DK1462442T3 - Krystaller af bicalutamid og fremgangsmåde til deres fremstilling - Google Patents

Krystaller af bicalutamid og fremgangsmåde til deres fremstilling

Info

Publication number
DK1462442T3
DK1462442T3 DK02788815T DK02788815T DK1462442T3 DK 1462442 T3 DK1462442 T3 DK 1462442T3 DK 02788815 T DK02788815 T DK 02788815T DK 02788815 T DK02788815 T DK 02788815T DK 1462442 T3 DK1462442 T3 DK 1462442T3
Authority
DK
Denmark
Prior art keywords
bicalutamide
crystal
preparation
chem
formula
Prior art date
Application number
DK02788815T
Other languages
Danish (da)
English (en)
Inventor
Tetsuya Shintaku
Tadashi Katsura
Nobushige Itaya
Original Assignee
Sumitomo Chemical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sumitomo Chemical Co filed Critical Sumitomo Chemical Co
Application granted granted Critical
Publication of DK1462442T3 publication Critical patent/DK1462442T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C315/00—Preparation of sulfones; Preparation of sulfoxides
    • C07C315/06—Separation; Purification; Stabilisation; Use of additives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/28—Antiandrogens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C315/00—Preparation of sulfones; Preparation of sulfoxides
    • C07C315/02—Preparation of sulfones; Preparation of sulfoxides by formation of sulfone or sulfoxide groups by oxidation of sulfides, or by formation of sulfone groups by oxidation of sulfoxides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • C07C317/46—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Epoxy Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Farming Of Fish And Shellfish (AREA)
  • Meat, Egg Or Seafood Products (AREA)
DK02788815T 2001-12-13 2002-12-13 Krystaller af bicalutamid og fremgangsmåde til deres fremstilling DK1462442T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2001380686 2001-12-13
JP2002166213 2002-06-06
PCT/JP2002/013058 WO2003053920A1 (fr) 2001-12-13 2002-12-13 Cristaux de bicalutamide et leur procede de production

Publications (1)

Publication Number Publication Date
DK1462442T3 true DK1462442T3 (da) 2009-12-14

Family

ID=26625048

Family Applications (1)

Application Number Title Priority Date Filing Date
DK02788815T DK1462442T3 (da) 2001-12-13 2002-12-13 Krystaller af bicalutamid og fremgangsmåde til deres fremstilling

Country Status (20)

Country Link
US (2) US6740770B2 (de)
EP (1) EP1462442B1 (de)
JP (2) JP4255381B2 (de)
KR (1) KR100938188B1 (de)
CN (1) CN1602299A (de)
AT (1) ATE440817T1 (de)
AU (2) AU2002354475B2 (de)
BR (1) BR0214933A (de)
CA (1) CA2469594C (de)
CY (1) CY1110550T1 (de)
DE (1) DE60233526D1 (de)
DK (1) DK1462442T3 (de)
ES (1) ES2331178T3 (de)
IL (3) IL162398A0 (de)
IS (1) IS2737B (de)
NZ (1) NZ533943A (de)
PT (1) PT1462442E (de)
SI (1) SI1462442T1 (de)
WO (1) WO2003053920A1 (de)
ZA (1) ZA200404891B (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU223950B1 (hu) * 1999-06-10 2005-03-29 Richter Gedeon Vegyészeti Gyár Rt. Eljárás a racém, valamint az R-(-)- és S-(+)-N-[4-ciano-3-(trifluor-metil)-fenil]-3-[(4-fluor-fenil)-szulfonil]-2-hidroxi-2-metil-propánsavamid előállítására
AU7734800A (en) * 1999-09-29 2001-04-30 General Hospital Corporation, The Polypeptide derivatives of parathyroid hormone (pth)
US7102026B2 (en) 2001-06-13 2006-09-05 Teva Gyógyszergyár Zártkörüen Müködö Részvénytársaság Process for preparing and isolating rac-bicalutamide and its intermediates
WO2003053920A1 (fr) * 2001-12-13 2003-07-03 Sumika Fine Chemicals Co., Ltd. Cristaux de bicalutamide et leur procede de production
US20040063782A1 (en) * 2002-09-27 2004-04-01 Westheim Raymond J.H. Bicalutamide forms
US20050020675A1 (en) * 2003-02-21 2005-01-27 Parthasaradhi Reddy Bandi Bicalutamide polymorphs
JP2007521224A (ja) * 2003-06-25 2007-08-02 テバ ジョジセルジャール ザ−トケルエン ムケド レ−スベニュタ−ルシャシャ−グ Ｒａｃ−ビカルタミドの精製及び単離方法
JP4322621B2 (ja) 2003-10-16 2009-09-02 住友化学株式会社 ４’−シアノ−３−［（４−フルオロフェニル）スルホニル］−２−ヒドロキシ−２−メチル−３’−トリフルオロメチルプロピオンアニリドの製造方法
WO2005089511A2 (en) * 2004-03-19 2005-09-29 Transform Pharmaceuticals, Inc. Novel pharmaceutical forms, and methods of making and using the same
JP4863664B2 (ja) * 2004-07-14 2012-01-25 住友化学株式会社 ビカルタミドの晶析方法
JP2008534575A (ja) * 2005-03-29 2008-08-28 ユーエスヴィー リミテッド ビカルタミドの調製のための新規プロセス
CA2513356A1 (en) * 2005-07-26 2007-01-26 Apotex Pharmachem Inc. Process for production of bicalutamide
CA2635461A1 (en) * 2005-12-27 2007-07-05 Dabur Pharma Limited An improved process for preparation of bicalutamide
JP2009067710A (ja) * 2007-09-12 2009-04-02 Sumitomo Chemical Co Ltd Ｎ−メタクリロイル−４−シアノ−３−トリフルオロメチルアニリンの製造方法
WO2009087666A2 (en) * 2008-01-04 2009-07-16 Kekule Pharma An improved process for production of bicalutamide useful in the treatment of prostate cancer
CN101987086B (zh) * 2009-08-03 2012-07-18 北京化工大学 一种超细比卡鲁胺口服片剂及其制备方法
EP3192464B1 (de) 2009-11-03 2018-08-22 Howmedica Osteonics Corp. Ein kit von chirurgischen instrumenten zur entfernung eines spinalen implantats
CN101891663A (zh) * 2010-07-21 2010-11-24 杭州民生药业有限公司 一种比卡鲁胺中间体的制备方法
JP2013544768A (ja) 2010-09-29 2013-12-19 シルパ メディケア リミテッド ビカルタミドの調製方法
CN102321000A (zh) * 2011-07-21 2012-01-18 宁波人健药业集团有限公司 氧化制备比卡鲁胺的方法
AR089702A1 (es) * 2012-01-13 2014-09-10 Medeia Therapeutics Ltd Derivados de heteroarilamida que tienen propiedades antiandrogenicas
CN105541680B (zh) * 2016-02-16 2017-12-22 重庆硕奥科技有限公司 一种比卡鲁胺的合成方法
CN105949095A (zh) * 2016-05-27 2016-09-21 山西振东制药股份有限公司 一种比卡鲁胺i晶型的制备方法
CN106748884B (zh) * 2016-12-13 2021-08-20 山西振东制药股份有限公司 一种比卡鲁胺中间体的制备方法
CN106905265A (zh) * 2017-03-09 2017-06-30 常州沃腾化工科技有限公司 N‑[4‑氰基‑3‑（三氟甲基）苯基]‑2,3‑环氧‑2‑甲基丙酰胺的制备方法
CN109336798B (zh) * 2018-11-19 2021-11-16 常州新星联生物科技有限公司 一种比卡鲁胺硫醚中间体的制备方法

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE225694C (de)
US4191775A (en) 1977-12-15 1980-03-04 Imperial Chemical Industries Limited Amide derivatives
ATE28864T1 (de) 1982-07-23 1987-08-15 Ici Plc Amide-derivate.
DD225694A1 (de) * 1984-06-14 1985-08-07 Univ Leipzig Verfahren zur darstellung substituierter 9-oxabicyclo/6.1.0/-nonane
HU223950B1 (hu) 1999-06-10 2005-03-29 Richter Gedeon Vegyészeti Gyár Rt. Eljárás a racém, valamint az R-(-)- és S-(+)-N-[4-ciano-3-(trifluor-metil)-fenil]-3-[(4-fluor-fenil)-szulfonil]-2-hidroxi-2-metil-propánsavamid előállítására
NZ518392A (en) * 1999-10-19 2004-02-27 Nobex Corp Methods of asymmetrically synthesizing enantiomers of casodex, its derivatives and intermediates thereof
CN1413188A (zh) * 1999-10-27 2003-04-23 诺贝克斯公司 基本纯的比卡鲁胺合成中中间体的拆分
AU2001295044A1 (en) * 2000-09-21 2002-04-02 Bristol-Myers Squibb Company Process for the preparation of N-(substituted phenyl)-3-alkyl-, aryl- and heteroarylsulfonyl-2-hydroxy-2-alkyl- and haloalkylpropanamide compounds
US6479692B1 (en) 2001-05-02 2002-11-12 Nobex Corporation Methods of synthesizing acylanilides including bicalutamide and derivatives thereof
US7102026B2 (en) 2001-06-13 2006-09-05 Teva Gyógyszergyár Zártkörüen Müködö Részvénytársaság Process for preparing and isolating rac-bicalutamide and its intermediates
CA2448571A1 (en) * 2001-06-13 2002-12-19 Biogal Gyogyszergyar Rt. Novel process for preparing rac-bicalutamide and its intermediates
WO2003053920A1 (fr) * 2001-12-13 2003-07-03 Sumika Fine Chemicals Co., Ltd. Cristaux de bicalutamide et leur procede de production
US20040063782A1 (en) * 2002-09-27 2004-04-01 Westheim Raymond J.H. Bicalutamide forms
US6818766B2 (en) * 2002-10-02 2004-11-16 Synthon Bv Process for making bicalutamide and intermediates thereof

Also Published As

Publication number Publication date
NZ533943A (en) 2006-06-30
JP2009108081A (ja) 2009-05-21
US20030191337A1 (en) 2003-10-09
ATE440817T1 (de) 2009-09-15
AU2008203026A1 (en) 2008-07-31
IL162398A (en) 2009-08-03
KR100938188B1 (ko) 2010-01-21
IS2737B (is) 2011-06-15
WO2003053920A1 (fr) 2003-07-03
SI1462442T1 (sl) 2010-01-29
IL189180A (en) 2010-12-30
JP4907634B2 (ja) 2012-04-04
IL162398A0 (en) 2005-11-20
US7132560B2 (en) 2006-11-07
ES2331178T3 (es) 2009-12-23
US6740770B2 (en) 2004-05-25
ZA200404891B (en) 2005-06-21
CA2469594C (en) 2011-01-25
KR20040063947A (ko) 2004-07-14
IS7302A (is) 2004-06-08
JPWO2003053920A1 (ja) 2005-04-28
EP1462442B1 (de) 2009-08-26
AU2002354475B2 (en) 2008-08-14
CY1110550T1 (el) 2015-04-29
AU2002354475A1 (en) 2003-07-09
PT1462442E (pt) 2009-10-09
US20040133031A1 (en) 2004-07-08
EP1462442A1 (de) 2004-09-29
JP4255381B2 (ja) 2009-04-15
IL189180A0 (en) 2009-02-11
EP1462442A4 (de) 2005-12-07
AU2008203026B2 (en) 2011-05-12
DE60233526D1 (de) 2009-10-08
CA2469594A1 (en) 2003-07-03
BR0214933A (pt) 2004-12-14
CN1602299A (zh) 2005-03-30

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