ATE423106T1 - Verfahren zur kristallisation von n-(1(s)- ethoxycarbonyl-3-phenylpropyl)-l-alanin n- carbonsäureanhydrid - Google Patents
Verfahren zur kristallisation von n-(1(s)- ethoxycarbonyl-3-phenylpropyl)-l-alanin n- carbonsäureanhydridInfo
- Publication number
- ATE423106T1 ATE423106T1 AT01930174T AT01930174T ATE423106T1 AT E423106 T1 ATE423106 T1 AT E423106T1 AT 01930174 T AT01930174 T AT 01930174T AT 01930174 T AT01930174 T AT 01930174T AT E423106 T1 ATE423106 T1 AT E423106T1
- Authority
- AT
- Austria
- Prior art keywords
- phenylpropyl
- ethoxycarbonyl
- alanine
- crystallization
- acid anhydride
- Prior art date
Links
- CEIWXEQZZZHLDM-AAEUAGOBSA-N (2s)-2-[[(2s)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoic acid Chemical compound CCOC(=O)[C@@H](N[C@@H](C)C(O)=O)CCC1=CC=CC=C1 CEIWXEQZZZHLDM-AAEUAGOBSA-N 0.000 title abstract 3
- 238000002425 crystallisation Methods 0.000 title abstract 3
- 230000008025 crystallization Effects 0.000 title abstract 3
- 238000000034 method Methods 0.000 title 1
- 239000002904 solvent Substances 0.000 abstract 4
- 150000001338 aliphatic hydrocarbons Chemical class 0.000 abstract 2
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/44—Two oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2000141717 | 2000-05-15 | ||
| JP2000330339 | 2000-10-30 | ||
| JP2000352892 | 2000-11-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE423106T1 true ATE423106T1 (de) | 2009-03-15 |
Family
ID=27343377
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01930174T ATE423106T1 (de) | 2000-05-15 | 2001-05-15 | Verfahren zur kristallisation von n-(1(s)- ethoxycarbonyl-3-phenylpropyl)-l-alanin n- carbonsäureanhydrid |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US6784310B2 (de) |
| EP (1) | EP1283204B1 (de) |
| JP (1) | JP4149706B2 (de) |
| KR (1) | KR100527648B1 (de) |
| CN (1) | CN1184213C (de) |
| AT (1) | ATE423106T1 (de) |
| AU (1) | AU5675801A (de) |
| CZ (1) | CZ2002532A3 (de) |
| DE (1) | DE60137686D1 (de) |
| ES (1) | ES2320413T3 (de) |
| HR (1) | HRP20020122A2 (de) |
| HU (1) | HUP0202516A3 (de) |
| IS (1) | IS6224A (de) |
| PL (1) | PL351841A1 (de) |
| SI (1) | SI20817A (de) |
| TW (1) | TW527351B (de) |
| WO (1) | WO2001087858A1 (de) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100487029C (zh) | 2003-08-29 | 2009-05-13 | 积水化成品工业株式会社 | 聚烯烃系树脂改性的聚苯乙烯系树脂的预发泡粒子及其制备方法和发泡成形体 |
| JP4852282B2 (ja) * | 2005-08-29 | 2012-01-11 | 保土谷化学工業株式会社 | Ｎ−カルボン酸無水物の製造方法 |
| CN101293887A (zh) * | 2007-04-26 | 2008-10-29 | 中国科学院福建物质结构研究所 | 一种高纯度环状硫酸酯的纯化方法 |
| JP2011016790A (ja) | 2009-06-08 | 2011-01-27 | Sumitomo Chemical Co Ltd | ピラゾリノン誘導体の精製方法 |
| WO2014202659A1 (en) | 2013-06-21 | 2014-12-24 | Sanofi-Aventis Deutschland Gmbh | Process for the preparation of amides of n-[1-(s)-(ethoxycarbonyl)-3-phenylpropyl]-l-alanine |
| WO2020064904A1 (en) | 2018-09-28 | 2020-04-02 | Lonza Ltd | Method for preparation of n-carboxyanhydrides |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4496542A (en) | 1981-03-30 | 1985-01-29 | Usv Pharmaceutical Corporation | N-substituted-amido-amino acids |
