ATE429515T1 - Biomolekülanalyse mittels rolling-circle- amplifikation und sers-nachweis - Google Patents
Biomolekülanalyse mittels rolling-circle- amplifikation und sers-nachweisInfo
- Publication number
- ATE429515T1 ATE429515T1 AT04775738T AT04775738T ATE429515T1 AT E429515 T1 ATE429515 T1 AT E429515T1 AT 04775738 T AT04775738 T AT 04775738T AT 04775738 T AT04775738 T AT 04775738T AT E429515 T1 ATE429515 T1 AT E429515T1
- Authority
- AT
- Austria
- Prior art keywords
- detection
- raman
- rca
- rolling circle
- amplification
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6804—Nucleic acid analysis using immunogens
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
- C12Q1/682—Signal amplification
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/65—Raman scattering
- G01N21/658—Raman scattering enhancement Raman, e.g. surface plasmons
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Pathology (AREA)
- Microbiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Physics & Mathematics (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/367,071 US7192703B2 (en) | 2003-02-14 | 2003-02-14 | Biomolecule analysis by rolling circle amplification and SERS detection |
PCT/US2004/002391 WO2005014860A2 (en) | 2003-02-14 | 2004-01-28 | Biomolecule analysis by rolling circle amplification and sers detection |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE429515T1 true ATE429515T1 (de) | 2009-05-15 |
Family
ID=32849891
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT04775738T ATE429515T1 (de) | 2003-02-14 | 2004-01-28 | Biomolekülanalyse mittels rolling-circle- amplifikation und sers-nachweis |
Country Status (8)
Country | Link |
---|---|
US (3) | US7192703B2 (de) |
EP (1) | EP1592812B1 (de) |
JP (1) | JP4885712B2 (de) |
CN (1) | CN1723290B (de) |
AT (1) | ATE429515T1 (de) |
DE (1) | DE602004020736D1 (de) |
TW (1) | TWI337623B (de) |
WO (1) | WO2005014860A2 (de) |
Families Citing this family (46)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7400395B2 (en) * | 2002-06-12 | 2008-07-15 | Intel Corporation | Metal coated nanocrystalline silicon as an active surface enhanced raman spectroscopy (SERS) substrate |
US7361313B2 (en) | 2003-02-18 | 2008-04-22 | Intel Corporation | Methods for uniform metal impregnation into a nanoporous material |
US6985223B2 (en) * | 2003-03-07 | 2006-01-10 | Purdue Research Foundation | Raman imaging and sensing apparatus employing nanoantennas |
US20070122808A1 (en) * | 2003-07-15 | 2007-05-31 | Densham Daniel H | Measurement of a polynuleotide amplification reaction |
CN100561281C (zh) * | 2004-03-05 | 2009-11-18 | 鸿富锦精密工业(深圳)有限公司 | 数码相机模块 |
US8617906B2 (en) * | 2004-10-13 | 2013-12-31 | Pharmagenesis, Inc. | Identification and screening of triptolide target molecules |
US7738096B2 (en) | 2004-10-21 | 2010-06-15 | University Of Georgia Research Foundation, Inc. | Surface enhanced Raman spectroscopy (SERS) systems, substrates, fabrication thereof, and methods of use thereof |
US7583379B2 (en) * | 2005-07-28 | 2009-09-01 | University Of Georgia Research Foundation | Surface enhanced raman spectroscopy (SERS) systems and methods of use thereof |
US7880876B2 (en) * | 2004-10-21 | 2011-02-01 | University Of Georgia Research Foundation, Inc. | Methods of use for surface enhanced raman spectroscopy (SERS) systems for the detection of bacteria |
US7656525B2 (en) * | 2004-10-21 | 2010-02-02 | University Of Georgia Research Foundation, Inc. | Fiber optic SERS sensor systems and SERS probes |
US7889334B2 (en) | 2005-03-15 | 2011-02-15 | University Of Georgia Research Foundation, Inc. | Surface enhanced Raman spectroscopy (SERS) systems for the detection of bacteria and methods of use thereof |
US7940387B2 (en) * | 2005-03-15 | 2011-05-10 | Univeristy Of Georgia Research Foundation, Inc. | Surface enhanced Raman spectroscopy (SERS) systems for the detection of viruses and methods of use thereof |
GB0510362D0 (en) | 2005-05-20 | 2005-06-29 | Univ Greenwich | Device for detecting mycotoxins |
EP2644615B1 (de) * | 2006-02-08 | 2017-04-05 | Becton Dickinson and Company | SERS-Nanoetikett-Assays |
US7398604B2 (en) * | 2006-10-16 | 2008-07-15 | The Stanley Works | Tape rule with resilient lock |
US20100047792A1 (en) * | 2007-04-10 | 2010-02-25 | Szendroe Istvan | Label-free optical detection method |
EP1992702A1 (de) * | 2007-05-14 | 2008-11-19 | Koninklijke Philips Electronics N.V. | Detektionsverfahren mit verbesserter Präzision und/oder Sensitivität |
GB2455492B (en) | 2007-10-08 | 2011-11-23 | Univ Greenwich | Apparatus and method for detection and measurement of target compounds such as food toxins |
US20100279272A1 (en) * | 2008-02-13 | 2010-11-04 | Michael Craig Burrell | Multiplexed analysis methods using sers-active nanoparticles |
GB0908633D0 (en) * | 2009-05-20 | 2009-06-24 | D3 Technologies Ltd | Detection of target analytie by signal amplication |
GB0912231D0 (en) * | 2009-07-14 | 2009-08-26 | Imp Innovations Ltd | Method and apparatus for determining an analyte parameter |
CN101985654A (zh) * | 2010-10-21 | 2011-03-16 | 徐州医学院 | 检测多样本多位点snp的检测方法 |
JP5870497B2 (ja) * | 2011-03-18 | 2016-03-01 | セイコーエプソン株式会社 | 測定装置及び測定方法 |
CN102320550A (zh) * | 2011-09-16 | 2012-01-18 | 中国科学院理化技术研究所 | 锗基半导体的拉曼散射增强基底及其制备方法和应用 |
TWI421494B (zh) * | 2011-10-27 | 2014-01-01 | Univ Nat Cheng Kung | 微藻總脂質之近紅外光譜定量方法 |
WO2013065016A1 (en) | 2011-11-02 | 2013-05-10 | University Of Cape Town | A method of detecting and/or quantifying an analyte in a biological sample |
US8810789B2 (en) | 2011-11-07 | 2014-08-19 | University Of Georgia Research Foundation, Inc. | Thin layer chromatography-surfaced enhanced Raman spectroscopy chips and methods of use |
CN103529011A (zh) * | 2012-07-06 | 2014-01-22 | 南京大学 | 高灵敏拉曼光谱检测dna的一种方法 |
CN104919054A (zh) * | 2012-07-31 | 2015-09-16 | 胡安·卡洛斯·海梅 | 获得并检测待鉴定对象之标志物的方法、相关标志物、认证方法以及验证方法 |
CN103212706B (zh) * | 2013-03-13 | 2016-03-23 | 江南大学 | 基于聚合酶链反应的大小金链状可控组装产物手性研究的方法 |
US10114015B2 (en) | 2013-03-13 | 2018-10-30 | Meso Scale Technologies, Llc. | Assay methods |
AU2014248759B2 (en) | 2013-03-13 | 2020-02-27 | Meso Scale Technologies, Llc. | Improved assay methods |
US10202500B2 (en) | 2013-03-15 | 2019-02-12 | Lubrizol Advanced Materials, Inc. | Heavy metal free CPVC compounds |
CN103255227B (zh) * | 2013-05-30 | 2015-02-25 | 上海快灵生物科技有限公司 | 引物介导环化的恒温核酸滚环扩增方法及试剂盒 |
AU2015259048B2 (en) | 2014-05-15 | 2021-09-09 | Meso Scale Technologies, Llc. | Improved assay methods |
CN104406952B (zh) * | 2014-11-19 | 2017-03-29 | 上海纳米技术及应用国家工程研究中心有限公司 | 基于滚环扩增技术和核壳纳米金结构的sers基底制备方法 |
CN104614358A (zh) * | 2014-12-09 | 2015-05-13 | 临沂大学 | 一种基于纳米粒子信号探针的拉曼放大检测凝血酶的方法 |
CN105567808B (zh) * | 2015-12-21 | 2019-11-12 | 山东大学 | 滚环扩增产物为模板的铜纳米颗粒合成方法及其在电化学检测中的应用 |
WO2018049101A1 (en) * | 2016-09-12 | 2018-03-15 | Schlereth Fritz H | Improved piezoelectric sensors and quartz crystal monitors |
CN109307669A (zh) * | 2017-07-28 | 2019-02-05 | 上海海洋大学 | 基于末端转移酶扩增核酸链制备核壳sers结构的方法 |
US10871485B2 (en) | 2018-04-13 | 2020-12-22 | Rarecyte, Inc. | Kits for labeling of biomarkers and methods of using the same |
TWI686599B (zh) | 2018-05-24 | 2020-03-01 | 國立清華大學 | 塵蟎抗原檢測系統及方法 |
AU2020232954A1 (en) | 2019-03-01 | 2021-09-09 | Meso Scale Technologies, Llc. | Electrochemiluminescent labeled probes for use in immunoassay methods, methods using such and kits comprising same |
CN110514829A (zh) * | 2019-07-30 | 2019-11-29 | 华东理工大学 | 一种基于信号级联双重放大系统以高灵敏且快速检测食源性致病菌的方法 |
CN112430644A (zh) * | 2020-12-15 | 2021-03-02 | 东南大学 | 一种基于滚环扩增的外泌体内多种miRNA同时扩增检测的方法 |
CN117070603B (zh) * | 2023-08-28 | 2024-09-20 | 海南医学院 | 一种用于miRNA检测的探针及其检测方法和应用 |
Family Cites Families (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4962037A (en) * | 1987-10-07 | 1990-10-09 | United States Of America | Method for rapid base sequencing in DNA and RNA |
US5744101A (en) | 1989-06-07 | 1998-04-28 | Affymax Technologies N.V. | Photolabile nucleoside protecting groups |
US6040138A (en) | 1995-09-15 | 2000-03-21 | Affymetrix, Inc. | Expression monitoring by hybridization to high density oligonucleotide arrays |
US5143854A (en) | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
US6379895B1 (en) | 1989-06-07 | 2002-04-30 | Affymetrix, Inc. | Photolithographic and other means for manufacturing arrays |
US5405747A (en) * | 1991-09-25 | 1995-04-11 | The Regents Of The University Of California Office Of Technology Transfer | Method for rapid base sequencing in DNA and RNA with two base labeling |
US5306403A (en) * | 1992-08-24 | 1994-04-26 | Martin Marietta Energy Systems, Inc. | Raman-based system for DNA sequencing-mapping and other separations |
US5578832A (en) | 1994-09-02 | 1996-11-26 | Affymetrix, Inc. | Method and apparatus for imaging a sample on a device |
US6287850B1 (en) | 1995-06-07 | 2001-09-11 | Affymetrix, Inc. | Bioarray chip reaction apparatus and its manufacture |
US5545531A (en) | 1995-06-07 | 1996-08-13 | Affymax Technologies N.V. | Methods for making a device for concurrently processing multiple biological chip assays |
GB9517955D0 (en) * | 1995-07-25 | 1995-11-08 | Univ Strathclyde | Nucleotide sequence detection and analysis |
US6174677B1 (en) * | 1995-10-13 | 2001-01-16 | Ut-Battelle, Llc | Advanced surface-enhanced Raman gene probe systems and methods thereof |
US5854033A (en) * | 1995-11-21 | 1998-12-29 | Yale University | Rolling circle replication reporter systems |
US5876480A (en) * | 1996-02-20 | 1999-03-02 | The United States Of America As Represented By The Secretary Of The Navy | Synthesis of unagglomerated metal nano-particles at membrane interfaces |
JP4068677B2 (ja) * | 1996-10-25 | 2008-03-26 | アークレイ株式会社 | 遺伝子の分析方法およびそれに用いる遺伝子分析用キット |
US6002471A (en) * | 1996-11-04 | 1999-12-14 | California Institute Of Technology | High resolution scanning raman microscope |
WO1998033939A1 (fr) * | 1997-01-31 | 1998-08-06 | Hitachi, Ltd. | Procede pour determiner une sequence de base d'acide nucleique et appareil correspondant |
CA2280794A1 (en) * | 1997-02-20 | 1998-08-27 | The Regents Of The University Of California | Plasmon resonant particles, methods and apparatus |
US6149868A (en) * | 1997-10-28 | 2000-11-21 | The Penn State Research Foundation | Surface enhanced raman scattering from metal nanoparticle-analyte-noble metal substrate sandwiches |
US6054274A (en) * | 1997-11-12 | 2000-04-25 | Hewlett-Packard Company | Method of amplifying the signal of target nucleic acid sequence analyte |
GB9810865D0 (en) * | 1998-05-20 | 1998-07-22 | Zeneca Ltd | Nucleic acid sequence identification |
US6210896B1 (en) * | 1998-08-13 | 2001-04-03 | Us Genomics | Molecular motors |
US6263286B1 (en) * | 1998-08-13 | 2001-07-17 | U.S. Genomics, Inc. | Methods of analyzing polymers using a spatial network of fluorophores and fluorescence resonance energy transfer |
US6203989B1 (en) | 1998-09-30 | 2001-03-20 | Affymetrix, Inc. | Methods and compositions for amplifying detectable signals in specific binding assays |
WO2000068434A2 (en) | 1999-05-07 | 2000-11-16 | Yale University | Multiple tag analysis |
US6376177B1 (en) * | 1999-10-06 | 2002-04-23 | Virtual Pro, Inc. | Apparatus and method for the analysis of nucleic acids hybridization on high density NA chips |
EP1804053A1 (de) * | 1999-10-06 | 2007-07-04 | Oxonica Inc. | Aktive Verbundnanopartikel für oberflächenverstärkte Spektroskopie |
US7332344B2 (en) * | 1999-12-01 | 2008-02-19 | Photonic Research Systems Limited | Luminescence assays |
US6368801B1 (en) * | 2000-04-12 | 2002-04-09 | Molecular Staging, Inc. | Detection and amplification of RNA using target-mediated ligation of DNA by RNA ligase |
US6291187B1 (en) * | 2000-05-12 | 2001-09-18 | Molecular Staging, Inc. | Poly-primed amplification of nucleic acid sequences |
US6531283B1 (en) | 2000-06-20 | 2003-03-11 | Molecular Staging, Inc. | Protein expression profiling |
US6323009B1 (en) * | 2000-06-28 | 2001-11-27 | Molecular Staging, Inc. | Multiply-primed amplification of nucleic acid sequences |
EP2801624B1 (de) | 2001-03-16 | 2019-03-06 | Singular Bio, Inc | Arrays und Verfahren zur Verwendung |
-
2003
- 2003-02-14 US US10/367,071 patent/US7192703B2/en not_active Expired - Fee Related
-
2004
- 2004-01-28 DE DE602004020736T patent/DE602004020736D1/de not_active Expired - Fee Related
- 2004-01-28 JP JP2006508629A patent/JP4885712B2/ja not_active Expired - Fee Related
- 2004-01-28 AT AT04775738T patent/ATE429515T1/de not_active IP Right Cessation
- 2004-01-28 WO PCT/US2004/002391 patent/WO2005014860A2/en active Application Filing
- 2004-01-28 EP EP04775738A patent/EP1592812B1/de not_active Expired - Lifetime
- 2004-01-28 CN CN200480001922.9A patent/CN1723290B/zh not_active Expired - Fee Related
- 2004-01-29 TW TW093101995A patent/TWI337623B/zh not_active IP Right Cessation
-
2005
- 2005-12-19 US US11/312,188 patent/US20060216729A1/en not_active Abandoned
- 2005-12-19 US US11/313,108 patent/US20060099636A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
WO2005014860A3 (en) | 2005-04-28 |
EP1592812B1 (de) | 2009-04-22 |
JP4885712B2 (ja) | 2012-02-29 |
US20040161750A1 (en) | 2004-08-19 |
US7192703B2 (en) | 2007-03-20 |
US20060099636A1 (en) | 2006-05-11 |
WO2005014860A2 (en) | 2005-02-17 |
TWI337623B (en) | 2011-02-21 |
TW200424316A (en) | 2004-11-16 |
JP2006520608A (ja) | 2006-09-14 |
DE602004020736D1 (de) | 2009-06-04 |
EP1592812A2 (de) | 2005-11-09 |
CN1723290B (zh) | 2012-05-02 |
US20060216729A1 (en) | 2006-09-28 |
CN1723290A (zh) | 2006-01-18 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |