ATE246202T1 - Gcsf konjugate - Google Patents
Gcsf konjugateInfo
- Publication number
- ATE246202T1 ATE246202T1 AT00904422T AT00904422T ATE246202T1 AT E246202 T1 ATE246202 T1 AT E246202T1 AT 00904422 T AT00904422 T AT 00904422T AT 00904422 T AT00904422 T AT 00904422T AT E246202 T1 ATE246202 T1 AT E246202T1
- Authority
- AT
- Austria
- Prior art keywords
- conjugates
- gcsf
- gcsf conjugates
- mixture
- formula
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/53—Colony-stimulating factor [CSF]
- C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11791799P | 1999-01-29 | 1999-01-29 | |
| PCT/US2000/001264 WO2000044785A1 (en) | 1999-01-29 | 2000-01-19 | Gcsf conjugates |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE246202T1 true ATE246202T1 (de) | 2003-08-15 |
Family
ID=22375505
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00904422T ATE246202T1 (de) | 1999-01-29 | 2000-01-19 | Gcsf konjugate |
Country Status (26)
| Country | Link |
|---|---|
| US (4) | US20030130193A1 (de) |
| EP (1) | EP1157037B1 (de) |
| JP (1) | JP2002540065A (de) |
| KR (1) | KR100689212B1 (de) |
| CN (1) | CN1376164A (de) |
| AT (1) | ATE246202T1 (de) |
| AU (1) | AU2618500A (de) |
| BG (1) | BG65213B1 (de) |
| BR (1) | BR0007781A (de) |
| CA (1) | CA2361766C (de) |
| CZ (1) | CZ300546B6 (de) |
| DE (1) | DE60004172T2 (de) |
| DK (1) | DK1157037T3 (de) |
| EA (2) | EA004685B1 (de) |
| ES (1) | ES2204509T3 (de) |
| HK (1) | HK1049673A1 (de) |
| HU (1) | HU228488B1 (de) |
| IL (1) | IL144361A0 (de) |
| MX (1) | MXPA01007609A (de) |
| NO (1) | NO331787B1 (de) |
| NZ (1) | NZ513113A (de) |
| PT (1) | PT1157037E (de) |
| RS (1) | RS50928B (de) |
| SK (1) | SK286898B6 (de) |
| WO (1) | WO2000044785A1 (de) |
| ZA (1) | ZA200105932B (de) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2618500A (en) * | 1999-01-29 | 2000-08-18 | Amgen, Inc. | Gcsf conjugates |
| US6555660B2 (en) | 2000-01-10 | 2003-04-29 | Maxygen Holdings Ltd. | G-CSF conjugates |
| US6831158B2 (en) | 2000-01-10 | 2004-12-14 | Maxygen Holdings Ltd. | G-CSF conjugates |
| US6646110B2 (en) | 2000-01-10 | 2003-11-11 | Maxygen Holdings Ltd. | G-CSF polypeptides and conjugates |
| DE60137525D1 (de) | 2000-10-16 | 2009-03-12 | Chugai Pharmaceutical Co Ltd | Peg-modifiziertes erythropoietin |
| PT2279753E (pt) * | 2001-10-10 | 2016-01-15 | Novo Nordisk As | Remodelação e glicoconjugação de péptidos |
| US7214660B2 (en) | 2001-10-10 | 2007-05-08 | Neose Technologies, Inc. | Erythropoietin: remodeling and glycoconjugation of erythropoietin |
| EP2305311A3 (de) * | 2001-10-10 | 2011-07-20 | BioGeneriX AG | Glykokonjugation von Peptiden |
| US7173003B2 (en) | 2001-10-10 | 2007-02-06 | Neose Technologies, Inc. | Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF |
| EA200700431A1 (ru) * | 2001-11-20 | 2008-02-28 | Фармация Корпорейшн | Конъюгаты химически модифицированного гормона роста человека |
| CA2492775C (en) * | 2002-07-24 | 2011-06-21 | F. Hoffmann-La Roche Ag | Polyalkylene glycol acid additives |
| US7695723B2 (en) | 2002-12-31 | 2010-04-13 | Sygnis Bioscience Gmbh & Co. Kg | Methods of treating neurological conditions with hematopoietic growth factors |
| US7785601B2 (en) | 2002-12-31 | 2010-08-31 | Sygnis Bioscience Gmbh & Co. Kg | Methods of treating neurological conditions with hematopoietic growth factors |
| CA2522345A1 (en) | 2003-04-09 | 2004-11-18 | Neose Technologies, Inc. | Glycopegylation methods and proteins/peptides produced by the methods |
| WO2005012484A2 (en) | 2003-07-25 | 2005-02-10 | Neose Technologies, Inc. | Antibody-toxin conjugates |
| US20070041937A1 (en) * | 2003-08-22 | 2007-02-22 | The Council Of The Queensland Institute Of Medical Research | G-csf derivative for inducing immunological tolerance |
| US20080305992A1 (en) | 2003-11-24 | 2008-12-11 | Neose Technologies, Inc. | Glycopegylated erythropoietin |
| WO2006050247A2 (en) | 2004-10-29 | 2006-05-11 | Neose Technologies, Inc. | Remodeling and glycopegylation of fibroblast growth factor (fgf) |
| WO2006074467A2 (en) | 2005-01-10 | 2006-07-13 | Neose Technologies, Inc. | Glycopegylated granulocyte colony stimulating factor |
| US20060174362A1 (en) * | 2005-02-01 | 2006-08-03 | Origen Therapeutics, Inc. | Long-term culture of avian primordial germ cells (PGCs) |
| US20070154992A1 (en) | 2005-04-08 | 2007-07-05 | Neose Technologies, Inc. | Compositions and methods for the preparation of protease resistant human growth hormone glycosylation mutants |
| US7381805B2 (en) | 2005-06-01 | 2008-06-03 | Maxygen Holdings, Ltd. | Compositions comprising mixtures of positional PEG isomers of PEGylated G-CSF |
| AU2006259225B2 (en) | 2005-06-16 | 2012-05-31 | Nektar Therapeutics | Conjugates having a degradable linkage and polymeric reagents useful in preparing such conjugates |
| CN101257926A (zh) * | 2005-08-04 | 2008-09-03 | 尼克塔治疗亚拉巴马公司 | G-csf部分与聚合物的轭合物 |
| US20070105755A1 (en) | 2005-10-26 | 2007-05-10 | Neose Technologies, Inc. | One pot desialylation and glycopegylation of therapeutic peptides |
| JP2007112924A (ja) * | 2005-10-21 | 2007-05-10 | National Institute For Materials Science | 高分子架橋剤及びこの架橋剤を用いたリポソーム又は細胞の架橋体 |
| WO2007056191A2 (en) | 2005-11-03 | 2007-05-18 | Neose Technologies, Inc. | Nucleotide sugar purification using membranes |
| CN101002943B (zh) * | 2006-01-17 | 2012-02-01 | 中国科学院过程工程研究所 | 支链peg-gcsf和peg-gmcsf结合物及其制备方法 |
| EP2049144B8 (de) | 2006-07-21 | 2015-02-18 | ratiopharm GmbH | Glycosylierung von peptiden über o-verbundene glycosylierungssequenzen |
| ITMI20061624A1 (it) | 2006-08-11 | 2008-02-12 | Bioker Srl | Mono-coniugati sito-specifici di g-csf |
| EP2054521A4 (de) | 2006-10-03 | 2012-12-19 | Novo Nordisk As | Verfahren zur reinigung von polypeptid-konjugate |
| US20100316631A1 (en) * | 2006-10-19 | 2010-12-16 | The Uab Research Foundation | Water Soluble Curcumin-Based Compounds |
| KR101079993B1 (ko) * | 2006-11-17 | 2011-11-04 | 동아제약주식회사 | 폴리에틸렌글리콜 과립구 콜로니 자극인자 접합체 |
| JP2008125952A (ja) * | 2006-11-24 | 2008-06-05 | National Institute For Materials Science | 複合架橋体 |
| CN101245109B (zh) * | 2007-02-12 | 2011-12-14 | 杭州九源基因工程有限公司 | 一种聚乙二醇单修饰的重组人粒细胞集落刺激因子突变体及其制备方法 |
| CN101796063B (zh) | 2007-04-03 | 2017-03-22 | 拉蒂奥法姆有限责任公司 | 使用糖聚乙二醇化g‑csf的治疗方法 |
| EP2170919B8 (de) | 2007-06-12 | 2016-01-20 | ratiopharm GmbH | Verbessertes verfahren zur herstellung von nukleotidzuckern |
| AR067536A1 (es) | 2007-07-17 | 2009-10-14 | Hoffmann La Roche | Metodo para obtener una eritropoyetina mono-pegilada en una forma sustancialmente homogenea |
| CL2008002053A1 (es) | 2007-07-17 | 2009-05-22 | Hoffmann La Roche | Metodo para la purificacion de una eritropoyetina monopeguilada (epompeg) que consiste en proporcionar una solucion que contiene eritropoyetina mono, poli y no peguilada y hacerla pasar por dos pasos de cromatografia de intercambio cationico y metodo para producir epo mpeg que incluye metodo de purificacion. |
| CN101352573B (zh) * | 2007-07-27 | 2011-02-09 | 杭州九源基因工程有限公司 | 聚乙二醇单修饰的重组人集落细胞刺激因子赖氨酸缺陷体 |
| JP5225393B2 (ja) | 2008-02-18 | 2013-07-03 | ジエンス ヘンルイ メデイシンカンパニー リミテッド | 水溶性高分子修飾ｇ−ｃｓｆ複合体 |
| AU2009219232B2 (en) | 2008-02-27 | 2014-02-27 | Novo Nordisk A/S | Conjugated Factor VIII molecules |
| RU2409669C9 (ru) * | 2008-08-18 | 2012-05-27 | ООО "Саентифик Фьючер Менеджмент" ("Scientific Future Management", "SFM") | Способ иммобилизации биологически активного вещества (бав) на носитель (варианты) и конъюгат бав-носитель, полученный данными способами |
| US20120172299A1 (en) | 2008-09-23 | 2012-07-05 | F. Hoffmann-La Roche Ag | Purification of erythropoietin |
| RU2584572C2 (ru) | 2010-02-11 | 2016-05-20 | Ф.Хоффманн-Ля Рош Аг | Способ получения полипептида, конъюгированного с поли(этиленгликолевым) фрагментом, нуклеиновая кислота и слитый полипептид, предназначенные для применения в способе |
| RU2566267C2 (ru) | 2010-09-14 | 2015-10-20 | Ф. Хоффманн-Ля Рош Аг | Способ очистки пегилированного эритропоэтина |
| US8889630B2 (en) | 2011-12-23 | 2014-11-18 | Carlos Lopez | Method for hair regrowth using Granulocyte-Colony Stimulating Factor |
| MX2018016033A (es) | 2016-07-15 | 2019-05-13 | Hoffmann La Roche | Metodo para purificar eritropoyetina pegilada. |
| EP3694535A4 (de) * | 2017-10-11 | 2021-07-28 | Elanco US Inc. | Varianten des porzinen g-csf und ihre verwendungen |
| US20200323993A1 (en) | 2017-12-29 | 2020-10-15 | Hoffmann-La Roche Inc. | Process for providing pegylated protein composition |
| PL3731872T3 (pl) | 2017-12-29 | 2022-03-21 | F. Hoffmann-La Roche Ag | Sposób dostarczania kompozycji pegylowanego białka |
| JP7227633B2 (ja) | 2017-12-29 | 2023-02-22 | エフ． ホフマン－ラ ロシュ エージー． | Ｐｅｇ化タンパク質組成物を提供するための方法 |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1609546A (en) * | 1925-11-19 | 1926-12-07 | Petroleum Rectifying Co | Process of separating water from emulsions |
| US4179337A (en) * | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| US4002531A (en) * | 1976-01-22 | 1977-01-11 | Pierce Chemical Company | Modifying enzymes with polyethylene glycol and product produced thereby |
| US6936694B1 (en) * | 1982-05-06 | 2005-08-30 | Intermune, Inc. | Manufacture and expression of large structural genes |
| DE3380726D1 (en) * | 1982-06-24 | 1989-11-23 | Japan Chem Res | Long-acting composition |
| US4514497B1 (en) * | 1983-12-30 | 1998-02-24 | Novagene Inc | Modified live pseudorabies viruses |
| JPS61227526A (ja) * | 1984-07-25 | 1986-10-09 | Chugai Pharmaceut Co Ltd | 新規なコロニー刺激因子 |
| US5532341A (en) * | 1985-03-28 | 1996-07-02 | Sloan-Kettering Institute For Cancer Research | Human pluripotent hematopoietic colony stimulating factor |
| US4766106A (en) * | 1985-06-26 | 1988-08-23 | Cetus Corporation | Solubilization of proteins for pharmaceutical compositions using polymer conjugation |
| US4810643A (en) * | 1985-08-23 | 1989-03-07 | Kirin- Amgen Inc. | Production of pluripotent granulocyte colony-stimulating factor |
| US4791192A (en) * | 1986-06-26 | 1988-12-13 | Takeda Chemical Industries, Ltd. | Chemically modified protein with polyethyleneglycol |
| US4894226A (en) * | 1986-11-14 | 1990-01-16 | Cetus Corporation | Solubilization of proteins for pharmaceutical compositions using polyproline conjugation |
| US5214132A (en) * | 1986-12-23 | 1993-05-25 | Kyowa Hakko Kogyo Co., Ltd. | Polypeptide derivatives of human granulocyte colony stimulating factor |
| US5194592A (en) * | 1986-12-23 | 1993-03-16 | Kyowa Hakko Kogyo Co. Ltd. | Monoclonal antibodies to novel polypeptide derivatives of human granulocyte colony stimulating factor |
| US5362853A (en) * | 1986-12-23 | 1994-11-08 | Kyowa Hakko Kogyo Co., Ltd. | Polypeptide derivatives of human granulocyte colony stimulating factor |
| US4904584A (en) * | 1987-12-23 | 1990-02-27 | Genetics Institute, Inc. | Site-specific homogeneous modification of polypeptides |
| US4847325A (en) * | 1988-01-20 | 1989-07-11 | Cetus Corporation | Conjugation of polymer to colony stimulating factor-1 |
| CA1340810C (en) * | 1988-03-31 | 1999-11-02 | Motoo Yamasaki | Polypeptide derivatives of human granulocyte colony stimulating factor |
| US5218092A (en) * | 1988-09-29 | 1993-06-08 | Kyowa Hakko Kogyo Co., Ltd. | Modified granulocyte-colony stimulating factor polypeptide with added carbohydrate chains |
| US5349052A (en) * | 1988-10-20 | 1994-09-20 | Royal Free Hospital School Of Medicine | Process for fractionating polyethylene glycol (PEG)-protein adducts and an adduct for PEG and granulocyte-macrophage colony stimulating factor |
| US6166183A (en) * | 1992-11-30 | 2000-12-26 | Kirin-Amgen, Inc. | Chemically-modified G-CSF |
| CA2006596C (en) * | 1988-12-22 | 2000-09-05 | Rika Ishikawa | Chemically-modified g-csf |
| US5166322A (en) * | 1989-04-21 | 1992-11-24 | Genetics Institute | Cysteine added variants of interleukin-3 and chemical modifications thereof |
| US5372808A (en) * | 1990-10-17 | 1994-12-13 | Amgen Inc. | Methods and compositions for the treatment of diseases with consensus interferon while reducing side effect |
| US5252714A (en) * | 1990-11-28 | 1993-10-12 | The University Of Alabama In Huntsville | Preparation and use of polyethylene glycol propionaldehyde |
| US5281698A (en) * | 1991-07-23 | 1994-01-25 | Cetus Oncology Corporation | Preparation of an activated polymer ester for protein conjugation |
| US5382657A (en) * | 1992-08-26 | 1995-01-17 | Hoffmann-La Roche Inc. | Peg-interferon conjugates |
