CY1119526T1 - Εμπλουτισμος και ταυτοποιηση εμβρυϊκων κυτταρων σε μητρικο αιμα και προσδετες για τετοια χρηση - Google Patents
Εμπλουτισμος και ταυτοποιηση εμβρυϊκων κυτταρων σε μητρικο αιμα και προσδετες για τετοια χρησηInfo
- Publication number
- CY1119526T1 CY1119526T1 CY20171101136T CY171101136T CY1119526T1 CY 1119526 T1 CY1119526 T1 CY 1119526T1 CY 20171101136 T CY20171101136 T CY 20171101136T CY 171101136 T CY171101136 T CY 171101136T CY 1119526 T1 CY1119526 T1 CY 1119526T1
- Authority
- CY
- Cyprus
- Prior art keywords
- cells
- identification
- enrichment
- ligand
- embryon
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6811—Selection methods for production or design of target specific oligonucleotides or binding molecules
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6881—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6486—Measuring fluorescence of biological material, e.g. DNA, RNA, cells
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56966—Animal cells
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
- G01N2333/4701—Details
- G01N2333/4742—Keratin; Cytokeratin
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/70596—Molecules with a "CD"-designation not provided for elsewhere in G01N2333/705
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Cell Biology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Η παρούσα εφεύρεση αφορά τον εμπλουτισμό και/ή την ταυτοποίηση εμβρυϊκών κυττάρων ενός δείγματος μητρικού αίματος, με τη χρήση ειδικών για τα εμβρυϊκά κύτταρα προσδετών και/ή ειδικών για τα εμβρυϊκά κύτταρα ανιχνευτών υβριδοποίησης, όπου ο προσδέτης ή οι ανιχνευτές κατευθύνονται προς έναν ενδοθηλιακό/μεσεγχυματικό δείκτη, π.χ. CD105, CD146 ή CD141, σε έναν πρώτο γύρο εμπλουτισμού και ο προσδέτης ή οι ανιχνευτές σε έναν δεύτερο γύρο εμπλουτισμού κατευθύνονται προς έναν επιθηλιακό δείκτη, παραδείγματος χάριν μία κυτταροκερατίνη όπως CK7, CK8, CK18 ή CK19. Τα εμπλουτισμένα ή ταυτοποιημένα εμβρυϊκά κύτταρα είναι δυνατόν να υποβάλλονται σε βήματα ανίχνευσης ή διάγνωσης, όπου προς τον σκοπό αυτόν η παρούσα εφεύρεση καθιστά δυνατά μη-επεμβατικά προγεννητικά διαγνωστικά μέσα.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA201001018 | 2010-11-09 | ||
| PCT/DK2011/050423 WO2012062325A1 (en) | 2010-11-09 | 2011-11-09 | Enrichment and identification of fetal cells in maternal blood and ligands for such use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1119526T1 true CY1119526T1 (el) | 2018-03-07 |
Family
ID=45001595
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20171101136T CY1119526T1 (el) | 2010-11-09 | 2017-10-31 | Εμπλουτισμος και ταυτοποιηση εμβρυϊκων κυτταρων σε μητρικο αιμα και προσδετες για τετοια χρηση |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US9429520B2 (el) |
| EP (1) | EP2638176B1 (el) |
| JP (2) | JP6068354B2 (el) |
| KR (2) | KR20130102612A (el) |
| CN (1) | CN103261439B (el) |
| CA (1) | CA2817390C (el) |
| CY (1) | CY1119526T1 (el) |
| DK (1) | DK2638176T3 (el) |
| EA (1) | EA027314B1 (el) |
| ES (1) | ES2642313T3 (el) |
| HR (1) | HRP20171468T1 (el) |
| HU (1) | HUE034937T2 (el) |
| IL (1) | IL226188A (el) |
| LT (1) | LT2638176T (el) |
| PL (1) | PL2638176T3 (el) |
| PT (1) | PT2638176T (el) |
| RS (1) | RS56402B1 (el) |
| SG (2) | SG190175A1 (el) |
| SI (1) | SI2638176T1 (el) |
| WO (1) | WO2012062325A1 (el) |
| ZA (1) | ZA201303148B (el) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20130102612A (ko) * | 2010-11-09 | 2013-09-17 | ?티백트 에이/에스 | 모체 혈액에서 태아 세포의 농화 및 확인 및 이러한 용도의 리간드 |
| WO2014067528A1 (en) | 2012-10-29 | 2014-05-08 | Arcedi Biotech Aps | Improved enrichment and detection of rare blood cells |
| US20160377624A1 (en) * | 2014-02-05 | 2016-12-29 | Fujirebio Diagnostics Ab | Composition and method for detecting malignant neoplastic disease |
| CN106537144A (zh) * | 2014-08-05 | 2017-03-22 | 富士胶片株式会社 | 有核红血球的分选方法 |
| CA2974373A1 (en) * | 2015-01-23 | 2016-07-28 | Unimed Biotech (Shanghai) Co., Ltd. | Microfluidics based fetal cell detection and isolation for non-invasive prenatal testing |
| CN104977284B (zh) * | 2015-07-03 | 2018-05-29 | 石莹 | 一种胎儿有核红细胞的捕获及鉴定方法 |
| CN107475353A (zh) * | 2016-06-08 | 2017-12-15 | 益善生物技术股份有限公司 | 肺癌组织溯源ctc分型鉴定试剂盒 |
| CN107475354A (zh) * | 2016-06-08 | 2017-12-15 | 益善生物技术股份有限公司 | 前列腺癌组织溯源ctc分型鉴定试剂盒 |
| CN107475358A (zh) * | 2016-06-08 | 2017-12-15 | 益善生物技术股份有限公司 | 结直肠癌组织溯源ctc分型鉴定试剂盒 |
| US20180299442A1 (en) * | 2017-04-14 | 2018-10-18 | Jennifer C. Chow | Enrichment and identification of fetal material |
| CN111122520A (zh) * | 2018-10-31 | 2020-05-08 | 四川大学华西第二医院 | 一种胚胎植入检测试剂盒及其应用和使用方法 |
| WO2020158824A1 (ja) | 2019-01-30 | 2020-08-06 | 大日本印刷株式会社 | 小腸上皮細胞を含む細胞構造物、その製造のための方法、及び、それを保持する基材 |
| KR20220047929A (ko) * | 2019-06-07 | 2022-04-19 | 아크에디 바이오테크 에이피에스 | Facs를 사용하는 태아 세포의 분리 |
| EP4165416A1 (en) | 2020-06-10 | 2023-04-19 | Board of Regents, The University of Texas System | Method for determining risk of pre-term birth |
| WO2023104773A1 (en) * | 2021-12-06 | 2023-06-15 | Arcedi Biotech Aps | Isolation and diagnostics of fetal cells |
| CN115109780A (zh) * | 2022-06-22 | 2022-09-27 | 湖南大学 | 一种特异性识别并结合循环胎儿有核红细胞的核酸适体、互补序列及它们的应用 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5641628A (en) | 1989-11-13 | 1997-06-24 | Children's Medical Center Corporation | Non-invasive method for isolation and detection of fetal DNA |
| EP0662152A1 (en) | 1992-07-17 | 1995-07-12 | Aprogenex, Inc. | Enriching and identyfying fetal cells in maternal blood for in situ hybridization |
| US5629147A (en) | 1992-07-17 | 1997-05-13 | Aprogenex, Inc. | Enriching and identifying fetal cells in maternal blood for in situ hybridization |
| US5714325A (en) * | 1993-09-24 | 1998-02-03 | New England Medical Center Hospitals | Prenatal diagnosis by isolation of fetal granulocytes from maternal blood |
| GB0009179D0 (en) | 2000-04-13 | 2000-05-31 | Imp College Innovations Ltd | Non-invasive prenatal diagnosis |
| WO2001088100A1 (fr) * | 2000-05-16 | 2001-11-22 | Kyowa Hakko Kogyo Co., Ltd. | Nouvelle methode permettant de declencher une differentiation de cellules embryonnaires dans des cellules de l'ectoderme et leurs applications |
| US20030148295A1 (en) | 2001-03-20 | 2003-08-07 | Wan Jackson Shek-Lam | Expression profiles and methods of use |
| US8338113B2 (en) * | 2007-05-01 | 2012-12-25 | Tel Hashomer Medical Research Infrastructure And Services Ltd. | Methods for detecting fetal cells in the maternal blood |
| EP2250497B1 (en) | 2008-02-18 | 2014-09-10 | Genetic Technologies Limited | Cell processing and/or enrichment methods |
| ES2533861T3 (es) * | 2009-01-07 | 2015-04-15 | Arcedi Biotech Aps | Enriquecimiento e identificación de células fetales en sangre materna y ligandos para tal uso |
| EP2389455A4 (en) | 2009-01-26 | 2012-12-05 | Verinata Health Inc | METHODS AND COMPOSITIONS FOR IDENTIFYING A FETAL CELL |
| WO2010121315A1 (en) | 2009-04-22 | 2010-10-28 | Clinical Genomics Pty. Ltd. | Method and apparatus for isolating a target bioentity from a biological sample |
| KR20130102612A (ko) * | 2010-11-09 | 2013-09-17 | ?티백트 에이/에스 | 모체 혈액에서 태아 세포의 농화 및 확인 및 이러한 용도의 리간드 |
-
2011
- 2011-11-09 KR KR1020137014118A patent/KR20130102612A/ko not_active Application Discontinuation
- 2011-11-09 EA EA201390638A patent/EA027314B1/ru unknown
- 2011-11-09 RS RS20170977A patent/RS56402B1/sr unknown
- 2011-11-09 CN CN201180056239.5A patent/CN103261439B/zh active Active
- 2011-11-09 WO PCT/DK2011/050423 patent/WO2012062325A1/en active Application Filing
- 2011-11-09 SG SG2013034756A patent/SG190175A1/en unknown
- 2011-11-09 SG SG10201509230VA patent/SG10201509230VA/en unknown
- 2011-11-09 SI SI201131305T patent/SI2638176T1/en unknown
- 2011-11-09 US US13/883,455 patent/US9429520B2/en active Active
- 2011-11-09 JP JP2013538070A patent/JP6068354B2/ja active Active
- 2011-11-09 ES ES11785308.5T patent/ES2642313T3/es active Active
- 2011-11-09 PT PT117853085T patent/PT2638176T/pt unknown
- 2011-11-09 PL PL11785308T patent/PL2638176T3/pl unknown
- 2011-11-09 DK DK11785308.5T patent/DK2638176T3/da active
- 2011-11-09 HU HUE11785308A patent/HUE034937T2/en unknown
- 2011-11-09 KR KR1020187009057A patent/KR102057931B1/ko active IP Right Grant
- 2011-11-09 CA CA2817390A patent/CA2817390C/en active Active
- 2011-11-09 LT LTEP11785308.5T patent/LT2638176T/lt unknown
- 2011-11-09 EP EP11785308.5A patent/EP2638176B1/en active Active
-
2013
- 2013-04-30 ZA ZA2013/03148A patent/ZA201303148B/en unknown
- 2013-05-06 IL IL226188A patent/IL226188A/en active IP Right Grant
-
2016
- 2016-12-22 JP JP2016249311A patent/JP6310540B2/ja active Active
-
2017
- 2017-10-02 HR HRP20171468TT patent/HRP20171468T1/hr unknown
- 2017-10-31 CY CY20171101136T patent/CY1119526T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2017060525A (ja) | 2017-03-30 |
| IL226188A (en) | 2017-08-31 |
| CA2817390C (en) | 2021-02-09 |
| PL2638176T3 (pl) | 2018-01-31 |
| US20130331284A1 (en) | 2013-12-12 |
| KR20130102612A (ko) | 2013-09-17 |
| HRP20171468T1 (hr) | 2017-12-15 |
| EP2638176A1 (en) | 2013-09-18 |
| JP2014503193A (ja) | 2014-02-13 |
| JP6310540B2 (ja) | 2018-04-11 |
| HUE034937T2 (en) | 2018-03-28 |
| SG10201509230VA (en) | 2015-12-30 |
| KR20180037308A (ko) | 2018-04-11 |
| PT2638176T (pt) | 2017-10-17 |
| EP2638176B1 (en) | 2017-08-23 |
| WO2012062325A1 (en) | 2012-05-18 |
| EA201390638A1 (ru) | 2013-09-30 |
| RS56402B1 (sr) | 2018-01-31 |
| CN103261439A (zh) | 2013-08-21 |
| KR102057931B1 (ko) | 2019-12-20 |
| SI2638176T1 (en) | 2018-01-31 |
| ES2642313T3 (es) | 2017-11-16 |
| JP6068354B2 (ja) | 2017-01-25 |
| ZA201303148B (en) | 2014-01-29 |
| DK2638176T3 (da) | 2017-11-20 |
| CA2817390A1 (en) | 2012-05-18 |
| US9429520B2 (en) | 2016-08-30 |
| LT2638176T (lt) | 2017-11-27 |
| CN103261439B (zh) | 2015-04-15 |
| SG190175A1 (en) | 2013-06-28 |
| EA027314B1 (ru) | 2017-07-31 |
| IL226188A0 (en) | 2013-07-31 |
| EA201390638A8 (ru) | 2014-01-30 |
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