SG10201509230VA - Enrichment And Identification Of Fetal Cells In Maternal Blood And Ligands For Such Use - Google Patents

Enrichment And Identification Of Fetal Cells In Maternal Blood And Ligands For Such Use

Info

Publication number
SG10201509230VA
SG10201509230VA SG10201509230VA SG10201509230VA SG10201509230VA SG 10201509230V A SG10201509230V A SG 10201509230VA SG 10201509230V A SG10201509230V A SG 10201509230VA SG 10201509230V A SG10201509230V A SG 10201509230VA SG 10201509230V A SG10201509230V A SG 10201509230VA
Authority
SG
Singapore
Prior art keywords
enrichment
ligands
identification
fetal cells
maternal blood
Prior art date
Application number
SG10201509230VA
Inventor
Andreas Eckelt
Britta Christensen
Steen Kølvraa
Marie Brinch
Ripudamen Singh
Lotte Hatt
Original Assignee
Arcedi Biotech Aps
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arcedi Biotech Aps filed Critical Arcedi Biotech Aps
Publication of SG10201509230VA publication Critical patent/SG10201509230VA/en

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6811Selection methods for production or design of target specific oligonucleotides or binding molecules
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6881Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/6486Measuring fluorescence of biological material, e.g. DNA, RNA, cells
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966Animal cells
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6806Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/156Polymorphic or mutational markers
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701Details
    • G01N2333/4742Keratin; Cytokeratin
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70596Molecules with a "CD"-designation not provided for elsewhere in G01N2333/705

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
SG10201509230VA 2010-11-09 2011-11-09 Enrichment And Identification Of Fetal Cells In Maternal Blood And Ligands For Such Use SG10201509230VA (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DKPA201001018 2010-11-09

Publications (1)

Publication Number Publication Date
SG10201509230VA true SG10201509230VA (en) 2015-12-30

Family

ID=45001595

Family Applications (2)

Application Number Title Priority Date Filing Date
SG2013034756A SG190175A1 (en) 2010-11-09 2011-11-09 Enrichment and identification of fetal cells in maternal blood and ligands for such use
SG10201509230VA SG10201509230VA (en) 2010-11-09 2011-11-09 Enrichment And Identification Of Fetal Cells In Maternal Blood And Ligands For Such Use

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SG2013034756A SG190175A1 (en) 2010-11-09 2011-11-09 Enrichment and identification of fetal cells in maternal blood and ligands for such use

Country Status (21)

Country Link
US (1) US9429520B2 (en)
EP (1) EP2638176B1 (en)
JP (2) JP6068354B2 (en)
KR (2) KR20130102612A (en)
CN (1) CN103261439B (en)
CA (1) CA2817390C (en)
CY (1) CY1119526T1 (en)
DK (1) DK2638176T3 (en)
EA (1) EA027314B1 (en)
ES (1) ES2642313T3 (en)
HR (1) HRP20171468T1 (en)
HU (1) HUE034937T2 (en)
IL (1) IL226188A (en)
LT (1) LT2638176T (en)
PL (1) PL2638176T3 (en)
PT (1) PT2638176T (en)
RS (1) RS56402B1 (en)
SG (2) SG190175A1 (en)
SI (1) SI2638176T1 (en)
WO (1) WO2012062325A1 (en)
ZA (1) ZA201303148B (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2817390C (en) * 2010-11-09 2021-02-09 Quantibact A/S Enrichment and identification of fetal cells in maternal blood and ligands for such use
WO2014067528A1 (en) 2012-10-29 2014-05-08 Arcedi Biotech Aps Improved enrichment and detection of rare blood cells
DK3102600T3 (en) * 2014-02-05 2019-04-01 Fujirebio Diagnostics Ab COMPOSITION AND PROCEDURE FOR DETECTIVE DEPARTURAL NEOPLASTIC DISEASE
JP6312835B2 (en) * 2014-08-05 2018-04-18 富士フイルム株式会社 Method for sorting nucleated red blood cells
EP3247789A4 (en) * 2015-01-23 2018-09-12 Unimed Biotech (Shanghai) Co., Ltd. Microfluidics based fetal cell detection and isolation for non-invasive prenatal testing
CN104977284B (en) * 2015-07-03 2018-05-29 石莹 A kind of capture of fetal nucleated red blood and identification method
CN107475353A (en) * 2016-06-08 2017-12-15 益善生物技术股份有限公司 Cancerous lung tissue is traced to the source CTC Classification Identification kits
CN107475354A (en) * 2016-06-08 2017-12-15 益善生物技术股份有限公司 Prostate cancer tissue is traced to the source CTC Classification Identification kits
CN107475358A (en) * 2016-06-08 2017-12-15 益善生物技术股份有限公司 Colorectal Carcinoma is traced to the source CTC Classification Identification kits
WO2018191194A1 (en) * 2017-04-14 2018-10-18 Rarecyte, Inc. Enrichment and identification of fetal material
CN111122520A (en) * 2018-10-31 2020-05-08 四川大学华西第二医院 Embryo implantation detection kit and application and use method thereof
AU2020289708A1 (en) * 2019-06-07 2022-01-20 Arcedi Biotech Aps Isolation of fetal cells using FACS
CN116137894A (en) 2020-06-10 2023-05-19 德州大学系统董事会 Method for determining risk of premature delivery
WO2023104773A1 (en) * 2021-12-06 2023-06-15 Arcedi Biotech Aps Isolation and diagnostics of fetal cells

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5641628A (en) 1989-11-13 1997-06-24 Children's Medical Center Corporation Non-invasive method for isolation and detection of fetal DNA
EP0662152A1 (en) 1992-07-17 1995-07-12 Aprogenex, Inc. Enriching and identyfying fetal cells in maternal blood for in situ hybridization
US5629147A (en) 1992-07-17 1997-05-13 Aprogenex, Inc. Enriching and identifying fetal cells in maternal blood for in situ hybridization
US5714325A (en) * 1993-09-24 1998-02-03 New England Medical Center Hospitals Prenatal diagnosis by isolation of fetal granulocytes from maternal blood
GB0009179D0 (en) * 2000-04-13 2000-05-31 Imp College Innovations Ltd Non-invasive prenatal diagnosis
AU5676701A (en) 2000-05-16 2001-11-26 Kyowa Hakko Kogyo Co. Ltd. Novel method of inducing the differentiation of embryonic stem cells into ectodermal cells and use thereof
WO2002074979A2 (en) * 2001-03-20 2002-09-26 Ortho-Clinical Diagnostics, Inc. Expression profiles and methods of use
US8338113B2 (en) 2007-05-01 2012-12-25 Tel Hashomer Medical Research Infrastructure And Services Ltd. Methods for detecting fetal cells in the maternal blood
EP2250497B1 (en) 2008-02-18 2014-09-10 Genetic Technologies Limited Cell processing and/or enrichment methods
DK2385992T3 (en) 2009-01-07 2015-04-07 Arcedi Biotech Aps Enriching and identifying fetal cells in maternal blood and ligand for such use
WO2010085815A1 (en) 2009-01-26 2010-07-29 Artemis Health, Inc. Methods and compositions for identifying a fetal cell
CN102458665A (en) 2009-04-22 2012-05-16 临床基因组学股份有限公司 Method and apparatus for isolating a target bioentity from a biological sample
CA2817390C (en) * 2010-11-09 2021-02-09 Quantibact A/S Enrichment and identification of fetal cells in maternal blood and ligands for such use

Also Published As

Publication number Publication date
EA027314B1 (en) 2017-07-31
JP6310540B2 (en) 2018-04-11
RS56402B1 (en) 2018-01-31
ES2642313T3 (en) 2017-11-16
SG190175A1 (en) 2013-06-28
IL226188A0 (en) 2013-07-31
WO2012062325A1 (en) 2012-05-18
US9429520B2 (en) 2016-08-30
PL2638176T3 (en) 2018-01-31
IL226188A (en) 2017-08-31
SI2638176T1 (en) 2018-01-31
EA201390638A8 (en) 2014-01-30
EA201390638A1 (en) 2013-09-30
JP2017060525A (en) 2017-03-30
KR20180037308A (en) 2018-04-11
JP6068354B2 (en) 2017-01-25
CN103261439B (en) 2015-04-15
KR20130102612A (en) 2013-09-17
JP2014503193A (en) 2014-02-13
PT2638176T (en) 2017-10-17
ZA201303148B (en) 2014-01-29
CA2817390A1 (en) 2012-05-18
EP2638176B1 (en) 2017-08-23
CN103261439A (en) 2013-08-21
DK2638176T3 (en) 2017-11-20
US20130331284A1 (en) 2013-12-12
HUE034937T2 (en) 2018-03-28
CA2817390C (en) 2021-02-09
KR102057931B1 (en) 2019-12-20
LT2638176T (en) 2017-11-27
CY1119526T1 (en) 2018-03-07
HRP20171468T1 (en) 2017-12-15
EP2638176A1 (en) 2013-09-18

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