BR9710636A - Análogo de somatostatina ciclizada da espinha dorsal, uso do mesmo, composição farmacêutica,e , processo de tratamento de distúrbios endócrinos, neoplasmas ou distúrbios metabólicos. - Google Patents
Análogo de somatostatina ciclizada da espinha dorsal, uso do mesmo, composição farmacêutica,e , processo de tratamento de distúrbios endócrinos, neoplasmas ou distúrbios metabólicos.Info
- Publication number
- BR9710636A BR9710636A BR9710636-4A BR9710636A BR9710636A BR 9710636 A BR9710636 A BR 9710636A BR 9710636 A BR9710636 A BR 9710636A BR 9710636 A BR9710636 A BR 9710636A
- Authority
- BR
- Brazil
- Prior art keywords
- disorders
- neoplasms
- treatment
- backbone
- analog
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
- C07K1/047—Simultaneous synthesis of different peptide species; Peptide libraries
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/655—Somatostatins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/655—Somatostatins
- C07K14/6555—Somatostatins at least 1 amino acid in D-form
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R31/00—Arrangements for testing electric properties; Arrangements for locating electric faults; Arrangements for electrical testing characterised by what is being tested not provided for elsewhere
- G01R31/28—Testing of electronic circuits, e.g. by signal tracer
- G01R31/317—Testing of digital circuits
- G01R31/3181—Functional testing
- G01R31/3185—Reconfiguring for testing, e.g. LSSD, partitioning
- G01R31/318533—Reconfiguring for testing, e.g. LSSD, partitioning using scanning techniques, e.g. LSSD, Boundary Scan, JTAG
- G01R31/318541—Scan latches or cell details
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Endocrinology (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Physics & Mathematics (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
''ANáLOGO DE SOMATOSTATINA CICLIZADA DA ESPINHA DORSAL, USO DO MESMO ,COMPOSIçãO FARMACêUTICA, E, PROCESSO DE TRATAMENTO DE DISTúRBIOS ENDóCRINOS, NEOPLASMAS OU DISTúRBIOS METABóLICAS''. Novos análogos de peptídos são apresentados. Novos análogos de peptídeo são apresentados. Os novos peptídeos são anólogos de somatostina ciclizada a espinha dorsal conformacionalmente constrangida. Processos para sintetização dos análogos da somatostina e para produção de uma coleção de análogos de somastostina são também apresentados. Além disso, composições farmaceuticas incluindo análogos da somatostina, e processos de uso de tais composições no tratamento distúrbios endócrinos, neoplasmas e distúrbios metabólicos são também apresentados.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/690,090 US5770687A (en) | 1995-06-07 | 1996-07-31 | Comformationally constrained backbone cyclized somatostatin analogs |
PCT/IL1997/000261 WO1998004583A1 (en) | 1996-07-31 | 1997-07-30 | Conformationally constrained backbone cyclized somatostatin analogs |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9710636A true BR9710636A (pt) | 2000-01-11 |
Family
ID=24771043
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9710636-4A BR9710636A (pt) | 1996-07-31 | 1997-07-30 | Análogo de somatostatina ciclizada da espinha dorsal, uso do mesmo, composição farmacêutica,e , processo de tratamento de distúrbios endócrinos, neoplasmas ou distúrbios metabólicos. |
Country Status (13)
Country | Link |
---|---|
US (1) | US5770687A (pt) |
EP (1) | EP0920446B1 (pt) |
JP (1) | JP4018752B2 (pt) |
KR (1) | KR100477710B1 (pt) |
CN (1) | CN1124282C (pt) |
AT (1) | ATE363911T1 (pt) |
AU (1) | AU711100B2 (pt) |
