ATE353079T1 - Verbessertes verfahren für die herstellung von wasserlöslichen o-phosphonooxymethyl-prodrugs - Google Patents

Verbessertes verfahren für die herstellung von wasserlöslichen o-phosphonooxymethyl-prodrugs

Info

Publication number
ATE353079T1
ATE353079T1 AT01981688T AT01981688T ATE353079T1 AT E353079 T1 ATE353079 T1 AT E353079T1 AT 01981688 T AT01981688 T AT 01981688T AT 01981688 T AT01981688 T AT 01981688T AT E353079 T1 ATE353079 T1 AT E353079T1
Authority
AT
Austria
Prior art keywords
improved process
production
water soluble
prodrugs
triazole antifungal
Prior art date
Application number
AT01981688T
Other languages
English (en)
Inventor
Chung-Pin Chen
Timothy Paul Connolly
Laxma Reddy Kolla
John D Matiskella
Richard H Mueller
Yadagiri Pendri
Dejah T Petsch
Original Assignee
Eisai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd
Application granted granted Critical
Publication of ATE353079T1 publication Critical patent/ATE353079T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having three nitrogen atoms as the only ring hetero atoms
    • C07F9/6518—Five-membered rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preventing Corrosion Or Incrustation Of Metals (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
AT01981688T 2000-11-20 2001-10-18 Verbessertes verfahren für die herstellung von wasserlöslichen o-phosphonooxymethyl-prodrugs ATE353079T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US25200100P 2000-11-20 2000-11-20

Publications (1)

Publication Number Publication Date
ATE353079T1 true ATE353079T1 (de) 2007-02-15

Family

ID=22954236

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01981688T ATE353079T1 (de) 2000-11-20 2001-10-18 Verbessertes verfahren für die herstellung von wasserlöslichen o-phosphonooxymethyl-prodrugs

Country Status (18)

Country Link
US (1) US6448401B1 (de)
EP (1) EP1345915B1 (de)
JP (1) JP4579496B2 (de)
KR (1) KR100734456B1 (de)
CN (1) CN1279033C (de)
AT (1) ATE353079T1 (de)
AU (2) AU1331702A (de)
BR (1) BR0115448A (de)
CA (1) CA2429378C (de)
CZ (1) CZ20031388A3 (de)
DE (1) DE60126425T2 (de)
ES (1) ES2280405T3 (de)
HU (1) HUP0301917A3 (de)
IL (2) IL155612A0 (de)
MX (1) MXPA03004332A (de)
NO (1) NO20032241D0 (de)
PL (1) PL361003A1 (de)
WO (1) WO2002042283A1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6362172B2 (en) * 2000-01-20 2002-03-26 Bristol-Myers Squibb Company Water soluble prodrugs of azole compounds
TWI329105B (en) 2002-02-01 2010-08-21 Rigel Pharmaceuticals Inc 2,4-pyrimidinediamine compounds and their uses
WO2005012294A1 (en) * 2003-07-30 2005-02-10 Rigel Pharmaceuticals, Inc. 2,4-pyrimidinediamine compounds for use in the treatment or prevention of autoimmune diseases
US20060047135A1 (en) * 2004-08-30 2006-03-02 Chadwick Scott T Process for preparing chloromethyl di-tert-butylphosphate
AU2006206458B2 (en) 2005-01-19 2012-10-25 Rigel Pharmaceuticals, Inc. Prodrugs of 2,4-pyrimidinediamine compounds and their uses
JO2691B1 (en) * 2005-05-03 2013-03-03 ايساي آر آند دي مانجمنت كو.، ليمتد Monolysine salts for azole compounds
JP4981673B2 (ja) * 2005-09-13 2012-07-25 エーザイ・アール・アンド・ディー・マネジメント株式会社 安定性が改善されたクロロメチルフォスフェイト誘導体を含む組成物およびその製造方法
US7803949B2 (en) * 2005-12-20 2010-09-28 Eisai R&D Management Co., Ltd. Process for preparation of water-soluble azole prodrugs
JP5058150B2 (ja) 2006-02-22 2012-10-24 エーザイ・アール・アンド・ディー・マネジメント株式会社 安定化医薬組成物
JP5221514B2 (ja) 2007-03-06 2013-06-26 エーザイ・アール・アンド・ディー・マネジメント株式会社 安定性が改善されたクロロメチルフォスフェイト誘導体を含む組成物及びその製造方法
FI20070574A0 (fi) * 2007-07-30 2007-07-30 Kuopion Yliopisto Vesiliukoinen propofolin etylideenifosfaatti-aihiolääke
CN103857440B (zh) 2011-06-22 2018-09-25 维奥姆生物科学有限公司 基于缀合物的抗真菌和抗细菌前药
IL265913B2 (en) * 2016-10-14 2024-07-01 Pulmatrix Operating Co Inc Respirable Dry Powder Comprising Itraconazole In Crystalline Form And Its Use For Manufacturing A Medicament For Treating Fungal Infection

