ATE365538T1 - O/w emulsion - Google Patents
O/w emulsionInfo
- Publication number
- ATE365538T1 ATE365538T1 AT01931897T AT01931897T ATE365538T1 AT E365538 T1 ATE365538 T1 AT E365538T1 AT 01931897 T AT01931897 T AT 01931897T AT 01931897 T AT01931897 T AT 01931897T AT E365538 T1 ATE365538 T1 AT E365538T1
- Authority
- AT
- Austria
- Prior art keywords
- compositions
- water
- parenteral administration
- emulsion
- propofol
- Prior art date
Links
- 239000000839 emulsion Substances 0.000 title 1
- 239000000203 mixture Substances 0.000 abstract 3
- 238000007911 parenteral administration Methods 0.000 abstract 2
- 208000028399 Critical Illness Diseases 0.000 abstract 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 abstract 1
- 239000002738 chelating agent Substances 0.000 abstract 1
- 239000003085 diluting agent Substances 0.000 abstract 1
- 238000010790 dilution Methods 0.000 abstract 1
- 239000012895 dilution Substances 0.000 abstract 1
- 229940009662 edetate Drugs 0.000 abstract 1
- 230000007760 free radical scavenging Effects 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 229910021645 metal ion Inorganic materials 0.000 abstract 1
- 239000007764 o/w emulsion Substances 0.000 abstract 1
- 235000020660 omega-3 fatty acid Nutrition 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- OLBCVFGFOZPWHH-UHFFFAOYSA-N propofol Chemical compound CC(C)C1=CC=CC(C(C)C)=C1O OLBCVFGFOZPWHH-UHFFFAOYSA-N 0.000 abstract 1
- 229960004134 propofol Drugs 0.000 abstract 1
- 239000000932 sedative agent Substances 0.000 abstract 1
- 229940125723 sedative agent Drugs 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 239000004094 surface-active agent Substances 0.000 abstract 1
- 230000004083 survival effect Effects 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Dispersion Chemistry (AREA)
- Dermatology (AREA)
- Anesthesiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Macromonomer-Based Addition Polymer (AREA)
- Colloid Chemistry (AREA)
- Edible Oils And Fats (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0012597.1A GB0012597D0 (en) | 2000-05-25 | 2000-05-25 | Formulation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE365538T1 true ATE365538T1 (de) | 2007-07-15 |
Family
ID=9892262
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01931897T ATE365538T1 (de) | 2000-05-25 | 2001-05-22 | O/w emulsion |
Country Status (18)
| Country | Link |
|---|---|
| US (3) | US20030144356A1 (https=) |
| EP (1) | EP1289503B1 (https=) |
| JP (1) | JP2003535057A (https=) |
| KR (1) | KR20030009501A (https=) |
| CN (1) | CN1430503A (https=) |
| AT (1) | ATE365538T1 (https=) |
| AU (2) | AU5858801A (https=) |
| BR (1) | BR0111136A (https=) |
| CA (1) | CA2407764A1 (https=) |
| DE (1) | DE60129134T2 (https=) |
| ES (1) | ES2287128T3 (https=) |
| GB (1) | GB0012597D0 (https=) |
| IL (1) | IL152773A0 (https=) |
| MX (1) | MXPA02011532A (https=) |
| NO (1) | NO20025629L (https=) |
| NZ (1) | NZ522365A (https=) |
| WO (1) | WO2001089474A2 (https=) |
| ZA (1) | ZA200208853B (https=) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1166368C (zh) * | 2003-02-26 | 2004-09-15 | 刘威 | 海狗油脂肪乳注射液、其制备方法及其在制备静脉注射剂中的应用 |
| US7780873B2 (en) * | 2004-02-23 | 2010-08-24 | Texas A&M University System | Bioactive complexes compositions and methods of use thereof |
| BRPI0512864B8 (pt) * | 2004-07-01 | 2021-05-25 | Johnson & Johnson Vision Care | composição oftálmica, uso de pelo menos um ácido graxo ômega-6 e pelo menos um ácido graxo ômega-3 e método para preparar a referida composição |
| CN100358513C (zh) * | 2005-04-07 | 2008-01-02 | 常州市第四制药厂有限公司 | 一种丙泊酚注射液的制备工艺 |