| US5581476A (en) * | 1993-01-28 | 1996-12-03 | Amgen Inc. | Computer-based methods and articles of manufacture for preparing G-CSF analogs |
| US5824784A (en) * | 1994-10-12 | 1998-10-20 | Amgen Inc. | N-terminally chemically modified protein compositions and methods |
| JP3708151B2 (ja) * | 1994-12-15 | 2005-10-19 | 協和醗酵工業株式会社 | Ｐｅｇ化したヒト顆粒球コロニー刺激因子の定量法 |
| US5672662A (en) * | 1995-07-07 | 1997-09-30 | Shearwater Polymers, Inc. | Poly(ethylene glycol) and related polymers monosubstituted with propionic or butanoic acids and functional derivatives thereof for biotechnical applications |
| KR0176625B1 (ko) * | 1996-11-05 | 1999-04-01 | 삼성전자주식회사 | 적외선 물체검출장치 |
| AU2618500A (en) * | 1999-01-29 | 2000-08-18 | Amgen, Inc. | Gcsf conjugates |
-
2000
- 2000-01-19 AU AU26185/00A patent/AU2618500A/en not_active Abandoned
- 2000-01-19 EP EP00904422A patent/EP1157037B1/de not_active Expired - Lifetime
- 2000-01-19 NZ NZ513113A patent/NZ513113A/xx not_active IP Right Cessation
- 2000-01-19 PT PT00904422T patent/PT1157037E/pt unknown
- 2000-01-19 DK DK00904422T patent/DK1157037T3/da active
- 2000-01-19 RS YUP-543/01A patent/RS50928B/sr unknown
- 2000-01-19 SK SK1035-2001A patent/SK286898B6/sk not_active IP Right Cessation
- 2000-01-19 WO PCT/US2000/001264 patent/WO2000044785A1/en active IP Right Grant
- 2000-01-19 CA CA2361766A patent/CA2361766C/en not_active Expired - Lifetime
- 2000-01-19 HU HU0203652A patent/HU228488B1/hu unknown
- 2000-01-19 CZ CZ20012654A patent/CZ300546B6/cs not_active IP Right Cessation
- 2000-01-19 EA EA200100838A patent/EA004685B1/ru not_active IP Right Cessation
- 2000-01-19 MX MXPA01007609A patent/MXPA01007609A/es active IP Right Grant
- 2000-01-19 KR KR1020017009533A patent/KR100689212B1/ko active IP Right Grant
- 2000-01-19 EA EA200400067A patent/EA200400067A1/ru unknown
- 2000-01-19 JP JP2000596041A patent/JP2002540065A/ja active Pending
- 2000-01-19 AT AT00904422T patent/ATE246202T1/de active
- 2000-01-19 ES ES00904422T patent/ES2204509T3/es not_active Expired - Lifetime
- 2000-01-19 CN CN00809241A patent/CN1376164A/zh active Pending
- 2000-01-19 IL IL14436100A patent/IL144361A0/xx not_active IP Right Cessation
- 2000-01-19 DE DE60004172T patent/DE60004172T2/de not_active Expired - Lifetime
- 2000-01-19 BR BR0007781-0A patent/BR0007781A/pt not_active Application Discontinuation
-
2001
- 2001-07-18 ZA ZA200105932A patent/ZA200105932B/en unknown
- 2001-07-27 NO NO20013700A patent/NO331787B1/no not_active IP Right Cessation
- 2001-08-29 BG BG105851A patent/BG65213B1/bg unknown
-
2002
- 2002-12-30 US US10/331,434 patent/US20030130193A1/en not_active Abandoned
-
2003
- 2003-03-13 HK HK03101820.1A patent/HK1049673A1/zh unknown
-
2005
- 2005-04-26 US US11/114,576 patent/US20050196378A1/en not_active Abandoned
-
2007
- 2007-03-12 US US11/717,536 patent/US20070219356A1/en not_active Abandoned
-
2008
- 2008-06-27 US US12/163,283 patent/US20080287659A1/en not_active Abandoned
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| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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