ATE543795T1 - Kondensierte bicyclische carbonsäureamidderivate zur verwendung als cxcr2-inhibitoren bei der behandlung von entzündungen - Google Patents

Kondensierte bicyclische carbonsäureamidderivate zur verwendung als cxcr2-inhibitoren bei der behandlung von entzündungen

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Publication number
ATE543795T1
ATE543795T1 AT05818685T AT05818685T ATE543795T1 AT E543795 T1 ATE543795 T1 AT E543795T1 AT 05818685 T AT05818685 T AT 05818685T AT 05818685 T AT05818685 T AT 05818685T AT E543795 T1 ATE543795 T1 AT E543795T1
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Austria
Prior art keywords
inflammation
treatment
amide derivatives
carboxylic amide
condensed bicyclic
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AT05818685T
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English (en)
Inventor
Stephanie Hachtel
Juergen Dedio
Holger Heitsch
Werngard Czechtizky
Sven Grueneberg
Stephen Shimshock
Raymond KOSLEY
Carolina Lanter
Hui Li
Rosy Sher
Aleksandra Weichsel
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Sanofi Aventis Deutschland
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AT05818685T 2004-12-30 2005-12-17 Kondensierte bicyclische carbonsäureamidderivate zur verwendung als cxcr2-inhibitoren bei der behandlung von entzündungen ATE543795T1 (de)

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Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005115384A2 (en) * 2004-05-25 2005-12-08 Metabolex, Inc. Bicyclic, substituted triazoles as modulators of ppar and methods of their preparation
EP1676834A1 (de) 2004-12-30 2006-07-05 Sanofi-Aventis Deutschland GmbH Kondensierte Bicyclische Carboxamid-Derivate zur Verwendung als CXCR2 Inhibitoren zur Behandlung von Entzündungen
US7928120B2 (en) 2006-01-27 2011-04-19 Fibrogen, Inc. Cyanoisoquinoline compounds and methods of use thereof
AU2007234408B2 (en) 2006-04-04 2011-05-19 Fibrogen, Inc. Pyrrolo- and thiazolo-pyridine compounds as HIF modulators
EP2040690B1 (de) 2006-06-28 2014-08-06 Sanofi Cxcr2-inhibitoren
KR20090023645A (ko) 2006-06-28 2009-03-05 사노피-아벤티스 신규한 cxcr2 억제제
EP2041072B1 (de) 2006-06-28 2013-09-11 Sanofi Cxcr2-antagonisten
WO2008000410A1 (en) * 2006-06-30 2008-01-03 Sanofi-Aventis Cxcr2 inhibitors
CN101573359A (zh) * 2006-11-23 2009-11-04 诺瓦提斯公司 作为cxcr2拮抗剂的5-硫基甲基-吡唑并[1,5-a]嘧啶-7-醇衍生物
MX2009005174A (es) * 2006-11-23 2009-05-25 Novartis Ag Derivados de 5-sulfanilmetil-[1,2,4]triazol[1,5-a]pirimidin-7-ol como antagonistas de cxcr2.
WO2008066558A2 (en) * 2006-11-30 2008-06-05 Dow Agrosciences Llc Process for the preparation of 2-substituted-5-(1-alkylthio)alkylpyridines
AU2008259804B2 (en) * 2007-06-05 2013-04-18 Sanofi-Aventis Substituted benzoylamino-indan-2-carboxylic acids and related compounds
CN102272117B (zh) 2008-11-14 2015-06-17 菲布罗根有限公司 作为hif羟化酶抑制剂的苯并噻喃衍生物
GB0907551D0 (en) * 2009-05-01 2009-06-10 Univ Dundee Treatment or prophylaxis of proliferative conditions
AU2013203591B2 (en) * 2009-05-01 2017-01-19 University Court Of The University Of Dundee Treatment or prophylaxis of proliferative conditions
WO2012079154A1 (en) * 2010-12-14 2012-06-21 Dalhousie University Selective estrogen receptor modulators
BR112014030474A2 (pt) * 2012-06-19 2017-06-27 Hoffmann La Roche novos compostos bicíclicos de tiofenilamida
JP6383357B2 (ja) * 2012-09-12 2018-08-29 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft 脂肪酸結合タンパク質(fabp)4及び/又は5のインヒビターとしての非環状チオフェニルアミド
WO2014114603A1 (en) * 2013-01-24 2014-07-31 F. Hoffmann-La Roche Ag Substituted thiazole compounds
DK2951159T3 (en) 2013-01-24 2018-11-19 Fibrogen Inc CRYSTALLIC FORMS OF {[1-CYANO-5- (4-CHLORPHENOXY) -4-HYDROXY-ISOQUINOLIN-3-CARBONYL] -AMINO} ACETIC ACID
JP2017513812A (ja) * 2014-02-28 2017-06-01 ザ ロイヤル インスティチューション フォー ジ アドヴァンスメント オブ ラーニング/マギル ユニヴァーシティ 免疫療法用のapc活性剤としてのtc−ptp阻害剤
SI3131582T1 (sl) * 2014-04-15 2018-09-28 Vertex Pharmaceuticals Incorporated Farmacevtski sestavki za zdravljenje bolezni, pri katerih posreduje regulator transmembranske prevodnosti
CN106660950A (zh) * 2014-07-31 2017-05-10 葛兰素史密斯克莱知识产权发展有限公司 Cxcr2拮抗剂用于预防和/或治疗化疗诱导的周围神经病变(cipn)的用途
CN105906608B (zh) * 2016-05-03 2018-10-19 中山大学 8-氨基喹啉-松果体素杂联体及其药物组合物
CN106187974B (zh) * 2016-07-01 2018-01-12 广州军区广州总医院 具有抗肿瘤作用的鱼藤素断环结构与氨基酸衍生物的合成方法
US11198869B2 (en) 2017-12-01 2021-12-14 The Texas A&M University System Angelman syndrome antisense treatment
EP3746134A1 (de) 2018-02-02 2020-12-09 Maverix Oncology, Inc. Kleinmolekülige wirkstoffkonjugate von gemcitabinmonophosphat
GB201807924D0 (en) 2018-05-16 2018-06-27 Ctxt Pty Ltd Compounds
WO2020191091A1 (en) 2019-03-19 2020-09-24 Boehringer Ingelheim Animal Health USA Inc. Anthelmintic aza-benzothiophene and aza-benzofuran compounds
WO2021113808A1 (en) * 2019-12-05 2021-06-10 Genzyme Corporation Cftr-modulating arylamides
MX2022015038A (es) 2020-05-29 2023-01-04 Boehringer Ingelheim Animal Health Usa Inc Compuestos heterociclicos como anthelminticos.
CN111559991B (zh) * 2020-06-01 2022-01-25 河南省锐达医药科技有限公司 一种萘胺类化合物及其盐的制备方法和应用
CN115385865B (zh) * 2022-06-29 2023-06-16 深圳大学 一种具有cxcr2抑制活性的小分子抑制剂及其制备方法与应用
CN116041300B (zh) * 2023-02-20 2024-04-26 沈阳药科大学 一种2,2-二甲基苯并吡喃类衍生物及其制备方法和应用