| KR20080043793A (ko) * | 2005-08-05 | 2008-05-19 | 바라트 쎄럼스 앤드 백신스 리미티드 | 방부 효능을 갖는 정맥 프로포폴 에멀젼 조성물 |
| US20070149617A1 (en) * | 2005-11-14 | 2007-06-28 | Deckelbaum Richard J | Use of an omega-3 lipid-based emulsion following ischemic injury to provide protection and recovery in human organs |
| WO2008036353A2 (en) * | 2006-09-19 | 2008-03-27 | The Trustees Of Columbia University In The City Of New York | Omega-3 diglyceride emulsions |
| CN101411685B (zh) * | 2007-10-19 | 2011-04-20 | 上海医药工业研究院 | 一种静脉麻醉药2,6-二异丙基苯酚微乳组合物及其制备方法 |
| US20110071090A1 (en) * | 2009-03-11 | 2011-03-24 | Stable Solutions Llc | Method of mitigating adverse drug events using omega-3-fatty acids as a parenteral therapeutic drug vehicle |
| US9034389B2 (en) | 2009-03-11 | 2015-05-19 | Stable Solutions Llc | Omega-3 enriched fish oil-in-water parenteral nutrition emulsions |
| US8993625B2 (en) | 2009-03-11 | 2015-03-31 | Stable Solutions Llc | Method of mitigating adverse drug events using omega-3 fatty acids as a parenteral therapeutic drug vehicle |
| US8241672B2 (en) * | 2009-03-11 | 2012-08-14 | Stable Solutions Llc | Omega-3 enriched fish oil-in-water parenteral nutrition emulsions |
| US8496976B2 (en) | 2009-06-05 | 2013-07-30 | Allergan, Inc. | Artificial tears and therapeutic uses |
| US20110086914A1 (en) * | 2009-10-13 | 2011-04-14 | Bailes Julian E | Methods for Treating Traumatic Brain Injury |
| WO2011103514A1 (en) * | 2010-02-18 | 2011-08-25 | Martek Biosciences Corporation | Dha triglyceride emulsions |
| US20110200644A1 (en) * | 2010-02-18 | 2011-08-18 | Martek Biosciences Corporation | DHA Ester Emulsions |
| WO2011103512A1 (en) * | 2010-02-18 | 2011-08-25 | Martek Biosciences Corporation | Dha free fatty acid emulsions |
| US9675572B2 (en) | 2010-04-23 | 2017-06-13 | The United States Of America As Represented By The Secretary Of The Army | Intravenous omega-3 fatty acid compositions and method of use |
| US11236351B2 (en) | 2010-05-17 | 2022-02-01 | Dow Agrosciences Llc | Production of DHA and other LC PUFAs in plants |
| WO2011149854A2 (en) * | 2010-05-25 | 2011-12-01 | Eric Kuhrts | Stable formulations of fatty acids |
| EP2590625B1 (en) * | 2010-07-06 | 2017-09-20 | GlaxoSmithKline Biologicals SA | Cationic oil-in-water emulsions |
| US8658676B2 (en) | 2010-10-12 | 2014-02-25 | The Medicines Company | Clevidipine emulsion formulations containing antimicrobial agents |
| EP2627173B2 (en) | 2010-10-12 | 2018-07-04 | Chiesi Farmaceutici S.p.A. | Clevidipine emulsion formulations containing antimicrobial agents |
| US20120251685A1 (en) * | 2011-04-04 | 2012-10-04 | Martek Biosciences Corporation | Oil-in-Water Emulsions Comprising a Polyunsaturated Fatty Acid and Methods of Making the Same |
| HRP20171431T1 (hr) * | 2011-06-15 | 2017-12-15 | Stable Solutions Llc | Terapijska parenteralna primjena krilovog ulja |
| US10052352B2 (en) | 2011-06-15 | 2018-08-21 | Stable Solutions Llc | Therapeutic application of parenteral krill oil |
| TW201307553A (zh) * | 2011-07-26 | 2013-02-16 | Dow Agrosciences Llc | 在植物中生產二十二碳六烯酸（ｄｈａ）及其他長鏈多元不飽和脂肪酸（ｌｃ－ｐｕｆａ）之技術 |
| CN102366404B (zh) * | 2011-10-20 | 2015-10-07 | 四川百利药业有限责任公司 | 一种丙泊酚中/长链脂肪乳剂 |
| WO2014033751A2 (en) * | 2012-08-16 | 2014-03-06 | Emcure Pharmaceuticals Limited | Pharmaceutical composition of propofol |
| EP2978307B1 (en) | 2013-03-28 | 2018-12-26 | The Trustees of Columbia University in the City of New York | Reperfusion with omega-3 glycerides promotes donor organ protection for transplantation |
| ES2607715B1 (es) * | 2015-10-01 | 2018-01-17 | Solutex Na, Lcc | Proceso para la preparación y estabilización de emulsiones con omega-3 mediante redes cristalinas isométricas de derivados de celulosa |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5637404A (en) * | 1992-01-31 | 1997-06-10 | Aluminum Company Of America | Reflective aluminum strip |
| US5478414A (en) * | 1992-01-31 | 1995-12-26 | Aluminum Company Of America | Reflective aluminum strip, protected with fluoropolymer coating and a laminate of the strip with a thermoplastic polymer |
| BR9506681A (pt) * | 1994-02-04 | 1997-11-18 | Scotia Lipidteknik Ab | Emulsão oleo em água e composição farmacêutica |
| GB9405593D0 (en) * | 1994-03-22 | 1994-05-11 | Zeneca Ltd | Pharmaceutical compositions |
| ES2211151T3 (es) * | 1998-08-19 | 2004-07-01 | Skyepharma Canada Inc. | Dispersiones acuosas inyectables de propofol. |
| US6140374A (en) * | 1998-10-23 | 2000-10-31 | Abbott Laboratories | Propofol composition |
| US6582723B2 (en) * | 2001-05-03 | 2003-06-24 | Wayne F. Gorsek | Cancer immune composition for prevention and treatment of individuals |
-
2000
- 2000-05-25 GB GBGB0012597.1A patent/GB0012597D0/en not_active Ceased
-
2001
- 2001-05-22 IL IL15277301A patent/IL152773A0/xx unknown
- 2001-05-22 MX MXPA02011532A patent/MXPA02011532A/es active IP Right Grant
- 2001-05-22 DE DE60129134T patent/DE60129134T2/de not_active Expired - Fee Related
- 2001-05-22 CN CN01810092A patent/CN1430503A/zh active Pending
- 2001-05-22 JP JP2001585719A patent/JP2003535057A/ja active Pending
- 2001-05-22 CA CA002407764A patent/CA2407764A1/en not_active Abandoned
- 2001-05-22 KR KR1020027015889A patent/KR20030009501A/ko not_active Ceased
- 2001-05-22 EP EP01931897A patent/EP1289503B1/en not_active Expired - Lifetime
- 2001-05-22 ES ES01931897T patent/ES2287128T3/es not_active Expired - Lifetime
- 2001-05-22 BR BR0111136-1A patent/BR0111136A/pt not_active Application Discontinuation
- 2001-05-22 US US10/275,912 patent/US20030144356A1/en not_active Abandoned
- 2001-05-22 AU AU5858801A patent/AU5858801A/xx active Pending
- 2001-05-22 NZ NZ522365A patent/NZ522365A/en unknown
- 2001-05-22 AU AU2001258588A patent/AU2001258588B2/en not_active Ceased
- 2001-05-22 AT AT01931897T patent/ATE365538T1/de not_active IP Right Cessation
- 2001-05-22 WO PCT/GB2001/002259 patent/WO2001089474A2/en not_active Ceased
-
2002
- 2002-10-31 ZA ZA200208853A patent/ZA200208853B/en unknown
- 2002-11-22 NO NO20025629A patent/NO20025629L/no not_active Application Discontinuation
-
2006
- 2006-03-30 US US11/392,934 patent/US20060257433A1/en not_active Abandoned
-
2008
- 2008-04-11 US US12/081,240 patent/US20080312338A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2001089474A2 (en) | 2001-11-29 |
| AU2001258588B2 (en) | 2005-05-19 |
| EP1289503A2 (en) | 2003-03-12 |
| US20080312338A1 (en) | 2008-12-18 |
| ZA200208853B (en) | 2004-02-19 |
| BR0111136A (pt) | 2003-04-08 |
| ES2287128T3 (es) | 2007-12-16 |
| MXPA02011532A (es) | 2003-04-25 |
| CA2407764A1 (en) | 2001-11-29 |
| GB0012597D0 (en) | 2000-07-12 |
| IL152773A0 (en) | 2003-06-24 |
| AU5858801A (en) | 2001-12-03 |
| WO2001089474A3 (en) | 2002-03-07 |
| KR20030009501A (ko) | 2003-01-29 |
| NZ522365A (en) | 2004-09-24 |
| DE60129134T2 (de) | 2008-02-28 |
| US20060257433A1 (en) | 2006-11-16 |
| EP1289503B1 (en) | 2007-06-27 |
| US20030144356A1 (en) | 2003-07-31 |
| JP2003535057A (ja) | 2003-11-25 |
| NO20025629D0 (no) | 2002-11-22 |
| CN1430503A (zh) | 2003-07-16 |
| DE60129134D1 (en) | 2007-08-09 |
| NO20025629L (no) | 2003-01-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |