ATE440817T1 - Bicalutamidkristalle und verfahren zu deren herstellung - Google Patents

Bicalutamidkristalle und verfahren zu deren herstellung

Info

Publication number
ATE440817T1
ATE440817T1 AT02788815T AT02788815T ATE440817T1 AT E440817 T1 ATE440817 T1 AT E440817T1 AT 02788815 T AT02788815 T AT 02788815T AT 02788815 T AT02788815 T AT 02788815T AT E440817 T1 ATE440817 T1 AT E440817T1
Authority
AT
Austria
Prior art keywords
bicalutamide
crystal
production
chem
formula
Prior art date
Application number
AT02788815T
Other languages
English (en)
Inventor
Tetsuya Shintaku
Tadashi Katsura
Nobushige Itaya
Original Assignee
Sumitomo Chemical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sumitomo Chemical Co filed Critical Sumitomo Chemical Co
Application granted granted Critical
Publication of ATE440817T1 publication Critical patent/ATE440817T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C315/00—Preparation of sulfones; Preparation of sulfoxides
    • C07C315/02—Preparation of sulfones; Preparation of sulfoxides by formation of sulfone or sulfoxide groups by oxidation of sulfides, or by formation of sulfone groups by oxidation of sulfoxides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C315/00—Preparation of sulfones; Preparation of sulfoxides
    • C07C315/06—Separation; Purification; Stabilisation; Use of additives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/28—Antiandrogens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • C07C317/46—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Epoxy Compounds (AREA)
  • Farming Of Fish And Shellfish (AREA)
  • Meat, Egg Or Seafood Products (AREA)
  • Peptides Or Proteins (AREA)
AT02788815T 2001-12-13 2002-12-13 Bicalutamidkristalle und verfahren zu deren herstellung ATE440817T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2001380686 2001-12-13
JP2002166213 2002-06-06
PCT/JP2002/013058 WO2003053920A1 (fr) 2001-12-13 2002-12-13 Cristaux de bicalutamide et leur procede de production

Publications (1)

Publication Number Publication Date
ATE440817T1 true ATE440817T1 (de) 2009-09-15

Family

ID=26625048

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02788815T ATE440817T1 (de) 2001-12-13 2002-12-13 Bicalutamidkristalle und verfahren zu deren herstellung

Country Status (20)

Country Link
US (2) US6740770B2 (de)
EP (1) EP1462442B1 (de)
JP (2) JP4255381B2 (de)
KR (1) KR100938188B1 (de)
CN (1) CN1602299A (de)
AT (1) ATE440817T1 (de)
AU (2) AU2002354475B2 (de)
BR (1) BR0214933A (de)
CA (1) CA2469594C (de)
CY (1) CY1110550T1 (de)
DE (1) DE60233526D1 (de)
DK (1) DK1462442T3 (de)
ES (1) ES2331178T3 (de)
IL (3) IL162398A0 (de)
IS (1) IS2737B (de)
NZ (1) NZ533943A (de)
PT (1) PT1462442E (de)
SI (1) SI1462442T1 (de)
WO (1) WO2003053920A1 (de)
ZA (1) ZA200404891B (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU223950B1 (hu) * 1999-06-10 2005-03-29 Richter Gedeon Vegyészeti Gyár Rt. Eljárás a racém, valamint az R-(-)- és S-(+)-N-[4-ciano-3-(trifluor-metil)-fenil]-3-[(4-fluor-fenil)-szulfonil]-2-hidroxi-2-metil-propánsavamid előállítására
AU7734800A (en) * 1999-09-29 2001-04-30 General Hospital Corporation, The Polypeptide derivatives of parathyroid hormone (pth)
US7102026B2 (en) 2001-06-13 2006-09-05 Teva Gyógyszergyár Zártkörüen Müködö Részvénytársaság Process for preparing and isolating rac-bicalutamide and its intermediates
ATE440817T1 (de) * 2001-12-13 2009-09-15 Sumitomo Chemical Co Bicalutamidkristalle und verfahren zu deren herstellung
US20040063782A1 (en) * 2002-09-27 2004-04-01 Westheim Raymond J.H. Bicalutamide forms
WO2004074350A2 (en) * 2003-02-21 2004-09-02 Hetero Drugs Limited Bicalutamide polymorphs
CN1819992A (zh) * 2003-06-25 2006-08-16 特瓦药厂私人有限公司 纯化和分离rac－比卡鲁胺的方法
JP4322621B2 (ja) 2003-10-16 2009-09-02 住友化学株式会社 ４’−シアノ−３−［（４−フルオロフェニル）スルホニル］−２−ヒドロキシ−２−メチル−３’−トリフルオロメチルプロピオンアニリドの製造方法
WO2005089511A2 (en) * 2004-03-19 2005-09-29 Transform Pharmaceuticals, Inc. Novel pharmaceutical forms, and methods of making and using the same
EP1775285B1 (de) * 2004-07-14 2011-08-24 Sumitomo Chemical Company, Limited Verfahren zur kristallisation von bicalutamid
WO2006103689A1 (en) * 2005-03-29 2006-10-05 Usv Limited Process for preparation of bicalutamide
CA2513356A1 (en) * 2005-07-26 2007-01-26 Apotex Pharmachem Inc. Process for production of bicalutamide
WO2007074473A1 (en) * 2005-12-27 2007-07-05 Dabur Pharma Limited An improved process for preparation of bicalutamide
JP2009067710A (ja) * 2007-09-12 2009-04-02 Sumitomo Chemical Co Ltd Ｎ−メタクリロイル−４−シアノ−３−トリフルオロメチルアニリンの製造方法
WO2009087666A2 (en) * 2008-01-04 2009-07-16 Kekule Pharma An improved process for production of bicalutamide useful in the treatment of prostate cancer
CN101987086B (zh) * 2009-08-03 2012-07-18 北京化工大学 一种超细比卡鲁胺口服片剂及其制备方法
EP2496187B1 (de) 2009-11-03 2016-12-21 Howmedica Osteonics Corp. Bandscheibenimplantat mit integrierter halterung
CN101891663A (zh) * 2010-07-21 2010-11-24 杭州民生药业有限公司 一种比卡鲁胺中间体的制备方法
JP2013544768A (ja) 2010-09-29 2013-12-19 シルパ メディケア リミテッド ビカルタミドの調製方法
CN102321000A (zh) * 2011-07-21 2012-01-18 宁波人健药业集团有限公司 氧化制备比卡鲁胺的方法
PL2802563T3 (pl) * 2012-01-13 2017-11-30 Aranda Pharma Ltd Nowe pochodne heteroaryloamidowe mające własności antyandrogenne
CN105541680B (zh) * 2016-02-16 2017-12-22 重庆硕奥科技有限公司 一种比卡鲁胺的合成方法
CN105949095A (zh) * 2016-05-27 2016-09-21 山西振东制药股份有限公司 一种比卡鲁胺i晶型的制备方法
CN106748884B (zh) * 2016-12-13 2021-08-20 山西振东制药股份有限公司 一种比卡鲁胺中间体的制备方法
CN106905265A (zh) * 2017-03-09 2017-06-30 常州沃腾化工科技有限公司 N‑[4‑氰基‑3‑（三氟甲基）苯基]‑2,3‑环氧‑2‑甲基丙酰胺的制备方法
CN109336798B (zh) * 2018-11-19 2021-11-16 常州新星联生物科技有限公司 一种比卡鲁胺硫醚中间体的制备方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE225694C (de)
US4191775A (en) 1977-12-15 1980-03-04 Imperial Chemical Industries Limited Amide derivatives
EP0100172B1 (de) 1982-07-23 1987-08-12 Imperial Chemical Industries Plc Amide-Derivate
DD225694A1 (de) * 1984-06-14 1985-08-07 Univ Leipzig Verfahren zur darstellung substituierter 9-oxabicyclo/6.1.0/-nonane
HU223950B1 (hu) * 1999-06-10 2005-03-29 Richter Gedeon Vegyészeti Gyár Rt. Eljárás a racém, valamint az R-(-)- és S-(+)-N-[4-ciano-3-(trifluor-metil)-fenil]-3-[(4-fluor-fenil)-szulfonil]-2-hidroxi-2-metil-propánsavamid előállítására
US6583306B1 (en) * 1999-10-19 2003-06-24 Nobex Corporation Methods of asymmetrically synthesizing enantiomers of Casodex, its derivatives and intermediates thereof
AU2619501A (en) 1999-10-27 2001-06-06 Nobex Corporation Resolution of intermediates in the synthesis of substantially pure bicalutamide
US6562994B2 (en) * 2000-09-21 2003-05-13 Bristol-Myers Squibb Co. Process for the preparation of N-(substituted phenyl)-3-alkyl-,aryl- and heteroarylsulfonyl-2-hydroxy-2-alkyl- and haloalkylpropanamide compounds
US6479692B1 (en) 2001-05-02 2002-11-12 Nobex Corporation Methods of synthesizing acylanilides including bicalutamide and derivatives thereof
WO2002100339A2 (en) * 2001-06-13 2002-12-19 Biogal Gyogyszergyar Rt. Novel process for preparing rac-bicalutamide and its intermediates
US7102026B2 (en) 2001-06-13 2006-09-05 Teva Gyógyszergyár Zártkörüen Müködö Részvénytársaság Process for preparing and isolating rac-bicalutamide and its intermediates
ATE440817T1 (de) * 2001-12-13 2009-09-15 Sumitomo Chemical Co Bicalutamidkristalle und verfahren zu deren herstellung
US20040063782A1 (en) 2002-09-27 2004-04-01 Westheim Raymond J.H. Bicalutamide forms
US6818766B2 (en) * 2002-10-02 2004-11-16 Synthon Bv Process for making bicalutamide and intermediates thereof

Also Published As

Publication number Publication date
US7132560B2 (en) 2006-11-07
IS2737B (is) 2011-06-15
JPWO2003053920A1 (ja) 2005-04-28
IL189180A (en) 2010-12-30
US6740770B2 (en) 2004-05-25
US20030191337A1 (en) 2003-10-09
DE60233526D1 (de) 2009-10-08
EP1462442B1 (de) 2009-08-26
IL162398A (en) 2009-08-03
JP2009108081A (ja) 2009-05-21
CA2469594C (en) 2011-01-25
DK1462442T3 (da) 2009-12-14
NZ533943A (en) 2006-06-30
CY1110550T1 (el) 2015-04-29
AU2008203026A1 (en) 2008-07-31
SI1462442T1 (sl) 2010-01-29
JP4907634B2 (ja) 2012-04-04
KR100938188B1 (ko) 2010-01-21
AU2008203026B2 (en) 2011-05-12
JP4255381B2 (ja) 2009-04-15
CN1602299A (zh) 2005-03-30
KR20040063947A (ko) 2004-07-14
PT1462442E (pt) 2009-10-09
IL162398A0 (en) 2005-11-20
BR0214933A (pt) 2004-12-14
AU2002354475A1 (en) 2003-07-09
WO2003053920A1 (fr) 2003-07-03
ES2331178T3 (es) 2009-12-23
EP1462442A1 (de) 2004-09-29
CA2469594A1 (en) 2003-07-03
ZA200404891B (en) 2005-06-21
EP1462442A4 (de) 2005-12-07
US20040133031A1 (en) 2004-07-08
IL189180A0 (en) 2009-02-11
AU2002354475B2 (en) 2008-08-14
IS7302A (is) 2004-06-08

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