DK0833646T3 - Multi-tyrosinerede somatostatinanaloger - Google Patents

Multi-tyrosinerede somatostatinanaloger

Info

Publication number
DK0833646T3
DK0833646T3 DK96917939T DK96917939T DK0833646T3 DK 0833646 T3 DK0833646 T3 DK 0833646T3 DK 96917939 T DK96917939 T DK 96917939T DK 96917939 T DK96917939 T DK 96917939T DK 0833646 T3 DK0833646 T3 DK 0833646T3
Authority
DK
Denmark
Prior art keywords
inclusive
integer
tyrosine
somatostatin
mnh2
Prior art date
Application number
DK96917939T
Other languages
English (en)
Inventor
David H Coy
Eugene A Woltering
M Sue O'dorisio
Thomas M O'dorisio
William A Murphy
Original Assignee
Univ Tulane
Univ Ohio State Res Found
Univ Louisiana State Med
Childrens Hospital Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Tulane, Univ Ohio State Res Found, Univ Louisiana State Med, Childrens Hospital Inc filed Critical Univ Tulane
Application granted granted Critical
Publication of DK0833646T3 publication Critical patent/DK0833646T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
DK96917939T 1995-06-05 1996-06-03 Multi-tyrosinerede somatostatinanaloger DK0833646T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/462,223 US5597894A (en) 1995-06-05 1995-06-05 Multi-tyrosinated somatostatin analogs
PCT/US1996/008437 WO1996039161A1 (en) 1995-06-05 1996-06-03 Multi-tyrosinated somatostatin analogs

Publications (1)

Publication Number Publication Date
DK0833646T3 true DK0833646T3 (da) 2000-05-08

Family

ID=23835647

Family Applications (1)

Application Number Title Priority Date Filing Date
DK96917939T DK0833646T3 (da) 1995-06-05 1996-06-03 Multi-tyrosinerede somatostatinanaloger

Country Status (14)

Country Link
US (1) US5597894A (da)
EP (1) EP0833646B1 (da)
JP (1) JPH11507622A (da)
AT (1) ATE187075T1 (da)
AU (1) AU709506B2 (da)
CA (1) CA2222962A1 (da)
CZ (1) CZ386297A3 (da)
DE (1) DE69605419T2 (da)
DK (1) DK0833646T3 (da)
ES (1) ES2140858T3 (da)
GR (1) GR3032437T3 (da)
NZ (1) NZ310006A (da)
PT (1) PT833646E (da)
WO (1) WO1996039161A1 (da)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
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US6355613B1 (en) * 1996-07-31 2002-03-12 Peptor Limited Conformationally constrained backbone cyclized somatostatin analogs
US6492330B1 (en) * 1996-08-16 2002-12-10 National Institute Of Immunology Antiangiogenic drugs
US6262229B1 (en) 1996-12-04 2001-07-17 Biomeasure Incorporated Somatostatin antagonists
AT405906B (de) * 1997-03-14 1999-12-27 Irene Dr Virgolini Radiomarkierte somatostatin rezeptor-liganden zur diagnose und therapie
CN1250361A (zh) * 1997-11-24 2000-04-12 路易斯安那州州立大学及农业机械学院管理委员会 提高放射性标记化合物的组织积累的方法
US6180082B1 (en) 1997-11-24 2001-01-30 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Method to enhance tissue accumulation of radiolabeled compounds
CA2246791A1 (en) * 1998-09-01 2000-03-01 Alison Buchan Treatment of endothelium with somatostatin analogues
US6465613B1 (en) 1998-11-19 2002-10-15 Tulane University Hydrophilic somatostatin analogs
US6600016B1 (en) * 1999-08-24 2003-07-29 Advanced Syntech Llc Multifunctionalized solid support resins for synthesis of combinatorial libraries and method for using the same
US6358491B1 (en) 1999-08-27 2002-03-19 Berlex Laboratories, Inc. Somatostatin analogs
US6579967B1 (en) 1999-12-14 2003-06-17 The Salk Institute For Biological Studies Receptor-selective somatostatin analogs
US6316414B1 (en) 2000-07-31 2001-11-13 Dabur Research Foundation Somatostatin analogs for the treatment of cancer
ES2284859T3 (es) * 2001-03-06 2007-11-16 Il Consorzio Ferrara Richerche Procedimiento para modular la proliferacion de celulas de carcinoma medular tiroideo.
US7019109B2 (en) * 2001-03-16 2006-03-28 The Salk Institute For Bilogical Studies SSTR1-selective analogs
US20020187099A1 (en) * 2001-05-16 2002-12-12 Rajesh Manchanda Stabilization of radionuclide-containing compositions
CA2461099A1 (en) * 2001-09-21 2003-04-10 The Administrators Of The Tulane Educational Fund Diagnostic or therapeutic somatostatin or bombesin analog conjugates and uses thereof
US20030083241A1 (en) * 2001-11-01 2003-05-01 Young Charles W. Use of somatostatin receptor agonists in the treatment of human disorders of sleep hypoxia and oxygen deprivation
KR101003622B1 (ko) * 2002-03-01 2010-12-24 더 어드미니스트레이터 오브 더 튜레인 에듀케이셔널 펀드 치료제 또는 세포독성제와 생물학적 활성 펩티드의컨쥬게이트
US20030207811A1 (en) * 2002-05-03 2003-11-06 Schrier Bruce K. Method of treating retinopathy of prematurity using somatostatin analogs
WO2004009614A2 (en) * 2002-07-24 2004-01-29 The Salk Institute For Biological Studies Receptor (sstr4)- selective somatostatin analogs
US20050118099A1 (en) * 2003-03-10 2005-06-02 Braslawsky Gary R. Thiol-mediated drug attachment to targeting peptides
US20070025910A1 (en) * 2005-07-29 2007-02-01 Norenberg Jeffrey P Anticancer therapy
WO2013007660A1 (en) 2011-07-08 2013-01-17 Biosynthema Inc. Enhanced in vivo targeting of radiolabelled peptides with the means of enzyme inhibitors
DK2722340T3 (da) 2012-10-19 2015-06-08 Txp Pharma Gmbh Alpha- og gamma-MSH analoger
BR112016024494B1 (pt) 2014-04-22 2024-02-06 Txp Pharma Gmbh Análogo de peptídeo e seu uso
WO2015162483A1 (en) * 2014-04-22 2015-10-29 Txp Pharma Gmbh Alpha- and gamma-msh analogues

