CY1110550T1 - Κρυσταλλοι βικαλουταμιδης και μεθοδος παραγωγης τους - Google Patents

Κρυσταλλοι βικαλουταμιδης και μεθοδος παραγωγης τους

Info

Publication number
CY1110550T1
CY1110550T1 CY20091101187T CY091101187T CY1110550T1 CY 1110550 T1 CY1110550 T1 CY 1110550T1 CY 20091101187 T CY20091101187 T CY 20091101187T CY 091101187 T CY091101187 T CY 091101187T CY 1110550 T1 CY1110550 T1 CY 1110550T1
Authority
CY
Cyprus
Prior art keywords
bicalutamide
crystal
production
vicalutamide
crystals
Prior art date
Application number
CY20091101187T
Other languages
English (en)
Inventor
Tetsuya Shintaku
Tadashi Katsura
Nobushige Itaya
Original Assignee
Sumitomo Chemical Company, Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sumitomo Chemical Company, Limited filed Critical Sumitomo Chemical Company, Limited
Publication of CY1110550T1 publication Critical patent/CY1110550T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C315/00—Preparation of sulfones; Preparation of sulfoxides
    • C07C315/06—Separation; Purification; Stabilisation; Use of additives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/28—Antiandrogens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C315/00—Preparation of sulfones; Preparation of sulfoxides
    • C07C315/02—Preparation of sulfones; Preparation of sulfoxides by formation of sulfone or sulfoxide groups by oxidation of sulfides, or by formation of sulfone groups by oxidation of sulfoxides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • C07C317/46—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Epoxy Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Farming Of Fish And Shellfish (AREA)
  • Meat, Egg Or Seafood Products (AREA)

Abstract

Η παρούσα εφεύρεση σχετίζεται με ένα κρύσταλλο βικαλουταμίδης η οποία έχει μια ορισμένη μορφή, καθώς επίσης και με οικονομικές και βιομηχανικώς πρακτικές μεθόδους παραγωγής βικαλουταμίδης και ενός κρυστάλλου αυτής, οι οποίες είναι ανώτερες ως προς την ηπιότητα έναντι του περιβάλλοντος και την ασφάλεια.
CY20091101187T 2001-12-13 2009-11-12 Κρυσταλλοι βικαλουταμιδης και μεθοδος παραγωγης τους CY1110550T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2001380686 2001-12-13
JP2002166213 2002-06-06
EP02788815A EP1462442B1 (en) 2001-12-13 2002-12-13 Crystals of bicalutamide and process for their production

Publications (1)

Publication Number Publication Date
CY1110550T1 true CY1110550T1 (el) 2015-04-29

Family

ID=26625048

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20091101187T CY1110550T1 (el) 2001-12-13 2009-11-12 Κρυσταλλοι βικαλουταμιδης και μεθοδος παραγωγης τους

Country Status (20)

Country Link
US (2) US6740770B2 (el)
EP (1) EP1462442B1 (el)
JP (2) JP4255381B2 (el)
KR (1) KR100938188B1 (el)
CN (1) CN1602299A (el)
AT (1) ATE440817T1 (el)
AU (2) AU2002354475B2 (el)
BR (1) BR0214933A (el)
CA (1) CA2469594C (el)
CY (1) CY1110550T1 (el)
DE (1) DE60233526D1 (el)
DK (1) DK1462442T3 (el)
ES (1) ES2331178T3 (el)
IL (3) IL162398A0 (el)
IS (1) IS2737B (el)
NZ (1) NZ533943A (el)
PT (1) PT1462442E (el)
SI (1) SI1462442T1 (el)
WO (1) WO2003053920A1 (el)
ZA (1) ZA200404891B (el)

