YU54301A - Konjugati gcsf - Google Patents
Konjugati gcsfInfo
- Publication number
- YU54301A YU54301A YU54301A YUP54301A YU54301A YU 54301 A YU54301 A YU 54301A YU 54301 A YU54301 A YU 54301A YU P54301 A YUP54301 A YU P54301A YU 54301 A YU54301 A YU 54301A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- conjugates
- gcsf conjugates
- gcsf
- conjugate
- mixture
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/53—Colony-stimulating factor [CSF]
- C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Steroid Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Polyethers (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Opisani su fiziološki aktivni konjugati PEG-GCSF koji imaju formulu (I), kao i jedinjenja koja sadrže smešu svakog od konjugata u kojim m i n mogu biti različiti integrali za konjugate u jedinjenju.[Physiologically active PEG-GCSF conjugates having formula (I) are described, as well as compositions containing a mixture of each conjugate in which m and n can be different integers for the conjugates in the composition.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11791799P | 1999-01-29 | 1999-01-29 |
Publications (2)
Publication Number | Publication Date |
---|---|
YU54301A true YU54301A (sh) | 2003-10-31 |
RS50928B RS50928B (sr) | 2010-08-31 |
Family
ID=22375505
Country Status (26)
Country | Link |
---|---|
US (4) | US20030130193A1 (sh) |
EP (1) | EP1157037B1 (sh) |
JP (1) | JP2002540065A (sh) |
KR (1) | KR100689212B1 (sh) |
CN (1) | CN1376164A (sh) |
AT (1) | ATE246202T1 (sh) |
AU (1) | AU2618500A (sh) |
BG (1) | BG65213B1 (sh) |
BR (1) | BR0007781A (sh) |
CA (1) | CA2361766C (sh) |
CZ (1) | CZ300546B6 (sh) |
DE (1) | DE60004172T2 (sh) |
DK (1) | DK1157037T3 (sh) |
EA (2) | EA200400067A1 (sh) |
ES (1) | ES2204509T3 (sh) |
HK (1) | HK1049673A1 (sh) |
HU (1) | HU228488B1 (sh) |
IL (1) | IL144361A0 (sh) |
MX (1) | MXPA01007609A (sh) |
NO (1) | NO331787B1 (sh) |
NZ (1) | NZ513113A (sh) |
PT (1) | PT1157037E (sh) |
RS (1) | RS50928B (sh) |
SK (1) | SK286898B6 (sh) |
WO (1) | WO2000044785A1 (sh) |
ZA (1) | ZA200105932B (sh) |
Families Citing this family (53)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HU228488B1 (en) * | 1999-01-29 | 2013-03-28 | Amgen Inc | Gcsf conjugates |
US6831158B2 (en) | 2000-01-10 | 2004-12-14 | Maxygen Holdings Ltd. | G-CSF conjugates |
US6646110B2 (en) | 2000-01-10 | 2003-11-11 | Maxygen Holdings Ltd. | G-CSF polypeptides and conjugates |
US6555660B2 (en) | 2000-01-10 | 2003-04-29 | Maxygen Holdings Ltd. | G-CSF conjugates |
JP5170931B2 (ja) | 2000-10-16 | 2013-03-27 | 中外製薬株式会社 | Peg修飾エリスロポエチン |
US7173003B2 (en) | 2001-10-10 | 2007-02-06 | Neose Technologies, Inc. | Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF |
CN102180944A (zh) * | 2001-10-10 | 2011-09-14 | 诺和诺德公司 | 肽的重构和糖缀合 |
ZA200700168B (en) * | 2001-10-10 | 2010-02-24 | Novo Nordisk As | Remodeling and glycoconjugation of peptides |
US7214660B2 (en) | 2001-10-10 | 2007-05-08 | Neose Technologies, Inc. | Erythropoietin: remodeling and glycoconjugation of erythropoietin |
AU2004236174B2 (en) | 2001-10-10 | 2011-06-02 | Novo Nordisk A/S | Glycopegylation methods and proteins/peptides produced by the methods |
EA008505B1 (ru) * | 2001-11-20 | 2007-06-29 | Фармация Корпорейшн | Конъюгаты химически модифицированного гормона роста человека |
PL375265A1 (en) * | 2002-07-24 | 2005-11-28 | F.Hoffmann-La Roche Ag | Polyalkylene glycol acid additives |
