ATE353079T1 - Verbessertes verfahren für die herstellung von wasserlöslichen o-phosphonooxymethyl-prodrugs - Google Patents
Verbessertes verfahren für die herstellung von wasserlöslichen o-phosphonooxymethyl-prodrugsInfo
- Publication number
- ATE353079T1 ATE353079T1 AT01981688T AT01981688T ATE353079T1 AT E353079 T1 ATE353079 T1 AT E353079T1 AT 01981688 T AT01981688 T AT 01981688T AT 01981688 T AT01981688 T AT 01981688T AT E353079 T1 ATE353079 T1 AT E353079T1
- Authority
- AT
- Austria
- Prior art keywords
- improved process
- production
- water soluble
- prodrugs
- triazole antifungal
- Prior art date
Links
- 229940002612 prodrug Drugs 0.000 title abstract 2
- 239000000651 prodrug Substances 0.000 title abstract 2
- -1 O-PHOSPHONOOXYMETHYL Chemical class 0.000 title 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title 1
- 230000000843 anti-fungal effect Effects 0.000 abstract 3
- 229940121375 antifungal agent Drugs 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- 150000003852 triazoles Chemical class 0.000 abstract 3
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having three nitrogen atoms as the only ring hetero atoms
- C07F9/6518—Five-membered rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preventing Corrosion Or Incrustation Of Metals (AREA)
- Plural Heterocyclic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25200100P | 2000-11-20 | 2000-11-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE353079T1 true ATE353079T1 (de) | 2007-02-15 |
Family
ID=22954236
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01981688T ATE353079T1 (de) | 2000-11-20 | 2001-10-18 | Verbessertes verfahren für die herstellung von wasserlöslichen o-phosphonooxymethyl-prodrugs |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US6448401B1 (de) |
| EP (1) | EP1345915B1 (de) |
| JP (1) | JP4579496B2 (de) |
| KR (1) | KR100734456B1 (de) |
| CN (1) | CN1279033C (de) |
| AT (1) | ATE353079T1 (de) |
| AU (2) | AU1331702A (de) |
| BR (1) | BR0115448A (de) |
| CA (1) | CA2429378C (de) |
| CZ (1) | CZ20031388A3 (de) |
| DE (1) | DE60126425T2 (de) |
| ES (1) | ES2280405T3 (de) |
| HU (1) | HUP0301917A3 (de) |
| IL (2) | IL155612A0 (de) |
| MX (1) | MXPA03004332A (de) |
| NO (1) | NO20032241D0 (de) |
| PL (1) | PL361003A1 (de) |
| WO (1) | WO2002042283A1 (de) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6362172B2 (en) * | 2000-01-20 | 2002-03-26 | Bristol-Myers Squibb Company | Water soluble prodrugs of azole compounds |
| TWI329105B (en) | 2002-02-01 | 2010-08-21 | Rigel Pharmaceuticals Inc | 2,4-pyrimidinediamine compounds and their uses |
| DK1656372T3 (da) | 2003-07-30 | 2013-07-01 | Rigel Pharmaceuticals Inc | 2,4-pyrimidindiaminforbindelser til anvendelse til behandling eller forebyggelse af autoimmunsygdomme |
| US20060047135A1 (en) * | 2004-08-30 | 2006-03-02 | Chadwick Scott T | Process for preparing chloromethyl di-tert-butylphosphate |
| CA2591948C (en) | 2005-01-19 | 2013-11-12 | Rigel Pharmaceuticals, Inc. | Prodrugs of 2,4-pyrimidinediamine compounds and their uses |
| JO2691B1 (en) * | 2005-05-03 | 2013-03-03 | ايساي آر آند دي مانجمنت كو.، ليمتد | Monolysine salts for azole compounds |
| US20090114877A1 (en) * | 2005-09-13 | 2009-05-07 | Eisai R&D Management Co., Ltd. | Composition Containing Stability-Improved Chloromethyl Phosphate Derivatve and Process for Producing Same |
| EP1964843B1 (de) * | 2005-12-20 | 2013-08-28 | Eisai R&D Management Co., Ltd. | Verfahren zur herstellung einer wasserlöslichen azol-prodrug |
| CN101389333A (zh) | 2006-02-22 | 2009-03-18 | 卫材R&D管理有限公司 | 稳定化药物组合物 |
| CN101622263B (zh) | 2007-03-06 | 2013-05-29 | 卫材R&D管理有限公司 | 稳定性被改善的含有磷酸氯甲酯衍生物的组合物及其制备方法 |
| FI20070574A0 (fi) * | 2007-07-30 | 2007-07-30 | Kuopion Yliopisto | Vesiliukoinen propofolin etylideenifosfaatti-aihiolääke |
| EA032840B8 (ru) | 2011-06-22 | 2020-06-18 | Вайоми Терапеутикс Лимитед | Пролекарства на основе конъюгатов противогрибковых агентов и их применение |
| EP3525759A1 (de) * | 2016-10-14 | 2019-08-21 | Pulmatrix Operating Company, Inc. | Antimykotische trockenpulver |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NO310238B1 (no) | 1992-12-24 | 2001-06-11 | Bristol Myers Squibb Co | Kjemiske forbindelser og farmasöytisk preparat samt anvendelse av slike preparater |
| CA2129288C (en) | 1993-08-17 | 2000-05-16 | Jerzy Golik | Phosphonooxymethyl esters of taxane derivatives |
| HU225062B1 (en) | 1993-12-21 | 2006-05-29 | Schering Corp | Tetrahydrofuran derivatives with antifungal- effect, pharmaceutical compositions containing them and process for their preparation |
| CN1078210C (zh) | 1994-01-24 | 2002-01-23 | 詹森药业有限公司 | 水溶性吡咯系杀真菌剂 |
| NZ270418A (en) * | 1994-02-07 | 1997-09-22 | Eisai Co Ltd | Polycyclic triazole & imidazole derivatives, antifungal compositions |
| TW357146B (en) | 1995-06-02 | 1999-05-01 | Schering Corp | Tetrahydrofuran antifungals |
| GB9602080D0 (en) * | 1996-02-02 | 1996-04-03 | Pfizer Ltd | Pharmaceutical compounds |
| EP0829478A3 (de) | 1996-09-09 | 1998-03-25 | F. Hoffmann-La Roche Ag | N-Benzylimidazolium und N-Benzyltriazolium Derivate, deren Herstellung und deren Verwendung als fungizides und anti-mykotisches Mittel |
| DK1056754T3 (da) | 1998-01-29 | 2004-02-16 | Bristol Myers Squibb Co | Phosphatderivater af diaryl-1,3,4-oxadiazolon |
| US5883097A (en) | 1998-04-16 | 1999-03-16 | Schering Corporation | Soluble azole antifungal salt |
| US6265584B1 (en) | 1998-05-22 | 2001-07-24 | Bristol-Myers Squibb Company | Water soluble prodrugs of azole compounds |
| US6204257B1 (en) * | 1998-08-07 | 2001-03-20 | Universtiy Of Kansas | Water soluble prodrugs of hindered alcohols |
| WO2000030655A1 (en) * | 1998-11-20 | 2000-06-02 | Bristol-Myers Squibb Company | Water soluble prodrugs of azole compounds |
| US6362172B2 (en) * | 2000-01-20 | 2002-03-26 | Bristol-Myers Squibb Company | Water soluble prodrugs of azole compounds |
-
2001
- 2001-10-16 US US09/982,199 patent/US6448401B1/en not_active Expired - Lifetime
- 2001-10-18 IL IL15561201A patent/IL155612A0/xx unknown
- 2001-10-18 MX MXPA03004332A patent/MXPA03004332A/es unknown
- 2001-10-18 HU HU0301917A patent/HUP0301917A3/hu unknown
- 2001-10-18 BR BR0115448-6A patent/BR0115448A/pt not_active IP Right Cessation
- 2001-10-18 AU AU1331702A patent/AU1331702A/xx active Pending
- 2001-10-18 ES ES01981688T patent/ES2280405T3/es not_active Expired - Lifetime
- 2001-10-18 DE DE60126425T patent/DE60126425T2/de not_active Expired - Lifetime
- 2001-10-18 CZ CZ20031388A patent/CZ20031388A3/cs unknown
- 2001-10-18 EP EP01981688A patent/EP1345915B1/de not_active Expired - Lifetime
- 2001-10-18 CN CNB018191665A patent/CN1279033C/zh not_active Expired - Fee Related
- 2001-10-18 WO PCT/US2001/032382 patent/WO2002042283A1/en active IP Right Grant
- 2001-10-18 JP JP2002544418A patent/JP4579496B2/ja not_active Expired - Lifetime
- 2001-10-18 AU AU2002213317A patent/AU2002213317B2/en not_active Ceased
- 2001-10-18 PL PL01361003A patent/PL361003A1/xx not_active Application Discontinuation
- 2001-10-18 CA CA002429378A patent/CA2429378C/en not_active Expired - Lifetime
- 2001-10-18 AT AT01981688T patent/ATE353079T1/de not_active IP Right Cessation
- 2001-10-18 KR KR1020037006747A patent/KR100734456B1/ko active IP Right Grant
-
2003
- 2003-04-28 IL IL155612A patent/IL155612A/en not_active IP Right Cessation
- 2003-05-19 NO NO20032241A patent/NO20032241D0/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US6448401B1 (en) | 2002-09-10 |
| HUP0301917A3 (en) | 2005-11-28 |
| EP1345915A4 (de) | 2005-08-03 |
| HUP0301917A2 (hu) | 2003-09-29 |
| AU1331702A (en) | 2002-06-03 |
| IL155612A0 (en) | 2003-11-23 |
| WO2002042283A1 (en) | 2002-05-30 |
| DE60126425T2 (de) | 2007-10-18 |
| CA2429378A1 (en) | 2002-05-30 |
| BR0115448A (pt) | 2004-02-17 |
| CA2429378C (en) | 2008-03-18 |
| CZ20031388A3 (cs) | 2003-08-13 |
| JP2004518640A (ja) | 2004-06-24 |
| CN1279033C (zh) | 2006-10-11 |
| IL155612A (en) | 2010-05-31 |
| EP1345915B1 (de) | 2007-01-31 |
| PL361003A1 (en) | 2004-09-20 |
| AU2002213317B2 (en) | 2007-03-15 |
| KR20040020865A (ko) | 2004-03-09 |
| KR100734456B1 (ko) | 2007-07-03 |
| ES2280405T3 (es) | 2007-09-16 |
| CN1474817A (zh) | 2004-02-11 |
| NO20032241D0 (no) | 2003-05-19 |
| EP1345915A1 (de) | 2003-09-24 |
| MXPA03004332A (es) | 2004-05-04 |
| US20020062028A1 (en) | 2002-05-23 |
| JP4579496B2 (ja) | 2010-11-10 |
| DE60126425D1 (de) | 2007-03-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |