WO2005038419A8 - A method and device for detecting small numbers of molecules using surface-enhanced coherent anti-stokes raman spectroscopy - Google Patents

A method and device for detecting small numbers of molecules using surface-enhanced coherent anti-stokes raman spectroscopy

Info

Publication number
WO2005038419A8
WO2005038419A8 PCT/US2004/034598 US2004034598W WO2005038419A8 WO 2005038419 A8 WO2005038419 A8 WO 2005038419A8 US 2004034598 W US2004034598 W US 2004034598W WO 2005038419 A8 WO2005038419 A8 WO 2005038419A8
Authority
WO
WIPO (PCT)
Prior art keywords
raman spectroscopy
coherent anti
stokes raman
molecules
small numbers
Prior art date
Application number
PCT/US2004/034598
Other languages
French (fr)
Other versions
WO2005038419A3 (en
WO2005038419A2 (en
Inventor
Tae-Woong Koo
Christopher Gerth
Mineo Yamakawa
Original Assignee
Intel Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/688,680 external-priority patent/US20050084980A1/en
Application filed by Intel Corp filed Critical Intel Corp
Priority to JP2006535446A priority Critical patent/JP2007509322A/en
Priority to GB0609804A priority patent/GB2423579B/en
Priority to DE112004001972T priority patent/DE112004001972T5/en
Publication of WO2005038419A2 publication Critical patent/WO2005038419A2/en
Publication of WO2005038419A8 publication Critical patent/WO2005038419A8/en
Publication of WO2005038419A3 publication Critical patent/WO2005038419A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering
    • G01N21/658—Raman scattering enhancement Raman, e.g. surface plasmons
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/28—Investigating the spectrum
    • G01J3/44—Raman spectrometry; Scattering spectrometry ; Fluorescence spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering
    • G01N2021/653—Coherent methods [CARS]

Abstract

The device and method disclosed herein concern detecting, identifying, and or quantifying analytes, such as nucleic acids, with high resolution and fast response times using surface enhanced coherent anti-Stokes Raman spectroscopy. In certain embodiments of the invention, a small number molecular sample of the analyte (210) such as a nucleotide, passes through a microfluidic channel, microchannel, or nanochannel (185) and sample cell (175) that contains Raman-active surfaces, and is detected by surface enhanced, coherent anti-Stokes Raman spectroscopy (SECARS). Other embodiments of the invention concern an apparatus for analyte detection.
PCT/US2004/034598 2003-10-17 2004-10-18 A method and device for detecting small numbers of molecules using surface-enhanced coherent anti-stokes raman spectroscopy WO2005038419A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2006535446A JP2007509322A (en) 2003-10-17 2004-10-18 Method and apparatus for detecting small numbers of molecules using surface-sensitized coherent anti-Stokes Raman spectroscopy
GB0609804A GB2423579B (en) 2003-10-17 2004-10-18 A method and device for detecting small numbers of molecules using surface-enhanced coherent anti-stokes raman spectroscopy
DE112004001972T DE112004001972T5 (en) 2003-10-17 2004-10-18 A method and apparatus for detecting small numbers of molecules using surface enhanced coherent anti-Stokes Raman spectroscopy

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US10/688,680 2003-10-17
US10/688,680 US20050084980A1 (en) 2003-10-17 2003-10-17 Method and device for detecting a small number of molecules using surface-enhanced coherant anti-stokes raman spectroscopy
US10/966,893 US20050110990A1 (en) 2003-10-17 2004-10-15 Method and device for detecting small numbers of molecules using surface-enhanced coherent anti-Stokes Raman spectroscopy
US10/966,893 2004-10-15

Publications (3)

Publication Number Publication Date
WO2005038419A2 WO2005038419A2 (en) 2005-04-28
WO2005038419A8 true WO2005038419A8 (en) 2005-06-30
WO2005038419A3 WO2005038419A3 (en) 2005-09-22

Family

ID=34713881

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/034598 WO2005038419A2 (en) 2003-10-17 2004-10-18 A method and device for detecting small numbers of molecules using surface-enhanced coherent anti-stokes raman spectroscopy

Country Status (4)

Country Link
JP (1) JP2007509322A (en)
DE (1) DE112004001972T5 (en)
GB (1) GB2423579B (en)
WO (1) WO2005038419A2 (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4749805B2 (en) * 2005-09-05 2011-08-17 オリンパスメディカルシステムズ株式会社 Raman scattered light observation system
DE102006053540B3 (en) * 2006-11-14 2008-01-31 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Optospectroscopic analysis of biological sample in fluid, comprises: fixing the biological sample in a sample holding unit, categorizing particles in biological sample based on an analysis of the image data and analyzing biological sample
DE102007021544A1 (en) * 2007-05-08 2008-11-13 Siemens Ag Measuring unit and method for optically examining a liquid for an analyte concentration
JP2009031023A (en) * 2007-07-25 2009-02-12 Keio Gijuku Production method of substrate for surface enhanced raman spectroscopic analysis, manufacturing method of micro-tas, and the micro-tas
DE102008010435B4 (en) * 2008-02-21 2010-07-29 Tecan Trading Ag Data acquisition procedure with a laser scanner device
JP4618341B2 (en) * 2008-06-26 2011-01-26 ソニー株式会社 A method for measuring the amount of substances in a living body using coherent anti-Stokes Raman scattering light
DE102011016059B4 (en) 2011-04-01 2019-02-21 Friedrich-Schiller-Universität Jena Method for correcting Raman spectroscopic data in a multiphase system
US10132755B2 (en) 2012-08-10 2018-11-20 Hamamatsu Photonics K.K. Surface-enhanced Raman scattering element, and method for manufacturing surface-enhanced Raman scattering element
JP5908370B2 (en) 2012-08-10 2016-04-26 浜松ホトニクス株式会社 Surface-enhanced Raman scattering unit
DE102012216164B4 (en) * 2012-09-12 2016-04-28 Forschungsverbund Berlin E.V. Device with an arrangement of optical elements
JP5655125B2 (en) * 2013-10-09 2015-01-14 富士フイルム株式会社 Fluorescence detection method
DE102016101001B4 (en) * 2016-01-21 2019-07-11 Leibniz - Institut Für Analytische Wissenschaften - Isas - E.V. Device for the detection and characterization of organic molecules in a liquid sample volume
DE102016111747B4 (en) 2016-06-27 2020-10-01 Forschungsverbund Berlin E.V. Method and device for Raman spectroscopy
DE102016118898B4 (en) 2016-10-05 2022-03-17 Ferdinand-Braun-Institut gGmbH, Leibniz- Institut für Höchstfrequenztechnik Optical system and method for spectroscopy
DE102019106194B4 (en) * 2019-03-12 2020-12-03 Surflay Nanotec Gmbh Device for the spectroscopic determination of the binding kinetics of an analyte
CN110433878B (en) * 2019-08-21 2021-06-25 北京工业大学 Liquid detection chip based on VCSEL coupling array optical phase difference
DE102021208185A1 (en) 2021-07-29 2023-02-02 Carl Zeiss Microscopy Gmbh Sample carrier and its use as well as methods, in particular for the detection of pathogens

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7476501B2 (en) * 2002-03-26 2009-01-13 Intel Corporation Methods and device for DNA sequencing using surface enhanced raman scattering (SERS)
US7361313B2 (en) * 2003-02-18 2008-04-22 Intel Corporation Methods for uniform metal impregnation into a nanoporous material
US6970239B2 (en) * 2002-06-12 2005-11-29 Intel Corporation Metal coated nanocrystalline silicon as an active surface enhanced Raman spectroscopy (SERS) substrate

Also Published As

Publication number Publication date
WO2005038419A3 (en) 2005-09-22
GB0609804D0 (en) 2006-06-28
GB2423579B (en) 2008-04-09
WO2005038419A2 (en) 2005-04-28
JP2007509322A (en) 2007-04-12
DE112004001972T5 (en) 2006-08-17
GB2423579A (en) 2006-08-30

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