US7785601B2 (en) | 2002-12-31 | 2010-08-31 | Sygnis Bioscience Gmbh & Co. Kg | Methods of treating neurological conditions with hematopoietic growth factors |
US7695723B2 (en) | 2002-12-31 | 2010-04-13 | Sygnis Bioscience Gmbh & Co. Kg | Methods of treating neurological conditions with hematopoietic growth factors |
US9005625B2 (en) | 2003-07-25 | 2015-04-14 | Novo Nordisk A/S | Antibody toxin conjugates |
WO2005018663A1 (en) * | 2003-08-22 | 2005-03-03 | The Council Of The Queensland Institute Of Medical Research | G-csf derivative for inducing immunological tolerance |
US20080305992A1 (en) | 2003-11-24 | 2008-12-11 | Neose Technologies, Inc. | Glycopegylated erythropoietin |
DK2586456T3 (en) | 2004-10-29 | 2016-03-21 | Ratiopharm Gmbh | Conversion and glycopegylation of fibroblast growth factor (FGF) |
EP1858543B1 (en) | 2005-01-10 | 2013-11-27 | BioGeneriX AG | Glycopegylated granulocyte colony stimulating factor |
US20060174362A1 (en) * | 2005-02-01 | 2006-08-03 | Origen Therapeutics, Inc. | Long-term culture of avian primordial germ cells (PGCs) |
EP2386571B1 (en) | 2005-04-08 | 2016-06-01 | ratiopharm GmbH | Compositions and methods for the preparation of protease resistant human growth hormone glycosylation mutants |
CN101193658B (zh) | 2005-06-01 | 2011-08-31 | 马克西根控股公司 | 聚乙二醇化g-csf多肽及其产生方法 |
AU2006259225B2 (en) | 2005-06-16 | 2012-05-31 | Nektar Therapeutics | Conjugates having a degradable linkage and polymeric reagents useful in preparing such conjugates |
WO2007019331A2 (en) * | 2005-08-04 | 2007-02-15 | Nektar Therapeutics Al, Corporation | Conjugates of a g-csf moiety and a polymer |
US20070105755A1 (en) | 2005-10-26 | 2007-05-10 | Neose Technologies, Inc. | One pot desialylation and glycopegylation of therapeutic peptides |
JP2007112924A (ja) * | 2005-10-21 | 2007-05-10 | National Institute For Materials Science | 高分子架橋剤及びこの架橋剤を用いたリポソーム又は細胞の架橋体 |
US20090048440A1 (en) | 2005-11-03 | 2009-02-19 | Neose Technologies, Inc. | Nucleotide Sugar Purification Using Membranes |
CN101002943B (zh) * | 2006-01-17 | 2012-02-01 | 中国科学院过程工程研究所 | 支链peg-gcsf和peg-gmcsf结合物及其制备方法 |
EP2049144B8 (en) | 2006-07-21 | 2015-02-18 | ratiopharm GmbH | Glycosylation of peptides via o-linked glycosylation sequences |
ITMI20061624A1 (it) | 2006-08-11 | 2008-02-12 | Bioker Srl | Mono-coniugati sito-specifici di g-csf |
US20100075375A1 (en) | 2006-10-03 | 2010-03-25 | Novo Nordisk A/S | Methods for the purification of polypeptide conjugates |
US20100316631A1 (en) * | 2006-10-19 | 2010-12-16 | The Uab Research Foundation | Water Soluble Curcumin-Based Compounds |
KR101079993B1 (ko) * | 2006-11-17 | 2011-11-04 | 동아제약주식회사 | 폴리에틸렌글리콜 과립구 콜로니 자극인자 접합체 |
JP2008125952A (ja) * | 2006-11-24 | 2008-06-05 | National Institute For Materials Science | 複合架橋体 |
CN101245109B (zh) * | 2007-02-12 | 2011-12-14 | 杭州九源基因工程有限公司 | 一种聚乙二醇单修饰的重组人粒细胞集落刺激因子突变体及其制备方法 |
CN101796063B (zh) | 2007-04-03 | 2017-03-22 | 拉蒂奥法姆有限责任公司 | 使用糖聚乙二醇化g‑csf的治疗方法 |
ES2551123T3 (es) | 2007-06-12 | 2015-11-16 | Ratiopharm Gmbh | Proceso mejorado para la producción de azúcares de nucleótido |
CL2008002054A1 (es) | 2007-07-17 | 2009-05-29 | Hoffmann La Roche | Metodo para la regeneracion de una columna de cromatografia de intercambio cationico despues de la elusion de eritropoyetina monopeguilada y metodo para obtener una eritropoyetina monopeguilada, incorporando el metodo de regeneracion de la columna de intercambio cationico. |
AR067537A1 (es) | 2007-07-17 | 2009-10-14 | Hoffmann La Roche | Purificacion de polipeptidos pegilados |
CN101352573B (zh) * | 2007-07-27 | 2011-02-09 | 杭州九源基因工程有限公司 | 聚乙二醇单修饰的重组人集落细胞刺激因子赖氨酸缺陷体 |
ES2523030T3 (es) | 2008-02-18 | 2014-11-20 | Jiangsu Hengrui Medicine Co., Ltd. | Un conjugado del G-CSF modificado por un polímero hidrosoluble |
MX2010009154A (es) | 2008-02-27 | 2010-09-09 | Novo Nordisk As | Moleculas conjugadas del factor viii. |
RU2409669C9 (ru) | 2008-08-18 | 2012-05-27 | ООО "Саентифик Фьючер Менеджмент" ("Scientific Future Management", "SFM") | Способ иммобилизации биологически активного вещества (бав) на носитель (варианты) и конъюгат бав-носитель, полученный данными способами |
EP2334699B1 (en) | 2008-09-23 | 2013-09-11 | F. Hoffmann-La Roche AG | Purification of erythropoietin |
BR112012019992A2 (pt) | 2010-02-11 | 2020-08-18 | F. Hoffmann-La Roche Ag. | conjugados de igf-i poli (etileno glicol) |
CA2808748C (en) | 2010-09-14 | 2018-09-11 | Roberto Falkenstein | Method for purifying pegylated erythropoietin |
US8889630B2 (en) | 2011-12-23 | 2014-11-18 | Carlos Lopez | Method for hair regrowth using Granulocyte-Colony Stimulating Factor |
PL3484911T3 (pl) | 2016-07-15 | 2021-03-08 | F. Hoffmann-La Roche Ag | Sposób oczyszczania PEGylowanej erytropoetyny |
CA3077215A1 (en) * | 2017-10-11 | 2019-04-18 | Elanco Us Inc. | Porcine g-csf variants and their uses |
EP3731873B1 (en) | 2017-12-29 | 2022-01-26 | F. Hoffmann-La Roche AG | Process for providing pegylated protein composition |
EP3731871B1 (en) | 2017-12-29 | 2023-10-04 | F. Hoffmann-La Roche AG | Process for providing pegylated protein composition |
EP3731872B1 (en) | 2017-12-29 | 2021-11-24 | F. Hoffmann-La Roche AG | Process for providing pegylated protein composition |
EP4267592A1 (en) * | 2020-12-23 | 2023-11-01 | Jazz Pharmaceuticals Ireland Ltd. | Methods of purifying charge-shielded fusion proteins |
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US4514497B1 (en) * | 1983-12-30 | 1998-02-24 | Novagene Inc | Modified live pseudorabies viruses |
JPS61227526A (ja) * | 1984-07-25 | 1986-10-09 | Chugai Pharmaceut Co Ltd | 新規なコロニー刺激因子 |
US5532341A (en) * | 1985-03-28 | 1996-07-02 | Sloan-Kettering Institute For Cancer Research | Human pluripotent hematopoietic colony stimulating factor |
US4766106A (en) * | 1985-06-26 | 1988-08-23 | Cetus Corporation | Solubilization of proteins for pharmaceutical compositions using polymer conjugation |
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US4894226A (en) * | 1986-11-14 | 1990-01-16 | Cetus Corporation | Solubilization of proteins for pharmaceutical compositions using polyproline conjugation |
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US5218092A (en) * | 1988-09-29 | 1993-06-08 | Kyowa Hakko Kogyo Co., Ltd. | Modified granulocyte-colony stimulating factor polypeptide with added carbohydrate chains |
US5349052A (en) * | 1988-10-20 | 1994-09-20 | Royal Free Hospital School Of Medicine | Process for fractionating polyethylene glycol (PEG)-protein adducts and an adduct for PEG and granulocyte-macrophage colony stimulating factor |
ATE135370T1 (de) * | 1988-12-22 | 1996-03-15 | Kirin Amgen Inc | Chemisch modifizierte granulocytenkolonie erregender faktor |
US6166183A (en) * | 1992-11-30 | 2000-12-26 | Kirin-Amgen, Inc. | Chemically-modified G-CSF |
US5166322A (en) * | 1989-04-21 | 1992-11-24 | Genetics Institute | Cysteine added variants of interleukin-3 and chemical modifications thereof |
US5372808A (en) * | 1990-10-17 | 1994-12-13 | Amgen Inc. | Methods and compositions for the treatment of diseases with consensus interferon while reducing side effect |
US5252714A (en) * | 1990-11-28 | 1993-10-12 | The University Of Alabama In Huntsville | Preparation and use of polyethylene glycol propionaldehyde |
US5281698A (en) * | 1991-07-23 | 1994-01-25 | Cetus Oncology Corporation | Preparation of an activated polymer ester for protein conjugation |
US5382657A (en) * | 1992-08-26 | 1995-01-17 | Hoffmann-La Roche Inc. | Peg-interferon conjugates |
US5581476A (en) * | 1993-01-28 | 1996-12-03 | Amgen Inc. | Computer-based methods and articles of manufacture for preparing G-CSF analogs |
US5824784A (en) * | 1994-10-12 | 1998-10-20 | Amgen Inc. | N-terminally chemically modified protein compositions and methods |
JP3708151B2 (ja) * | 1994-12-15 | 2005-10-19 | 協和醗酵工業株式会社 | Peg化したヒト顆粒球コロニー刺激因子の定量法 |
US5672662A (en) * | 1995-07-07 | 1997-09-30 | Shearwater Polymers, Inc. | Poly(ethylene glycol) and related polymers monosubstituted with propionic or butanoic acids and functional derivatives thereof for biotechnical applications |
KR0176625B1 (ko) * | 1996-11-05 | 1999-04-01 | 삼성전자주식회사 | 적외선 물체검출장치 |
HU228488B1 (en) * | 1999-01-29 | 2013-03-28 | Amgen Inc | Gcsf conjugates |
-
2000
- 2000-01-19 HU HU0203652A patent/HU228488B1/hu unknown
- 2000-01-19 SK SK1035-2001A patent/SK286898B6/sk not_active IP Right Cessation
- 2000-01-19 PT PT00904422T patent/PT1157037E/pt unknown
- 2000-01-19 CN CN00809241A patent/CN1376164A/zh active Pending
- 2000-01-19 MX MXPA01007609A patent/MXPA01007609A/es active IP Right Grant
- 2000-01-19 RS YUP-543/01A patent/RS50928B/sr unknown
- 2000-01-19 CA CA2361766A patent/CA2361766C/en not_active Expired - Lifetime
- 2000-01-19 DE DE60004172T patent/DE60004172T2/de not_active Expired - Lifetime
- 2000-01-19 EP EP00904422A patent/EP1157037B1/en not_active Expired - Lifetime
- 2000-01-19 KR KR1020017009533A patent/KR100689212B1/ko active IP Right Grant
- 2000-01-19 EA EA200400067A patent/EA200400067A1/ru unknown
- 2000-01-19 ES ES00904422T patent/ES2204509T3/es not_active Expired - Lifetime
- 2000-01-19 WO PCT/US2000/001264 patent/WO2000044785A1/en active IP Right Grant
- 2000-01-19 DK DK00904422T patent/DK1157037T3/da active
- 2000-01-19 JP JP2000596041A patent/JP2002540065A/ja active Pending
- 2000-01-19 CZ CZ20012654A patent/CZ300546B6/cs not_active IP Right Cessation
- 2000-01-19 AU AU26185/00A patent/AU2618500A/en not_active Abandoned
- 2000-01-19 NZ NZ513113A patent/NZ513113A/xx not_active IP Right Cessation
- 2000-01-19 IL IL14436100A patent/IL144361A0/xx not_active IP Right Cessation
- 2000-01-19 AT AT00904422T patent/ATE246202T1/de active
- 2000-01-19 EA EA200100838A patent/EA004685B1/ru not_active IP Right Cessation
- 2000-01-19 BR BR0007781-0A patent/BR0007781A/pt not_active Application Discontinuation
-
2001
- 2001-07-18 ZA ZA200105932A patent/ZA200105932B/en unknown
- 2001-07-27 NO NO20013700A patent/NO331787B1/no not_active IP Right Cessation
- 2001-08-29 BG BG105851A patent/BG65213B1/bg unknown
-
2002
- 2002-12-30 US US10/331,434 patent/US20030130193A1/en not_active Abandoned
-
2003
- 2003-03-13 HK HK03101820.1A patent/HK1049673A1/zh unknown
-
2005
- 2005-04-26 US US11/114,576 patent/US20050196378A1/en not_active Abandoned
-
2007
- 2007-03-12 US US11/717,536 patent/US20070219356A1/en not_active Abandoned
-
2008
- 2008-06-27 US US12/163,283 patent/US20080287659A1/en not_active Abandoned
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