ATE363911T1 - Zyklische somatostatin-analoge mit einer hauptkette mit einer gespannten konformation - Google Patents

Zyklische somatostatin-analoge mit einer hauptkette mit einer gespannten konformation

Info

Publication number
ATE363911T1
ATE363911T1 AT97932978T AT97932978T ATE363911T1 AT E363911 T1 ATE363911 T1 AT E363911T1 AT 97932978 T AT97932978 T AT 97932978T AT 97932978 T AT97932978 T AT 97932978T AT E363911 T1 ATE363911 T1 AT E363911T1
Authority
AT
Austria
Prior art keywords
main chain
somatostatin analogues
disclosed
somatostatin analogs
cyclic somatostatin
Prior art date
Application number
AT97932978T
Other languages
German (de)
English (en)
Inventor
Vered Hornik
Alon Seri-Levy
Gary Gellerman
Chaim Gilon
Original Assignee
Develogen Israel Ltd
Yissum Res Dev Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Develogen Israel Ltd, Yissum Res Dev Co filed Critical Develogen Israel Ltd
Application granted granted Critical
Publication of ATE363911T1 publication Critical patent/ATE363911T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/047—Simultaneous synthesis of different peptide species; Peptide libraries
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins
    • C07K14/6555—Somatostatins at least 1 amino acid in D-form
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R31/00—Arrangements for testing electric properties; Arrangements for locating electric faults; Arrangements for electrical testing characterised by what is being tested not provided for elsewhere
    • G01R31/28—Testing of electronic circuits, e.g. by signal tracer
    • G01R31/317—Testing of digital circuits
    • G01R31/3181—Functional testing
    • G01R31/3185—Reconfiguring for testing, e.g. LSSD, partitioning
    • G01R31/318533—Reconfiguring for testing, e.g. LSSD, partitioning using scanning techniques, e.g. LSSD, Boundary Scan, JTAG
    • G01R31/318541—Scan latches or cell details
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Analytical Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
AT97932978T 1996-07-31 1997-07-30 Zyklische somatostatin-analoge mit einer hauptkette mit einer gespannten konformation ATE363911T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/690,090 US5770687A (en) 1995-06-07 1996-07-31 Comformationally constrained backbone cyclized somatostatin analogs

Publications (1)

Publication Number Publication Date
ATE363911T1 true ATE363911T1 (de) 2007-06-15

Family

ID=24771043

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97932978T ATE363911T1 (de) 1996-07-31 1997-07-30 Zyklische somatostatin-analoge mit einer hauptkette mit einer gespannten konformation

Country Status (13)

Country Link
US (1) US5770687A (enExample)
EP (1) EP0920446B1 (enExample)
JP (1) JP4018752B2 (enExample)
KR (1) KR100477710B1 (enExample)
CN (1) CN1124282C (enExample)
AT (1) ATE363911T1 (enExample)
AU (1) AU711100B2 (enExample)
BR (1) BR9710636A (enExample)
CA (1) CA2262778C (enExample)
DE (1) DE69737787T2 (enExample)
IL (1) IL128084A0 (enExample)
NZ (1) NZ334046A (enExample)
WO (1) WO1998004583A1 (enExample)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6117974A (en) * 1991-10-02 2000-09-12 Peptor Limited Libraries of backbone-cyclized peptidomimetics
IL109943A (en) * 1994-06-08 2006-08-01 Develogen Israel Ltd Conformationally constrained backbone cyclized peptide analogs
US6051554A (en) * 1995-06-07 2000-04-18 Peptor Limited Conformationally constrained backbone cyclized somatostatin analogs
US6841533B1 (en) 1995-12-07 2005-01-11 Peptor Limited Conformationally constrained backbone cyclized interleukin-6 antagonists
ATE252109T1 (de) * 1995-12-22 2003-11-15 Univ Technologies Int Kupplungsarm für festträger oligonukleotid- synthese und verfahren zur herstellung davon
US6355613B1 (en) * 1996-07-31 2002-03-12 Peptor Limited Conformationally constrained backbone cyclized somatostatin analogs
EP1086131A1 (en) * 1998-06-16 2001-03-28 Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S. Cyclic somatostatin analogs
US6602849B1 (en) 1998-06-16 2003-08-05 Societe De Conseils De Recherche Et D'applications Scientifiques, S.A.S. Cyclic somatostatin analogs
US7135564B1 (en) * 1998-07-02 2006-11-14 University Technologies International Inc. Reusable solid support for oligonucleotide synthesis
AU6382999A (en) * 1998-08-24 2000-03-14 Jeffrey D. White Somatostatin analogs
US6465613B1 (en) 1998-11-19 2002-10-15 Tulane University Hydrophilic somatostatin analogs
US6358491B1 (en) 1999-08-27 2002-03-19 Berlex Laboratories, Inc. Somatostatin analogs
WO2001043691A2 (en) * 1999-12-15 2001-06-21 Peptor Ltd. Fragments and antagonists of heat shock protein 60
GB0018891D0 (en) 2000-08-01 2000-09-20 Novartis Ag Organic compounds
CN1589151A (zh) 2001-09-21 2005-03-02 图兰恩教育基金管理人 诊断或治疗性促生长素抑制素或铃蟾肽类似物的连接物及其用途
ATE455561T1 (de) * 2002-03-01 2010-02-15 Univ Tulane Konjugate von zytotoxischen mitteln und biologisch aktiven peptiden
IL148921A0 (en) 2002-03-26 2002-09-12 Peptor Ltd Photo active backbone cyclized somatostatin analogs for optical imaging and photodynamic therapy
US7304128B2 (en) * 2002-06-04 2007-12-04 E.I. Du Pont De Nemours And Company Carbon nanotube binding peptides
IL150384A0 (en) * 2002-06-24 2002-12-01 Peptor Ltd Radiolabelled somatostatin analogs backbone cyclized through metal complexation
US20040121407A1 (en) * 2002-09-06 2004-06-24 Elixir Pharmaceuticals, Inc. Regulation of the growth hormone/IGF-1 axis
AU2004220104A1 (en) * 2003-03-10 2004-09-23 Biogen Idec Inc. Thiol-mediated drug attachment to targeting peptides
US20070185031A1 (en) * 2003-07-14 2007-08-09 Northwestern University Reducing polyglutamine-based aggregation
JP4928263B2 (ja) 2003-07-31 2012-05-09 トランザイム・ファーマ ペプチド結合サロゲートを組み入れた空間的に規定された大環状分子
GB0318682D0 (en) 2003-08-08 2003-09-10 Novartis Ag Organic compounds
CN100475271C (zh) * 2003-08-20 2009-04-08 加利福尼亚大学董事会 具有抑制生长激素释放活性的促生长素抑制素类似物
WO2005041901A2 (en) * 2003-11-03 2005-05-12 Elixir Pharmaceuticals, Inc. Therapeutics using somatostatin agonists
KR101276463B1 (ko) * 2004-10-19 2013-06-19 론자 아게 수지 상 펩티드 고리화
WO2006129317A1 (en) * 2005-05-31 2006-12-07 Yissum Research Development Company Of The Hebrew University Of Jerusalem BACKBONE CYCLIZED MELANOCORTIN STIMULATING HORMONE (α S ) ANALOGS
US20120270774A1 (en) 2009-08-28 2012-10-25 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd Macrocyclic compounds, compositions comprising them and methods for preventing or treating hiv infection
FR2956115B1 (fr) 2010-02-05 2012-04-06 Isp Investments Inc Nouveaux peptides activateurs de la caspase-14 et compositions les comprenant
EP2604281B1 (en) 2011-12-14 2014-07-30 Centre National de la Recherche Scientifique (CNRS) Clicked somatostatin conjugated analogs for biological applications
WO2013111129A1 (en) 2012-01-23 2013-08-01 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Stabilized peptide helices for inhibiting dimerization of chemokine c motif receptor 2 (ccr2)
WO2015087334A1 (en) 2013-12-15 2015-06-18 Yissum Research Develoment Company Of The Hebrew University Of Jerusalem Ltd. Viperistatin-derived peptides and uses thereof
EP3464325A1 (en) 2016-06-07 2019-04-10 Yissum Research Development Company of The Hebrew University of Jerusalem Ltd. Backbone cyclized inhibitory peptides of myeloid differentiation factor 88 (myd88)
WO2019058365A1 (en) 2017-09-19 2019-03-28 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. SOMATOSTATIN PRODUCTS
EP3927737A1 (en) 2019-02-21 2021-12-29 Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. Par4 derived peptides, analogs and uses thereof
WO2022003673A1 (en) 2020-06-30 2022-01-06 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Humanin analogs and uses thereof
WO2025141573A1 (en) 2023-12-27 2025-07-03 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Calreticulin peptidomimetic inhibitors and prodrugs

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4011182A (en) * 1975-03-21 1977-03-08 American Home Products Corporation Cyclic undecapeptide analogs of somatostatin and intermediates
US3988304A (en) * 1975-08-25 1976-10-26 American Home Products Corporation Cyclic dodecapeptide derivatives of somatostatin and intermediates thereof
US4054558A (en) * 1976-05-24 1977-10-18 American Home Products Corporation Cyclic dodecapeptide and intermediates therefor
SU798098A1 (ru) * 1977-12-14 1981-01-23 Ордена Трудового Красного Знамениинститут Органического Синтезаан Латвийской Ccp Циклический аналог брадикинина,обла-дАющий СпОСОбНОСТью СОздАВАТь пРОлОНги-РОВАННый дЕпРЕССОРНый эффЕКТ B эКСпЕРиМЕН-TE ,A ТАКжЕ ВАСКул РНую пРОНи-цАЕМОСТь B эКСпЕРиМЕНТЕ
US4235886A (en) * 1979-10-31 1980-11-25 Merck & Co., Inc. Cyclic hexapeptide somatostatin analogs
US4310518A (en) * 1979-10-31 1982-01-12 Merck & Co., Inc. Cyclic hexapeptide somatostatin analogs
US4360516A (en) * 1981-04-13 1982-11-23 Merck & Co., Inc. Modified D-retro cyclic hexapeptide somatostatin analogs
JPS5852259A (ja) * 1981-09-22 1983-03-28 Shiraimatsu Shinyaku Kk アミノ酸９個で構成された新規ソマトスタチン類似体
ATE14226T1 (de) * 1981-12-24 1985-07-15 Ciba Geigy Ag Cyclische octapeptide und pharmazeutische praeparate davon, sowie verfahren zur herstellung derselben und ihre anwendung.
US4725577A (en) * 1985-04-25 1988-02-16 Administrators Of The Tulane Educational Fund Biologically active lysine containing octapeptides
US4923963A (en) * 1987-09-02 1990-05-08 Nova Technology Limited Partnership Bradykinin antagonist peptides
EP0334244A3 (en) * 1988-03-25 1991-05-29 The Procter & Gamble Company Bradykinin antagonist peptides
WO1989009783A1 (en) * 1988-04-08 1989-10-19 Scripps Clinic And Research Foundation Polypeptides stabilized by covalent hydrogen bond replacements
IE63490B1 (en) * 1988-11-24 1995-05-03 Hoechst Ag Peptides having bradykinin antagonist action
KR0173119B1 (ko) * 1989-04-26 1999-02-01 닐 에이. 밴스로우 선형 소마토스타틴 유사체
US5650489A (en) * 1990-07-02 1997-07-22 The Arizona Board Of Regents Random bio-oligomer library, a method of synthesis thereof, and a method of use thereof
DE4119544C1 (enExample) * 1991-06-13 1992-10-15 Gesellschaft Fuer Biotechnologische Forschung Mbh (Gbf), 3300 Braunschweig, De
US5364851A (en) * 1991-06-14 1994-11-15 International Synthecon, Llc Conformationally restricted biologically active peptides, methods for their production and uses thereof
US6117974A (en) * 1991-10-02 2000-09-12 Peptor Limited Libraries of backbone-cyclized peptidomimetics
IL99628A (en) * 1991-10-02 2004-07-25 Yissum Res Dev Co Processes for the preparation of cyclic peptides, and pharmaceutical compositions containing them
US5371070A (en) * 1992-11-09 1994-12-06 The Salk Institute For Biological Studies Bicyclic GnRH antagonists and a method for regulating the secretion of gonadotropins
US6194544B1 (en) * 1993-07-09 2001-02-27 Smithkline Beecham Corporation Cyclic semi-random peptide libraries
IL109943A (en) * 1994-06-08 2006-08-01 Develogen Israel Ltd Conformationally constrained backbone cyclized peptide analogs

Also Published As

Publication number Publication date
KR20000029654A (ko) 2000-05-25
AU3633197A (en) 1998-02-20
US5770687A (en) 1998-06-23
EP0920446B1 (en) 2007-06-06
CN1231672A (zh) 1999-10-13
BR9710636A (pt) 2000-01-11
JP2000516592A (ja) 2000-12-12
IL128084A0 (en) 1999-11-30
EP0920446A1 (en) 1999-06-09
AU711100B2 (en) 1999-10-07
CA2262778C (en) 2006-10-10
DE69737787D1 (de) 2007-07-19
CA2262778A1 (en) 1998-02-05
JP4018752B2 (ja) 2007-12-05
NZ334046A (en) 1999-10-28
CN1124282C (zh) 2003-10-15
DE69737787T2 (de) 2008-03-06
KR100477710B1 (ko) 2005-03-18
WO1998004583A1 (en) 1998-02-05
EP0920446A4 (en) 2004-06-02

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