ATE543795T1 - Kondensierte bicyclische carbonsäureamidderivate zur verwendung als cxcr2-inhibitoren bei der behandlung von entzündungen - Google Patents
Kondensierte bicyclische carbonsäureamidderivate zur verwendung als cxcr2-inhibitoren bei der behandlung von entzündungenInfo
- Publication number
- ATE543795T1 ATE543795T1 AT05818685T AT05818685T ATE543795T1 AT E543795 T1 ATE543795 T1 AT E543795T1 AT 05818685 T AT05818685 T AT 05818685T AT 05818685 T AT05818685 T AT 05818685T AT E543795 T1 ATE543795 T1 AT E543795T1
- Authority
- AT
- Austria
- Prior art keywords
- inflammation
- treatment
- amide derivatives
- carboxylic amide
- condensed bicyclic
- Prior art date
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-
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- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
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PCT/EP2005/013624 WO2006069656A1 (en) | 2004-12-30 | 2005-12-17 | Fused bicyclic carboxamide derivatives for use as cxcr2 inhibitors in the treatment of inflammation |
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AU2007234408B2 (en) | 2006-04-04 | 2011-05-19 | Fibrogen, Inc. | Pyrrolo- and thiazolo-pyridine compounds as HIF modulators |
EP2040690B1 (de) | 2006-06-28 | 2014-08-06 | Sanofi | Cxcr2-inhibitoren |
KR20090023645A (ko) | 2006-06-28 | 2009-03-05 | 사노피-아벤티스 | 신규한 cxcr2 억제제 |
EP2041072B1 (de) | 2006-06-28 | 2013-09-11 | Sanofi | Cxcr2-antagonisten |
WO2008000410A1 (en) * | 2006-06-30 | 2008-01-03 | Sanofi-Aventis | Cxcr2 inhibitors |
CN101573359A (zh) * | 2006-11-23 | 2009-11-04 | 诺瓦提斯公司 | 作为cxcr2拮抗剂的5-硫基甲基-吡唑并[1,5-a]嘧啶-7-醇衍生物 |
MX2009005174A (es) * | 2006-11-23 | 2009-05-25 | Novartis Ag | Derivados de 5-sulfanilmetil-[1,2,4]triazol[1,5-a]pirimidin-7-ol como antagonistas de cxcr2. |
WO2008066558A2 (en) * | 2006-11-30 | 2008-06-05 | Dow Agrosciences Llc | Process for the preparation of 2-substituted-5-(1-alkylthio)alkylpyridines |
AU2008259804B2 (en) * | 2007-06-05 | 2013-04-18 | Sanofi-Aventis | Substituted benzoylamino-indan-2-carboxylic acids and related compounds |
CN102272117B (zh) | 2008-11-14 | 2015-06-17 | 菲布罗根有限公司 | 作为hif羟化酶抑制剂的苯并噻喃衍生物 |
GB0907551D0 (en) * | 2009-05-01 | 2009-06-10 | Univ Dundee | Treatment or prophylaxis of proliferative conditions |
AU2013203591B2 (en) * | 2009-05-01 | 2017-01-19 | University Court Of The University Of Dundee | Treatment or prophylaxis of proliferative conditions |
WO2012079154A1 (en) * | 2010-12-14 | 2012-06-21 | Dalhousie University | Selective estrogen receptor modulators |
BR112014030474A2 (pt) * | 2012-06-19 | 2017-06-27 | Hoffmann La Roche | novos compostos bicíclicos de tiofenilamida |
JP6383357B2 (ja) * | 2012-09-12 | 2018-08-29 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | 脂肪酸結合タンパク質(fabp)4及び/又は5のインヒビターとしての非環状チオフェニルアミド |
WO2014114603A1 (en) * | 2013-01-24 | 2014-07-31 | F. Hoffmann-La Roche Ag | Substituted thiazole compounds |
DK2951159T3 (en) | 2013-01-24 | 2018-11-19 | Fibrogen Inc | CRYSTALLIC FORMS OF {[1-CYANO-5- (4-CHLORPHENOXY) -4-HYDROXY-ISOQUINOLIN-3-CARBONYL] -AMINO} ACETIC ACID |
JP2017513812A (ja) * | 2014-02-28 | 2017-06-01 | ザ ロイヤル インスティチューション フォー ジ アドヴァンスメント オブ ラーニング/マギル ユニヴァーシティ | 免疫療法用のapc活性剤としてのtc−ptp阻害剤 |
SI3131582T1 (sl) * | 2014-04-15 | 2018-09-28 | Vertex Pharmaceuticals Incorporated | Farmacevtski sestavki za zdravljenje bolezni, pri katerih posreduje regulator transmembranske prevodnosti |
CN106660950A (zh) * | 2014-07-31 | 2017-05-10 | 葛兰素史密斯克莱知识产权发展有限公司 | Cxcr2拮抗剂用于预防和/或治疗化疗诱导的周围神经病变(cipn)的用途 |
CN105906608B (zh) * | 2016-05-03 | 2018-10-19 | 中山大学 | 8-氨基喹啉-松果体素杂联体及其药物组合物 |
CN106187974B (zh) * | 2016-07-01 | 2018-01-12 | 广州军区广州总医院 | 具有抗肿瘤作用的鱼藤素断环结构与氨基酸衍生物的合成方法 |
US11198869B2 (en) | 2017-12-01 | 2021-12-14 | The Texas A&M University System | Angelman syndrome antisense treatment |
EP3746134A1 (de) | 2018-02-02 | 2020-12-09 | Maverix Oncology, Inc. | Kleinmolekülige wirkstoffkonjugate von gemcitabinmonophosphat |
GB201807924D0 (en) | 2018-05-16 | 2018-06-27 | Ctxt Pty Ltd | Compounds |
WO2020191091A1 (en) | 2019-03-19 | 2020-09-24 | Boehringer Ingelheim Animal Health USA Inc. | Anthelmintic aza-benzothiophene and aza-benzofuran compounds |
WO2021113808A1 (en) * | 2019-12-05 | 2021-06-10 | Genzyme Corporation | Cftr-modulating arylamides |
MX2022015038A (es) | 2020-05-29 | 2023-01-04 | Boehringer Ingelheim Animal Health Usa Inc | Compuestos heterociclicos como anthelminticos. |
CN111559991B (zh) * | 2020-06-01 | 2022-01-25 | 河南省锐达医药科技有限公司 | 一种萘胺类化合物及其盐的制备方法和应用 |
CN115385865B (zh) * | 2022-06-29 | 2023-06-16 | 深圳大学 | 一种具有cxcr2抑制活性的小分子抑制剂及其制备方法与应用 |
CN116041300B (zh) * | 2023-02-20 | 2024-04-26 | 沈阳药科大学 | 一种2,2-二甲基苯并吡喃类衍生物及其制备方法和应用 |
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GB9716657D0 (en) * | 1997-08-07 | 1997-10-15 | Zeneca Ltd | Chemical compounds |
IT1317826B1 (it) | 2000-02-11 | 2003-07-15 | Dompe Spa | Ammidi, utili nell'inibizione della chemiotassi dei neutrofiliindotta da il-8. |
FR2825706B1 (fr) | 2001-06-06 | 2003-12-12 | Pf Medicament | Nouveaux derives de benzothienyle ou d'indole, leur preparation et leur utilisation comme inhibiteurs de proteines prenyl transferase |
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GB2389580A (en) * | 2002-06-12 | 2003-12-17 | Bayer Ag | 2-Naphthamide PGI2 antagonists |
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AU2004270394A1 (en) | 2003-09-10 | 2005-03-17 | Gpc Biotech Ag | Heterobicyclic compounds as pharmaceutically active agents |
US20050085531A1 (en) | 2003-10-03 | 2005-04-21 | Hodge Carl N. | Thiophene-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions, and uses thereof |
DE602004008505T2 (de) | 2003-11-20 | 2008-05-21 | Eli Lilly And Co., Indianapolis | Modulatoren des vitamin-d-rezeptors |
GB0401334D0 (en) | 2004-01-21 | 2004-02-25 | Novartis Ag | Organic compounds |
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EP1812383A1 (de) | 2004-11-09 | 2007-08-01 | Smithkline Beecham Corporation | Glycogenphosphorylasehemmerverbindungen und pharmazeutische zusammensetzungen daraus |
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AR055319A1 (es) | 2005-03-17 | 2007-08-15 | Wyeth Corp | Derivados de isoquinoleina, composiciones farmaceuticas y usos |
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AU2005321609B2 (en) | 2011-02-17 |
CN101094830A (zh) | 2007-12-26 |
JP5123667B2 (ja) | 2013-01-23 |
BRPI0519452A2 (pt) | 2009-01-27 |
US7919628B2 (en) | 2011-04-05 |
US20110184177A1 (en) | 2011-07-28 |
EP1836158A1 (de) | 2007-09-26 |
JP2008526695A (ja) | 2008-07-24 |
RU2404962C2 (ru) | 2010-11-27 |
PE20060855A1 (es) | 2006-10-10 |
EP1836158B1 (de) | 2012-02-01 |
US8283479B2 (en) | 2012-10-09 |
UY29322A1 (es) | 2006-07-31 |
IL184173A (en) | 2011-10-31 |
NZ556192A (en) | 2010-06-25 |
MX2007007068A (es) | 2007-08-08 |
ZA200704089B (en) | 2008-09-25 |
IL184173A0 (en) | 2007-10-31 |
RU2007128949A (ru) | 2009-02-10 |
MA29113B1 (fr) | 2007-12-03 |
CA2592430A1 (en) | 2006-07-06 |
AR055830A1 (es) | 2007-09-12 |
US20080090854A1 (en) | 2008-04-17 |
AU2005321609A1 (en) | 2006-07-06 |
TW200639141A (en) | 2006-11-16 |
NO20073932L (no) | 2007-08-09 |
WO2006069656A1 (en) | 2006-07-06 |
KR20070091634A (ko) | 2007-09-11 |
EP1676834A1 (de) | 2006-07-05 |
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