ATE435233T1 - Verfahren und zwischenprodukte zur synthese des caspofungins - Google Patents

Verfahren und zwischenprodukte zur synthese des caspofungins

Info

Publication number
ATE435233T1
ATE435233T1 AT06818498T AT06818498T ATE435233T1 AT E435233 T1 ATE435233 T1 AT E435233T1 AT 06818498 T AT06818498 T AT 06818498T AT 06818498 T AT06818498 T AT 06818498T AT E435233 T1 ATE435233 T1 AT E435233T1
Authority
AT
Austria
Prior art keywords
caspofungin
synthesis
intermediate products
intermediates
processes
Prior art date
Application number
AT06818498T
Other languages
English (en)
Inventor
Johannes Ludescher
Ingolf Macher
Ole Storm
Stephan Bertel
Original Assignee
Sandoz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Ag filed Critical Sandoz Ag
Application granted granted Critical
Publication of ATE435233T1 publication Critical patent/ATE435233T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Analytical Chemistry (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT06818498T 2005-11-15 2006-11-13 Verfahren und zwischenprodukte zur synthese des caspofungins ATE435233T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05024961A EP1785432A1 (de) 2005-11-15 2005-11-15 Verfahren und Zwischenprodukte zur Synthese des Caspofungins
PCT/EP2006/010867 WO2007057141A1 (en) 2005-11-15 2006-11-13 Process and intermediates for the synthesis of caspofungin

Publications (1)

Publication Number Publication Date
ATE435233T1 true ATE435233T1 (de) 2009-07-15

Family

ID=36001076

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06818498T ATE435233T1 (de) 2005-11-15 2006-11-13 Verfahren und zwischenprodukte zur synthese des caspofungins

Country Status (17)

Country Link
US (1) US20080319162A1 (de)
EP (2) EP1785432A1 (de)
JP (1) JP4966314B2 (de)
KR (1) KR101342304B1 (de)
CN (1) CN101305018B (de)
AT (1) ATE435233T1 (de)
BR (1) BRPI0618591A2 (de)
CA (1) CA2626921C (de)
DE (1) DE602006007612D1 (de)
DK (1) DK1951747T3 (de)
ES (1) ES2327962T3 (de)
HR (1) HRP20090474T1 (de)
IL (1) IL190333A (de)
PL (1) PL1951747T3 (de)
PT (1) PT1951747E (de)
SI (1) SI1951747T1 (de)
WO (1) WO2007057141A1 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI2049142T2 (sl) 2006-07-26 2016-04-29 Sandoz Ag Formulacije kaspofungina
WO2009142761A1 (en) * 2008-05-21 2009-11-26 Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag Caspofungin bo free of caspofungin co
US8048853B2 (en) 2008-06-13 2011-11-01 Xellia Pharmaceuticals Aps Process for preparing pharmaceutical compound and intermediates thereof
EP2183271A1 (de) * 2008-06-25 2010-05-12 TEVA Gyógyszergyár Zártkörüen Müködö Részvénytársaság Von der caspofungin-unreinheit a freies caspofungin
EP2240507A2 (de) * 2008-06-25 2010-10-20 TEVA Gyógyszergyár Zártkörüen Müködö Részvénytársaság Verfahren zur herstellung von hochreinen azacyclohexapeptiden
TW201024322A (en) * 2008-12-31 2010-07-01 Chunghwa Chemical Synthesis & Biotech Co Ltd Preparation method for nitrogen containing heterocyclic hexapeptide with high conversion rate
WO2010108637A1 (en) 2009-03-27 2010-09-30 Axellia Pharmaceuticals Aps Crystalline compound
EP2463293A4 (de) * 2009-08-06 2013-06-05 Shanghai Techwell Biopharm Co Azacyclohexapeptid bzw. sein pharmazeutisch akzeptables salz, herstellungsverfahren und verwendung
CN103180336B (zh) * 2010-09-28 2016-06-15 中化帝斯曼制药有限公司荷兰公司 用于分离环六肽的方法
CN102367268B (zh) 2010-11-10 2013-11-06 上海天伟生物制药有限公司 一种卡泊芬净类似物及其用途
CN102367267B (zh) 2010-11-10 2013-09-04 上海天伟生物制药有限公司 一种卡泊芬净的制备方法
CN102367269B (zh) 2010-11-10 2013-11-06 上海天伟生物制药有限公司 一种卡泊芬净类似物及其制备方法和用途
KR101331984B1 (ko) 2010-12-09 2013-11-25 종근당바이오 주식회사 카스포펀진 제조방법 및 그의 신규 중간체
CN102219833A (zh) * 2011-04-18 2011-10-19 深圳市健元医药科技有限公司 一种更加安全的棘白菌类抗真菌药的制备方法
CN102746384B (zh) * 2011-04-22 2016-01-20 上海天伟生物制药有限公司 一种高纯度的卡泊芬净或其盐及其制备方法和用途
TWI597293B (zh) 2011-04-28 2017-09-01 江蘇盛迪醫藥有限公司 用於合成卡帕芬淨的中間體及其製備方法
CN106478781B (zh) * 2015-09-02 2020-04-07 正大天晴药业集团股份有限公司 卡泊芬净的制备方法
CN105440109B (zh) * 2015-11-26 2019-03-05 成都摩尔生物医药有限公司 一种卡泊芬净的制备方法
CN109721641B (zh) * 2017-10-31 2021-08-03 鲁南制药集团股份有限公司 一种卡泊芬净的合成方法
EP3620462A1 (de) 2018-09-04 2020-03-11 Xellia Pharmaceuticals ApS Verfahren zur herstellung von caspofungin

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5194377A (en) 1989-06-30 1993-03-16 Merck & Co., Inc. Antibiotic agent
US5202309A (en) 1989-06-30 1993-04-13 Merck & Co., Inc. Antibiotic cyclopeptide fermentation product
US6030944A (en) 1991-10-01 2000-02-29 Merck & Co., Inc. Cyclohexapeptidyl bisamine compounds
AU5354094A (en) * 1992-10-16 1994-05-09 Merck & Co., Inc. An improved process for cyclohexapeptidyl bisamine compounds
US5378804A (en) 1993-03-16 1995-01-03 Merck & Co., Inc. Aza cyclohexapeptide compounds
DE69513408T2 (de) * 1994-08-23 2000-06-08 Merck & Co Inc Ein verbessertes verfahren für die herstellung von seitenketten-derivaten von cyclohexapeptidyl-lipopeptiden
US5552521A (en) 1995-02-10 1996-09-03 Merck & Co., Inc. Process for preparing certain aza cyclohexapeptides
HRP970318B1 (en) 1996-06-14 2002-06-30 Merck & Co Inc A process for preparing certain aza cyclohexapeptides
US5936062A (en) 1997-06-12 1999-08-10 Merck & Co., Inc. Process for preparing certain aza cyclohexapeptides
US5972996A (en) * 1997-08-22 1999-10-26 Merck & Co., Inc. 4-cyano-4-deformylsordarin derivatives
US5965612A (en) * 1997-08-22 1999-10-12 Merck & Co., Inc. 4-cyano-4-deformylsordaricin derivatives
JP2004521102A (ja) * 2001-01-09 2004-07-15 メルク　エンド　カムパニー　インコーポレーテッド 抗真菌化合物の活性代謝物
AR035808A1 (es) 2001-04-12 2004-07-14 Merck & Co Inc Proceso de deshidratacion capaz de minimizar la epimerizacion de un grupo hidroxilo por ciertas equinocandinas

Also Published As

Publication number Publication date
SI1951747T1 (sl) 2009-12-31
KR101342304B1 (ko) 2013-12-16
JP2009515917A (ja) 2009-04-16
CN101305018A (zh) 2008-11-12
PT1951747E (pt) 2009-08-12
PL1951747T3 (pl) 2009-12-31
CA2626921A1 (en) 2007-05-24
BRPI0618591A2 (pt) 2011-09-06
CA2626921C (en) 2013-09-17
HRP20090474T1 (en) 2009-10-31
EP1785432A1 (de) 2007-05-16
WO2007057141A1 (en) 2007-05-24
ES2327962T3 (es) 2009-11-05
DE602006007612D1 (de) 2009-08-13
IL190333A (en) 2010-12-30
US20080319162A1 (en) 2008-12-25
CN101305018B (zh) 2013-03-27
JP4966314B2 (ja) 2012-07-04
KR20080069998A (ko) 2008-07-29
DK1951747T3 (da) 2009-10-12
EP1951747B1 (de) 2009-07-01
EP1951747A1 (de) 2008-08-06

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