BR (1) | BR9710636A (pt) |
CA (1) | CA2262778C (pt) |
DE (1) | DE69737787T2 (pt) |
IL (1) | IL128084A0 (pt) |
NZ (1) | NZ334046A (pt) |
WO (1) | WO1998004583A1 (pt) |
Families Citing this family (37)
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US6117974A (en) * | 1991-10-02 | 2000-09-12 | Peptor Limited | Libraries of backbone-cyclized peptidomimetics |
IL109943A (en) * | 1994-06-08 | 2006-08-01 | Develogen Israel Ltd | Conformationally constrained backbone cyclized peptide analogs |
US6051554A (en) * | 1995-06-07 | 2000-04-18 | Peptor Limited | Conformationally constrained backbone cyclized somatostatin analogs |
US6841533B1 (en) | 1995-12-07 | 2005-01-11 | Peptor Limited | Conformationally constrained backbone cyclized interleukin-6 antagonists |
DE69630400T2 (de) * | 1995-12-22 | 2005-04-14 | University Technologies International Inc., Calgary | Kupplungsarm für festträger oligonukleotid-synthese und verfahren zur herstellung davon |
US6355613B1 (en) * | 1996-07-31 | 2002-03-12 | Peptor Limited | Conformationally constrained backbone cyclized somatostatin analogs |
JP2002518409A (ja) * | 1998-06-16 | 2002-06-25 | ソシエテ・ドゥ・コンセイユ・ドゥ・ルシェルシュ・エ・ダプリカーション・シャンティフィック・エス・ア・エス | サイクリックソマトスタチン類似体 |
US6602849B1 (en) | 1998-06-16 | 2003-08-05 | Societe De Conseils De Recherche Et D'applications Scientifiques, S.A.S. | Cyclic somatostatin analogs |
US7135564B1 (en) * | 1998-07-02 | 2006-11-14 | University Technologies International Inc. | Reusable solid support for oligonucleotide synthesis |
WO2000010589A1 (en) * | 1998-08-24 | 2000-03-02 | White Jeffrey D | Somatostatin analogs |
US6465613B1 (en) | 1998-11-19 | 2002-10-15 | Tulane University | Hydrophilic somatostatin analogs |
US6358491B1 (en) | 1999-08-27 | 2002-03-19 | Berlex Laboratories, Inc. | Somatostatin analogs |
EP1237570A4 (en) * | 1999-12-15 | 2005-01-05 | Peptor Ltd | FRAGMENTS AND ANTAGONISTS OF THERMAL SHOCK PROTEINS 60 |
GB0018891D0 (en) | 2000-08-01 | 2000-09-20 | Novartis Ag | Organic compounds |
CA2461099A1 (en) | 2001-09-21 | 2003-04-10 | The Administrators Of The Tulane Educational Fund | Diagnostic or therapeutic somatostatin or bombesin analog conjugates and uses thereof |
KR101003622B1 (ko) * | 2002-03-01 | 2010-12-24 | 더 어드미니스트레이터 오브 더 튜레인 에듀케이셔널 펀드 | 치료제 또는 세포독성제와 생물학적 활성 펩티드의컨쥬게이트 |
IL148921A0 (en) | 2002-03-26 | 2002-09-12 | Peptor Ltd | Photo active backbone cyclized somatostatin analogs for optical imaging and photodynamic therapy |
US7304128B2 (en) | 2002-06-04 | 2007-12-04 | E.I. Du Pont De Nemours And Company | Carbon nanotube binding peptides |
IL150384A0 (en) * | 2002-06-24 | 2002-12-01 | Peptor Ltd | Radiolabelled somatostatin analogs backbone cyclized through metal complexation |
US20040121407A1 (en) * | 2002-09-06 | 2004-06-24 | Elixir Pharmaceuticals, Inc. | Regulation of the growth hormone/IGF-1 axis |
US20050118099A1 (en) * | 2003-03-10 | 2005-06-02 | Braslawsky Gary R. | Thiol-mediated drug attachment to targeting peptides |
US20070185031A1 (en) * | 2003-07-14 | 2007-08-09 | Northwestern University | Reducing polyglutamine-based aggregation |
EP1648923B1 (en) | 2003-07-31 | 2008-12-31 | Tranzyme Pharma Inc. | Spatially-defined macrocycles incorporating peptide bond surrogates |
GB0318682D0 (en) | 2003-08-08 | 2003-09-10 | Novartis Ag | Organic compounds |
CN100475271C (zh) * | 2003-08-20 | 2009-04-08 | 加利福尼亚大学董事会 | 具有抑制生长激素释放活性的促生长素抑制素类似物 |
WO2005041901A2 (en) * | 2003-11-03 | 2005-05-12 | Elixir Pharmaceuticals, Inc. | Therapeutics using somatostatin agonists |
CN101111510B (zh) * | 2004-10-19 | 2011-09-14 | 隆萨股份公司 | 树脂上肽环化 |
CN101203527A (zh) * | 2005-05-31 | 2008-06-18 | 耶路撒冷希伯来大学伊森姆研究发展公司 | 主链环化的促黑皮质素激素(αMSH)类似物 |
WO2011024175A1 (en) | 2009-08-28 | 2011-03-03 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Macrocyclic compounds, compositions comprising them and methods for preventing or treating hiv infection |
FR2956115B1 (fr) | 2010-02-05 | 2012-04-06 | Isp Investments Inc | Nouveaux peptides activateurs de la caspase-14 et compositions les comprenant |
EP2604281B1 (en) | 2011-12-14 | 2014-07-30 | Centre National de la Recherche Scientifique (CNRS) | Clicked somatostatin conjugated analogs for biological applications |
EP2807182A1 (en) | 2012-01-23 | 2014-12-03 | Yissum Research Development Company of the Hebrew University of Jerusalem, Ltd. | Stabilized peptide helices for inhibiting dimerization of chemokine c motif receptor 2 (ccr2) |
WO2015087334A1 (en) | 2013-12-15 | 2015-06-18 | Yissum Research Develoment Company Of The Hebrew University Of Jerusalem Ltd. | Viperistatin-derived peptides and uses thereof |
EP3464325A1 (en) | 2016-06-07 | 2019-04-10 | Yissum Research Development Company of The Hebrew University of Jerusalem Ltd. | Backbone cyclized inhibitory peptides of myeloid differentiation factor 88 (myd88) |
US11261215B2 (en) | 2017-09-19 | 2022-03-01 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Somatostatin prodrugs |
WO2020170249A1 (en) | 2019-02-21 | 2020-08-27 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Par4 derived peptides, analogs and uses thereof |
WO2022003673A1 (en) | 2020-06-30 | 2022-01-06 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Humanin analogs and uses thereof |
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US4011182A (en) * | 1975-03-21 | 1977-03-08 | American Home Products Corporation | Cyclic undecapeptide analogs of somatostatin and intermediates |
US3988304A (en) * | 1975-08-25 | 1976-10-26 | American Home Products Corporation | Cyclic dodecapeptide derivatives of somatostatin and intermediates thereof |
US4054558A (en) * | 1976-05-24 | 1977-10-18 | American Home Products Corporation | Cyclic dodecapeptide and intermediates therefor |
SU798098A1 (ru) * | 1977-12-14 | 1981-01-23 | Ордена Трудового Красного Знамениинститут Органического Синтезаан Латвийской Ccp | Циклический аналог брадикинина,обла-дАющий СпОСОбНОСТью СОздАВАТь пРОлОНги-РОВАННый дЕпРЕССОРНый эффЕКТ B эКСпЕРиМЕН-TE ,A ТАКжЕ ВАСКул РНую пРОНи-цАЕМОСТь B эКСпЕРиМЕНТЕ |
US4235886A (en) * | 1979-10-31 | 1980-11-25 | Merck & Co., Inc. | Cyclic hexapeptide somatostatin analogs |
US4310518A (en) * | 1979-10-31 | 1982-01-12 | Merck & Co., Inc. | Cyclic hexapeptide somatostatin analogs |
US4360516A (en) * | 1981-04-13 | 1982-11-23 | Merck & Co., Inc. | Modified D-retro cyclic hexapeptide somatostatin analogs |
JPS5852259A (ja) * | 1981-09-22 | 1983-03-28 | Shiraimatsu Shinyaku Kk | アミノ酸9個で構成された新規ソマトスタチン類似体 |
ATE14226T1 (de) * | 1981-12-24 | 1985-07-15 | Ciba Geigy Ag | Cyclische octapeptide und pharmazeutische praeparate davon, sowie verfahren zur herstellung derselben und ihre anwendung. |
US4725577A (en) * | 1985-04-25 | 1988-02-16 | Administrators Of The Tulane Educational Fund | Biologically active lysine containing octapeptides |
US4923963A (en) * | 1987-09-02 | 1990-05-08 | Nova Technology Limited Partnership | Bradykinin antagonist peptides |
EP0334244A3 (en) * | 1988-03-25 | 1991-05-29 | The Procter & Gamble Company | Bradykinin antagonist peptides |
AU3534989A (en) * | 1988-04-08 | 1989-11-03 | Scripps Clinic And Research Foundation | Polypeptides stabilized by covalent hydrogen bond replacements |
IE63490B1 (en) * | 1988-11-24 | 1995-05-03 | Hoechst Ag | Peptides having bradykinin antagonist action |
WO1990012811A1 (en) * | 1989-04-26 | 1990-11-01 | The Administrators Of The Tulane Educational Fund | Linear somatostatin analogs |
US5650489A (en) * | 1990-07-02 | 1997-07-22 | The Arizona Board Of Regents | Random bio-oligomer library, a method of synthesis thereof, and a method of use thereof |
DE4119544C1 (pt) * | 1991-06-13 | 1992-10-15 | Gesellschaft Fuer Biotechnologische Forschung Mbh (Gbf), 3300 Braunschweig, De | |
US5364851A (en) * | 1991-06-14 | 1994-11-15 | International Synthecon, Llc | Conformationally restricted biologically active peptides, methods for their production and uses thereof |
IL99628A (en) * | 1991-10-02 | 2004-07-25 | Yissum Res Dev Co | Processes for the preparation of cyclic peptides, and pharmaceutical compositions containing them |
US6117974A (en) * | 1991-10-02 | 2000-09-12 | Peptor Limited | Libraries of backbone-cyclized peptidomimetics |
US5371070A (en) * | 1992-11-09 | 1994-12-06 | The Salk Institute For Biological Studies | Bicyclic GnRH antagonists and a method for regulating the secretion of gonadotropins |
US6194544B1 (en) * | 1993-07-09 | 2001-02-27 | Smithkline Beecham Corporation | Cyclic semi-random peptide libraries |
IL109943A (en) * | 1994-06-08 | 2006-08-01 | Develogen Israel Ltd | Conformationally constrained backbone cyclized peptide analogs |
-
1996
- 1996-07-31 US US08/690,090 patent/US5770687A/en not_active Expired - Lifetime
-
1997
- 1997-07-30 DE DE69737787T patent/DE69737787T2/de not_active Expired - Fee Related
- 1997-07-30 JP JP50866698A patent/JP4018752B2/ja not_active Expired - Fee Related
- 1997-07-30 WO PCT/IL1997/000261 patent/WO1998004583A1/en active IP Right Grant
- 1997-07-30 IL IL12808497A patent/IL128084A0/xx unknown
- 1997-07-30 CN CN97198197A patent/CN1124282C/zh not_active Expired - Fee Related
- 1997-07-30 CA CA002262778A patent/CA2262778C/en not_active Expired - Fee Related
- 1997-07-30 NZ NZ334046A patent/NZ334046A/en unknown
- 1997-07-30 AU AU36331/97A patent/AU711100B2/en not_active Ceased
- 1997-07-30 KR KR10-1999-7000727A patent/KR100477710B1/ko not_active IP Right Cessation
- 1997-07-30 EP EP97932978A patent/EP0920446B1/en not_active Expired - Lifetime
- 1997-07-30 BR BR9710636-4A patent/BR9710636A/pt not_active Application Discontinuation
- 1997-07-30 AT AT97932978T patent/ATE363911T1/de not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
DE69737787D1 (de) | 2007-07-19 |
NZ334046A (en) | 1999-10-28 |
AU3633197A (en) | 1998-02-20 |
JP4018752B2 (ja) | 2007-12-05 |
CN1124282C (zh) | 2003-10-15 |
DE69737787T2 (de) | 2008-03-06 |
KR20000029654A (ko) | 2000-05-25 |
EP0920446B1 (en) | 2007-06-06 |
US5770687A (en) | 1998-06-23 |
CA2262778A1 (en) | 1998-02-05 |
EP0920446A4 (en) | 2004-06-02 |
ATE363911T1 (de) | 2007-06-15 |
AU711100B2 (en) | 1999-10-07 |
KR100477710B1 (ko) | 2005-03-18 |
IL128084A0 (en) | 1999-11-30 |
CN1231672A (zh) | 1999-10-13 |
EP0920446A1 (en) | 1999-06-09 |
JP2000516592A (ja) | 2000-12-12 |
WO1998004583A1 (en) | 1998-02-05 |
CA2262778C (en) | 2006-10-10 |
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Legal Events
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B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: O DEPOSITANTE DEIXOU DE APRESENTAR MANIFESTACAO SOBRE O PARECER NEGATIVO, ASSIM, DE ACORDO COM O ART. 36 DA LPI (LEI 9279/96) 2O, O PEDIDO VOLTA A EXAME SENDO CONSIDERADO NAO PATENTEAVEL PELAS RAZOES EXPOSTAS NO PARECER TECNICO ANTERIOR. |