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4962224A (en) * 1987-12-23 1990-10-09 American Home Products Corporation N-naphthoylglycines as aldose reductase inhibitors
US4994477A (en) * 1988-03-24 1991-02-19 Abbott Laboratories Heterocyclic renin inhibitors
US6531467B2 (en) * 1996-09-12 2003-03-11 Idun Pharmaceuticals, Inc. Inhibition of inflammation using interleukin-1β-converting enzyme (ICE)/CED-3 family inhibitors
GB9716657D0 (en) * 1997-08-07 1997-10-15 Zeneca Ltd Chemical compounds
IT1317826B1 (it) 2000-02-11 2003-07-15 Dompe Spa Ammidi, utili nell'inibizione della chemiotassi dei neutrofiliindotta da il-8.
FR2825706B1 (fr) 2001-06-06 2003-12-12 Pf Medicament Nouveaux derives de benzothienyle ou d'indole, leur preparation et leur utilisation comme inhibiteurs de proteines prenyl transferase
US6673791B2 (en) * 2001-07-30 2004-01-06 Boehringer Ingelheim (Canada) Ltd. Non-nucleoside reverse transcriptase inhibitors
GB2389580A (en) * 2002-06-12 2003-12-17 Bayer Ag 2-Naphthamide PGI2 antagonists
PT1644336E (pt) * 2003-06-06 2011-04-21 Fibrogen Inc Compostos de heteroarilo que contêm azoto e sua utilização no aumento da eritropoetina endógena
US7544699B2 (en) * 2003-08-08 2009-06-09 Transtech Pharma, Inc. Aryl and heteroaryl compounds, compositions, and methods of use
AU2004270394A1 (en) 2003-09-10 2005-03-17 Gpc Biotech Ag Heterobicyclic compounds as pharmaceutically active agents
US20050085531A1 (en) 2003-10-03 2005-04-21 Hodge Carl N. Thiophene-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions, and uses thereof
DE602004008505T2 (de) 2003-11-20 2008-05-21 Eli Lilly And Co., Indianapolis Modulatoren des vitamin-d-rezeptors
GB0401334D0 (en) 2004-01-21 2004-02-25 Novartis Ag Organic compounds
WO2006040646A1 (en) 2004-10-14 2006-04-20 Pfizer, Inc. Benzimidazole or indole amides as inhibitors of pin1
EP1812383A1 (de) 2004-11-09 2007-08-01 Smithkline Beecham Corporation Glycogenphosphorylasehemmerverbindungen und pharmazeutische zusammensetzungen daraus
EP1676834A1 (de) 2004-12-30 2006-07-05 Sanofi-Aventis Deutschland GmbH Kondensierte Bicyclische Carboxamid-Derivate zur Verwendung als CXCR2 Inhibitoren zur Behandlung von Entzündungen
AR055319A1 (es) 2005-03-17 2007-08-15 Wyeth Corp Derivados de isoquinoleina, composiciones farmaceuticas y usos

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