ATE450268T1 - G-csf zur behandlung von amyotropher lateralsklerose - Google Patents

G-csf zur behandlung von amyotropher lateralsklerose

Info

Publication number
ATE450268T1
ATE450268T1 AT03799727T AT03799727T ATE450268T1 AT E450268 T1 ATE450268 T1 AT E450268T1 AT 03799727 T AT03799727 T AT 03799727T AT 03799727 T AT03799727 T AT 03799727T AT E450268 T1 ATE450268 T1 AT E450268T1
Authority
AT
Austria
Prior art keywords
csf
treatment
lateral sclerosis
amyotrophic lateral
gcsf
Prior art date
Application number
AT03799727T
Other languages
German (de)
English (en)
Inventor
Wolf-Ruediger Schaebitz
Armin Schneider
Carola Krueger
Clemens Sommer
Stefan Schwab
Rainer Kollmar
Martin Maurer
Daniela Weber
Nikolaus Gassler
Original Assignee
Sygnis Bioscience Gmbh & Co Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sygnis Bioscience Gmbh & Co Kg filed Critical Sygnis Bioscience Gmbh & Co Kg
Priority claimed from PCT/IB2003/006446 external-priority patent/WO2004058287A2/en
Application granted granted Critical
Publication of ATE450268T1 publication Critical patent/ATE450268T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/193—Colony stimulating factors [CSF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/49—Urokinase; Tissue plasminogen activator
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G01N33/5023—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects on expression patterns
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G01N33/5041—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects involving analysis of members of signalling pathways
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5058—Neurological cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Neurology (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Neurosurgery (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Toxicology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Psychology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Zoology (AREA)
AT03799727T 2002-12-31 2003-12-31 G-csf zur behandlung von amyotropher lateralsklerose ATE450268T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US33175502A 2002-12-31 2002-12-31
US10/659,295 US7785601B2 (en) 2002-12-31 2003-09-11 Methods of treating neurological conditions with hematopoietic growth factors
PCT/IB2003/006446 WO2004058287A2 (en) 2002-12-31 2003-12-31 Methods of treating neurological conditions with hematopoeitic growth factors

Publications (1)

Publication Number Publication Date
ATE450268T1 true ATE450268T1 (de) 2009-12-15

Family

ID=32710846

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03799727T ATE450268T1 (de) 2002-12-31 2003-12-31 G-csf zur behandlung von amyotropher lateralsklerose

Country Status (8)

Country Link
US (8) US7785601B2 (enExample)
EP (2) EP2186525A3 (enExample)
JP (2) JP4733521B2 (enExample)
CN (3) CN101693107A (enExample)
AT (1) ATE450268T1 (enExample)
AU (1) AU2009201467A1 (enExample)
DE (1) DE60330390D1 (enExample)
RU (1) RU2008146718A (enExample)

Families Citing this family (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1019082B2 (en) * 1997-10-02 2008-06-04 Max-Planck-Gesellschaft Zur Förderung Der Wissenschaften E.V. Use of a colony stimulating factor (csf) for enhancing collateral growth of collateral arteries and/or other arteries from preexisting arteriolar connections
JP4783013B2 (ja) * 2002-07-30 2011-09-28 ステム セル セラピューティクス インコーポレイテッド 多能性神経幹細胞からの希突起神経膠細胞産生
US7785601B2 (en) * 2002-12-31 2010-08-31 Sygnis Bioscience Gmbh & Co. Kg Methods of treating neurological conditions with hematopoietic growth factors
KR20060002743A (ko) * 2002-12-31 2006-01-09 악사론 바이오사이언스 아게 조혈성장인자에 의한 신경학적 질환의 치료방법
US7695723B2 (en) * 2002-12-31 2010-04-13 Sygnis Bioscience Gmbh & Co. Kg Methods of treating neurological conditions with hematopoietic growth factors
MXPA05012880A (es) * 2003-06-02 2006-02-22 Evolutec Ltd Inhibidores de complemento.
AU2005306894B2 (en) * 2004-11-05 2011-11-24 Northwestern University Use of SCF and G-CSF in the treatment of cerebral ischemia and neurological disorders
US20060257943A1 (en) * 2005-01-25 2006-11-16 Cis Biotech, Inc. Ischemic biomarkers and their use to predict adverse neurological events from surgery
WO2007019522A2 (en) * 2005-08-04 2007-02-15 Carlos Lopez Reversal of adult onset disorders with granulocyte-colony stimulating factors
US8227572B2 (en) * 2005-08-19 2012-07-24 Commonwealth Scientific And Industrial Research Organisation Arachnocampa luciferases
GB0518443D0 (en) 2005-09-09 2005-10-19 Evolutec Ltd Method of treating myasthenia gravis
US9770485B2 (en) * 2006-02-21 2017-09-26 Academia Sinica Methods for rescuing learning and/or memory deficits caused by alzheimer's disease by G-CSF
US20070196279A1 (en) * 2006-02-21 2007-08-23 Shen Che-Kun J Methods for treating progressive neurodegenerative disorders
WO2007105305A1 (ja) * 2006-03-14 2007-09-20 Japan Tobacco Inc. 新規なβ－ガラクトシド－α２，６－シアル酸転移酵素、それをコードする遺伝子およびその製造方法
JP5153114B2 (ja) * 2006-10-12 2013-02-27 知宏 千葉 新規のアルツハイマー病検出方法
KR100812274B1 (ko) * 2006-10-30 2008-03-13 한양대학교 산학협력단 Ｇ-ｃｓｆ를 유효성분으로 하는 당뇨성 말초신경병 예방 및치료제
CA2669599A1 (en) * 2006-11-17 2008-05-22 Biogen Idec Ma Inc. Systemic administration of colony stimulating factors to treat amyloid associated disorders
WO2008080900A2 (en) * 2006-12-29 2008-07-10 Evonik Degussa Gmbh Methionine synthases with reduced product inhibition
US7618938B2 (en) * 2007-02-07 2009-11-17 Academia Sinica Treating cerebrovascular diseases with erythropoietin and granulocyte-colony stimulating factor jointly
US7723302B2 (en) * 2007-05-01 2010-05-25 Florida Atlantic University Method of treating Parkinson's disease
JP4927774B2 (ja) * 2007-10-12 2012-05-09 サントリーホールディングス株式会社 Ｕｄｐ−グルクロン酸転移酵素およびそれをコードするポリヌクレオチド
WO2009055454A2 (en) * 2007-10-22 2009-04-30 University Of Florida Research Foundation, Inc. Xylan-utilization regulon for efficient bioprocessing of hemicellulose and uses thereof
TW200948964A (en) * 2008-04-17 2009-12-01 Novozymes As Laccase variants
US9132168B2 (en) * 2008-08-05 2015-09-15 University Of South Florida Methods of treating cognitive impairment
KR20110068993A (ko) * 2008-08-05 2011-06-22 유니버시티 오브 사우스 플로리다 인지장애의 치료방법
CA2736230C (en) * 2008-09-04 2021-06-29 Abt Holding Company Use of stem cells to prevent neuronal dieback
WO2010049752A1 (en) 2008-10-31 2010-05-06 Katholieke Universiteit Leuven Optimized methods for differentiation of cells into cells with hepatocyte and hepatocyte progenitor phenotypes, cells produced by the methods, and methods for using the cells
CN102316891A (zh) * 2009-02-17 2012-01-11 森格尼斯生物科学有限两合公司 G-csf用于延长卒中溶栓治疗的治疗时间窗的用途
JP6243119B2 (ja) * 2009-07-21 2017-12-06 エイビーティー ホールディング カンパニー 白血球溢出を低下させる幹細胞の使用
WO2011011477A1 (en) * 2009-07-21 2011-01-27 Abt Holding Company Use of stem cells to reduce leukocyte extravasation
ES2532006T3 (es) 2009-11-20 2015-03-23 Pharnext Nuevas herramientas de diagnóstico para la enfermedad de Charcot-Marie-Tooth
WO2011066187A1 (en) 2009-11-25 2011-06-03 Codexis, Inc. Recombinant thermoascus aurantiacus beta-glucosidase variants for production of fermentable sugars from cellulosic biomass
WO2011083317A1 (en) 2010-01-08 2011-07-14 Varleigh Immuno Pharmaceuticals Limited Ev576 for use in the treatment of viral infections of the respiratory tract
US20160208011A1 (en) 2010-01-28 2016-07-21 The Board Of Trustees Of The Leland Stanford Junior University Ccr3 modulation in the treatment of aging-associated impairments, and compositions for practicing the same
US10626399B2 (en) 2010-01-28 2020-04-21 The Board Of Trustees Of The Leland Stanford Junior University Methods of treating cognitive symptoms of an aging-associated impairment by modulating C-C chemokine receptor type 3 (CCR3)
US10487148B2 (en) 2010-01-28 2019-11-26 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for treating aging-associated impairments
US9795652B2 (en) * 2010-02-25 2017-10-24 University Of South Florida Use of endogenous antioxidant proteins in the treatment of stroke
CN102260343A (zh) 2010-05-25 2011-11-30 健能隆医药技术（上海）有限公司 重组人g-csf二聚体在治疗神经损伤疾病中的用途
US9090878B2 (en) 2010-06-17 2015-07-28 Katholieke Universiteit Leuven Methods for differentiating cells into hepatic stellate cells and hepatic sinusoidal endothelial cells, cells produced by the methods, and methods for using the cells
GB201011589D0 (en) * 2010-07-09 2010-08-25 Reneuron Ltd Therapeutic cells
WO2012083128A2 (en) * 2010-12-16 2012-06-21 The Mclean Hospital Corporation Prevention and treatment of diseases characterized by mesencephalic dopaminergic neuron cell death
US9161968B2 (en) * 2011-04-08 2015-10-20 The Board Of Trustees Of The Leland Stanford Junior University Methods of neuroprotection involving macrophage colony stimulating factor receptor agonists
CN102212542B (zh) * 2011-04-11 2012-12-19 上海赛伦生物技术有限公司 重组马gmcsf的制备方法及相关马gmcsf核苷酸序列
EP3628325A1 (en) * 2011-07-22 2020-04-01 The University of Chicago Treatments for migraine and related disorders
AU2012289433B2 (en) 2011-07-25 2017-07-27 Evive Biotechnology (Shanghai) Ltd Use of G-CSF dimer in preparation of medicament for treatment of neurodegenerative diseases
US9534239B2 (en) * 2011-09-06 2017-01-03 Novozymes A/S Glucoamylase variants and polynucleotides encoding same
WO2013067096A2 (en) * 2011-11-01 2013-05-10 Metselex, Inc. Prevention or attenuation of neuropathic pain and kidney injury by tauroursodeoxycholic acid
US8889630B2 (en) 2011-12-23 2014-11-18 Carlos Lopez Method for hair regrowth using Granulocyte-Colony Stimulating Factor
WO2013149064A1 (en) * 2012-03-30 2013-10-03 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Uridine diphosphate compounds as mobilizers of hematopoietic progenitor cells
CN113559280A (zh) * 2012-07-19 2021-10-29 宾夕法尼亚州研究基金会 再生用于在神经系统中治疗疾病和损伤的功能性神经元
CN103193882B (zh) * 2013-03-29 2014-11-05 浙江大学 胚胎干细胞特异性标志物GM-CSFRα及其应用
RU2665364C2 (ru) 2013-04-12 2018-08-29 Саверио ЛАФРАНЧЕСКА Улучшение органов для трансплантации
JP6667438B2 (ja) 2013-12-09 2020-03-18 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー 老化に関連する状態を処置する方法及び組成物
US10905779B2 (en) 2013-12-09 2021-02-02 The Board Of Trustees Of The Leland Stanford Junior University Methods for screening human blood products comprising plasma using immunocompromised rodent models
WO2015185602A1 (en) * 2014-06-04 2015-12-10 Affiris Ag Treatment and prevention of parkinson's disease (pd)
US10039808B2 (en) * 2014-10-22 2018-08-07 Michael Chez Method of treating or improving neurological function in a human subject
US9925244B1 (en) 2015-02-17 2018-03-27 Michael Chez Treatment of warts in non-immunosuppressed patients
DK3307296T3 (da) 2015-06-15 2021-12-13 Univ Leland Stanford Junior Timp2 til anvendelse til behandling af aldringsassocierede tilstande
US10245285B2 (en) 2016-04-28 2019-04-02 Alkahest, Inc. Blood plasma and plasma fractions as therapy for tumor growth and progression
EA039316B1 (ru) 2016-10-24 2022-01-12 Алкахест, Инк. Фракции плазмы крови в качестве лечения когнитивных расстройств, связанных со старением
ES2971462T3 (es) 2017-04-26 2024-06-05 Alkahest Inc Pauta posológica para el tratamiento de los trastornos cognitivos con productos de plasma sanguíneo
US11040068B2 (en) 2017-04-26 2021-06-22 Alkahest, Inc. Dosing regimen for treatment of cognitive and motor impairments with blood plasma and blood plasma products
CN108404118A (zh) * 2017-06-14 2018-08-17 张建宁 人源乳凝集素亚型蛋白的新用途
US10863912B2 (en) 2017-08-24 2020-12-15 Myneurva Holdings, Inc. System and method for analyzing electroencephalogram signals
CA3077215A1 (en) 2017-10-11 2019-04-18 Elanco Us Inc. Porcine g-csf variants and their uses
EP3762013A4 (en) * 2018-03-05 2022-05-11 The Schepens Eye Research Institute, Inc. THERAPY FOR GLAUCOMA AND OPTICAL NEUROPATHY BY TARGETING COLONY-STIMULATING FACTORS
JP7504090B2 (ja) 2018-10-26 2024-06-21 アルカヘスト，インコーポレイテッド 疼痛、創傷治癒及び術後回復の改善のための血漿及び血漿画分の使用
US20250134959A1 (en) * 2022-02-11 2025-05-01 Partner Therapeutics, Inc. Granulocyte-macrophage colony-stimulating factor-based treatments for neurodegenerative or neurological diseases or disorders
US20240058419A1 (en) * 2022-08-22 2024-02-22 Buddhist Tzu Chi Medical Foundation Method for treating optic neuropathy

Family Cites Families (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4810643A (en) 1985-08-23 1989-03-07 Kirin- Amgen Inc. Production of pluripotent granulocyte colony-stimulating factor
US6004548A (en) 1985-08-23 1999-12-21 Amgen, Inc. Analogs of pluripotent granulocyte colony-stimulating factor
US5641663A (en) 1985-11-06 1997-06-24 Cangene Corporation Expression system for the secretion of bioactive human granulocyte macrophage colony stimulating factor (GM-CSF) and other heterologous proteins from steptomyces
ES2036530T3 (es) * 1986-01-22 1993-06-01 Chugai Seiyaku Kabushiki Kaisha Utilizacion de un factor estimulante de las colonias granulociticas humano para preparar una composicion farmaceutica para el tratamiento de la leucemia mielogena.
DK203187A (da) 1986-04-22 1987-10-23 Immunex Corp Human g-csf proteinekspression
ATE145986T1 (de) 1986-09-30 1996-12-15 Colloidal Dynamics Pty Ltd Bestimmung der teilchengrösse und der elektrischen ladung
NO176799C (no) 1986-12-23 1995-05-31 Kyowa Hakko Kogyo Kk DNA som koder for et polypeptid, rekombinant plasmid som koder for og kan uttrykke et polypeptid og fremgangsmåte for fremstilling av dette polypeptid
US5214132A (en) 1986-12-23 1993-05-25 Kyowa Hakko Kogyo Co., Ltd. Polypeptide derivatives of human granulocyte colony stimulating factor
US4904584A (en) 1987-12-23 1990-02-27 Genetics Institute, Inc. Site-specific homogeneous modification of polypeptides
GB2213821B (en) 1987-12-23 1992-01-02 British Bio Technology Synthetic human granulocyte colony stimulating factor gene
US5599690A (en) * 1988-02-01 1997-02-04 Amgen Inc. Control of norleucine incorporation into recombinant proteins
US5021239A (en) 1988-03-21 1991-06-04 Genetics Institute, Inc. Use of M-CSF to improve lipoprotein cholesterol profiles
CA1340810C (en) 1988-03-31 1999-11-02 Motoo Yamasaki Polypeptide derivatives of human granulocyte colony stimulating factor
EP0344796B1 (en) 1988-06-03 1994-09-21 Chugai Seiyaku Kabushiki Kaisha Crystalline human granulocyte colony stimulating factor and process for preparing the same
US5218092A (en) 1988-09-29 1993-06-08 Kyowa Hakko Kogyo Co., Ltd. Modified granulocyte-colony stimulating factor polypeptide with added carbohydrate chains
US5166322A (en) 1989-04-21 1992-11-24 Genetics Institute Cysteine added variants of interleukin-3 and chemical modifications thereof
US5629283A (en) 1989-08-11 1997-05-13 Amrad Corporation Limited Granulocyte-macrophage colony-stimulating factor receptor and derivatives thereof
EP0439952A3 (en) 1990-01-31 1992-09-09 Sgs-Thomson Microelectronics, Inc. Dual-port cache tag memory
US5492534A (en) 1990-04-02 1996-02-20 Pharmetrix Corporation Controlled release portable pump
GB9107846D0 (en) 1990-04-30 1991-05-29 Ici Plc Polypeptides
DE4014750A1 (de) 1990-05-08 1991-11-14 Boehringer Mannheim Gmbh Muteine des granulozyten-stimulierenden faktors (g-csf)
JP2946231B2 (ja) 1990-05-31 1999-09-06 株式会社栗本鐵工所 超微粉分級機
JPH04198134A (ja) 1990-11-28 1992-07-17 Eisai Co Ltd 老人性痴呆症の治療・予防剤
DE4105480A1 (de) 1991-02-21 1992-08-27 Boehringer Mannheim Gmbh Verbesserte aktivierung von rekombinanten proteinen
JP3537151B2 (ja) 1991-12-26 2004-06-14 中外製薬株式会社 脳機能障害による疾患の予防・治療薬
US5581476A (en) 1993-01-28 1996-12-03 Amgen Inc. Computer-based methods and articles of manufacture for preparing G-CSF analogs
WO1994028919A1 (fr) * 1993-06-08 1994-12-22 Ajinomoto Co., Inc. Accelerateur de la proliferation des cellules hematopietiques
US6465616B1 (en) * 1994-04-08 2002-10-15 Bresagen Limited Interleukin-5 antagonist
US5585245A (en) 1994-04-22 1996-12-17 California Institute Of Technology Ubiquitin-based split protein sensor
US5474552A (en) 1994-06-27 1995-12-12 Cb-Carmel Biotechnology Ltd. Implantable drug delivery pump
DE19518505A1 (de) 1995-05-19 1996-11-21 Max Planck Gesellschaft Verfahren zur Genexpressionsanalyse
US5995860A (en) 1995-07-06 1999-11-30 Thomas Jefferson University Implantable sensor and system for measurement and control of blood constituent levels
US6121246A (en) 1995-10-20 2000-09-19 St. Elizabeth's Medical Center Of Boston, Inc. Method for treating ischemic tissue
CA2213906A1 (en) * 1996-09-23 1998-03-23 Dusica Maysinger Pharmaceutical composition and method for neuron rescue in ischemic stroke
JPH10158188A (ja) * 1996-11-29 1998-06-16 Senju Pharmaceut Co Ltd 角膜治療用組成物
US5895647A (en) * 1996-12-20 1999-04-20 The United States Of America As Represented By The Secretary Of The Navy Use of oral interleukin-6 as therapy for hemorrhagic shock
JP3503418B2 (ja) 1997-05-15 2004-03-08 ミノルタ株式会社 誘導加熱定着装置
US20010049381A1 (en) * 1997-06-04 2001-12-06 Gpl Nil Holdings, Inc., Pyrrolidine derivative hair growth compositions and uses
US6093167A (en) 1997-06-16 2000-07-25 Medtronic, Inc. System for pancreatic stimulation and glucose measurement
EP1019082B2 (en) 1997-10-02 2008-06-04 Max-Planck-Gesellschaft Zur Förderung Der Wissenschaften E.V. Use of a colony stimulating factor (csf) for enhancing collateral growth of collateral arteries and/or other arteries from preexisting arteriolar connections
US6617171B2 (en) * 1998-02-27 2003-09-09 The General Hospital Corporation Methods for diagnosing and treating autoimmune disease
CA2323638A1 (en) 1998-04-03 1999-10-14 Phylos, Inc. Addressable protein arrays
WO1999061446A1 (en) 1998-05-22 1999-12-02 Smithkline Beecham Corporation G-csf mimetics
EP1080093A4 (en) 1998-05-22 2002-10-28 Smithkline Beecham Corp G-CSF mimetics
US6406921B1 (en) 1998-07-14 2002-06-18 Zyomyx, Incorporated Protein arrays for high-throughput screening
DK1098664T3 (da) 1998-07-22 2003-11-17 Osprey Pharmaceuticals Ltd Sammensætninger og deres anvendelser til at behandle sekundær vævsskade og andre inflammatoriske tilstande og forstyrrelser
US6554798B1 (en) 1998-08-18 2003-04-29 Medtronic Minimed, Inc. External infusion device with remote programming, bolus estimator and/or vibration alarm capabilities
US6261250B1 (en) 1998-08-20 2001-07-17 Rle Corporation Method and apparatus for enhancing cardiovascular activity and health through rhythmic limb elevation
US6610540B1 (en) 1998-11-18 2003-08-26 California Institute Of Technology Low oxygen culturing of central nervous system progenitor cells
ATE246202T1 (de) 1999-01-29 2003-08-15 Hoffmann La Roche Gcsf konjugate
JP2004500058A (ja) * 1999-12-03 2004-01-08 ヒューマン　ジノーム　サイエンシーズ，　インコーポレイテッド サイトカインレセプター様ポリヌクレオチド、ポリペプチド、および抗体
DE10033219A1 (de) 2000-07-07 2002-01-24 Univ Heidelberg Neuroprotektive Wirkung von Granulocyten-Colony Stimmulierendem Faktor (G-CSF)
JP2004512832A (ja) * 2000-09-01 2004-04-30 バイオアクタ・リミテッド 抗−血管新生ペプチド
PT1317537E (pt) * 2000-09-08 2007-02-28 Massachusetts Inst Technology Composições e métodos de análogos de g-csf
US8329641B2 (en) 2000-09-13 2012-12-11 Chugai Seiyaku Kabushiki Kaisha Remedies for ischemic disease of the limbs comprising administration of G-CSF
US20020168350A1 (en) * 2000-11-10 2002-11-14 Brazelton Timothy R. Methods for treating disorders of neuronal deficiency with bone marrow-derived cells
JP3607271B2 (ja) 2001-03-12 2005-01-05 株式会社Ｇｂｓ研究所 神経損傷の治療薬
JP3763749B2 (ja) 2001-03-28 2006-04-05 独立行政法人科学技術振興機構 脊髄におけるシナプス形成ニューロンを誘導する中枢神経系前駆細胞
US20020198150A1 (en) * 2001-06-07 2002-12-26 Ayelet Chajut Methods of using colony stimulating factors in the treatment of tissue damage and ischemia
FR2834898B1 (fr) 2002-01-18 2005-06-10 Didier Pourquier Nouvelle application therapeutique du g-csf, du gm-csf et du scf
DE10211063A1 (de) 2002-03-13 2003-10-09 Axaron Bioscience Ag Neue Verfahren zur Detektion und Analyse von Protein-Interaktionen in vivo
WO2003094950A2 (en) 2002-05-10 2003-11-20 Ipf Pharmaceuticals Gmbh A method of inhibiting the emigration of cells from the intravascular compartment into tissues
CA2752140A1 (en) * 2002-05-17 2003-11-27 Celgene Corporation Methods and compositions using 3-(4-amino-1-oxo-1,3-dihydroisoindol-1-yl)-piperidine-2,6-dione for treatment and management of renal cancer
CN1668296A (zh) * 2002-05-17 2005-09-14 细胞基因公司 使用选择性细胞因子抑制性药物用于治疗和控制癌症和其它疾病的方法及组合物
JP4783013B2 (ja) 2002-07-30 2011-09-28 ステム セル セラピューティクス インコーポレイテッド 多能性神経幹細胞からの希突起神経膠細胞産生
US20040186052A1 (en) * 2002-10-24 2004-09-23 Suhasini Iyer Cytomodulating peptides and methods for treating neurological disorders
US7695723B2 (en) * 2002-12-31 2010-04-13 Sygnis Bioscience Gmbh & Co. Kg Methods of treating neurological conditions with hematopoietic growth factors
US7785601B2 (en) 2002-12-31 2010-08-31 Sygnis Bioscience Gmbh & Co. Kg Methods of treating neurological conditions with hematopoietic growth factors
JP4198134B2 (ja) 2005-04-13 2008-12-17 京セラミタ株式会社 給紙装置
EP2036571A1 (de) * 2007-09-13 2009-03-18 Sygnis Bioscience GmbH & Co. KG Verwendung von G-CSF für die Behandlung von Schlaganfall

Also Published As

Publication number Publication date
US20080241097A1 (en) 2008-10-02
EP2186525A2 (en) 2010-05-19
EP2311483A1 (en) 2011-04-20
EP2186525A3 (en) 2011-02-09
US20080279814A1 (en) 2008-11-13
US20040141946A1 (en) 2004-07-22
JP4733521B2 (ja) 2011-07-27
US20080181865A1 (en) 2008-07-31
US20080175894A1 (en) 2008-07-24
US7785601B2 (en) 2010-08-31
AU2009201467A1 (en) 2009-05-14
US20120231065A1 (en) 2012-09-13
US8053407B2 (en) 2011-11-08
CN1756556A (zh) 2006-04-05
CN100558397C (zh) 2009-11-11
JP2006512419A (ja) 2006-04-13
CN101926981A (zh) 2010-12-29
JP2010270158A (ja) 2010-12-02
US8071543B2 (en) 2011-12-06
US7884069B2 (en) 2011-02-08
RU2008146718A (ru) 2010-06-10
CN101693107A (zh) 2010-04-14
US20080171080A1 (en) 2008-07-17
US20090087481A1 (en) 2009-04-02
DE60330390D1 (de) 2010-01-14

Similar Documents

Publication Publication Date Title
ATE450268T1 (de) G-csf zur behandlung von amyotropher lateralsklerose
ATE170082T1 (de) Verfahren zur wachstumshemmung von leukämischen zellen durch her-2-protein-zeilen
DE60329756D1 (de) Mitotische kinesin-hemmer
DE60231439D1 (de) Mitotische kinesinhemmer
DE60234278D1 (de) Mitotische kinesin-hemmer
CY1108927T1 (el) Αναστολεις μιτωτικης κινεσινης
IL250826B (en) Methods for treating bone cancer pain by administering a growth factor antagonist
ATE264869T1 (de) Glucagonähnliche, insulinotrope komplexe, ihre zusammensetzungen und ihr herstellungsverfahren
DE60222302D1 (de) Inhibitoren von mitotischem kinesin
DE60329990D1 (de) Mitotische kinesin-hemmer
ATE192045T1 (de) Verwendung von substituierten adeninderivaten zur behandlung von multiplesklerose
DE68929566D1 (de) Verfahren zur Isolierung und Reinigung von G-CSF
DE69902154D1 (de) Eisen-dextran verbindung zur verwendung als komponente in einer therapeutischen zusammensetzung zur behandlung oder prophylaxe von eisenmangel, sowie verfahren zur herstellung der eisen-dextran verbindung und ihre anwendung zur herstellung einer parenteral anwendbaren therapeutischen zubereitung.
WO2004058287A3 (en) Methods of treating neurological conditions with hematopoeitic growth factors
WO2005065183A3 (en) Mitotic kinesin inhibitors
ATE193323T1 (de) Verwendung einer zellulären zusammensetzung zur behandlung von menschlichen oder tierischen organismen
ATE426605T1 (de) Inhibitoren von mitotischem kinesin
ATE453386T1 (de) Polyamin-verbindungen zur behandlung von chemokin-rezeptor-vermittelten krankheiten
DE50108711D1 (de) Verwendung von substituierten 6-dimethylaminomethyl-1-phenyl-cyclohexanverbindungen zur therapie der harninkontinenz
ATE342372T1 (de) Verfahren zur herstellung von d-pantothensäure und/oder deren salze als zusatz zu tierfuttermitteln
ATE349544T1 (de) Verfahren zur herstellung von d-pantothensäure und/oder deren salze als zusatz zu tierfuttermitteln
DE60303296D1 (de) Verwendung von (3-(2-ethylphenyl)-5-methoxyphenyl)-1h-(1,2,4)-triazol zur behandung von autoimmunkrankheiten
WO2004043353A3 (en) Compositions and methods for treating acute myeloid leukemia
ATE350034T1 (de) Verwendung von epothilone zur behandlung hyperparathyreoidismus
ATE269090T1 (de) Tiermodell zum testen von arzneistoffen zur behandlung von leukämie oder hiv

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties