DE60223003D1 - Verfahren zur herstellung von amlodipin - Google Patents

Verfahren zur herstellung von amlodipin

Info

Publication number
DE60223003D1
DE60223003D1 DE60223003T DE60223003T DE60223003D1 DE 60223003 D1 DE60223003 D1 DE 60223003D1 DE 60223003 T DE60223003 T DE 60223003T DE 60223003 T DE60223003 T DE 60223003T DE 60223003 D1 DE60223003 D1 DE 60223003D1
Authority
DE
Germany
Prior art keywords
amlodipin
preparing
pyrrole
derivative
chlorobenzaldehyde
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60223003T
Other languages
English (en)
Other versions
DE60223003T2 (de
Inventor
Young Ho Moon
Nam Du Kim
Kyung Ik Lee
Gwan Sun Lee
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hanmi Holdings Co Ltd
Original Assignee
Hanmi Pharmaceutical Co Ltd
Hanmi Pharmaceutical Industries Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hanmi Pharmaceutical Co Ltd, Hanmi Pharmaceutical Industries Co Ltd filed Critical Hanmi Pharmaceutical Co Ltd
Application granted granted Critical
Publication of DE60223003D1 publication Critical patent/DE60223003D1/de
Publication of DE60223003T2 publication Critical patent/DE60223003T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/325—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
DE60223003T 2001-03-13 2002-03-13 Verfahren zur herstellung von amlodipin Expired - Lifetime DE60223003T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR2001012858 2001-03-13
KR10-2001-0012858A KR100374767B1 (ko) 2001-03-13 2001-03-13 개선된 암로디핀의 제조 방법
PCT/KR2002/000434 WO2002072552A1 (en) 2001-03-13 2002-03-13 Method for preparing amlodipine

Publications (2)

Publication Number Publication Date
DE60223003D1 true DE60223003D1 (de) 2007-11-29
DE60223003T2 DE60223003T2 (de) 2008-02-07

Family

ID=19706839

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60223003T Expired - Lifetime DE60223003T2 (de) 2001-03-13 2002-03-13 Verfahren zur herstellung von amlodipin

Country Status (9)

Country Link
US (1) US6492523B2 (de)
EP (1) EP1368315B1 (de)
JP (1) JP4031366B2 (de)
KR (1) KR100374767B1 (de)
CN (1) CN1229348C (de)
AT (1) ATE375979T1 (de)
DE (1) DE60223003T2 (de)
ES (1) ES2291443T3 (de)
WO (1) WO2002072552A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100374767B1 (ko) * 2001-03-13 2003-03-03 한미약품공업 주식회사 개선된 암로디핀의 제조 방법
JP5678438B2 (ja) * 2010-03-05 2015-03-04 国立大学法人名古屋大学 ピロールの製造方法
CN102070516A (zh) * 2011-02-22 2011-05-25 广东东阳光药业有限公司 一种制备氨氯地平的方法
CN102659673A (zh) * 2012-05-07 2012-09-12 山东新华制药股份有限公司 氨氯地平自由碱的制备方法
CN103044316A (zh) * 2013-01-23 2013-04-17 石家庄学院 一种以咪唑离子液体为催化剂制备1,4-二氢吡啶的方法
CN115536577B (zh) * 2022-11-09 2024-04-30 浙江昂利康制药股份有限公司 一种氨氯地平碱的制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK161312C (da) * 1982-03-11 1991-12-09 Pfizer Analogifremgangsmaade til fremstilling af 2-aminoalkoxymethyl-4-phenyl-6-methyl-1,4-dihydropyridin-3,5-dicarboxylsyreestere eller syreadditionssalte deraf samt phthalimidoderivater til anvendelse som udgangsmateriale ved fremgangsmaaden
US4515799A (en) * 1983-02-02 1985-05-07 Pfizer Inc. Dihydropyridine anti-ischaemic and antihypertensive agents
US5389654A (en) * 1992-11-26 1995-02-14 Lek, Tovarna, Farmacevtskih In Kemicnih . . . 3-ethyl 5-methyl(±)2-[2-(N-tritylamino)ethoxymethyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-6-methyl-3,5-pyridinedicarboxylate
KR100217240B1 (ko) * 1996-10-31 1999-09-01 조생현 암로디핀 베실레이트의 제조방법
KR200151609Y1 (ko) * 1996-11-30 1999-07-15 양재신 차량용 컴팩트 디스크 박스
EP1017113B1 (de) * 1997-01-09 2012-08-22 Nichia Corporation Halbleiteranordnung aus einer nitridverbindung
HU221810B1 (hu) * 1997-08-12 2003-01-28 EGIS Gyógyszergyár Rt. Eljárás amlodipin-bezilát előállítására és az eljárás intermedierjei
KR100374767B1 (ko) * 2001-03-13 2003-03-03 한미약품공업 주식회사 개선된 암로디핀의 제조 방법

Also Published As

Publication number Publication date
CN1229348C (zh) 2005-11-30
EP1368315A4 (de) 2005-02-09
DE60223003T2 (de) 2008-02-07
ES2291443T3 (es) 2008-03-01
EP1368315A1 (de) 2003-12-10
US6492523B2 (en) 2002-12-10
KR20020072847A (ko) 2002-09-19
CN1496353A (zh) 2004-05-12
WO2002072552A1 (en) 2002-09-19
KR100374767B1 (ko) 2003-03-03
US20020132834A1 (en) 2002-09-19
ATE375979T1 (de) 2007-11-15
EP1368315B1 (de) 2007-10-17
JP4031366B2 (ja) 2008-01-09
JP2004523572A (ja) 2004-08-05

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Legal Events

Date Code Title Description
8381 Inventor (new situation)

Inventor name: MOON, YOUNG HO, PALDAL-GU, 442-470 SUWON-SI, K, KR

Inventor name: KIM, NAM DU, GYEONGGI-DO 445-717, KR

Inventor name: LEE, KYUNG IK, MANAN-GU ANYANG-SI GYEONGGI-DO , KR

Inventor name: LEE, GWAN SUN, SONGPA-GU SEOUL 138-739, KR

8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: HANMI HOLDINGS CO., LTD., SEOUL, KR

R082 Change of representative

Ref document number: 1368315

Country of ref document: EP

Representative=s name: BOEHMERT & BOEHMERT, DE