PL1951747T3 - Sposób syntezy i związki pośrednie do syntezy kaspofunginy - Google Patents
Sposób syntezy i związki pośrednie do syntezy kaspofunginyInfo
- Publication number
- PL1951747T3 PL1951747T3 PL06818498T PL06818498T PL1951747T3 PL 1951747 T3 PL1951747 T3 PL 1951747T3 PL 06818498 T PL06818498 T PL 06818498T PL 06818498 T PL06818498 T PL 06818498T PL 1951747 T3 PL1951747 T3 PL 1951747T3
- Authority
- PL
- Poland
- Prior art keywords
- intermediates
- caspofungin
- synthesis
- processes
- preparing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
- C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
- C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Analytical Chemistry (AREA)
- Public Health (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP05024961A EP1785432A1 (en) | 2005-11-15 | 2005-11-15 | Process and intermediates for the synthesis of caspofungin. |
EP06818498A EP1951747B1 (en) | 2005-11-15 | 2006-11-13 | Process and intermediates for the synthesis of caspofungin |
PCT/EP2006/010867 WO2007057141A1 (en) | 2005-11-15 | 2006-11-13 | Process and intermediates for the synthesis of caspofungin |
Publications (1)
Publication Number | Publication Date |
---|---|
PL1951747T3 true PL1951747T3 (pl) | 2009-12-31 |
Family
ID=36001076
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL06818498T PL1951747T3 (pl) | 2005-11-15 | 2006-11-13 | Sposób syntezy i związki pośrednie do syntezy kaspofunginy |
Country Status (17)
Country | Link |
---|---|
US (1) | US20080319162A1 (pl) |
EP (2) | EP1785432A1 (pl) |
JP (1) | JP4966314B2 (pl) |
KR (1) | KR101342304B1 (pl) |
CN (1) | CN101305018B (pl) |
AT (1) | ATE435233T1 (pl) |
BR (1) | BRPI0618591A2 (pl) |
CA (1) | CA2626921C (pl) |
DE (1) | DE602006007612D1 (pl) |
DK (1) | DK1951747T3 (pl) |
ES (1) | ES2327962T3 (pl) |
HR (1) | HRP20090474T1 (pl) |
IL (1) | IL190333A (pl) |
PL (1) | PL1951747T3 (pl) |
PT (1) | PT1951747E (pl) |
SI (1) | SI1951747T1 (pl) |
WO (1) | WO2007057141A1 (pl) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PL2049142T5 (pl) | 2006-07-26 | 2016-09-30 | Sandoz Ag | Preparaty kaspofunginy |
US20090291996A1 (en) * | 2008-05-21 | 2009-11-26 | Ferenc Korodi | Caspofungin free of caspofungin Co |
US8048853B2 (en) | 2008-06-13 | 2011-11-01 | Xellia Pharmaceuticals Aps | Process for preparing pharmaceutical compound and intermediates thereof |
EP2240507A2 (en) * | 2008-06-25 | 2010-10-20 | TEVA Gyógyszergyár Zártkörüen Müködö Részvénytársaság | Processes for preparing high purity aza cyclohexapeptides |
CN102076707A (zh) * | 2008-06-25 | 2011-05-25 | 特瓦药厂私人有限公司 | 无卡泊芬净杂质a的卡泊芬净 |
TW201024322A (en) * | 2008-12-31 | 2010-07-01 | Chunghwa Chemical Synthesis & Biotech Co Ltd | Preparation method for nitrogen containing heterocyclic hexapeptide with high conversion rate |
WO2010108637A1 (en) | 2009-03-27 | 2010-09-30 | Axellia Pharmaceuticals Aps | Crystalline compound |
US20120190815A1 (en) * | 2009-08-06 | 2012-07-26 | Tianhui Xu | Azacyclohexapeptide or its pharmaceutical acceptable salt, preparing method and use thereof |
WO2012041801A1 (en) * | 2010-09-28 | 2012-04-05 | Dsm Sinochem Pharmaceuticals Netherlands B.V. | Method for isolating a cyclohexapeptide |
CN102367267B (zh) | 2010-11-10 | 2013-09-04 | 上海天伟生物制药有限公司 | 一种卡泊芬净的制备方法 |
CN102367268B (zh) | 2010-11-10 | 2013-11-06 | 上海天伟生物制药有限公司 | 一种卡泊芬净类似物及其用途 |
CN102367269B (zh) | 2010-11-10 | 2013-11-06 | 上海天伟生物制药有限公司 | 一种卡泊芬净类似物及其制备方法和用途 |
KR101331984B1 (ko) | 2010-12-09 | 2013-11-25 | 종근당바이오 주식회사 | 카스포펀진 제조방법 및 그의 신규 중간체 |
CN102219833A (zh) * | 2011-04-18 | 2011-10-19 | 深圳市健元医药科技有限公司 | 一种更加安全的棘白菌类抗真菌药的制备方法 |
CN102746384B (zh) | 2011-04-22 | 2016-01-20 | 上海天伟生物制药有限公司 | 一种高纯度的卡泊芬净或其盐及其制备方法和用途 |
EP2703409B1 (en) | 2011-04-28 | 2017-01-18 | Unitris Biopharma Co., Ltd | Intermediate for synthesizing caspofungin and preparation method therefor |
CN106478781B (zh) * | 2015-09-02 | 2020-04-07 | 正大天晴药业集团股份有限公司 | 卡泊芬净的制备方法 |
CN105440109B (zh) * | 2015-11-26 | 2019-03-05 | 成都摩尔生物医药有限公司 | 一种卡泊芬净的制备方法 |
CN109721641B (zh) * | 2017-10-31 | 2021-08-03 | 鲁南制药集团股份有限公司 | 一种卡泊芬净的合成方法 |
EP3620462A1 (en) * | 2018-09-04 | 2020-03-11 | Xellia Pharmaceuticals ApS | Process for the preparation of caspofungin |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5202309A (en) | 1989-06-30 | 1993-04-13 | Merck & Co., Inc. | Antibiotic cyclopeptide fermentation product |
US5194377A (en) | 1989-06-30 | 1993-03-16 | Merck & Co., Inc. | Antibiotic agent |
US6030944A (en) | 1991-10-01 | 2000-02-29 | Merck & Co., Inc. | Cyclohexapeptidyl bisamine compounds |
WO1994009033A1 (en) * | 1992-10-16 | 1994-04-28 | Merck & Co., Inc. | An improved process for cyclohexapeptidyl bisamine compounds |
US5378804A (en) | 1993-03-16 | 1995-01-03 | Merck & Co., Inc. | Aza cyclohexapeptide compounds |
WO1996006109A1 (en) * | 1994-08-23 | 1996-02-29 | Merck & Co., Inc. | An improved process for preparing side chain derivatives of cyclohexapeptidyl lipopeptides |
US5552521A (en) | 1995-02-10 | 1996-09-03 | Merck & Co., Inc. | Process for preparing certain aza cyclohexapeptides |
HRP970318B1 (en) | 1996-06-14 | 2002-06-30 | Merck & Co Inc | A process for preparing certain aza cyclohexapeptides |
US5936062A (en) | 1997-06-12 | 1999-08-10 | Merck & Co., Inc. | Process for preparing certain aza cyclohexapeptides |
US5965612A (en) * | 1997-08-22 | 1999-10-12 | Merck & Co., Inc. | 4-cyano-4-deformylsordaricin derivatives |
US5972996A (en) * | 1997-08-22 | 1999-10-26 | Merck & Co., Inc. | 4-cyano-4-deformylsordarin derivatives |
EP1351701A2 (en) * | 2001-01-09 | 2003-10-15 | Merck & Co., Inc. | Active metabolite of antifungal compound |
AR035808A1 (es) | 2001-04-12 | 2004-07-14 | Merck & Co Inc | Proceso de deshidratacion capaz de minimizar la epimerizacion de un grupo hidroxilo por ciertas equinocandinas |
-
2005
- 2005-11-15 EP EP05024961A patent/EP1785432A1/en not_active Withdrawn
-
2006
- 2006-11-13 PT PT06818498T patent/PT1951747E/pt unknown
- 2006-11-13 AT AT06818498T patent/ATE435233T1/de active
- 2006-11-13 DK DK06818498T patent/DK1951747T3/da active
- 2006-11-13 WO PCT/EP2006/010867 patent/WO2007057141A1/en active Application Filing
- 2006-11-13 ES ES06818498T patent/ES2327962T3/es active Active
- 2006-11-13 JP JP2008540498A patent/JP4966314B2/ja not_active Expired - Fee Related
- 2006-11-13 US US12/093,657 patent/US20080319162A1/en not_active Abandoned
- 2006-11-13 DE DE602006007612T patent/DE602006007612D1/de active Active
- 2006-11-13 BR BRPI0618591-6A patent/BRPI0618591A2/pt not_active IP Right Cessation
- 2006-11-13 PL PL06818498T patent/PL1951747T3/pl unknown
- 2006-11-13 SI SI200630411T patent/SI1951747T1/sl unknown
- 2006-11-13 CN CN2006800422331A patent/CN101305018B/zh not_active Expired - Fee Related
- 2006-11-13 EP EP06818498A patent/EP1951747B1/en active Active
- 2006-11-13 CA CA2626921A patent/CA2626921C/en not_active Expired - Fee Related
-
2008
- 2008-03-20 IL IL190333A patent/IL190333A/en not_active IP Right Cessation
- 2008-05-14 KR KR1020087011523A patent/KR101342304B1/ko not_active IP Right Cessation
-
2009
- 2009-09-07 HR HR20090474T patent/HRP20090474T1/xx unknown
Also Published As
Publication number | Publication date |
---|---|
KR101342304B1 (ko) | 2013-12-16 |
EP1785432A1 (en) | 2007-05-16 |
HRP20090474T1 (en) | 2009-10-31 |
EP1951747A1 (en) | 2008-08-06 |
IL190333A (en) | 2010-12-30 |
ES2327962T3 (es) | 2009-11-05 |
US20080319162A1 (en) | 2008-12-25 |
BRPI0618591A2 (pt) | 2011-09-06 |
CA2626921C (en) | 2013-09-17 |
JP4966314B2 (ja) | 2012-07-04 |
DE602006007612D1 (de) | 2009-08-13 |
SI1951747T1 (sl) | 2009-12-31 |
WO2007057141A1 (en) | 2007-05-24 |
PT1951747E (pt) | 2009-08-12 |
CA2626921A1 (en) | 2007-05-24 |
DK1951747T3 (da) | 2009-10-12 |
JP2009515917A (ja) | 2009-04-16 |
CN101305018A (zh) | 2008-11-12 |
CN101305018B (zh) | 2013-03-27 |
ATE435233T1 (de) | 2009-07-15 |
KR20080069998A (ko) | 2008-07-29 |
EP1951747B1 (en) | 2009-07-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL190333A (en) | Process and intermediates for the synthesis of caspofungin | |
UA101060C2 (ru) | Способ получения соединения n-[транс-4-[4-(циклопропилметил)-1-пиперазинил]циклогексил]-4-[[(7r)-7-этил-5,6,7,8-тетрагидро-5-метил-8-(1-метилетил)-6-оксо-2-птеридинил]амино]-3-метоксибензамида | |
GB0305704D0 (en) | Radiofluorination methods | |
MY149070A (en) | 1h-quinazoline-2,4-diones | |
MY147633A (en) | Preparation of azoxystrobin | |
ZA200702700B (en) | Diagnostic compounds | |
TW200616995A (en) | Novel compounds | |
TW200618796A (en) | Ammonolysis process for the preparation of intermediates for DPP IV inhibitors | |
PL1758852T3 (pl) | Podstawione związki cyklopentenu | |
TW200716529A (en) | New compounds II | |
TW200640914A (en) | Novel processes for the preparation of a benzofuran | |
TW200728310A (en) | Process for the preparation of ferri-succinylcasein | |
MXPA05013751A (es) | Procedimiento e intermediarios para la preparacion de 3-(amino)-3-ciclobutilmetil-2-hidroxi-propionamida o sus sales. | |
TNSN06260A1 (en) | Process for the preparation of tryptase inhibitors | |
TW200719889A (en) | Amino acid derivatives | |
TW200722418A (en) | Novel compounds | |
PL1912954T3 (pl) | Nowe inhibitory proteaz cysteinowych i ich terapeutyczne zastosowania | |
UA94604C2 (en) | Neuroprotective compounds and uses thereof | |
DE602004031129D1 (de) | Verfahren zur herstellung von quetiapin | |
MXPA05013649A (es) | Fluorbutenos nematicidas que contienen tiazolina. | |
WO2004096828A3 (fr) | Nouveau procede et intermediaires de preparation de composes 19-nor-steroïdes | |
SG155231A1 (en) | Process for synthesis of dialkoxyorganoboranes | |
MXPA05007696A (es) | Modificacion cristalina de un complejo de manganeso. | |
MX2007012472A (es) | (+)-y-(-)-8-alquil-3-(trifluoralquilsulfoniloxi)-8-azabicicl (3.2.1)cot-2-eno. | |
TW200716530A (en) | New compounds I |