ATE353079T1 - Verbessertes verfahren für die herstellung von wasserlöslichen o-phosphonooxymethyl-prodrugs - Google Patents

Verbessertes verfahren für die herstellung von wasserlöslichen o-phosphonooxymethyl-prodrugs

Info

Publication number
ATE353079T1
ATE353079T1 AT01981688T AT01981688T ATE353079T1 AT E353079 T1 ATE353079 T1 AT E353079T1 AT 01981688 T AT01981688 T AT 01981688T AT 01981688 T AT01981688 T AT 01981688T AT E353079 T1 ATE353079 T1 AT E353079T1
Authority
AT
Austria
Prior art keywords
improved process
production
water soluble
prodrugs
triazole antifungal
Prior art date
Application number
AT01981688T
Other languages
English (en)
Inventor
Chung-Pin Chen
Timothy Paul Connolly
Laxma Reddy Kolla
John D Matiskella
Richard H Mueller
Yadagiri Pendri
Dejah T Petsch
Original Assignee
Eisai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd
Application granted granted Critical
Publication of ATE353079T1 publication Critical patent/ATE353079T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having three nitrogen atoms as the only ring hetero atoms
    • C07F9/6518—Five-membered rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preventing Corrosion Or Incrustation Of Metals (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
AT01981688T 2000-11-20 2001-10-18 Verbessertes verfahren für die herstellung von wasserlöslichen o-phosphonooxymethyl-prodrugs ATE353079T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US25200100P 2000-11-20 2000-11-20

Publications (1)

Publication Number Publication Date
ATE353079T1 true ATE353079T1 (de) 2007-02-15

Family

ID=22954236

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01981688T ATE353079T1 (de) 2000-11-20 2001-10-18 Verbessertes verfahren für die herstellung von wasserlöslichen o-phosphonooxymethyl-prodrugs

Country Status (18)

Country Link
US (1) US6448401B1 (de)
EP (1) EP1345915B1 (de)
JP (1) JP4579496B2 (de)
KR (1) KR100734456B1 (de)
CN (1) CN1279033C (de)
AT (1) ATE353079T1 (de)
AU (2) AU1331702A (de)
BR (1) BR0115448A (de)
CA (1) CA2429378C (de)
CZ (1) CZ20031388A3 (de)
DE (1) DE60126425T2 (de)
ES (1) ES2280405T3 (de)
HU (1) HUP0301917A3 (de)
IL (2) IL155612A0 (de)
MX (1) MXPA03004332A (de)
NO (1) NO20032241D0 (de)
PL (1) PL361003A1 (de)
WO (1) WO2002042283A1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6362172B2 (en) * 2000-01-20 2002-03-26 Bristol-Myers Squibb Company Water soluble prodrugs of azole compounds
TWI329105B (en) 2002-02-01 2010-08-21 Rigel Pharmaceuticals Inc 2,4-pyrimidinediamine compounds and their uses
CN102358738A (zh) * 2003-07-30 2012-02-22 里格尔药品股份有限公司 2,4-嘧啶二胺化合物及其预防和治疗自体免疫疾病的用途
US20060047135A1 (en) * 2004-08-30 2006-03-02 Chadwick Scott T Process for preparing chloromethyl di-tert-butylphosphate
JP4801096B2 (ja) * 2005-01-19 2011-10-26 ライジェル ファーマシューティカルズ， インコーポレイテッド ２，４−ピリミジンジアミン化合物のプロドラッグおよびそれらの使用
JO2691B1 (en) * 2005-05-03 2013-03-03 ايساي آر آند دي مانجمنت كو.، ليمتد Monolysine salts for azole compounds
CN101282979B (zh) * 2005-09-13 2011-09-21 卫材R&D管理有限公司 稳定性被改善的含有磷酸氯甲酯衍生物的组合物及其制备方法
JP5046959B2 (ja) * 2005-12-20 2012-10-10 エーザイ・アール・アンド・ディー・マネジメント株式会社 水溶性アゾールプロドラッグの製造方法
ES2351365T3 (es) 2006-02-22 2011-02-03 EISAI R&D MANAGEMENT CO., LTD. Composición farmacéutica estabilizada.
CN101622263B (zh) 2007-03-06 2013-05-29 卫材R&D管理有限公司 稳定性被改善的含有磷酸氯甲酯衍生物的组合物及其制备方法
FI20070574A0 (fi) * 2007-07-30 2007-07-30 Kuopion Yliopisto Vesiliukoinen propofolin etylideenifosfaatti-aihiolääke
EP2723452A2 (de) 2011-06-22 2014-04-30 Vyome Biosciences Pvt Ltd Konjugatbasierte antimykotische und antibakterielle prodrugs
EP3525759A1 (de) * 2016-10-14 2019-08-21 Pulmatrix Operating Company, Inc. Antimykotische trockenpulver

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2111527C (en) 1992-12-24 2000-07-18 Jerzy Golik Phosphonooxymethyl ethers of taxane derivatives
CA2129288C (en) 1993-08-17 2000-05-16 Jerzy Golik Phosphonooxymethyl esters of taxane derivatives
PL181193B1 (pl) 1993-12-21 2001-06-29 Schering Corp Nowe pochodne tetrahydrofuranowe o działaniu przeciwgrzybicznym, kompozycja farmaceutyczna do leczenia infekcji grzybiczych oraz sposób wytwarzania tych związków
NZ278882A (en) 1994-01-24 1997-06-24 Janssen Pharmaceutica Nv Piperazine-containing azole antifungal compounds
NZ270418A (en) * 1994-02-07 1997-09-22 Eisai Co Ltd Polycyclic triazole & imidazole derivatives, antifungal compositions
SK27097A3 (en) 1995-06-02 1997-09-10 Schering Corp Tetrahydrofuran antifungals
GB9602080D0 (en) * 1996-02-02 1996-04-03 Pfizer Ltd Pharmaceutical compounds
EP0829478A3 (de) 1996-09-09 1998-03-25 F. Hoffmann-La Roche Ag N-Benzylimidazolium und N-Benzyltriazolium Derivate, deren Herstellung und deren Verwendung als fungizides und anti-mykotisches Mittel
PT1056754E (pt) 1998-01-29 2004-03-31 Bristol Myers Squibb Co Derivados fosfatados de 1,3,4-oxadiazolona de diarilo
US5883097A (en) 1998-04-16 1999-03-16 Schering Corporation Soluble azole antifungal salt
US6265584B1 (en) 1998-05-22 2001-07-24 Bristol-Myers Squibb Company Water soluble prodrugs of azole compounds
US6204257B1 (en) * 1998-08-07 2001-03-20 Universtiy Of Kansas Water soluble prodrugs of hindered alcohols
AU1915500A (en) * 1998-11-20 2000-06-13 Bristol-Myers Squibb Company Water soluble prodrugs of azole compounds
US6362172B2 (en) * 2000-01-20 2002-03-26 Bristol-Myers Squibb Company Water soluble prodrugs of azole compounds

Also Published As

Publication number Publication date
NO20032241D0 (no) 2003-05-19
HUP0301917A3 (en) 2005-11-28
EP1345915B1 (de) 2007-01-31
CZ20031388A3 (cs) 2003-08-13
AU1331702A (en) 2002-06-03
HUP0301917A2 (hu) 2003-09-29
CN1474817A (zh) 2004-02-11
IL155612A0 (en) 2003-11-23
KR100734456B1 (ko) 2007-07-03
AU2002213317B2 (en) 2007-03-15
MXPA03004332A (es) 2004-05-04
BR0115448A (pt) 2004-02-17
CA2429378A1 (en) 2002-05-30
DE60126425T2 (de) 2007-10-18
KR20040020865A (ko) 2004-03-09
PL361003A1 (en) 2004-09-20
WO2002042283A1 (en) 2002-05-30
IL155612A (en) 2010-05-31
EP1345915A4 (de) 2005-08-03
DE60126425D1 (de) 2007-03-22
JP4579496B2 (ja) 2010-11-10
CN1279033C (zh) 2006-10-11
CA2429378C (en) 2008-03-18
ES2280405T3 (es) 2007-09-16
EP1345915A1 (de) 2003-09-24
US6448401B1 (en) 2002-09-10
US20020062028A1 (en) 2002-05-23
JP2004518640A (ja) 2004-06-24

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Legal Events

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