ATE471334T1 - Phosphoramidatderivate von nukleosidverbindungen zur verwendung bei der behandlung von krebs - Google Patents
Phosphoramidatderivate von nukleosidverbindungen zur verwendung bei der behandlung von krebsInfo
- Publication number
- ATE471334T1 ATE471334T1 AT06710096T AT06710096T ATE471334T1 AT E471334 T1 ATE471334 T1 AT E471334T1 AT 06710096 T AT06710096 T AT 06710096T AT 06710096 T AT06710096 T AT 06710096T AT E471334 T1 ATE471334 T1 AT E471334T1
- Authority
- AT
- Austria
- Prior art keywords
- cancer
- treatment
- nucleoside compounds
- phosphoramidate derivatives
- compounds
- Prior art date
Links
- -1 NUCLEOSIDE COMPOUNDS Chemical class 0.000 title abstract 3
- 206010028980 Neoplasm Diseases 0.000 title abstract 2
- 201000011510 cancer Diseases 0.000 title abstract 2
- 239000002777 nucleoside Substances 0.000 title abstract 2
- 150000008298 phosphoramidates Chemical class 0.000 title abstract 2
- PTOAARAWEBMLNO-KVQBGUIXSA-N Cladribine Chemical compound C1=NC=2C(N)=NC(Cl)=NC=2N1[C@H]1C[C@H](O)[C@@H](CO)O1 PTOAARAWEBMLNO-KVQBGUIXSA-N 0.000 abstract 1
- 229960002436 cladribine Drugs 0.000 abstract 1
- 229960000928 clofarabine Drugs 0.000 abstract 1
- WDDPHFBMKLOVOX-AYQXTPAHSA-N clofarabine Chemical compound C1=NC=2C(N)=NC(Cl)=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@@H]1F WDDPHFBMKLOVOX-AYQXTPAHSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229960000390 fludarabine Drugs 0.000 abstract 1
- GIUYCYHIANZCFB-FJFJXFQQSA-N fludarabine phosphate Chemical compound C1=NC=2C(N)=NC(F)=NC=2N1[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@@H]1O GIUYCYHIANZCFB-FJFJXFQQSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0505781.5A GB0505781D0 (en) | 2005-03-21 | 2005-03-21 | Chemical compounds |
| PCT/GB2006/000932 WO2006100439A1 (en) | 2005-03-21 | 2006-03-16 | Phosphoramidate derivatives of nucleoside compounds for use in the treatment of cancer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE471334T1 true ATE471334T1 (de) | 2010-07-15 |
Family
ID=34531603
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06710096T ATE471334T1 (de) | 2005-03-21 | 2006-03-16 | Phosphoramidatderivate von nukleosidverbindungen zur verwendung bei der behandlung von krebs |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US8263575B2 (OSRAM) |
| EP (1) | EP1866324B1 (OSRAM) |
| JP (2) | JP5345381B2 (OSRAM) |
| CN (2) | CN103936807A (OSRAM) |
| AT (1) | ATE471334T1 (OSRAM) |
| AU (1) | AU2006226182C1 (OSRAM) |
| BR (1) | BRPI0609704B8 (OSRAM) |
| CA (1) | CA2602324C (OSRAM) |
| CY (1) | CY1111538T1 (OSRAM) |
| DE (1) | DE602006014949D1 (OSRAM) |
| DK (1) | DK1866324T3 (OSRAM) |
| ES (1) | ES2348741T3 (OSRAM) |
| GB (1) | GB0505781D0 (OSRAM) |
| IL (1) | IL186104A (OSRAM) |
| MX (1) | MX2007011666A (OSRAM) |
| PL (1) | PL1866324T3 (OSRAM) |
| PT (1) | PT1866324E (OSRAM) |
| SI (1) | SI1866324T1 (OSRAM) |
| WO (1) | WO2006100439A1 (OSRAM) |
| ZA (1) | ZA200709011B (OSRAM) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2012216500B2 (en) * | 2006-11-24 | 2013-06-20 | Katholieke Universiteit Leuven | Nucleoside aryl phosphoramidates and their use as anti-viral agents for the treatment of hepatitis C virus |
| GB0623493D0 (en) * | 2006-11-24 | 2007-01-03 | Univ Cardiff | Chemical compounds |
| US8173621B2 (en) | 2008-06-11 | 2012-05-08 | Gilead Pharmasset Llc | Nucleoside cyclicphosphates |
| BRPI0923815A2 (pt) | 2008-12-23 | 2015-07-14 | Pharmasset Inc | Síntese de nucleosídeos de purina |
| CN102695513A (zh) | 2008-12-23 | 2012-09-26 | 吉利德制药有限责任公司 | 核苷氨基磷酸酯 |
| AU2009329917B2 (en) | 2008-12-23 | 2016-03-31 | Gilead Pharmasset Llc | Nucleoside analogs |
| JP2012514657A (ja) | 2009-01-09 | 2012-06-28 | ユニバーシテイ・カレツジ・オブ・カーデイフ・コンサルタンツ・リミテツド | ウィルス感染を治療するためのグアノシンヌクレオシド化合物のホスホルアミダート誘導体 |
| SMT201700412T1 (it) | 2010-03-31 | 2017-11-15 | Gilead Pharmasset Llc | Procedimento per la cristallizzazione di (s)-isopropil 2-(((s)-(perfluorofenossi)(fenossi)fosforil)ammino)propanoato |
| GB201016855D0 (en) * | 2010-10-06 | 2010-11-17 | Nucana Biomed Ltd | Chemical compounds |
| EP2658857B1 (en) | 2010-12-29 | 2016-11-02 | Inhibitex, Inc. | Substituted purine nucleosides, phosphoroamidate and phosphorodiamidate derivatives for treatment of viral infections |
| WO2012094248A1 (en) * | 2011-01-03 | 2012-07-12 | Nanjing Molecular Research, Inc. | O-(substituted benzyl) phosphoramidate compounds and therapeutic use |
| CA2828326C (en) | 2011-03-01 | 2019-05-07 | Nucana Biomed Limited | Phosphoramidate derivatives of 5 - fluoro - 2' - deoxyuridine for use in the treatment of cancer |
| US9085599B2 (en) | 2011-03-16 | 2015-07-21 | Enanta Pharmaceuticals, Inc. | 2′allene-substituted nucleoside derivatives |
| SI3150616T1 (sl) * | 2012-11-16 | 2017-08-31 | University College Cardiff Consultants Limited | Mešanica rp/sp gemcitabin-(fenil-(benziloksi-l-alaninil))-fosfata |
| WO2014197578A1 (en) | 2013-06-05 | 2014-12-11 | Idenix Pharmaceuticals, Inc. | 1',4'-thio nucleosides for the treatment of hcv |
| BR112016011949A8 (pt) * | 2013-11-27 | 2020-04-28 | Idenix Pharmaceuticals Llc | composto, composição farmacêutica, e, uso dos mesmos |
| WO2015181624A2 (en) * | 2014-05-28 | 2015-12-03 | Idenix Pharmaceuticals, Inc | Nucleoside derivatives for the treatment of cancer |
| CN106459127A (zh) * | 2014-05-28 | 2017-02-22 | 艾登尼克斯药业有限公司 | 用于治疗癌症的核苷衍生物 |
| MX394059B (es) | 2014-11-28 | 2025-03-24 | NuCana plc | Nuevos derivados de ester fosforamidato 3'-desoxiadenosina de 2' y/o 5' aminoacido como compuestos anti-cancer |
| HK1247829A1 (zh) | 2015-03-06 | 2018-10-05 | Atea Pharmaceuticals, Inc. | 用於治疗HCV的β-D-2'-脱氧-2'Α-氟-2'-β-C-取代-2-改性N6-取代的嘌呤核苷酸 |
| CN108431016A (zh) | 2015-11-16 | 2018-08-21 | 艾可瑞恩治疗公司 | 核酸前体药物 |
| GB201522764D0 (en) | 2015-12-23 | 2016-02-03 | Nucana Biomed Ltd | Formulations of phosphate derivatives |
| GB201609601D0 (en) * | 2016-06-01 | 2016-07-13 | Nucana Biomed Ltd | Phosphoramidate compounds |
| GB201609602D0 (en) * | 2016-06-01 | 2016-07-13 | Nucuna Biomed Ltd | Chemical compounds |
| GB201609600D0 (en) | 2016-06-01 | 2016-07-13 | Nucuna Biomed Ltd | Cancer treatments |
| LU100724B1 (en) | 2016-07-14 | 2018-07-31 | Atea Pharmaceuticals Inc | Beta-d-2'-deoxy-2'-alpha-fluoro-2'-beta-c-substituted-4'-fluoro-n6-substituted-6-amino-2-substituted purine nucleotides for the treatment of hepatitis c virus infection |
| EP3512863B1 (en) | 2016-09-07 | 2021-12-08 | ATEA Pharmaceuticals, Inc. | 2'-substituted-n6-substituted purine nucleotides for rna virus treatment |
| WO2018071675A1 (en) * | 2016-10-12 | 2018-04-19 | Georgetown University | Cd99 inhibitors and their uses |
| GB201709471D0 (en) | 2017-06-14 | 2017-07-26 | Nucana Biomed Ltd | Diastereoselective synthesis of hosphate derivatives |
| GB201715011D0 (en) | 2017-09-18 | 2017-11-01 | Nucana Biomed Ltd | Floxuridine synthesis |
| GB201720279D0 (en) | 2017-12-05 | 2018-01-17 | Nucana Biomed Ltd | Anticancer compounds |
| JP2020164521A (ja) * | 2019-03-29 | 2020-10-08 | 国立大学法人 長崎大学 | 抗ウィルス薬 |
| GB201904544D0 (en) | 2019-04-01 | 2019-05-15 | NuCana plc | Anticancer compounds |
| US10874687B1 (en) | 2020-02-27 | 2020-12-29 | Atea Pharmaceuticals, Inc. | Highly active compounds against COVID-19 |
| WO2021173713A1 (en) | 2020-02-27 | 2021-09-02 | Atea Pharmaceuticals, Inc. | Highly active compounds against covid-19 |
| CN113549076B (zh) * | 2021-07-23 | 2022-12-06 | 中国药科大学 | 一种多取代嘌呤类化合物及其制备方法和应用 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR880000094B1 (ko) | 1984-12-07 | 1988-02-23 | 보령제약 주식회사 | 뉴클레오시드 유도체의 제조방법 |
| CA2004695C (en) * | 1988-12-12 | 1999-08-10 | Rosanne Bonjouklian | Phospholipid nucleosides |
| DE4418690A1 (de) | 1994-05-28 | 1996-01-11 | Boehringer Mannheim Gmbh | Neue Lipidester von Nucleosid-Monophosphaten und deren Verwendung als immunsuppressive Arzneimittel |
| GB9505025D0 (en) * | 1995-03-13 | 1995-05-03 | Medical Res Council | Chemical compounds |
| ES2256845T3 (es) * | 1995-04-21 | 2006-07-16 | University Of South Florida | Inmunopotencia de derivados de inosina monofosfato resistentes a 5'-nucleotidasa y utilizacion del mismo. |
| JP3761958B2 (ja) * | 1996-03-12 | 2006-03-29 | 彰 松田 | ３′−カルバモイルアルキルヌクレオシド誘導体 |
| CN1192102C (zh) * | 1998-01-23 | 2005-03-09 | 新生物生物公司 | 酶催化的治疗剂 |
| GB9821058D0 (en) * | 1998-09-28 | 1998-11-18 | Univ Cardiff | Chemical compound |
| JP4768909B2 (ja) * | 2000-09-29 | 2011-09-07 | 扶桑薬品工業株式会社 | トポイソメラーゼ阻害剤 |
| US20030073618A1 (en) * | 2001-02-08 | 2003-04-17 | Kozhemyakin Leonid A. | Compounds comprising disulfide-containing peptides and nitrogenous bases, and medical uses thereof |
| DE10108851A1 (de) * | 2001-02-23 | 2002-09-12 | Resprotect Gmbh | Verwendung von 5'-substituierten Nukleosiden und/oder deren Prodrugs zur resistenzfreien Therapie von Infektionskrankheiten |
