PE20060855A1 - Derivados de carboxamida biciclicos fusionados como inhibidores de cxcr2 - Google Patents
Derivados de carboxamida biciclicos fusionados como inhibidores de cxcr2Info
- Publication number
- PE20060855A1 PE20060855A1 PE2006000027A PE2006000027A PE20060855A1 PE 20060855 A1 PE20060855 A1 PE 20060855A1 PE 2006000027 A PE2006000027 A PE 2006000027A PE 2006000027 A PE2006000027 A PE 2006000027A PE 20060855 A1 PE20060855 A1 PE 20060855A1
- Authority
- PE
- Peru
- Prior art keywords
- cxcr2
- bicycle
- inhibitors
- independently
- triathione
- Prior art date
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- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/68—One oxygen atom attached in position 4
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Abstract
SE REFIERE A COMPUESTOS DERIVADOS DE CARBOXAMIDA BICICLICOS FUSIONADOS DE FORMULA (I), EN DONDE X ES -CR3=CR4-, -S-, -CR5=N-, ENTRE OTROS, DONDE R3, R4, R5 SON INDEPENDIENTEMENTE H, F, Cl, Br, ENTRE OTROS; Y1, Y2, Y3 E Y4 SON INDEPENDIENTEMENTE -CR8-, DONDE R8 ES H, F, Cl; A ES CICLOALQUILO(C3-C8), HETEROCICLO O ARILO, OPCIONALMENTE CONDENSADOS AL ARILO TAL COMO CICLOHEXILO, FENILO, PIPERIDILO, NAFTILO, BENZO[1,4]DIOXANILO, TIENILO, ISOXAZOLILO, TRIAZOLILO, ENTRE OTROS, OPCIONALMENTE SUSTITUIDOS; B ES -OC(R11R12)-, NR17-C(R18R19)-, ENTRE OTROS; D ES C(O)OH, C(O)NHR21, C(N-OH)NHR22, ENTRE OTROS; R1 Y R2 SON INDEPENDIENTEMENTE ALQUILO(C1-C3) O JUNTOS FORMAN UN ANILLO(C3-C5). SON PREFERIDOS: ACIDO 2-[(1-CICLOHEXILMETOXI-NAFTALENO-2-CARBONIL-AMINO]-PROPIONICO, ACIDO 2-{[1-(4-BROMO-BENCILOXI)NAFTALENO-2-CARBONIL]-AMINO}-2-METIL-PROPIONICO, ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. ESTOS COMPUESTOS SON INHIBIDORES DE RECEPTORES DE QUIMIOQUINAS CXC, Y PARTICULARMENTE DE CXCR2, POR LO QUE SON UTILES EN EL TRATAMIENTO Y PROFILAXIS DE ENFERMEDADES INFLAMATORIAS AGUDAS Y CRONICAS
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EP04031009A EP1676834A1 (en) | 2004-12-30 | 2004-12-30 | Fused bicyclic carboxamide derivates for use as CXCR2 inhibitors in the treatment of inflammation |
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JP2008500358A (ja) * | 2004-05-25 | 2008-01-10 | メタボレックス インコーポレーティッド | Pparのモジュレーターとしての、二環式の置換されたトリアゾール、およびこれらの調製方法 |
EP1676834A1 (en) | 2004-12-30 | 2006-07-05 | Sanofi-Aventis Deutschland GmbH | Fused bicyclic carboxamide derivates for use as CXCR2 inhibitors in the treatment of inflammation |
AU2007211077B2 (en) | 2006-01-27 | 2012-09-20 | Fibrogen, Inc. | Cyanoisoquinoline compounds that stabilize hypoxia inducible factor (HIF) |
MX2008012734A (es) | 2006-04-04 | 2009-01-29 | Fibrogen Inc | Compuestos pirrolo- y tiazolo-piridina como moduladores del factor inducible de hipoxia (hif). |
WO2008000407A1 (en) | 2006-06-28 | 2008-01-03 | Sanofi-Aventis | Inhibitors of cxcr2 |
JP5237938B2 (ja) | 2006-06-28 | 2013-07-17 | サノフイ | 新規なcxcr2阻害剤 |
JP5352454B2 (ja) * | 2006-06-28 | 2013-11-27 | サノフイ | Cxcr2アンンタゴニスト |
WO2008000410A1 (en) | 2006-06-30 | 2008-01-03 | Sanofi-Aventis | Cxcr2 inhibitors |
WO2008061741A1 (en) * | 2006-11-23 | 2008-05-29 | Novartis Ag | 5-sulfanylmethyl-[1,2,4] triazol[1, 5-a] pyrimidin-7-ol derivatives as cxcr2 antagonists |
MX2009005358A (es) * | 2006-11-23 | 2009-06-05 | Novartis Ag | Derivados de 5-sulfanilmetil-pirazolo[1,5-a]pirimidin-7-ol como antagonistas de cxcr2. |
KR101364353B1 (ko) * | 2006-11-30 | 2014-02-18 | 다우 아그로사이언시즈 엘엘씨 | 2-치환된-5-(1-알킬티오)알킬피리딘의 제조 방법 |
EP2155711A1 (en) * | 2007-06-05 | 2010-02-24 | Sanofi-Aventis | Substituted benzoylamino-indan-2-carboxylic acids and related compounds |
JP5649584B2 (ja) | 2008-11-14 | 2015-01-07 | フィブロジェン インコーポレイテッド | Hifヒドロキシラーゼ阻害剤としてのチオクロメン誘導体 |
GB0907551D0 (en) * | 2009-05-01 | 2009-06-10 | Univ Dundee | Treatment or prophylaxis of proliferative conditions |
AU2013203591B2 (en) * | 2009-05-01 | 2017-01-19 | University Court Of The University Of Dundee | Treatment or prophylaxis of proliferative conditions |
WO2012079154A1 (en) * | 2010-12-14 | 2012-06-21 | Dalhousie University | Selective estrogen receptor modulators |
RU2644565C2 (ru) * | 2012-06-19 | 2018-02-13 | Ф. Хоффманн-Ля Рош Аг | Новые бициклические соединения тиофениламида |
BR112015004008A8 (pt) * | 2012-09-12 | 2018-01-23 | Hoffmann La Roche | novas tiofenilamidas não anuladas |
WO2014114603A1 (en) * | 2013-01-24 | 2014-07-31 | F. Hoffmann-La Roche Ag | Substituted thiazole compounds |
TWI685487B (zh) | 2013-01-24 | 2020-02-21 | 美商費比羅根公司 | {[1-氰基-5-(4-氯苯氧基)-4-羥基-異喹啉-3-羰基]-胺基}-乙酸之晶形 |
CA2977839C (en) * | 2014-02-28 | 2022-07-26 | The Royal Institution For The Advancement Of Learning / Mcgill University | Tc-ptp inhibitors as apc activators for immunotherapy |
PL3424534T3 (pl) * | 2014-04-15 | 2021-11-22 | Vertex Pharmaceuticals Incorporated | Kompozycje farmaceutyczne do leczenia chorób, w których pośredniczy mukowiscydozowy przezbłonowy regulator przewodnictwa |
CA2956785A1 (en) * | 2014-07-31 | 2016-02-04 | Glaxosmithkline Intellectual Property Development Limited | Use of cxcr2 antagonists for the prevention and/or treatment of chemotherapy induced peripheral neuropathy (cipn) |
CN105906608B (zh) * | 2016-05-03 | 2018-10-19 | 中山大学 | 8-氨基喹啉-松果体素杂联体及其药物组合物 |
CN106187974B (zh) * | 2016-07-01 | 2018-01-12 | 广州军区广州总医院 | 具有抗肿瘤作用的鱼藤素断环结构与氨基酸衍生物的合成方法 |
MX2020005680A (es) | 2017-12-01 | 2020-08-20 | Texas A & M Univ Sys | Tratamiento antisentido del sindrome de angelman. |
KR20200118827A (ko) | 2018-02-02 | 2020-10-16 | 마베릭스 온콜로지, 잉크. | 젬시타빈 모노포스페이트의 소분자 약물 컨쥬게이트 |
GB201807924D0 (en) * | 2018-05-16 | 2018-06-27 | Ctxt Pty Ltd | Compounds |
SG11202109786UA (en) | 2019-03-19 | 2021-10-28 | Boehringer Ingelheim Animal Health Usa Inc | Anthelmintic aza-benzothiophene and aza-benzofuran compounds |
WO2021113808A1 (en) * | 2019-12-05 | 2021-06-10 | Genzyme Corporation | Cftr-modulating arylamides |
WO2021242581A1 (en) | 2020-05-29 | 2021-12-02 | Boehringer Ingelheim Animal Health USA Inc. | Anthelmintic heterocyclic compounds |
CN111559991B (zh) * | 2020-06-01 | 2022-01-25 | 河南省锐达医药科技有限公司 | 一种萘胺类化合物及其盐的制备方法和应用 |
CA3236894A1 (en) | 2021-11-01 | 2023-05-04 | Boehringer Ingelheim Vetmedica Gmbh | Anthelmintic pyrrolopyridazine compounds |
CN115385865B (zh) * | 2022-06-29 | 2023-06-16 | 深圳大学 | 一种具有cxcr2抑制活性的小分子抑制剂及其制备方法与应用 |
CN116041300B (zh) * | 2023-02-20 | 2024-04-26 | 沈阳药科大学 | 一种2,2-二甲基苯并吡喃类衍生物及其制备方法和应用 |
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US4962224A (en) * | 1987-12-23 | 1990-10-09 | American Home Products Corporation | N-naphthoylglycines as aldose reductase inhibitors |
US4994477A (en) * | 1988-03-24 | 1991-02-19 | Abbott Laboratories | Heterocyclic renin inhibitors |
US6531467B2 (en) * | 1996-09-12 | 2003-03-11 | Idun Pharmaceuticals, Inc. | Inhibition of inflammation using interleukin-1β-converting enzyme (ICE)/CED-3 family inhibitors |
GB9716657D0 (en) * | 1997-08-07 | 1997-10-15 | Zeneca Ltd | Chemical compounds |
IT1317826B1 (it) | 2000-02-11 | 2003-07-15 | Dompe Spa | Ammidi, utili nell'inibizione della chemiotassi dei neutrofiliindotta da il-8. |
FR2825706B1 (fr) | 2001-06-06 | 2003-12-12 | Pf Medicament | Nouveaux derives de benzothienyle ou d'indole, leur preparation et leur utilisation comme inhibiteurs de proteines prenyl transferase |
US6673791B2 (en) * | 2001-07-30 | 2004-01-06 | Boehringer Ingelheim (Canada) Ltd. | Non-nucleoside reverse transcriptase inhibitors |
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WO2005014533A2 (en) * | 2003-08-08 | 2005-02-17 | Transtech Pharma, Inc. | Aryl and heteroaryl compounds, compositions, and methods of use |
EP1670804A2 (en) | 2003-09-10 | 2006-06-21 | GPC Biotech AG | Heterobicyclic compounds as pharmaceutically active agents |
US20050085531A1 (en) | 2003-10-03 | 2005-04-21 | Hodge Carl N. | Thiophene-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions, and uses thereof |
ATE370941T1 (de) | 2003-11-20 | 2007-09-15 | Lilly Co Eli | Modulatoren des vitamin-d-rezeptors |
GB0401334D0 (en) | 2004-01-21 | 2004-02-25 | Novartis Ag | Organic compounds |
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CA2586446A1 (en) | 2004-11-09 | 2006-05-18 | Smithkline Beecham Corporation | Glycogen phosphorylase inhibitor compounds and pharmaceutical compositions thereof |
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AR055319A1 (es) | 2005-03-17 | 2007-08-15 | Wyeth Corp | Derivados de isoquinoleina, composiciones farmaceuticas y usos |
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- 2005-12-17 RU RU2007128949/04A patent/RU2404962C2/ru not_active IP Right Cessation
- 2005-12-17 KR KR1020077015119A patent/KR20070091634A/ko not_active Application Discontinuation
- 2005-12-17 CN CNA2005800454624A patent/CN101094830A/zh active Pending
- 2005-12-17 AT AT05818685T patent/ATE543795T1/de active
- 2005-12-17 EP EP05818685A patent/EP1836158B1/en active Active
- 2005-12-17 NZ NZ556192A patent/NZ556192A/en not_active IP Right Cessation
- 2005-12-17 CA CA002592430A patent/CA2592430A1/en not_active Withdrawn
- 2005-12-17 MX MX2007007068A patent/MX2007007068A/es active IP Right Grant
- 2005-12-17 BR BRPI0519452-0A patent/BRPI0519452A2/pt not_active Application Discontinuation
- 2005-12-28 TW TW094146875A patent/TW200639141A/zh unknown
- 2005-12-28 AR ARP050105577A patent/AR055830A1/es unknown
- 2005-12-30 UY UY29322A patent/UY29322A1/es unknown
-
2006
- 2006-01-03 PE PE2006000027A patent/PE20060855A1/es not_active Application Discontinuation
-
2007
- 2007-05-21 ZA ZA200704089A patent/ZA200704089B/xx unknown
- 2007-06-24 IL IL184173A patent/IL184173A/en unknown
- 2007-06-26 MA MA30032A patent/MA29113B1/fr unknown
- 2007-06-29 US US11/771,958 patent/US7919628B2/en not_active Expired - Fee Related
- 2007-07-26 NO NO20073932A patent/NO20073932L/no unknown
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2011
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Also Published As
Publication number | Publication date |
---|---|
RU2007128949A (ru) | 2009-02-10 |
EP1836158B1 (en) | 2012-02-01 |
TW200639141A (en) | 2006-11-16 |
AR055830A1 (es) | 2007-09-12 |
WO2006069656A1 (en) | 2006-07-06 |
KR20070091634A (ko) | 2007-09-11 |
MX2007007068A (es) | 2007-08-08 |
EP1836158A1 (en) | 2007-09-26 |
BRPI0519452A2 (pt) | 2009-01-27 |
NZ556192A (en) | 2010-06-25 |
JP5123667B2 (ja) | 2013-01-23 |
US8283479B2 (en) | 2012-10-09 |
US20080090854A1 (en) | 2008-04-17 |
EP1676834A1 (en) | 2006-07-05 |
MA29113B1 (fr) | 2007-12-03 |
CN101094830A (zh) | 2007-12-26 |
IL184173A0 (en) | 2007-10-31 |
AU2005321609A1 (en) | 2006-07-06 |
RU2404962C2 (ru) | 2010-11-27 |
AU2005321609B2 (en) | 2011-02-17 |
CA2592430A1 (en) | 2006-07-06 |
US20110184177A1 (en) | 2011-07-28 |
IL184173A (en) | 2011-10-31 |
JP2008526695A (ja) | 2008-07-24 |
UY29322A1 (es) | 2006-07-31 |
ATE543795T1 (de) | 2012-02-15 |
ZA200704089B (en) | 2008-09-25 |
US7919628B2 (en) | 2011-04-05 |
NO20073932L (no) | 2007-08-09 |
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