DE68925918D1 - Methode zur Reinigung von Antithrombin-III und Antithrombin-III-Zusammensetzung enthaltend dieses Antithrombin-III - Google Patents

Methode zur Reinigung von Antithrombin-III und Antithrombin-III-Zusammensetzung enthaltend dieses Antithrombin-III

Info

Publication number
DE68925918D1
DE68925918D1 DE68925918T DE68925918T DE68925918D1 DE 68925918 D1 DE68925918 D1 DE 68925918D1 DE 68925918 T DE68925918 T DE 68925918T DE 68925918 T DE68925918 T DE 68925918T DE 68925918 D1 DE68925918 D1 DE 68925918D1
Authority
DE
Germany
Prior art keywords
antithrombin iii
purifying
composition containing
antithrombin
iii
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE68925918T
Other languages
English (en)
Other versions
DE68925918T2 (de
Inventor
Yoshinobu Honda
Yoshio Itagaki
Yasuaki Morisada
Ryouzi Nishii
Isahiko Matsumoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsubishi Tanabe Pharma Corp
Original Assignee
Green Cross Corp Japan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP63105783A external-priority patent/JP2729484B2/ja
Priority claimed from JP63155740A external-priority patent/JP2678249B2/ja
Application filed by Green Cross Corp Japan filed Critical Green Cross Corp Japan
Application granted granted Critical
Publication of DE68925918D1 publication Critical patent/DE68925918D1/de
Publication of DE68925918T2 publication Critical patent/DE68925918T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/20—Partition-, reverse-phase or hydrophobic interaction chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8121—Serpins
    • C07K14/8128—Antithrombin III
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Analytical Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
DE68925918T 1988-04-28 1989-04-25 Methode zur Reinigung von Antithrombin-III und Antithrombin-III-Zusammensetzung enthaltend dieses Antithrombin-III Expired - Fee Related DE68925918T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP63105783A JP2729484B2 (ja) 1988-04-28 1988-04-28 アンチトロンビン−▲ｉｉｉ▼の精製方法
JP63155740A JP2678249B2 (ja) 1988-06-22 1988-06-22 アンチトロンビン−▲ｉｉｉ▼製剤

Publications (2)

Publication Number Publication Date
DE68925918D1 true DE68925918D1 (de) 1996-04-18
DE68925918T2 DE68925918T2 (de) 1996-10-02

Family

ID=26446018

Family Applications (1)

Application Number Title Priority Date Filing Date
DE68925918T Expired - Fee Related DE68925918T2 (de) 1988-04-28 1989-04-25 Methode zur Reinigung von Antithrombin-III und Antithrombin-III-Zusammensetzung enthaltend dieses Antithrombin-III

Country Status (5)

Country Link
EP (2) EP0682949A1 (de)
KR (1) KR0139049B1 (de)
CA (1) CA1341379C (de)
DE (1) DE68925918T2 (de)
ES (1) ES2084599T3 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5319072A (en) * 1992-01-10 1994-06-07 Alpha Therapeutic Corporation Human antithrombin-III preparation
WO1994022471A1 (en) * 1993-04-05 1994-10-13 The Green Cross Corporation Liquid antithrombin iii preparation and method of stabilizing the same
DE19932782A1 (de) * 1999-07-14 2001-01-18 Biotest Pharma Gmbh Verfahren zur chromatographischen Fraktionierung von Plasma oder Serum, so erhaltene Präparate und deren Verwendung
AU2002248384A1 (en) 2001-01-26 2002-08-06 The General Hospital Corporation Serpin drugs for treatment of hiv infection and method of use thereof
US8563693B2 (en) 2001-01-26 2013-10-22 Acceleration Biopharmaceuticals, Inc. Method of treating human immunodeficiency virus infection in a mammal comprising administering heparin-activated antithrombin III
EP1912660A1 (de) * 2005-08-11 2008-04-23 Medigenes Co., Ltd. Pharmazeutische zusammensetzung zur behandlung von nervenschäden mit blutplasma oder serum
US8076462B2 (en) 2007-04-02 2011-12-13 Kyowa Hakko Kirin Co., Ltd Method for producing antithrombin composition
CN104672328B (zh) * 2015-02-13 2019-04-16 山东泰邦生物制品有限公司 一种人抗凝血酶ⅲ的生产方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE392038B (sv) 1971-09-08 1977-03-14 Kabi Ab Forfarande for isolering av antitrombin ur blod eller blodprodukter
JPS597693B2 (ja) 1978-01-07 1984-02-20 株式会社ミドリ十字 抗トロンビン製剤及びその製法
DE2902158A1 (de) * 1979-01-20 1980-07-31 Biotest Serum Institut Gmbh Verfahren zur herstellung von fibrinogen, einem die gerinnungsfaktoren ii, vii, ix und x enthaltenden prothrombinkomplex, antithrombin iii und einer loesung von lagerstabilen serumproteinen
AT379310B (de) * 1983-05-20 1985-12-27 Immuno Ag Verfahren zur herstellung eines antithrombin iii-heparin- bzw. antithrombin iii-heparinoidkonzentrates
CA1286843C (en) * 1985-10-30 1991-07-23 Leo S. Lin Purification method for proteins
US4749783A (en) 1986-07-11 1988-06-07 Miles Laboratories, Inc. Viral inactivation and purification of active proteins

Also Published As

Publication number Publication date
EP0682949A1 (de) 1995-11-22
EP0339919A2 (de) 1989-11-02
EP0339919B1 (de) 1996-03-13
DE68925918T2 (de) 1996-10-02
CA1341379C (en) 2002-07-23
KR900015748A (ko) 1990-11-10
EP0339919A3 (en) 1990-06-27
KR0139049B1 (ko) 1998-04-30
ES2084599T3 (es) 1996-05-16

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee