ATE375979T1 - Verfahren zur herstellung von amlodipin - Google Patents

Verfahren zur herstellung von amlodipin

Info

Publication number
ATE375979T1
ATE375979T1 AT02705570T AT02705570T ATE375979T1 AT E375979 T1 ATE375979 T1 AT E375979T1 AT 02705570 T AT02705570 T AT 02705570T AT 02705570 T AT02705570 T AT 02705570T AT E375979 T1 ATE375979 T1 AT E375979T1
Authority
AT
Austria
Prior art keywords
amlodipine
pyrrole
derivative
producing amlodipine
producing
Prior art date
Application number
AT02705570T
Other languages
English (en)
Inventor
Young Ho Moon
Nam Du Kim
Kyung Ik Lee
Gwan Sun Lee
Original Assignee
Hanmi Pharm Ind Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hanmi Pharm Ind Co Ltd filed Critical Hanmi Pharm Ind Co Ltd
Application granted granted Critical
Publication of ATE375979T1 publication Critical patent/ATE375979T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/325—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
AT02705570T 2001-03-13 2002-03-13 Verfahren zur herstellung von amlodipin ATE375979T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR10-2001-0012858A KR100374767B1 (ko) 2001-03-13 2001-03-13 개선된 암로디핀의 제조 방법

Publications (1)

Publication Number Publication Date
ATE375979T1 true ATE375979T1 (de) 2007-11-15

Family

ID=19706839

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02705570T ATE375979T1 (de) 2001-03-13 2002-03-13 Verfahren zur herstellung von amlodipin

Country Status (9)

Country Link
US (1) US6492523B2 (de)
EP (1) EP1368315B1 (de)
JP (1) JP4031366B2 (de)
KR (1) KR100374767B1 (de)
CN (1) CN1229348C (de)
AT (1) ATE375979T1 (de)
DE (1) DE60223003T2 (de)
ES (1) ES2291443T3 (de)
WO (1) WO2002072552A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100374767B1 (ko) * 2001-03-13 2003-03-03 한미약품공업 주식회사 개선된 암로디핀의 제조 방법
JP5678438B2 (ja) * 2010-03-05 2015-03-04 国立大学法人名古屋大学 ピロールの製造方法
CN102070516A (zh) * 2011-02-22 2011-05-25 广东东阳光药业有限公司 一种制备氨氯地平的方法
CN102659673A (zh) * 2012-05-07 2012-09-12 山东新华制药股份有限公司 氨氯地平自由碱的制备方法
CN103044316A (zh) * 2013-01-23 2013-04-17 石家庄学院 一种以咪唑离子液体为催化剂制备1,4-二氢吡啶的方法
CN115536577B (zh) * 2022-11-09 2024-04-30 浙江昂利康制药股份有限公司 一种氨氯地平碱的制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK161312C (da) * 1982-03-11 1991-12-09 Pfizer Analogifremgangsmaade til fremstilling af 2-aminoalkoxymethyl-4-phenyl-6-methyl-1,4-dihydropyridin-3,5-dicarboxylsyreestere eller syreadditionssalte deraf samt phthalimidoderivater til anvendelse som udgangsmateriale ved fremgangsmaaden
US4515799A (en) * 1983-02-02 1985-05-07 Pfizer Inc. Dihydropyridine anti-ischaemic and antihypertensive agents
US5389654A (en) * 1992-11-26 1995-02-14 Lek, Tovarna, Farmacevtskih In Kemicnih . . . 3-ethyl 5-methyl(±)2-[2-(N-tritylamino)ethoxymethyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-6-methyl-3,5-pyridinedicarboxylate
KR100217240B1 (ko) * 1996-10-31 1999-09-01 조생현 암로디핀 베실레이트의 제조방법
KR200151609Y1 (ko) * 1996-11-30 1999-07-15 양재신 차량용 컴팩트 디스크 박스
EP1017113B1 (de) * 1997-01-09 2012-08-22 Nichia Corporation Halbleiteranordnung aus einer nitridverbindung
HU221810B1 (hu) * 1997-08-12 2003-01-28 EGIS Gyógyszergyár Rt. Eljárás amlodipin-bezilát előállítására és az eljárás intermedierjei
KR100374767B1 (ko) * 2001-03-13 2003-03-03 한미약품공업 주식회사 개선된 암로디핀의 제조 방법

Also Published As

Publication number Publication date
CN1229348C (zh) 2005-11-30
EP1368315A4 (de) 2005-02-09
DE60223003T2 (de) 2008-02-07
ES2291443T3 (es) 2008-03-01
EP1368315A1 (de) 2003-12-10
US6492523B2 (en) 2002-12-10
KR20020072847A (ko) 2002-09-19
CN1496353A (zh) 2004-05-12
WO2002072552A1 (en) 2002-09-19
KR100374767B1 (ko) 2003-03-03
US20020132834A1 (en) 2002-09-19
DE60223003D1 (de) 2007-11-29
EP1368315B1 (de) 2007-10-17
JP4031366B2 (ja) 2008-01-09
JP2004523572A (ja) 2004-08-05

Similar Documents

Publication Publication Date Title
ATE334220T1 (de) Verfahren zur herstellung von l-aminosäuren unter verwendung von stämmen der familie enterobacteriaceae
DK0788481T3 (da) Fremgangsmåde til fremstilling af levobupivacain og analoger deraf
ATE375979T1 (de) Verfahren zur herstellung von amlodipin
DE60306667D1 (de) Cefdinir salze als zwischenprodukte
ATE307114T1 (de) Kristalline polymorphe formen von lercanidipin hydrochlorid und verfahren zu deren herstellung
DK0804417T3 (da) Fremgangsmåde til racemisering til brug ved fremstilling af levobupivacain og beslægtede piperidincarboxanilid bedøvelsesmidler
ATE312809T1 (de) Verfahren zur herstellung von gabapentin
DE69622552D1 (de) Verfahren zur herstellung von lercanidipin hydrochlorid
MXPA04004063A (es) Procedimientos para elaboracion de 3-hidroxi-n, 1, 6-trialquil-4 -oxo-1 ,4-dihidropiridin-2 -carboxamida.
ATE283841T1 (de) Verfahren zur herstellung von amlodipin- benzolsulfonat
NO20002490D0 (no) FremgangsmÕte for fremstilling av 1,4-dihydropyridiner og forbindelser anvendt ved denne fremgangsmÕten
DE69907656D1 (de) Polyethoxylierte retinamid-derivate und verfahren zu ihrer herstellung
ATE386021T1 (de) Verfahren zur herstellung des piperidinderivats fexofenadin
DK1049674T3 (da) Fremgangsmåde til fremstilling af (-) cis-3-hydroxy-1-methyl-4-(2,4,6-trimethoxyphenyl) -piperidin
ATE252543T1 (de) Verfahren zur herstellung chiraler (s)-2,3- disubstituierter 1-propylamin-derivate
HUP0002709A1 (hu) Eljárás 1-helyzetben szubsztituált 4-(4-fluor-fenil)-3-(hidroxi-metil)-tetrahidropiridinek redukciójára
DE60105314D1 (de) Verfahren zur herstellung von taxanderivaten
DE50112449D1 (de) Verfahren zur herstellung von 3,3-diarylpropylaminen
WO1998005640A3 (en) Process for the preparation of 3,3-disubstituted piperidines
ATE330927T1 (de) Verfahren zur herstellung von alpha-beta- ungesättigten ketonen
DE60104822D1 (de) Pseudopolymorph von (-)-cis-2-(2-chlorphenyl)-5,7-dihydroxy-8[4r-(3s-hydroxy-1-methyl)piperidinyl]-4h-1-benzopyran-4-on hydrochlorid
ATE421953T1 (de) Verfahren zur racemisierung von 1-benzyl-4-(4- fluorophenyl)-3-hydroxymethyl-1,2,3,6- tetrahydropyridin und dessen verwendung in der synthese von paroxetin
DE60128336D1 (de) Eine zwischenverbindung und verfahren zu deren herstellung
ATE402146T1 (de) Industrielles verfahren zur herstellung isobutylmethyl-1,4-dihydro-2,6-dimethyl-4-(2- nitrobenzol)
DK1163257T3 (da) Fremgangsmåde til fremstilling af 4,4-dimethyl-3beta-hydroxypregna-8,14-dien-21-carboxylsyreestere og mellemprodukter i fremgangsmåden

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties