ATE455168T1 - Methode zur reinigung von adenoviren - Google Patents

Methode zur reinigung von adenoviren

Info

Publication number
ATE455168T1
ATE455168T1 AT01991967T AT01991967T ATE455168T1 AT E455168 T1 ATE455168 T1 AT E455168T1 AT 01991967 T AT01991967 T AT 01991967T AT 01991967 T AT01991967 T AT 01991967T AT E455168 T1 ATE455168 T1 AT E455168T1
Authority
AT
Austria
Prior art keywords
adenovirus
hydroxyapatite
purifying adenoviruses
adenoviruses
purifying
Prior art date
Application number
AT01991967T
Other languages
English (en)
Inventor
Susan Cannon-Carlson
Collette Cutler
Gary Vellekamp
Marcio Voloch
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Application granted granted Critical
Publication of ATE455168T1 publication Critical patent/ATE455168T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4746—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used p53
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10351—Methods of production or purification of viral material

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Toxicology (AREA)
  • Virology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Filtering Materials (AREA)
  • Saccharide Compounds (AREA)
AT01991967T 2000-11-29 2001-11-28 Methode zur reinigung von adenoviren ATE455168T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25382300P 2000-11-29 2000-11-29
PCT/US2001/044684 WO2002044348A2 (en) 2000-11-29 2001-11-28 Method for purifying adenoviruses

Publications (1)

Publication Number Publication Date
ATE455168T1 true ATE455168T1 (de) 2010-01-15

Family

ID=22961846

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01991967T ATE455168T1 (de) 2000-11-29 2001-11-28 Methode zur reinigung von adenoviren

Country Status (7)

