 2006-06-28 | 2013-07-10 | サノフイ | Cxcr2阻害剤 |
| WO2008000410A1 (en) * | 2006-06-30 | 2008-01-03 | Sanofi-Aventis | Cxcr2 inhibitors |
| KR20090082424A (ko) * | 2006-11-23 | 2009-07-30 | 노파르티스 아게 | Cxcr2 길항제로서의 5-술파닐메틸-피라졸로[1,5-a]피리미딘-7-올 유도체 |
| BRPI0718947A2 (pt) * | 2006-11-23 | 2013-12-17 | Novartis Ag | Derivados de 5-sulfanilmetil-[1,2,4] triazol [1,5-a] pirimidin-7-ol como antagonistas de cxcr2 |
| JP5162598B2 (ja) * | 2006-11-30 | 2013-03-13 | ダウ アグロサイエンシィズ エルエルシー | 2−置換−5−(1−アルキルチオ)アルキルピリミジンの製造方法 |
| KR101583487B1 (ko) * | 2007-06-05 | 2016-01-08 | 사노피 | 치환된 벤조일아미노-인단-2-카복실산 및 관련된 화합물 |
| NZ592741A (en) | 2008-11-14 | 2013-03-28 | Fibrogen Inc | Thiochromene derivatives as hif hydroxylase inhibitors |
| GB0907551D0 (en) * | 2009-05-01 | 2009-06-10 | Univ Dundee | Treatment or prophylaxis of proliferative conditions |
| AU2013203591B2 (en) * | 2009-05-01 | 2017-01-19 | University Court Of The University Of Dundee | Treatment or prophylaxis of proliferative conditions |
| WO2012079154A1 (en) * | 2010-12-14 | 2012-06-21 | Dalhousie University | Selective estrogen receptor modulators |
| EP2861574B1 (de) * | 2012-06-19 | 2016-04-20 | F. Hoffmann-La Roche AG | Neue bicyclische thiophenylamidverbindungen |
| RU2647587C2 (ru) * | 2012-09-12 | 2018-03-16 | Ф. Хоффманн-Ля Рош Аг | Неаннелированные тиофениламиды в качестве ингибиторов белков, связывающих жирные кислоты fabp 4 и/или 5 |
| WO2014114603A1 (en) * | 2013-01-24 | 2014-07-31 | F. Hoffmann-La Roche Ag | Substituted thiazole compounds |
| DK2951159T3 (en) | 2013-01-24 | 2018-11-19 | Fibrogen Inc | CRYSTALLIC FORMS OF {[1-CYANO-5- (4-CHLORPHENOXY) -4-HYDROXY-ISOQUINOLIN-3-CARBONYL] -AMINO} ACETIC ACID |
| WO2015127548A1 (en) * | 2014-02-28 | 2015-09-03 | The Royal Institution For The Advancement Of Learning / Mcgill University | Tc-ptp inhibitors as apc activators for immunotherapy |
| ES2675858T3 (es) * | 2014-04-15 | 2018-07-13 | Vertex Pharmaceuticals Incorporated | Composiciones farmacéuticas para el tratamiento de enfermedades mediadas por el regulador de la conductancia transmembrana de fibrosis quística |
| JP2017527542A (ja) * | 2014-07-31 | 2017-09-21 | グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドGlaxosmithkline Intellectual Property Development Limited | 化学療法誘発末梢神経障害(cipn)の予防および/または治療のためのcxcr2アンタゴニストの使用 |
| CN105906608B (zh) * | 2016-05-03 | 2018-10-19 | 中山大学 | 8-氨基喹啉-松果体素杂联体及其药物组合物 |
| CN106187974B (zh) * | 2016-07-01 | 2018-01-12 | 广州军区广州总医院 | 具有抗肿瘤作用的鱼藤素断环结构与氨基酸衍生物的合成方法 |
| PL3717646T3 (pl) | 2017-12-01 | 2025-10-27 | The Texas A&M University System | Leczenie antysensowe zespołu angelmana |
| BR112020015745A2 (pt) | 2018-02-02 | 2020-12-08 | Maverix Oncology, Inc. | Conjugados de fármacos de moléculas pequenas de monofosfato de gemcitabina |
| GB201807924D0 (en) | 2018-05-16 | 2018-06-27 | Ctxt Pty Ltd | Compounds |
| MX2021000293A (es) | 2018-07-09 | 2021-07-15 | Boehringer Ingelheim Animal Health Usa Inc | Compuestos heterociclicos antihelminticos. |
| BR112021018631A2 (pt) | 2019-03-19 | 2021-11-23 | Boehringer Ingelheim Animal Health Usa Inc | Compostos anti-helmínticos de aza-benzotiofeno e aza-benzofurano |
| WO2021113806A1 (en) * | 2019-12-05 | 2021-06-10 | Genzyme Corporation | Arylamides and methods of use thereof |
| WO2021113808A1 (en) * | 2019-12-05 | 2021-06-10 | Genzyme Corporation | Cftr-modulating arylamides |
| EP4077318B1 (de) | 2019-12-18 | 2025-10-15 | Ctxt Pty Ltd | Benzimidazol-dimere als modulatoren von sting |
