ATE453636T1 - Substituierte 2,3-dihydro-1h-isoindol-1-one derivate und anwendungsverfahren - Google Patents
Substituierte 2,3-dihydro-1h-isoindol-1-one derivate und anwendungsverfahrenInfo
- Publication number
- ATE453636T1 ATE453636T1 AT04782152T AT04782152T ATE453636T1 AT E453636 T1 ATE453636 T1 AT E453636T1 AT 04782152 T AT04782152 T AT 04782152T AT 04782152 T AT04782152 T AT 04782152T AT E453636 T1 ATE453636 T1 AT E453636T1
- Authority
- AT
- Austria
- Prior art keywords
- methods
- diseases
- isoindol
- dihydro
- derivatives
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- PXZQEOJJUGGUIB-UHFFFAOYSA-N isoindolin-1-one Chemical class C1=CC=C2C(=O)NCC2=C1 PXZQEOJJUGGUIB-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 201000010099 disease Diseases 0.000 abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 3
- 238000011321 prophylaxis Methods 0.000 abstract 2
- 238000011282 treatment Methods 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 230000033115 angiogenesis Effects 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
- C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
- C04B35/00—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
- C04B35/622—Forming processes; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
- C04B35/626—Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B
- C04B35/63—Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B using additives specially adapted for forming the products, e.g.. binder binders
- C04B35/632—Organic additives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Virology (AREA)
- Manufacturing & Machinery (AREA)
- Pulmonology (AREA)
- Ceramic Engineering (AREA)
- Communicable Diseases (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Urology & Nephrology (AREA)
- Ophthalmology & Optometry (AREA)
- Rheumatology (AREA)
- Obesity (AREA)
- Inorganic Chemistry (AREA)
- Molecular Biology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurology (AREA)
- Structural Engineering (AREA)
- Materials Engineering (AREA)
- Tropical Medicine & Parasitology (AREA)
- Endocrinology (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US49787803P | 2003-08-25 | 2003-08-25 | |
| US10/926,238 US7320992B2 (en) | 2003-08-25 | 2004-08-24 | Substituted 2,3-dihydro-1h-isoindol-1-one derivatives and methods of use |
| PCT/US2004/027595 WO2005021532A1 (en) | 2003-08-25 | 2004-08-25 | Substituted 2,3-dihydro-1h-isoindol-1-one derivatives and methods of use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE453636T1 true ATE453636T1 (de) | 2010-01-15 |
Family
ID=34228620
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04782152T ATE453636T1 (de) | 2003-08-25 | 2004-08-25 | Substituierte 2,3-dihydro-1h-isoindol-1-one derivate und anwendungsverfahren |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US7320992B2 (enExample) |
| EP (1) | EP1664027B1 (enExample) |
| JP (1) | JP2007503450A (enExample) |
| AT (1) | ATE453636T1 (enExample) |
| AU (1) | AU2004269000A1 (enExample) |
| CA (1) | CA2534570A1 (enExample) |
| DE (1) | DE602004024900D1 (enExample) |
| ES (1) | ES2337062T3 (enExample) |
| MX (1) | MXPA06001923A (enExample) |
| WO (1) | WO2005021532A1 (enExample) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7745641B2 (en) * | 2005-04-19 | 2010-06-29 | Kyowa Hakko Kirin Co., Ltd. | Nitrogen-containing heterocyclic compound |
| WO2006134989A1 (ja) * | 2005-06-15 | 2006-12-21 | Kyowa Hakko Kogyo Co., Ltd. | 含窒素複素環化合物 |
| BRPI0614995A2 (pt) * | 2005-08-31 | 2010-01-12 | Celgene Corp | composto ou um sal, solvato ou estereoisemero farmaceuticamente aceitável do mesmo, composição farmacêutica, uso de uma quantidade terapêutica ou profilaticamente eficaz de um composto ou um sal, solvato ou estereoisemero farmaceuticamente aceitável do mesmo, e, forma de dosagem unitária única |
| US7989461B2 (en) | 2005-12-23 | 2011-08-02 | Amgen Inc. | Substituted quinazolinamine compounds for the treatment of cancer |
| US8110681B2 (en) * | 2006-03-17 | 2012-02-07 | The United States Of America As Represented By The Secretary, Department Of Health And Human Services | Compounds for the treatment of spinal muscular atrophy and other uses |
| AR060635A1 (es) | 2006-04-27 | 2008-07-02 | Banyu Pharma Co Ltd | Derivados de 1,2-dihidro-3h-pirazolo[3,4-d]pirimidin-3-ona, composiciones farmaceuticas que los comprenden y su uso en el tratamiento del cancer |
| EP2046753A2 (en) * | 2006-07-06 | 2009-04-15 | Brystol-Myers Squibb Company | Pyridone/hydroxypyridine 11-beta hydroxysteroid dehydrogenase type i inhibitors |
| US8268868B2 (en) * | 2007-01-10 | 2012-09-18 | Albany Molecular Research, Inc. | 5-pyridinone substituted indazoles |
| WO2008100715A1 (en) * | 2007-02-09 | 2008-08-21 | Astrazeneca Ab | Aza-isoindolones and their use as metabotropic glutamate receptor potentiators - 613 |
| EP2142534B1 (en) | 2007-03-20 | 2016-08-10 | Celgene Corporation | 4'-o-substituted isoindoline derivatives and compositions comprising and methods of using the same |
| EP2176251B1 (en) * | 2007-07-21 | 2012-02-08 | Albany Molecular Research, Inc. | 5-pyridinone substituted indazoles and pharmaceutical compositions thereof |
| TW200918062A (en) * | 2007-09-12 | 2009-05-01 | Wyeth Corp | Azacyclylisoquinolinone and-isoindolinone derivatives as histamine-3 antagonists |
| CA2700841A1 (en) * | 2007-09-27 | 2009-04-02 | The United States Of America, As Represented By The Secretary, Departmen T Of Health And Human Services | Isoindoline compounds for the treatment of spinal muscular atrophy and other uses |
| EP2213673B1 (en) * | 2007-10-23 | 2013-06-05 | Msd K.K. | Pyridone-substituted-dihydropyrazolopyrimidinone derivative |
| KR101068835B1 (ko) * | 2007-10-26 | 2011-09-30 | 한국과학기술연구원 | 베타-아밀로이드 집적체 및 피브릴에 우수한 결합 친화도를가지는 이소인돌론 화합물 및 이의 제조 방법 |
| JP5632612B2 (ja) * | 2007-12-05 | 2014-11-26 | あすか製薬株式会社 | ラクタム化合物又はその塩及びppar活性化剤 |
| WO2009111644A2 (en) * | 2008-03-05 | 2009-09-11 | The Regents Of The University Of Michigan | Compositions and methods for diagnosing and treating pancreatic cancer |
| UA103323C2 (ru) | 2008-05-08 | 2013-10-10 | Басф Се | Способ получения арилкарбоксамидов |
| GB0811643D0 (en) * | 2008-06-25 | 2008-07-30 | Cancer Rec Tech Ltd | New therapeutic agents |
| JP2012522750A (ja) | 2009-04-01 | 2012-09-27 | ビーエーエスエフ ソシエタス・ヨーロピア | 無脊椎動物害虫を駆除するためのイソキサゾリン化合物 |
| ES2604305T3 (es) * | 2009-07-14 | 2017-03-06 | Nerviano Medical Sciences S.R.L. | 3-oxo-2,3-dihidro-1H-isoindol-4-carboxamida con inhibición selectiva de PARP-1 |
| EA201200471A1 (ru) * | 2009-09-10 | 2012-10-30 | Новартис Аг | Простые эфирные производные бициклических гетероарилов |
| RU2017109664A (ru) * | 2009-10-06 | 2019-01-23 | Милленниум Фармасьютикалз, Инк. | Гетероциклические соединения, используемые в качестве ингибиторов pdk1 |
| US8440710B2 (en) | 2009-10-15 | 2013-05-14 | Hoffmann-La Roche Inc. | HSL inhibitors useful in the treatment of diabetes |
| KR101790255B1 (ko) | 2009-12-23 | 2017-10-26 | 다케다 야쿠힌 고교 가부시키가이샤 | Syk 억제제로서의 융합된 헤테로방향족 피롤리디논 |
| EP2723739B1 (en) | 2011-06-22 | 2016-08-24 | Takeda Pharmaceutical Company Limited | Substituted 6-aza-isoindolin-1-one derivatives |
| US8895571B2 (en) | 2011-10-14 | 2014-11-25 | Incyte Corporation | Isoindolinone and pyrrolopyridinone derivatives as Akt inhibitors |
| JP6211509B2 (ja) | 2012-03-02 | 2017-10-11 | 武田薬品工業株式会社 | 複素環化合物およびその用途 |
| US9777005B2 (en) * | 2012-11-19 | 2017-10-03 | Takeda Pharmaceutical Company Limited | Bicyclic heterocyclic compound containing a substituted pyrrole ring |
| EP2976343A2 (en) * | 2013-03-20 | 2016-01-27 | Bayer Pharma Aktiengesellschaft | Substituted n-biphenyl-3-acetylamino-benzamides and n-[3-(acetylamino)phenyl]-biphenyl-carboxamides and their use as inhibitors of the wnt signalling pathway |
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-
2004
- 2004-08-24 US US10/926,238 patent/US7320992B2/en not_active Expired - Lifetime
- 2004-08-25 AT AT04782152T patent/ATE453636T1/de not_active IP Right Cessation
- 2004-08-25 MX MXPA06001923A patent/MXPA06001923A/es not_active Application Discontinuation
- 2004-08-25 AU AU2004269000A patent/AU2004269000A1/en not_active Abandoned
- 2004-08-25 JP JP2006524818A patent/JP2007503450A/ja not_active Withdrawn
- 2004-08-25 DE DE602004024900T patent/DE602004024900D1/de not_active Expired - Lifetime
- 2004-08-25 ES ES04782152T patent/ES2337062T3/es not_active Expired - Lifetime
- 2004-08-25 CA CA002534570A patent/CA2534570A1/en not_active Abandoned
- 2004-08-25 EP EP04782152A patent/EP1664027B1/en not_active Expired - Lifetime
- 2004-08-25 WO PCT/US2004/027595 patent/WO2005021532A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| JP2007503450A (ja) | 2007-02-22 |
| EP1664027A1 (en) | 2006-06-07 |
| AU2004269000A1 (en) | 2005-03-10 |
| DE602004024900D1 (de) | 2010-02-11 |
| WO2005021532A1 (en) | 2005-03-10 |
| US20050054670A1 (en) | 2005-03-10 |
| US7320992B2 (en) | 2008-01-22 |
| ES2337062T3 (es) | 2010-04-20 |
| EP1664027B1 (en) | 2009-12-30 |
| MXPA06001923A (es) | 2006-05-17 |
| CA2534570A1 (en) | 2005-03-10 |
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| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |