ATE432242T1 - Kristallines mesoporöses siliciumdioxid material, verwendung desgleichen für die fixation und die freisetzung von medikamenten - Google Patents

Kristallines mesoporöses siliciumdioxid material, verwendung desgleichen für die fixation und die freisetzung von medikamenten

Info

Publication number
ATE432242T1
ATE432242T1 AT04737677T AT04737677T ATE432242T1 AT E432242 T1 ATE432242 T1 AT E432242T1 AT 04737677 T AT04737677 T AT 04737677T AT 04737677 T AT04737677 T AT 04737677T AT E432242 T1 ATE432242 T1 AT E432242T1
Authority
AT
Austria
Prior art keywords
fixation
medications
release
silicon dioxide
mesoporous silicon
Prior art date
Application number
AT04737677T
Other languages
English (en)
Inventor
Johan Martens
Christine Kirschhock
Sebastien Kremer
Alexander Aerts
Den Mooter Guy Van
Humbeeck Jan Van
Original Assignee
Leuven K U Res & Dev
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Leuven K U Res & Dev filed Critical Leuven K U Res & Dev
Application granted granted Critical
Publication of ATE432242T1 publication Critical patent/ATE432242T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/5115—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/143—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with inorganic compounds
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
    • C01B37/00—Compounds having molecular sieve properties but not having base-exchange properties
    • C01B37/005—Silicates, i.e. so-called metallosilicalites or metallozeosilites
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
    • C01B37/00—Compounds having molecular sieve properties but not having base-exchange properties
    • C01B37/02—Crystalline silica-polymorphs, e.g. silicalites dealuminated aluminosilicate zeolites
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/70—Nanostructure
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/70—Nanostructure
    • Y10S977/701—Integrated with dissimilar structures on a common substrate
    • Y10S977/712—Integrated with dissimilar structures on a common substrate formed from plural layers of nanosized material, e.g. stacked structures
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/70—Nanostructure
    • Y10S977/831—Of specified ceramic or electrically insulating compositions

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • General Life Sciences & Earth Sciences (AREA)
  • Geology (AREA)
  • Physics & Mathematics (AREA)
  • Silicates, Zeolites, And Molecular Sieves (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Catalysts (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Mechanical Treatment Of Semiconductor (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT04737677T 2003-06-27 2004-06-28 Kristallines mesoporöses siliciumdioxid material, verwendung desgleichen für die fixation und die freisetzung von medikamenten ATE432242T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0315012.5A GB0315012D0 (en) 2003-06-27 2003-06-27 Zeotiles
PCT/BE2004/000094 WO2005000740A2 (en) 2003-06-27 2004-06-28 Crystalline mesoporous oxide based materials useful for the fixation and controlled release of drugs

Publications (1)

Publication Number Publication Date
ATE432242T1 true ATE432242T1 (de) 2009-06-15

Family

ID=27637462

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04737677T ATE432242T1 (de) 2003-06-27 2004-06-28 Kristallines mesoporöses siliciumdioxid material, verwendung desgleichen für die fixation und die freisetzung von medikamenten

Country Status (15)

Country Link
US (1) US7749521B2 (de)
EP (3) EP2336086A1 (de)
JP (2) JP4709140B2 (de)
CN (1) CN100420628C (de)
AT (1) ATE432242T1 (de)
AU (1) AU2004251792B2 (de)
CA (2) CA2529456A1 (de)
DE (1) DE602004021256D1 (de)
DK (1) DK1638888T3 (de)
ES (2) ES2414959T3 (de)
GB (1) GB0315012D0 (de)
IL (2) IL172525A0 (de)
PL (1) PL1638888T3 (de)
WO (1) WO2005000740A2 (de)
ZA (1) ZA200510399B (de)

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US8097269B2 (en) 2004-02-18 2012-01-17 Celonova Biosciences, Inc. Bioactive material delivery systems comprising sol-gel compositions
US7981441B2 (en) 2004-02-18 2011-07-19 The Board Of Trustees Of The Leland Stanford Junior University Drug delivery systems using mesoporous oxide films
US7589041B2 (en) * 2004-04-23 2009-09-15 Massachusetts Institute Of Technology Mesostructured zeolitic materials, and methods of making and using the same
EP1809349B1 (de) * 2004-07-05 2009-10-14 Ziscoat N.V. Biokompatible beschichtung von medizinischen vorrichtungen mit molekularsieben
GB0420016D0 (en) * 2004-09-09 2004-10-13 Leuven K U Res & Dev Controlled release oral delivery system
US7776682B1 (en) * 2005-04-20 2010-08-17 Spansion Llc Ordered porosity to direct memory element formation
WO2007133758A1 (en) * 2006-05-15 2007-11-22 Physical Pharmaceutica, Llc Composition and improved method for preparation of small particles
CN101516339B (zh) 2006-08-16 2012-06-13 诺瓦提斯公司 制备高度结晶的治疗化合物的固体分散体的方法
JP5509595B2 (ja) * 2006-09-08 2014-06-04 日立化成株式会社 カーボンナノチューブの製造方法
EP2089040B1 (de) * 2006-12-05 2012-01-04 Unilever PLC Mundpflegeprodukt
CN101209970B (zh) * 2006-12-25 2011-06-22 上海海隼化工科技有限公司 二乙二醇单乙酯和二乙二醇双乙酯的制备方法
JP5158670B2 (ja) * 2007-02-14 2013-03-06 独立行政法人産業技術総合研究所 円筒のアルミナ細孔内における界面活性剤を鋳型としたメソポーラスシリカの構造
CA2691956A1 (en) * 2007-06-25 2008-12-31 Pharmathen S.A. Improved pharmaceutical formulation containing an hmg-coa reductase inhibitor and method for the preparation thereof
US8258137B2 (en) * 2008-01-29 2012-09-04 Katholieke Universiteit Leuven Process for release of biologically active species from mesoporous oxide systems
AU2009214118B2 (en) * 2008-02-11 2014-06-12 Nanologica Ab Method for manufacturing mesoporous materials, materials so produced and use of mesoporous materials
US9114125B2 (en) 2008-04-11 2015-08-25 Celonova Biosciences, Inc. Drug eluting expandable devices
TWI410279B (zh) * 2008-08-27 2013-10-01 China Steel Corp A Synthetic Method of Double - pore Molecular Sieve in Cave
US8778401B2 (en) * 2008-10-28 2014-07-15 Agency For Science, Technology And Research Mesoporous material excipients for poorly aqueous soluble ingredients
US20130203602A1 (en) * 2010-03-11 2013-08-08 Danmarks Tekniske Universitet Supported biologically active compounds
CN102451158A (zh) * 2010-10-28 2012-05-16 沈阳药科大学 尼莫地平-SiO2纳米球及其制备和应用
WO2012138910A2 (en) * 2011-04-08 2012-10-11 Rive Technology, Inc. Mesoporous framework-modified zeolites
EP2707329B1 (de) * 2011-05-13 2017-11-01 Merck Patent GmbH Verfahren zur herstellung anorganischer partikel
US10577250B2 (en) 2011-05-13 2020-03-03 Merck Patent Gmbh Process for producing of inorganic particulate material
CN102676494B (zh) * 2012-05-03 2013-10-30 天津大学 核壳结构固定化酶颗粒及其制备方法
WO2013192609A1 (en) 2012-06-22 2013-12-27 Cornell University Mesoporous oxide nanoparticles and methods of making and using same
WO2014078435A1 (en) * 2012-11-14 2014-05-22 W. R. Grace & Co.-Conn. Compositions containing a biologically active material and a non-ordered inorganic oxide
US20160374943A1 (en) 2013-11-26 2016-12-29 Merck Patent Gmbh Process for producing inorganic particulate material
US20180105430A1 (en) * 2015-03-11 2018-04-19 Stc.Unm Generation of mesoporous materials using multiphase surfactant systems
WO2017120504A1 (en) 2016-01-08 2017-07-13 Durfee Paul N Osteotropic nanoparticles for prevention or treatment of bone metastases
US11344629B2 (en) 2017-03-01 2022-05-31 Charles Jeffrey Brinker Active targeting of cells by monosized protocells
CN110678206B (zh) * 2017-05-19 2023-03-21 株式会社德山 医药原料药载体及其制造方法
KR102140687B1 (ko) 2017-11-30 2020-08-05 한국생산기술연구원 다양한 약물의 방출 제어가 가능한 다공성 나노입자로 코팅된 임플란트
WO2020127281A1 (en) 2018-12-20 2020-06-25 Merck Patent Gmbh A release system comprising a bioactive agent and a particulate material
CN111904946B (zh) * 2019-05-10 2021-09-17 西安电子科技大学 一种基于仿生狂犬病毒的纳米诊疗制剂及其制备方法与应用
KR102368479B1 (ko) * 2020-03-03 2022-02-28 서울대학교산학협력단 나노입자 구조체 및 그 형성 방법
US20230263728A1 (en) * 2022-02-22 2023-08-24 DGP Technology Limited Biologically active additive based on mesoporous silicon dioxide and on micellar solutions of active substrates and method for preparing same

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Also Published As

Publication number Publication date
US7749521B2 (en) 2010-07-06
WO2005000740A2 (en) 2005-01-06
ZA200510399B (en) 2006-12-27
EP1638888B1 (de) 2009-05-27
CA2723328A1 (en) 2005-01-06
JP5296761B2 (ja) 2013-09-25
IL172525A0 (en) 2006-04-10
EP1638888A2 (de) 2006-03-29
GB0315012D0 (en) 2003-07-30
US20060134219A1 (en) 2006-06-22
EP2336086A1 (de) 2011-06-22
PL1638888T3 (pl) 2009-10-30
EP1852393A1 (de) 2007-11-07
ES2414959T3 (es) 2013-07-23
CA2723328C (en) 2013-02-05
AU2004251792B2 (en) 2009-08-13
JP2011063601A (ja) 2011-03-31
ES2326651T3 (es) 2009-10-16
JP2007523817A (ja) 2007-08-23
DK1638888T3 (da) 2009-08-10
IL213176A0 (en) 2011-07-31
WO2005000740A3 (en) 2005-02-17
CA2529456A1 (en) 2005-01-06
IL213176A (en) 2016-11-30
DE602004021256D1 (de) 2009-07-09
AU2004251792A1 (en) 2005-01-06
CN1812932A (zh) 2006-08-02
JP4709140B2 (ja) 2011-06-22
EP1852393B1 (de) 2013-04-10
CN100420628C (zh) 2008-09-24

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