ATE435233T1 - Verfahren und zwischenprodukte zur synthese des caspofungins - Google Patents
Verfahren und zwischenprodukte zur synthese des caspofunginsInfo
- Publication number
- ATE435233T1 ATE435233T1 AT06818498T AT06818498T ATE435233T1 AT E435233 T1 ATE435233 T1 AT E435233T1 AT 06818498 T AT06818498 T AT 06818498T AT 06818498 T AT06818498 T AT 06818498T AT E435233 T1 ATE435233 T1 AT E435233T1
- Authority
- AT
- Austria
- Prior art keywords
- caspofungin
- synthesis
- intermediate products
- intermediates
- processes
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 108010020326 Caspofungin Proteins 0.000 title abstract 2
- JYIKNQVWKBUSNH-WVDDFWQHSA-N caspofungin Chemical compound C1([C@H](O)[C@@H](O)[C@H]2C(=O)N[C@H](C(=O)N3CC[C@H](O)[C@H]3C(=O)N[C@H](NCCN)[C@H](O)C[C@@H](C(N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)N2)[C@@H](C)O)=O)NC(=O)CCCCCCCC[C@@H](C)C[C@@H](C)CC)[C@H](O)CCN)=CC=C(O)C=C1 JYIKNQVWKBUSNH-WVDDFWQHSA-N 0.000 title abstract 2
- 229960003034 caspofungin Drugs 0.000 title abstract 2
- 230000015572 biosynthetic process Effects 0.000 title 1
- 239000013067 intermediate product Substances 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- 239000000543 intermediate Substances 0.000 abstract 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical group CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 2
- -1 caspofungin Chemical class 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 150000002825 nitriles Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
- C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
- C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Analytical Chemistry (AREA)
- Public Health (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05024961A EP1785432A1 (de) | 2005-11-15 | 2005-11-15 | Verfahren und Zwischenprodukte zur Synthese des Caspofungins |
| PCT/EP2006/010867 WO2007057141A1 (en) | 2005-11-15 | 2006-11-13 | Process and intermediates for the synthesis of caspofungin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE435233T1 true ATE435233T1 (de) | 2009-07-15 |
Family
ID=36001076
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06818498T ATE435233T1 (de) | 2005-11-15 | 2006-11-13 | Verfahren und zwischenprodukte zur synthese des caspofungins |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US20080319162A1 (de) |
| EP (2) | EP1785432A1 (de) |
| JP (1) | JP4966314B2 (de) |
| KR (1) | KR101342304B1 (de) |
| CN (1) | CN101305018B (de) |
| AT (1) | ATE435233T1 (de) |
| BR (1) | BRPI0618591A2 (de) |
| CA (1) | CA2626921C (de) |
| DE (1) | DE602006007612D1 (de) |
| DK (1) | DK1951747T3 (de) |
| ES (1) | ES2327962T3 (de) |
| HR (1) | HRP20090474T1 (de) |
| IL (1) | IL190333A (de) |
| PL (1) | PL1951747T3 (de) |
| PT (1) | PT1951747E (de) |
| SI (1) | SI1951747T1 (de) |
| WO (1) | WO2007057141A1 (de) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008012310A1 (en) | 2006-07-26 | 2008-01-31 | Sandoz Ag | Caspofungin formulations |
| US20090291996A1 (en) * | 2008-05-21 | 2009-11-26 | Ferenc Korodi | Caspofungin free of caspofungin Co |
| US8048853B2 (en) * | 2008-06-13 | 2011-11-01 | Xellia Pharmaceuticals Aps | Process for preparing pharmaceutical compound and intermediates thereof |
| US20100256074A1 (en) * | 2008-06-25 | 2010-10-07 | Chaim Eidelman | Processes for preparing high purity aza cyclohexapeptides |
| KR20110011704A (ko) * | 2008-06-25 | 2011-02-08 | 테바 기오기스제르갸르 자르트쾨렌 뮈쾨되 레스즈베니타르사사그 | 카스포펀진 불순물 ａ를 함유하지 않는 카스포펀진 |
| TW201024322A (en) * | 2008-12-31 | 2010-07-01 | Chunghwa Chemical Synthesis & Biotech Co Ltd | Preparation method for nitrogen containing heterocyclic hexapeptide with high conversion rate |
| WO2010108637A1 (en) | 2009-03-27 | 2010-09-30 | Axellia Pharmaceuticals Aps | Crystalline compound |
| EP2463293A4 (de) * | 2009-08-06 | 2013-06-05 | Shanghai Techwell Biopharm Co | Azacyclohexapeptid bzw. sein pharmazeutisch akzeptables salz, herstellungsverfahren und verwendung |
| US9056897B2 (en) * | 2010-09-28 | 2015-06-16 | DSM Sinochem Pharmaceuticals | Method for isolating a cyclohexapeptide |
| CN102367267B (zh) | 2010-11-10 | 2013-09-04 | 上海天伟生物制药有限公司 | 一种卡泊芬净的制备方法 |
| CN102367268B (zh) | 2010-11-10 | 2013-11-06 | 上海天伟生物制药有限公司 | 一种卡泊芬净类似物及其用途 |
| CN102367269B (zh) | 2010-11-10 | 2013-11-06 | 上海天伟生物制药有限公司 | 一种卡泊芬净类似物及其制备方法和用途 |
| KR101331984B1 (ko) | 2010-12-09 | 2013-11-25 | 종근당바이오 주식회사 | 카스포펀진 제조방법 및 그의 신규 중간체 |
| CN102219833A (zh) * | 2011-04-18 | 2011-10-19 | 深圳市健元医药科技有限公司 | 一种更加安全的棘白菌类抗真菌药的制备方法 |
| CN102746384B (zh) | 2011-04-22 | 2016-01-20 | 上海天伟生物制药有限公司 | 一种高纯度的卡泊芬净或其盐及其制备方法和用途 |
| RU2592280C2 (ru) * | 2011-04-28 | 2016-07-20 | Юнитрис Биофарма Ко., Лтд | Промежуточное соединение для синтеза каспофунгина и способ его получения |
| CN106478781B (zh) * | 2015-09-02 | 2020-04-07 | 正大天晴药业集团股份有限公司 | 卡泊芬净的制备方法 |
| CN105440109B (zh) * | 2015-11-26 | 2019-03-05 | 成都摩尔生物医药有限公司 | 一种卡泊芬净的制备方法 |
| CN109721641B (zh) * | 2017-10-31 | 2021-08-03 | 鲁南制药集团股份有限公司 | 一种卡泊芬净的合成方法 |
| EP3620462A1 (de) | 2018-09-04 | 2020-03-11 | Xellia Pharmaceuticals ApS | Verfahren zur herstellung von caspofungin |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5194377A (en) | 1989-06-30 | 1993-03-16 | Merck & Co., Inc. | Antibiotic agent |
| US5202309A (en) | 1989-06-30 | 1993-04-13 | Merck & Co., Inc. | Antibiotic cyclopeptide fermentation product |
| US6030944A (en) | 1991-10-01 | 2000-02-29 | Merck & Co., Inc. | Cyclohexapeptidyl bisamine compounds |
| AU5354094A (en) * | 1992-10-16 | 1994-05-09 | Merck & Co., Inc. | An improved process for cyclohexapeptidyl bisamine compounds |
| US5378804A (en) | 1993-03-16 | 1995-01-03 | Merck & Co., Inc. | Aza cyclohexapeptide compounds |
| ATE186737T1 (de) * | 1994-08-23 | 1999-12-15 | Merck & Co Inc | Ein verbessertes verfahren für die herstellung von seitenketten-derivaten von cyclohexapeptidyl- lipopeptiden |
| US5552521A (en) | 1995-02-10 | 1996-09-03 | Merck & Co., Inc. | Process for preparing certain aza cyclohexapeptides |
| HRP970318B1 (en) | 1996-06-14 | 2002-06-30 | Merck & Co Inc | A process for preparing certain aza cyclohexapeptides |
| US5936062A (en) | 1997-06-12 | 1999-08-10 | Merck & Co., Inc. | Process for preparing certain aza cyclohexapeptides |
| US5972996A (en) * | 1997-08-22 | 1999-10-26 | Merck & Co., Inc. | 4-cyano-4-deformylsordarin derivatives |
| US5965612A (en) * | 1997-08-22 | 1999-10-12 | Merck & Co., Inc. | 4-cyano-4-deformylsordaricin derivatives |
| CA2433652A1 (en) * | 2001-01-09 | 2002-07-18 | Merck & Co., Inc. | Active metabolite of antifungal compound |
| AR035808A1 (es) | 2001-04-12 | 2004-07-14 | Merck & Co Inc | Proceso de deshidratacion capaz de minimizar la epimerizacion de un grupo hidroxilo por ciertas equinocandinas |
-
2005
- 2005-11-15 EP EP05024961A patent/EP1785432A1/de not_active Withdrawn
-
2006
- 2006-11-13 PL PL06818498T patent/PL1951747T3/pl unknown
- 2006-11-13 SI SI200630411T patent/SI1951747T1/sl unknown
- 2006-11-13 DE DE602006007612T patent/DE602006007612D1/de active Active
- 2006-11-13 BR BRPI0618591-6A patent/BRPI0618591A2/pt not_active IP Right Cessation
- 2006-11-13 DK DK06818498T patent/DK1951747T3/da active
- 2006-11-13 AT AT06818498T patent/ATE435233T1/de active
- 2006-11-13 EP EP06818498A patent/EP1951747B1/de not_active Not-in-force
- 2006-11-13 CA CA2626921A patent/CA2626921C/en not_active Expired - Fee Related
- 2006-11-13 HR HR20090474T patent/HRP20090474T1/xx unknown
- 2006-11-13 ES ES06818498T patent/ES2327962T3/es active Active
- 2006-11-13 CN CN2006800422331A patent/CN101305018B/zh not_active Expired - Fee Related
- 2006-11-13 US US12/093,657 patent/US20080319162A1/en not_active Abandoned
- 2006-11-13 JP JP2008540498A patent/JP4966314B2/ja not_active Expired - Fee Related
- 2006-11-13 WO PCT/EP2006/010867 patent/WO2007057141A1/en not_active Ceased
- 2006-11-13 PT PT06818498T patent/PT1951747E/pt unknown
-
2008
- 2008-03-20 IL IL190333A patent/IL190333A/en not_active IP Right Cessation
- 2008-05-14 KR KR1020087011523A patent/KR101342304B1/ko not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN101305018B (zh) | 2013-03-27 |
| JP4966314B2 (ja) | 2012-07-04 |
| HRP20090474T1 (hr) | 2009-10-31 |
| CN101305018A (zh) | 2008-11-12 |
| DK1951747T3 (da) | 2009-10-12 |
| CA2626921A1 (en) | 2007-05-24 |
| CA2626921C (en) | 2013-09-17 |
| WO2007057141A1 (en) | 2007-05-24 |
| PT1951747E (pt) | 2009-08-12 |
| EP1951747B1 (de) | 2009-07-01 |
| PL1951747T3 (pl) | 2009-12-31 |
| KR20080069998A (ko) | 2008-07-29 |
| ES2327962T3 (es) | 2009-11-05 |
| KR101342304B1 (ko) | 2013-12-16 |
| US20080319162A1 (en) | 2008-12-25 |
| BRPI0618591A2 (pt) | 2011-09-06 |
| DE602006007612D1 (de) | 2009-08-13 |
| IL190333A (en) | 2010-12-30 |
| EP1785432A1 (de) | 2007-05-16 |
| EP1951747A1 (de) | 2008-08-06 |
| SI1951747T1 (sl) | 2009-12-31 |
| JP2009515917A (ja) | 2009-04-16 |
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Legal Events
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