| US4831184A (en) * | 1981-03-30 | 1989-05-16 | Rorer Pharmaceutical Corporation | N-substituted-amido-amino acids |
| JPS6248696A (ja) | 1985-08-27 | 1987-03-03 | Kanegafuchi Chem Ind Co Ltd | Ｎ−〔１（ｓ）−エトキシカルボニル−３−フエニルプロピル〕−ｌ−アラニル−ｌ−プロリンの製造法 |
| SI9200213A (en) | 1992-09-16 | 1994-03-31 | Krka | Process for preparing alkyl-l-alanil-l-proline derivates |
| EP0668859B1 (de) | 1992-11-13 | 1997-02-26 | E.I. Du Pont De Nemours And Company | Verfahren zur herstellung von 2,4-oxazolidinedionen |
| IN184759B (de) * | 1997-07-22 | 2000-09-23 | Kaneka Corp | |
| JP4505917B2 (ja) | 1999-01-22 | 2010-07-21 | 田辺三菱製薬株式会社 | 新規微生物およびそれを用いるｌ−アミノ酸の製法 |
-
2001
- 2001-05-15 DE DE60137686T patent/DE60137686D1/de not_active Expired - Lifetime
- 2001-05-15 AT AT01930174T patent/ATE423106T1/de active
- 2001-05-15 KR KR10-2002-7000541A patent/KR100527648B1/ko not_active Expired - Fee Related
- 2001-05-15 CN CNB018012582A patent/CN1184213C/zh not_active Expired - Lifetime
- 2001-05-15 PL PL01351841A patent/PL351841A1/xx not_active IP Right Cessation
- 2001-05-15 AU AU56758/01A patent/AU5675801A/en not_active Abandoned
- 2001-05-15 WO PCT/JP2001/004059 patent/WO2001087858A1/ja not_active Ceased
- 2001-05-15 TW TW090111623A patent/TW527351B/zh not_active IP Right Cessation
- 2001-05-15 HU HU0202516A patent/HUP0202516A3/hu unknown
- 2001-05-15 HR HR20020122A patent/HRP20020122A2/hr not_active Application Discontinuation
- 2001-05-15 JP JP2001584254A patent/JP4149706B2/ja not_active Expired - Fee Related
- 2001-05-15 US US10/019,318 patent/US6784310B2/en not_active Expired - Fee Related
- 2001-05-15 CZ CZ2002532A patent/CZ2002532A3/cs unknown
- 2001-05-15 ES ES01930174T patent/ES2320413T3/es not_active Expired - Lifetime
- 2001-05-15 EP EP01930174A patent/EP1283204B1/de not_active Expired - Lifetime
- 2001-05-15 SI SI200120002A patent/SI20817A/sl not_active IP Right Cessation
-
2002
- 2002-01-09 IS IS6224A patent/IS6224A/is unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HUP0202516A3 (en) | 2003-04-28 |
| HUP0202516A2 (hu) | 2003-01-28 |
| HRP20020122A2 (en) | 2003-04-30 |
| PL351841A1 (en) | 2003-06-16 |
| CZ2002532A3 (cs) | 2002-05-15 |
| EP1283204A4 (de) | 2007-09-05 |
| KR20020038689A (ko) | 2002-05-23 |
| WO2001087858A1 (en) | 2001-11-22 |
| AU5675801A (en) | 2001-11-26 |
| KR100527648B1 (ko) | 2005-11-09 |
| SI20817A (sl) | 2002-08-31 |
| EP1283204A1 (de) | 2003-02-12 |
| CN1380881A (zh) | 2002-11-20 |
| EP1283204B1 (de) | 2009-02-18 |
| DE60137686D1 (de) | 2009-04-02 |
| JP4149706B2 (ja) | 2008-09-17 |
| IS6224A (is) | 2002-01-09 |
| TW527351B (en) | 2003-04-11 |
| US6784310B2 (en) | 2004-08-31 |
| ES2320413T3 (es) | 2009-05-22 |
| US20020137944A1 (en) | 2002-09-26 |
| CN1184213C (zh) | 2005-01-12 |
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| UEP | Publication of translation of european patent specification |
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