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US4291022A (en) * 1975-03-11 1981-09-22 Sandoz Ltd. Organic compounds
US4133782A (en) * 1976-06-07 1979-01-09 The Salk Institute For Biological Studies Somatostatin analogs with dissociated biological activities
IE47421B1 (en) * 1977-06-08 1984-03-07 Merck & Co Inc Somatostatin analogs,process for their preparation and pharmaceutical compositions containing them
DK153293C (da) * 1977-07-22 1988-11-14 Stamicarbon Katalysator til dehydrogenering af organiske forbindelser, isaer aminer, thioler og alkoholer, og fremgangsmaade til fremstilling deraf
US4211693A (en) * 1977-09-20 1980-07-08 The Salk Institute For Biological Studies Peptides with para-substituted phenylalanine
LU78191A1 (de) * 1977-09-28 1979-05-25 Ciba Geigy Ag Verfahren zur herstellung von neuen cyclopeptiden
US4190648A (en) * 1979-03-13 1980-02-26 Merck & Co., Inc. Peptides having somatostatin activity
US4316890A (en) * 1979-03-16 1982-02-23 Ciba-Geigy Corporation Peptides and processes for the manufacture thereof
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ATE2512T1 (de) * 1979-11-27 1983-03-15 Sandoz Ag Polypeptide, verfahren zu ihrer herstellung, pharmazeutische zusammensetzungen, die diese polypeptide enthalten, und ihre verwendung.
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EP0031303A3 (de) * 1979-12-21 1981-11-04 Ciba-Geigy Ag Cyclooctapeptide und pharmazeutische Präparate davon, sowie Verfahren zur Herstellung derselben und ihre Anwendung
DK81082A (da) * 1981-03-06 1982-09-07 Sandoz Ag Fremgangsmaade til fremstilling af polypeptider
US4360516A (en) * 1981-04-13 1982-11-23 Merck & Co., Inc. Modified D-retro cyclic hexapeptide somatostatin analogs
ATE14226T1 (de) * 1981-12-24 1985-07-15 Ciba Geigy Ag Cyclische octapeptide und pharmazeutische praeparate davon, sowie verfahren zur herstellung derselben und ihre anwendung.
US4486415A (en) * 1983-08-15 1984-12-04 Merck & Co., Inc. Cyclic hexapeptide somatostatin analogs
US4485101A (en) * 1983-10-11 1984-11-27 Administrators Of The Tulane Educational Fund Peptides
US4522813A (en) * 1983-10-27 1985-06-11 Merck & Co., Inc. Cyclic hexapeptide somatostatin analogs
US4684620A (en) * 1984-09-04 1987-08-04 Gibson-Stephens Neuropharmaceuticals, Inc. Cyclic polypeptides having mu-receptor specificity
US4650787A (en) * 1985-04-25 1987-03-17 Schally Andrew Victor Biologically active octapeptides
US4725577A (en) * 1985-04-25 1988-02-16 Administrators Of The Tulane Educational Fund Biologically active lysine containing octapeptides
US4585755A (en) * 1985-04-29 1986-04-29 Merck & Co., Inc. Cyclic and bridged cyclic somatostatin analogs useful as local anti-inflammatory agents
US4904642A (en) * 1985-09-12 1990-02-27 The Administrators Of The Tulane Educational Fund Therapeutic somatostatin analogs
JPH085913B2 (ja) * 1985-09-12 1996-01-24 ザ・アドミニストレ−タ−ズ・オブ・ザ・ツ−レイン・エデユケイシヨナル・フアンド 治療用ソマトスタチン同族体
US4853371A (en) * 1986-06-17 1989-08-01 The Administrators Of The Tulane Educational Fund Therapeutic somatostatin analogs
US4871717A (en) * 1987-01-07 1989-10-03 Administrators Of The Tulane Educational Fund Peptides
US5070878A (en) * 1988-11-14 1991-12-10 Neoprobe Corporation Detector and localizer for low energy radiation emissions
US4801803A (en) * 1987-03-17 1989-01-31 Neoprobe Corporation Detector and localizer for low energy radiation emissions
DK375789A (da) * 1988-08-18 1990-02-19 Syntex Inc Peptidderivater
US4889991A (en) * 1988-09-23 1989-12-26 Neoprobe Corporation Gamma radiation detector with enhanced signal treatment
GB9111199D0 (en) * 1991-05-23 1991-07-17 Sandoz Ltd Improvements in or relating to organic compounds
DE69018226T2 (de) * 1989-07-20 1995-09-21 Sandoz-Patent-Gmbh, 79539 Loerrach Markierte polypeptidderivate.
DK0457888T3 (da) * 1989-12-08 1996-08-12 Univ Tulane Octapeptidanaloger af somatostatin med threonin i 6-stillingen
US5008546A (en) * 1990-06-18 1991-04-16 The Regents Of The University Of California Intraoperative beta probe and method of using the same
HU207104B (en) * 1991-01-25 1993-03-01 Biosignal Kutato Fejlesztoe Kf Process for producing new somatostatin analogs inhibiting tumour growth and pharmaceutical compositions comprising such compounds
ATE181240T1 (de) * 1991-02-08 1999-07-15 Biomeasure Inc Verwendung von somatostatinanalogen zur behandlung von melanomen
US5462926A (en) * 1992-07-27 1995-10-31 Biomeasure, Inc. Neuromedin B receptor antagonists which demonstrate selectivity
US5590656A (en) * 1992-09-15 1997-01-07 The Ohio State University Research Foundation Application of peptide/cell receptor kinetics utilizing radiolabeled somatostatin congeners in the in situ, in vivo detection and differentiation of neoplastic tissue
EP0607103A3 (en) * 1993-01-12 1997-07-09 Sandoz Ltd Somatostatin analogs containing chelating groups and their radiolabeled compositions.

Also Published As

Publication number Publication date
GR3032437T3 (en) 2000-05-31
WO1996039161A1 (en) 1996-12-12
EP0833646A4 (en) 1998-05-27
NZ310006A (en) 1998-12-23
CZ386297A3 (cs) 1998-07-15
AU709506B2 (en) 1999-09-02
ATE187075T1 (de) 1999-12-15
JPH11507622A (ja) 1999-07-06
PT833646E (pt) 2000-04-28
AU6031796A (en) 1996-12-24
EP0833646B1 (en) 1999-12-01
DE69605419D1 (de) 2000-01-05
DE69605419T2 (de) 2000-06-08
ES2140858T3 (es) 2000-03-01
CA2222962A1 (en) 1996-12-12
EP0833646A1 (en) 1998-04-08
US5597894A (en) 1997-01-28

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