ATE526331T1 - Pyrrolopyrimidine für pharmazeutische zusammensetzungen - Google Patents
Pyrrolopyrimidine für pharmazeutische zusammensetzungenInfo
- Publication number
- ATE526331T1 ATE526331T1 AT07785972T AT07785972T ATE526331T1 AT E526331 T1 ATE526331 T1 AT E526331T1 AT 07785972 T AT07785972 T AT 07785972T AT 07785972 T AT07785972 T AT 07785972T AT E526331 T1 ATE526331 T1 AT E526331T1
- Authority
- AT
- Austria
- Prior art keywords
- pharmaceutical compositions
- pyrrolopyrimidines
- pyrrolopyrimidine compounds
- relates
- present
- Prior art date
Links
- 150000004944 pyrrolopyrimidines Chemical class 0.000 title abstract 4
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 3
- 102100026299 MAP kinase-interacting serine/threonine-protein kinase 1 Human genes 0.000 abstract 1
- 101710139011 MAP kinase-interacting serine/threonine-protein kinase 1 Proteins 0.000 abstract 1
- 102100033610 MAP kinase-interacting serine/threonine-protein kinase 2 Human genes 0.000 abstract 1
- 101710138999 MAP kinase-interacting serine/threonine-protein kinase 2 Proteins 0.000 abstract 1
- 108091000080 Phosphotransferase Proteins 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 102000020233 phosphotransferase Human genes 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Physical Education & Sports Medicine (AREA)
- Obesity (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Urology & Nephrology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurology (AREA)
- Endocrinology (AREA)
- Dermatology (AREA)
- Pain & Pain Management (AREA)
- Emergency Medicine (AREA)
- Oncology (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Neurosurgery (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Ophthalmology & Optometry (AREA)
- Communicable Diseases (AREA)
- Vascular Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06014297A EP1889847A1 (de) | 2006-07-10 | 2006-07-10 | Pyrrolopyrimidine zur pharmazeutischen Anwendung |
| PCT/EP2007/006109 WO2008006547A2 (en) | 2006-07-10 | 2007-07-10 | Pyrrolopyrimidines for pharmaceutical compositions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE526331T1 true ATE526331T1 (de) | 2011-10-15 |
Family
ID=37496429
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT07785972T ATE526331T1 (de) | 2006-07-10 | 2007-07-10 | Pyrrolopyrimidine für pharmazeutische zusammensetzungen |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US8697713B2 (de) |
| EP (2) | EP1889847A1 (de) |
| JP (1) | JP5331951B2 (de) |
| KR (1) | KR20090039757A (de) |
| CN (1) | CN101511837A (de) |
| AT (1) | ATE526331T1 (de) |
| AU (1) | AU2007271928A1 (de) |
| BR (1) | BRPI0712882A2 (de) |
| CA (1) | CA2690277A1 (de) |
| CO (1) | CO6150162A2 (de) |
| EA (1) | EA200900136A1 (de) |
| IL (1) | IL196391A0 (de) |
| MX (1) | MX2009000333A (de) |
| NO (1) | NO20090029L (de) |
| WO (1) | WO2008006547A2 (de) |
| ZA (1) | ZA200810785B (de) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20090047391A (ko) | 2006-04-07 | 2009-05-12 | 데벨로겐 악틴게젤샤프트 | 약제학적 조성물을 위한 Mnk1/Mnk2 억제 활성을 갖는티에노피리미딘 |
| EP1889847A1 (de) | 2006-07-10 | 2008-02-20 | DeveloGen Aktiengesellschaft | Pyrrolopyrimidine zur pharmazeutischen Anwendung |
| US8946239B2 (en) * | 2008-07-10 | 2015-02-03 | Duquesne University Of The Holy Spirit | Substituted pyrrolo, -furano, and cyclopentylpyrimidines having antimitotic and/or antitumor activity and methods of use thereof |
| EP2331551B1 (de) | 2008-08-26 | 2016-06-29 | Evotec International GmbH | Thienopyrimidine für pharmazeutische zusammensetzungen |