Country Link
US (2) US20020064860A1 (de)
EP (1) EP1337627B1 (de)
AT (1) ATE455168T1 (de)
AU (1) AU2002232443A1 (de)
DE (1) DE60141081D1 (de)
ES (1) ES2337768T3 (de)
WO (1) WO2002044348A2 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2455499C (en) 2001-08-08 2011-06-21 The Trustees Of The University Of Pennsylvania Method for purification of viral vectors having proteins which bind sialic acid
DE602005015332D1 (de) 2004-02-23 2009-08-20 Crucell Holland Bv Verfahren zur Reinigung von Viren
WO2006065827A2 (en) * 2004-12-13 2006-06-22 Canji, Inc. Cell lines for production of replication-defective adenovirus
ES2317517T5 (es) 2005-04-11 2016-01-21 Crucell Holland B.V. Purificación de virus usando ultrafiltración
EP1736538A1 (de) 2005-06-21 2006-12-27 Cytos Biotechnology AG Prozess für die preparative Reinigung von Virus-ähnlichen Partikeln (VLPs)
JP5097714B2 (ja) * 2005-12-12 2012-12-12 カンジ，インコーポレイテッド Ｅ１領域内の発現カセットと不活性化されたｅ２ｂポリメラーゼを有するアデノウイルス発現ベクター
US20080107629A1 (en) * 2006-09-29 2008-05-08 Canji, Inc. Methods and compositions for gene therapy
ES2337973B8 (es) 2008-05-16 2011-07-21 Proyecto De Biomedicina Cima, S.L. Adenovirus auxiliares auto-inactivantes para la produccion de adenovirus recombinantes de alta capacidad.
ES2330826B1 (es) 2008-06-04 2010-07-26 Proyecto De Biomedicina Cima, S.L. Sistema para empaquetamiento de adenovirus de alta capacidad.
DK2350268T3 (en) 2008-11-03 2015-03-23 Crucell Holland Bv PROCEDURE FOR PRODUCING ADENOVIRUS VECTORS
JP2011097918A (ja) * 2009-10-07 2011-05-19 Hoya Corp 精製方法およびワクチンの製造方法
PL2488636T3 (pl) 2009-10-15 2014-07-31 Crucell Holland Bv Sposób oczyszczania cząsteczek adenowirusów z hodowli o wysokim zagęszczeniu komórkowym
JP5465331B2 (ja) 2009-10-15 2014-04-09 クルセル ホランド ベー ヴェー 高細胞密度の培養物からのアデノウイルスの精製方法
EA023816B1 (ru) 2010-02-15 2016-07-29 Круселл Холланд Б.В. СПОСОБ ПРОДУЦИРОВАНИЯ ВИРУСНЫХ ЧАСТИЦ Ad26
AR102198A1 (es) 2014-10-09 2017-02-08 Regeneron Pharma Proceso para reducir partículas subvisibles en una formulación farmacéutica
KR102369014B1 (ko) 2016-08-16 2022-03-02 리제너론 파아마슈티컬스, 인크. 혼합물로부터 개별 항체들을 정량하는 방법
KR20230119729A (ko) 2016-10-25 2023-08-16 리제너론 파아마슈티컬스, 인크. 크로마토그래피 데이터 분석을 위한 방법 및 시스템
BR112020005335A2 (pt) 2017-09-19 2020-09-24 Regeneron Pharmaceuticals, Inc. métodos para reduzir a formação de partículas e composições formadas pelos mesmos
US11884698B2 (en) 2018-07-02 2024-01-30 Regeneron Pharmaceuticals, Inc. Systems and methods for preparing a polypeptide from a mixture
WO2021255835A1 (ja) * 2020-06-16 2021-12-23 ＨＯＹＡ Ｔｅｃｈｎｏｓｕｒｇｉｃａｌ株式会社 アパタイトカラムを使用したウイルスの精製方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2507339B2 (ja) * 1986-08-11 1996-06-12 三井東圧化学株式会社 粗ｔＰＡの精製方法
US5496926A (en) * 1992-01-19 1996-03-05 Yeda Research And Development Co. Ltd. Process of preparing a soluble LDL receptor
JPH07173189A (ja) 1993-12-17 1995-07-11 Masashi Kosakai リガンド存在下で二段階に分けて行うヒドロキシアパタイトクロマトグラフィーの用法
JPH08188599A (ja) 1995-01-09 1996-07-23 Toagosei Co Ltd ＩｇＹ抗体の分離精製方法
US5837520A (en) * 1995-03-07 1998-11-17 Canji, Inc. Method of purification of viral vectors
CA2625279A1 (en) * 1995-08-30 1997-03-06 Genzyme Corporation Chromatographic purification of adenovirus and aav
JPH09169794A (ja) 1995-12-22 1997-06-30 Mitsubishi Materials Corp 蛋白質類の分離方法
EP1760151B1 (de) 1996-11-20 2012-03-21 Crucell Holland B.V. Adenovirus-Zusammensetzungen erhältlich durch ein verbessertes Produktions- und Reinigungsverfahren
US7732129B1 (en) 1998-12-01 2010-06-08 Crucell Holland B.V. Method for the production and purification of adenoviral vectors
US6261823B1 (en) 1996-12-13 2001-07-17 Schering Corporation Methods for purifying viruses
WO1999041416A2 (en) 1998-02-17 1999-08-19 Schering Corporation Compositions comprising viruses and methods for concentrating virus preparations
US6689600B1 (en) 1998-11-16 2004-02-10 Introgen Therapeutics, Inc. Formulation of adenovirus for gene therapy
JP2000262280A (ja) 1999-03-18 2000-09-26 Asahi Optical Co Ltd ウィルスまたはウィルス性抗原の精製方法およびワクチンの製造方法

Also Published As

Publication number Publication date
WO2002044348A3 (en) 2002-11-07
WO2002044348A2 (en) 2002-06-06
EP1337627B1 (de) 2010-01-13
DE60141081D1 (de) 2010-03-04
US20060105456A1 (en) 2006-05-18
US7393631B2 (en) 2008-07-01
EP1337627A2 (de) 2003-08-27
US20020064860A1 (en) 2002-05-30
AU2002232443A1 (en) 2002-06-11
ES2337768T3 (es) 2010-04-29

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