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HU223950B1 (hu) * 1999-06-10 2005-03-29 Richter Gedeon Vegyészeti Gyár Rt. Eljárás a racém, valamint az R-(-)- és S-(+)-N-[4-ciano-3-(trifluor-metil)-fenil]-3-[(4-fluor-fenil)-szulfonil]-2-hidroxi-2-metil-propánsavamid előállítására
AU7734800A (en) * 1999-09-29 2001-04-30 General Hospital Corporation, The Polypeptide derivatives of parathyroid hormone (pth)
US7102026B2 (en) 2001-06-13 2006-09-05 Teva Gyógyszergyár Zártkörüen Müködö Részvénytársaság Process for preparing and isolating rac-bicalutamide and its intermediates
KR100938188B1 (ko) * 2001-12-13 2010-01-21 스미또모 가가꾸 가부시키가이샤 비칼루타미드의 결정 및 그 제조 방법
US20040063782A1 (en) * 2002-09-27 2004-04-01 Westheim Raymond J.H. Bicalutamide forms
AU2003209667A1 (en) * 2003-02-21 2004-09-09 Hetero Drugs Limited Bicalutamide polymorphs
JP2007521224A (ja) * 2003-06-25 2007-08-02 テバ ジョジセルジャール ザ−トケルエン ムケド レ−スベニュタ−ルシャシャ−グ Ｒａｃ−ビカルタミドの精製及び単離方法
JP4322621B2 (ja) 2003-10-16 2009-09-02 住友化学株式会社 ４’−シアノ−３−［（４−フルオロフェニル）スルホニル］−２−ヒドロキシ−２−メチル−３’−トリフルオロメチルプロピオンアニリドの製造方法
US8436029B2 (en) 2004-03-19 2013-05-07 Transform Pharmaceuticals, Inc. Pharmaceutical forms, and methods of making and using the same
JP4863664B2 (ja) * 2004-07-14 2012-01-25 住友化学株式会社 ビカルタミドの晶析方法
WO2006103689A1 (en) * 2005-03-29 2006-10-05 Usv Limited Process for preparation of bicalutamide
CA2513356A1 (en) * 2005-07-26 2007-01-26 Apotex Pharmachem Inc. Process for production of bicalutamide
AU2006329551A1 (en) * 2005-12-27 2007-07-05 Dabur Pharma Limited An improved process for preparation of Bicalutamide
JP2009067710A (ja) * 2007-09-12 2009-04-02 Sumitomo Chemical Co Ltd Ｎ−メタクリロイル−４−シアノ−３−トリフルオロメチルアニリンの製造方法
WO2009087666A2 (en) * 2008-01-04 2009-07-16 Kekule Pharma An improved process for production of bicalutamide useful in the treatment of prostate cancer
CN101987086B (zh) * 2009-08-03 2012-07-18 北京化工大学 一种超细比卡鲁胺口服片剂及其制备方法
EP3192464B1 (en) 2009-11-03 2018-08-22 Howmedica Osteonics Corp. A kit of surgical instruments for removing a spinal implant
CN101891663A (zh) * 2010-07-21 2010-11-24 杭州民生药业有限公司 一种比卡鲁胺中间体的制备方法
US8895772B2 (en) 2010-09-29 2014-11-25 Shilpa Medicare Limited Process for preparing bicalutamide
CN102321000A (zh) * 2011-07-21 2012-01-18 宁波人健药业集团有限公司 氧化制备比卡鲁胺的方法
NZ626715A (en) 2012-01-13 2016-07-29 Medeia Therapeutics Ltd Novel heteroarylamide derivatives having antiandrogenic properties
CN105541680B (zh) * 2016-02-16 2017-12-22 重庆硕奥科技有限公司 一种比卡鲁胺的合成方法
CN105949095A (zh) * 2016-05-27 2016-09-21 山西振东制药股份有限公司 一种比卡鲁胺i晶型的制备方法
CN106748884B (zh) * 2016-12-13 2021-08-20 山西振东制药股份有限公司 一种比卡鲁胺中间体的制备方法
CN106905265A (zh) * 2017-03-09 2017-06-30 常州沃腾化工科技有限公司 N‑[4‑氰基‑3‑（三氟甲基）苯基]‑2,3‑环氧‑2‑甲基丙酰胺的制备方法
CN109336798B (zh) * 2018-11-19 2021-11-16 常州新星联生物科技有限公司 一种比卡鲁胺硫醚中间体的制备方法

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ATE28864T1 (de) 1982-07-23 1987-08-15 Ici Plc Amide-derivate.
DD225694A1 (de) * 1984-06-14 1985-08-07 Univ Leipzig Verfahren zur darstellung substituierter 9-oxabicyclo/6.1.0/-nonane
HU223950B1 (hu) 1999-06-10 2005-03-29 Richter Gedeon Vegyészeti Gyár Rt. Eljárás a racém, valamint az R-(-)- és S-(+)-N-[4-ciano-3-(trifluor-metil)-fenil]-3-[(4-fluor-fenil)-szulfonil]-2-hidroxi-2-metil-propánsavamid előállítására
CZ20021340A3 (cs) 1999-10-19 2002-08-14 Nobex Corporation Způsoby asymetrické přípravy enantiomerů acylanilidů, jejich derivátů a meziproduktů pro uvedené přípravy
CZ20021434A3 (cs) 1999-10-27 2002-11-13 Nobex Corporation Způsob přípravy v podstatě čistého enantiomeru acylanilidu
BR0114277A (pt) * 2000-09-21 2004-12-21 Bristol Myers Squibb Co Processo para a preparação de compostos de n-(fenil substituìda)-3-alquil-,aril-e heteroarilsulfonil-2-hidróxi-2-alquil-e-haloalquilp ropanamida
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EP1406855A4 (en) 2001-06-13 2006-04-19 Teva Gyogyszergyar Reszvenytar NOVEL PROCESS FOR THE PREPARATION OF RAC-BICALUTAMIDE AND INTERMEDIATE PRODUCTS THEREOF
US7102026B2 (en) 2001-06-13 2006-09-05 Teva Gyógyszergyár Zártkörüen Müködö Részvénytársaság Process for preparing and isolating rac-bicalutamide and its intermediates
KR100938188B1 (ko) * 2001-12-13 2010-01-21 스미또모 가가꾸 가부시키가이샤 비칼루타미드의 결정 및 그 제조 방법
US20040063782A1 (en) 2002-09-27 2004-04-01 Westheim Raymond J.H. Bicalutamide forms
US6818766B2 (en) 2002-10-02 2004-11-16 Synthon Bv Process for making bicalutamide and intermediates thereof

Also Published As

Publication number Publication date
EP1462442A4 (en) 2005-12-07
ZA200404891B (en) 2005-06-21
PT1462442E (pt) 2009-10-09
IL189180A0 (en) 2009-02-11
CN1602299A (zh) 2005-03-30
DK1462442T3 (da) 2009-12-14
JPWO2003053920A1 (ja) 2005-04-28
SI1462442T1 (sl) 2010-01-29
ATE440817T1 (de) 2009-09-15
AU2008203026A1 (en) 2008-07-31
JP2009108081A (ja) 2009-05-21
JP4907634B2 (ja) 2012-04-04
NZ533943A (en) 2006-06-30
US20030191337A1 (en) 2003-10-09
BR0214933A (pt) 2004-12-14
DE60233526D1 (de) 2009-10-08
EP1462442A1 (en) 2004-09-29
US6740770B2 (en) 2004-05-25
AU2008203026B2 (en) 2011-05-12
IL189180A (en) 2010-12-30
CA2469594A1 (en) 2003-07-03
IS7302A (is) 2004-06-08
IS2737B (is) 2011-06-15
ES2331178T3 (es) 2009-12-23
KR100938188B1 (ko) 2010-01-21
EP1462442B1 (en) 2009-08-26
AU2002354475A1 (en) 2003-07-09
CA2469594C (en) 2011-01-25
IL162398A0 (en) 2005-11-20
US7132560B2 (en) 2006-11-07
JP4255381B2 (ja) 2009-04-15
WO2003053920A1 (fr) 2003-07-03
KR20040063947A (ko) 2004-07-14
US20040133031A1 (en) 2004-07-08
AU2002354475B2 (en) 2008-08-14
IL162398A (en) 2009-08-03

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