| BR0210594A (pt) | 2001-06-22 | 2005-11-01 | Pharmasset Ltd | (beta)-d ou (beta)-l-3-halonucleosìdeo |
| GB0317009D0 (en) | 2003-07-21 | 2003-08-27 | Univ Cardiff | Chemical compounds |
| GB0401088D0 (en) * | 2004-01-19 | 2004-02-18 | Univ Cardiff | Phosphoramidate derivatives |
| AU2005267421B2 (en) * | 2004-06-24 | 2010-06-03 | Merck Sharp & Dohme Corp. | Nucleoside aryl phosphoramidates for the treatment of RNA-dependent RNA viral infection |
| JP2009504704A (ja) * | 2005-08-15 | 2009-02-05 | エフ．ホフマン−ラ ロシュ アーゲー | 抗ウイルス４′−置換プロヌクレオチドホスホルアミダート |
-
2005
- 2005-03-21 GB GBGB0505781.5A patent/GB0505781D0/en not_active Ceased
-
2006
- 2006-03-16 PT PT06710096T patent/PT1866324E/pt unknown
- 2006-03-16 CN CN201410186829.5A patent/CN103936807A/zh active Pending
- 2006-03-16 CA CA2602324A patent/CA2602324C/en active Active
- 2006-03-16 ZA ZA200709011A patent/ZA200709011B/xx unknown
- 2006-03-16 EP EP06710096A patent/EP1866324B1/en active Active
- 2006-03-16 PL PL06710096T patent/PL1866324T3/pl unknown
- 2006-03-16 WO PCT/GB2006/000932 patent/WO2006100439A1/en not_active Ceased
- 2006-03-16 MX MX2007011666A patent/MX2007011666A/es active IP Right Grant
- 2006-03-16 JP JP2008502453A patent/JP5345381B2/ja not_active Expired - Fee Related
- 2006-03-16 AU AU2006226182A patent/AU2006226182C1/en not_active Ceased
- 2006-03-16 SI SI200630762T patent/SI1866324T1/sl unknown
- 2006-03-16 CN CNA200680016708XA patent/CN101175763A/zh active Pending
- 2006-03-16 DE DE602006014949T patent/DE602006014949D1/de active Active
- 2006-03-16 AT AT06710096T patent/ATE471334T1/de active
- 2006-03-16 ES ES06710096T patent/ES2348741T3/es active Active
- 2006-03-16 US US11/886,931 patent/US8263575B2/en not_active Expired - Fee Related
- 2006-03-16 BR BRPI0609704A patent/BRPI0609704B8/pt not_active IP Right Cessation
- 2006-03-16 DK DK06710096.6T patent/DK1866324T3/da active
-
2007
- 2007-09-20 IL IL186104A patent/IL186104A/en active IP Right Grant
-
2010
- 2010-09-10 CY CY20101100826T patent/CY1111538T1/el unknown
-
2013
- 2013-05-07 JP JP2013097919A patent/JP5863702B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN101175763A (zh) | 2008-05-07 |
| PL1866324T3 (pl) | 2010-12-31 |
| ZA200709011B (en) | 2009-01-28 |
| EP1866324B1 (en) | 2010-06-16 |
| AU2006226182B2 (en) | 2011-09-01 |
| MX2007011666A (es) | 2007-11-14 |
| CY1111538T1 (el) | 2015-08-05 |
| JP5345381B2 (ja) | 2013-11-20 |
| IL186104A (en) | 2013-06-27 |
| WO2006100439A1 (en) | 2006-09-28 |
| ES2348741T3 (es) | 2010-12-13 |
| EP1866324A1 (en) | 2007-12-19 |
| GB0505781D0 (en) | 2005-04-27 |
| DK1866324T3 (da) | 2010-09-27 |
| US8263575B2 (en) | 2012-09-11 |
| IL186104A0 (en) | 2008-01-20 |
| JP2008533191A (ja) | 2008-08-21 |
| CA2602324C (en) | 2015-02-24 |
| BRPI0609704B1 (pt) | 2020-12-01 |
| AU2006226182A1 (en) | 2006-09-28 |
| DE602006014949D1 (de) | 2010-07-29 |
| CN103936807A (zh) | 2014-07-23 |
| US20090215715A1 (en) | 2009-08-27 |
| JP5863702B2 (ja) | 2016-02-17 |
| BRPI0609704B8 (pt) | 2021-09-28 |
| AU2006226182C1 (en) | 2012-06-14 |
| BRPI0609704A2 (pt) | 2010-04-20 |
| JP2013173786A (ja) | 2013-09-05 |
| PT1866324E (pt) | 2010-09-16 |
| CA2602324A1 (en) | 2006-09-28 |
| SI1866324T1 (sl) | 2010-10-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE471334T1 (de) | Phosphoramidatderivate von nukleosidverbindungen zur verwendung bei der behandlung von krebs | |
| DE602004015811D1 (de) | Verfahren zur inhibierung der proliferation von tumorzellen, bei dem platinkomplexe eingesetzt werden | |
| ECSP088440A (es) | Imidazopirazinas como inhibidores de proteinquinasa | |
| TW200716141A (en) | Compositions and methods for treatment for neoplasms | |
| EA201692543A1 (ru) | Антагонисты активина-actriia и их применение для стимулирования роста кости | |
| CY1109741T1 (el) | Sns-595 και μεθοδοι χρησης αυτου | |
| TR200906131T1 (tr) | Aktivin -actrIIa antagonistleri ve göğüs kanserinin tedavi e | |
| BRPI0513310A (pt) | análogos de tetrapeptìdeo | |
| CY1113963T1 (el) | Φαρμακευτικες συνθεσεις οι οποιες περιλαμβανουν ανταγωνιστες ακτιβινης-actriia και χρηση αυτων στην προληψη η' θεραπευτικη αγωγη πολλαπλου μυελωματος | |
| CY1126007T1 (el) | Προαγωγεις αποπτωσης | |
| TW200801008A (en) | Protein kinase inhibitors | |
| EP4023299C0 (en) | 5-FLUORO-2'-DEOXYURIDINE PHOSPHORAMIDATE DERIVATIVES FOR USE IN THE TREATMENT OF CANCER | |
| ATE554114T1 (de) | Copolymer mit zwitterionischen einheiten und anderen einheiten, das copolymer umfassende zusammensetzung und verwendung | |
| CY1112743T1 (el) | Στερεοϊσομερως εμπλουτισμενες ενωσεις 3-αμινοκαρβονυλ δικυκλοεπτενο πυριμιδινοδιαμινης και οι χρησεις τους | |
| DE602006018709D1 (de) | Estergebundene geminitensidverbindungen zur verwendung in der gentherapie | |
| ATE527241T1 (de) | Pyridiazinonderivate zur behandlung von tumoren | |
| DE502006005290D1 (de) | Niedrigviskose uretdiongruppenhaltige polyadditionsverbindungen, verfahren zur herstellung und verwendung | |
| NO20082425L (no) | Formuleringer omfattende jorumycin-, reni-eramycin-, safracin- eller saframycin-relaterte forbindelser for behandling av proliferative sykdommer | |
| MX2008001538A (es) | Aril piridinas y metodos para su uso. | |
| MX2010005324A (es) | Composiciones y metodos para inhibir el avance del tumor. | |
| EP1863520A4 (en) | USE OF INTERLEUKIN 17E FOR THE TREATMENT OF CANCER | |
| ATE397000T1 (de) | Tetrahydropyridothiophenen zur verwendung in der behandlung von krebs | |
| DE602006017367D1 (de) | Amino-oxo-indolyliden-verbindungen zur verwendung in der behandlung von juckender kopfhaut | |
| DE602006003094D1 (de) | 4-phenyl-5-oxo-1,4,5,6,7,8-hexahydrochinolin-derivate zur behandlung von unfruchtbarkeit | |
| DK1606233T3 (da) | Phospholipidestere af Clofarabin |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1866324 Country of ref document: EP |