| CA3183100A1 (en) | 2020-05-29 | 2021-12-02 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Anthelmintic heterocyclic compounds |
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| CN116041300B (zh) * | 2023-02-20 | 2024-04-26 | 沈阳药科大学 | 一种2,2-二甲基苯并吡喃类衍生物及其制备方法和应用 |
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| CA2586446A1 (en) | 2004-11-09 | 2006-05-18 | Smithkline Beecham Corporation | Glycogen phosphorylase inhibitor compounds and pharmaceutical compositions thereof |
| EP1676834A1 (de) | 2004-12-30 | 2006-07-05 | Sanofi-Aventis Deutschland GmbH | Kondensierte Bicyclische Carboxamid-Derivate zur Verwendung als CXCR2 Inhibitoren zur Behandlung von Entzündungen |
| AR055319A1 (es) | 2005-03-17 | 2007-08-15 | Wyeth Corp | Derivados de isoquinoleina, composiciones farmaceuticas y usos |
-
2004
- 2004-12-30 EP EP04031009A patent/EP1676834A1/de not_active Withdrawn
-
2005
- 2005-12-17 CN CNA2005800454624A patent/CN101094830A/zh active Pending
- 2005-12-17 CA CA002592430A patent/CA2592430A1/en not_active Withdrawn
- 2005-12-17 RU RU2007128949/04A patent/RU2404962C2/ru not_active IP Right Cessation
- 2005-12-17 MX MX2007007068A patent/MX2007007068A/es active IP Right Grant
- 2005-12-17 KR KR1020077015119A patent/KR20070091634A/ko not_active Withdrawn
- 2005-12-17 BR BRPI0519452-0A patent/BRPI0519452A2/pt not_active Application Discontinuation
- 2005-12-17 AT AT05818685T patent/ATE543795T1/de active
- 2005-12-17 WO PCT/EP2005/013624 patent/WO2006069656A1/en not_active Ceased
- 2005-12-17 EP EP05818685A patent/EP1836158B1/de not_active Expired - Lifetime
- 2005-12-17 JP JP2007548720A patent/JP5123667B2/ja not_active Expired - Fee Related
- 2005-12-17 AU AU2005321609A patent/AU2005321609B2/en not_active Ceased
- 2005-12-17 NZ NZ556192A patent/NZ556192A/en not_active IP Right Cessation
- 2005-12-28 AR ARP050105577A patent/AR055830A1/es unknown
- 2005-12-28 TW TW094146875A patent/TW200639141A/zh unknown
- 2005-12-30 UY UY29322A patent/UY29322A1/es unknown
-
2006
- 2006-01-03 PE PE2006000027A patent/PE20060855A1/es not_active Application Discontinuation
-
2007
- 2007-05-21 ZA ZA200704089A patent/ZA200704089B/xx unknown
- 2007-06-24 IL IL184173A patent/IL184173A/en unknown
- 2007-06-26 MA MA30032A patent/MA29113B1/fr unknown
- 2007-06-29 US US11/771,958 patent/US7919628B2/en not_active Expired - Fee Related
- 2007-07-26 NO NO20073932A patent/NO20073932L/no unknown
-
2011
- 2011-04-04 US US13/079,522 patent/US8283479B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| KR20070091634A (ko) | 2007-09-11 |
| AR055830A1 (es) | 2007-09-12 |
| IL184173A (en) | 2011-10-31 |
| BRPI0519452A2 (pt) | 2009-01-27 |
| ZA200704089B (en) | 2008-09-25 |
| EP1676834A1 (de) | 2006-07-05 |
| IL184173A0 (en) | 2007-10-31 |
| RU2404962C2 (ru) | 2010-11-27 |
| AU2005321609A1 (en) | 2006-07-06 |
| US20110184177A1 (en) | 2011-07-28 |
| PE20060855A1 (es) | 2006-10-10 |
| US20080090854A1 (en) | 2008-04-17 |
| US8283479B2 (en) | 2012-10-09 |
| CA2592430A1 (en) | 2006-07-06 |
| MX2007007068A (es) | 2007-08-08 |
| US7919628B2 (en) | 2011-04-05 |
| EP1836158B1 (de) | 2012-02-01 |
| UY29322A1 (es) | 2006-07-31 |
| JP2008526695A (ja) | 2008-07-24 |
| MA29113B1 (fr) | 2007-12-03 |
| NZ556192A (en) | 2010-06-25 |
| CN101094830A (zh) | 2007-12-26 |
| JP5123667B2 (ja) | 2013-01-23 |
| TW200639141A (en) | 2006-11-16 |
| AU2005321609B2 (en) | 2011-02-17 |
| EP1836158A1 (de) | 2007-09-26 |
| WO2006069656A1 (en) | 2006-07-06 |
| NO20073932L (no) | 2007-08-09 |
| RU2007128949A (ru) | 2009-02-10 |
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