| US20130065914A1 (en) * | 2010-02-26 | 2013-03-14 | Boehringer Ingelheim International Gmbh | Halogen or cyano substituted thieno [2,3-d]pyrimidines having mnk1/mnk2 inhibiting activity for pharmaceutical compositions |
| UY33241A (es) | 2010-02-26 | 2011-09-30 | Boehringer Ingelheim Int | ?Tienopirimidinas que contienen heterocicloalquilo para composiciones farmacéuticas?. |
| AU2011219758A1 (en) | 2010-02-26 | 2012-08-16 | Boehringer Ingelheim International Gmbh | 4 - [cycloalkyloxy (hetero) arylamino] thieno [2, 3 - d] pyrimidines having Mnkl/ Mnk2 inhibiting activity for pharmaceutical compositions |
| BR112012021453A2 (pt) * | 2010-02-26 | 2017-02-21 | Boehringer Ingelheim Int | tienopirimidina, sua composição farmacêutica e seu uso |
| US20120295911A1 (en) | 2010-11-29 | 2012-11-22 | Galleon Pharmaceuticals, Inc. | Novel Compounds and Compositions for Treatment of Breathing Control Disorders or Diseases |
| SG10201601507YA (en) * | 2010-11-29 | 2016-04-28 | Galleon Pharmaceuticals Inc | Novel compounds as respiratory stimulants for treatment of breathing control disorders or diseases |
| KR101286743B1 (ko) * | 2011-02-18 | 2013-07-15 | 충남대학교산학협력단 | 페노피브레이트를 함유하는 패혈증 예방용 약학 조성물 |
| US9643974B2 (en) | 2011-12-12 | 2017-05-09 | Bayer Intellectual Property Gmbh | Amino-substituted imidazopyridazines |
| US20150133426A1 (en) * | 2012-05-21 | 2015-05-14 | Bayer Pharma Aktiengesellschaft | Substituted pyrrolopyrimidines |
| US11186575B2 (en) | 2012-08-07 | 2021-11-30 | Alber Einslein College of Medicine | Treatment of helicobacter pylori infections |
| EP2900670A1 (de) | 2012-09-26 | 2015-08-05 | Bayer Pharma Aktiengesellschaft | Substituierte indazolpyrrolopyrimidine zur behandlung von hyperfoliferativen erkrankungen |
| CA2885783A1 (en) * | 2012-09-26 | 2014-04-03 | Bayer Pharma Aktiengesellschaft | Substituted indazol-pyrrolopyrimidines useful in the treatment of hyperproliferative diseases |
| EP2917185B1 (de) * | 2012-11-09 | 2017-05-10 | Evotec International GmbH | Sulfoximinsubstituierte chinazoline für pharmazeutische zusammensetzungen |
| JP2016506944A (ja) * | 2013-02-01 | 2016-03-07 | バイエル・ファルマ・アクティエンゲゼルシャフト | 置換ピラゾロピリミジニルアミノ−インダゾール |
| WO2014145576A2 (en) | 2013-03-15 | 2014-09-18 | Northwestern University | Substituted pyrrolo(2,3-d)pyrimidines for the treatment of cancer |
| DK3013805T3 (en) * | 2013-06-28 | 2018-04-23 | Evotec Int Gmbh | Sulfoximine-substituted quinazolines and their use as MNK1 and / or MNK2 kinase inhibitors |
| CN105531279A (zh) * | 2013-07-08 | 2016-04-27 | 拜耳制药股份公司 | 取代的吡唑并吡啶胺 |
| WO2015091156A1 (en) * | 2013-12-17 | 2015-06-25 | Boehringer Ingelheim International Gmbh | Sulfoximine substituted pyrrolotriazines for pharmaceutical compositions |
| WO2015169677A1 (en) * | 2014-05-07 | 2015-11-12 | Boehringer Ingelheim International Gmbh | Sulfoximine substituted quinazolines for pharmaceutical compositions |
| TWI713455B (zh) * | 2014-06-25 | 2020-12-21 | 美商伊凡克特治療公司 | MnK抑制劑及其相關方法 |
| CN104225597A (zh) * | 2014-09-29 | 2014-12-24 | 武汉大学 | Mapk信号整合激酶1在治疗动脉粥样硬化中的功能和应用 |
| US10676475B2 (en) * | 2015-01-16 | 2020-06-09 | The General Hospital Corporation | Compounds for improving mRNA splicing |
| CA2982984C (en) | 2015-04-20 | 2023-10-17 | Effector Therapeutics, Inc. | Inhibitors of immune checkpoint modulators for use in treating cancer and infections |
| EP3331895B1 (de) | 2015-08-06 | 2020-07-29 | Chimerix, Inc. | Pyrrolopyrimidin nucleoside und analaoga davon nützlich als antivirale mittel |
| SG11201803242TA (en) | 2015-10-29 | 2018-05-30 | Effector Therapeutics Inc | Isoindoline, azaisoindoline, dihydroindenone and dihydroazaindenone inhibitors of mnk1 and mnk2 |
| WO2017075412A1 (en) | 2015-10-29 | 2017-05-04 | Effector Therapeutics, Inc. | Pyrrolo-, pyrazolo-, imidazo-pyrimidine and pyridine compounds that inhibit mnk1 and mnk2 |
| GB201520500D0 (en) * | 2015-11-20 | 2016-01-06 | Medical Res Council Technology | Compounds |
| WO2017087808A1 (en) * | 2015-11-20 | 2017-05-26 | Effector Therapeutics, Inc. | Heterocyclic compounds that inhibit the kinase activity of mnk useful for treating various cancers |
| GB201520499D0 (en) * | 2015-11-20 | 2016-01-06 | Medical Res Council Technology | Compounds |
| US9630968B1 (en) | 2015-12-23 | 2017-04-25 | Arqule, Inc. | Tetrahydropyranyl amino-pyrrolopyrimidinone and methods of use thereof |
| EP3397774A1 (de) | 2015-12-31 | 2018-11-07 | Effector Therapeutics Inc. | Mnk-biomarker und verwendungen davon |
| JP2019510061A (ja) * | 2016-03-31 | 2019-04-11 | サウス オーストラリアン ヘルス アンド メディカル リサーチ インスティテュート リミテッドSouth Australian Health And Medical Research Institute Limited | 高脂肪食関連疾患を阻害する方法 |
| GB2550977B (en) | 2016-05-31 | 2020-07-22 | Cirrus Logic Int Semiconductor Ltd | Monitoring of devices |
| BR112019003504A2 (pt) | 2016-08-24 | 2019-05-21 | Arqule, Inc. | compostos de amino-pirrolopirimidinona e métodos de uso dos mesmos |
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2007
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- 2007-07-10 AU AU2007271928A patent/AU2007271928A1/en not_active Abandoned
- 2007-07-10 AT AT07785972T patent/ATE526331T1/de not_active IP Right Cessation
- 2007-07-10 BR BRPI0712882-7A patent/BRPI0712882A2/pt not_active IP Right Cessation
- 2007-07-10 CA CA2690277A patent/CA2690277A1/en not_active Abandoned
- 2007-07-10 US US12/373,224 patent/US8697713B2/en active Active
- 2007-07-10 KR KR1020097002707A patent/KR20090039757A/ko not_active Withdrawn
- 2007-07-10 WO PCT/EP2007/006109 patent/WO2008006547A2/en not_active Ceased
- 2007-07-10 JP JP2009518781A patent/JP5331951B2/ja not_active Expired - Fee Related
- 2007-07-10 EA EA200900136A patent/EA200900136A1/ru unknown
- 2007-07-10 EP EP07785972A patent/EP2041137B1/de not_active Not-in-force
- 2007-07-10 MX MX2009000333A patent/MX2009000333A/es not_active Application Discontinuation
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2008
- 2008-12-22 ZA ZA200810785A patent/ZA200810785B/xx unknown
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2009
- 2009-01-05 NO NO20090029A patent/NO20090029L/no not_active Application Discontinuation
- 2009-01-08 CO CO09001490A patent/CO6150162A2/es unknown
- 2009-01-08 IL IL196391A patent/IL196391A0/en unknown
Also Published As
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| NO20090029L (no) | 2009-01-28 |
| AU2007271928A1 (en) | 2008-01-17 |
| CN101511837A (zh) | 2009-08-19 |
| BRPI0712882A2 (pt) | 2012-10-09 |
| KR20090039757A (ko) | 2009-04-22 |
| JP2009542749A (ja) | 2009-12-03 |
| EP2041137A2 (de) | 2009-04-01 |
| EP2041137B1 (de) | 2011-09-28 |
| MX2009000333A (es) | 2009-03-13 |
| ZA200810785B (en) | 2009-10-28 |
| WO2008006547A2 (en) | 2008-01-17 |
| CO6150162A2 (es) | 2010-04-20 |
| EP1889847A1 (de) | 2008-02-20 |
| EA200900136A1 (ru) | 2009-06-30 |
| IL196391A0 (en) | 2009-09-22 |
| US20100105708A1 (en) | 2010-04-29 |
| CA2690277A1 (en) | 2008-01-17 |
| JP5331951B2 (ja) | 2013-10-30 |
| US8697713B2 (en) | 2014-04-15 |
| WO2008006547A3 (en) | 2008-03-06 |
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