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX9308012A (es) 1992-12-24 1994-08-31 Bristol Myers Squibb Co Eteres fosfonooximetilicos de derivados de taxano, solubles en agua y composiciones farmaceuticas que los incluyen.
CA2129288C (en) 1993-08-17 2000-05-16 Jerzy Golik Phosphonooxymethyl esters of taxane derivatives
IL112081A (en) 1993-12-21 2001-08-26 Schering Plough Corp Tetrahydrofuran derivatives, their preparation and antifungal pharmaceutical compositions containing them
ES2141329T3 (es) * 1994-01-24 2000-03-16 Janssen Pharmaceutica Nv Antifungicos azolicos solubles en agua.
NZ270418A (en) * 1994-02-07 1997-09-22 Eisai Co Ltd Polycyclic triazole & imidazole derivatives, antifungal compositions
IL118464A (en) 1995-06-02 2000-08-13 Schering Corp (2R-cis)-4-¬4-¬4-¬4¬¬-5-(2',4 dihalophenyl)-tetrahydro-5-(1-H-1,2,4,triazol-1-yl-methyl)furan-3-yl(methoxy¾phenyl¾-1-piperazinyl¬phenyl2,4,dihydro2¬(5)-1-ethyl-2-(5)hydroxy propyl¾-3H-1,2,4-triazol-3-one and pharmaceutical compositions comprising them
GB9602080D0 (en) * 1996-02-02 1996-04-03 Pfizer Ltd Pharmaceutical compounds
EP0829478A3 (de) 1996-09-09 1998-03-25 F. Hoffmann-La Roche Ag N-Benzylimidazolium und N-Benzyltriazolium Derivate, deren Herstellung und deren Verwendung als fungizides und anti-mykotisches Mittel
DE69912250T2 (de) 1998-01-29 2004-07-29 Bristol-Myers Squibb Co., Wallingford Phosphorylierte derivate des diaryl 1,3,4 oxadiazolon
US5883097A (en) 1998-04-16 1999-03-16 Schering Corporation Soluble azole antifungal salt
US6265584B1 (en) 1998-05-22 2001-07-24 Bristol-Myers Squibb Company Water soluble prodrugs of azole compounds
US6204257B1 (en) * 1998-08-07 2001-03-20 Universtiy Of Kansas Water soluble prodrugs of hindered alcohols
AU1915500A (en) * 1998-11-20 2000-06-13 Bristol-Myers Squibb Company Water soluble prodrugs of azole compounds
US6362172B2 (en) * 2000-01-20 2002-03-26 Bristol-Myers Squibb Company Water soluble prodrugs of azole compounds

Also Published As

Publication number Publication date
CN1279033C (zh) 2006-10-11
EP1345915B1 (de) 2007-01-31
HUP0301917A3 (en) 2005-11-28
CZ20031388A3 (cs) 2003-08-13
EP1345915A4 (de) 2005-08-03
US6448401B1 (en) 2002-09-10
KR20040020865A (ko) 2004-03-09
IL155612A0 (en) 2003-11-23
HUP0301917A2 (hu) 2003-09-29
WO2002042283A1 (en) 2002-05-30
AU1331702A (en) 2002-06-03
DE60126425D1 (de) 2007-03-22
CA2429378A1 (en) 2002-05-30
BR0115448A (pt) 2004-02-17
EP1345915A1 (de) 2003-09-24
IL155612A (en) 2010-05-31
PL361003A1 (en) 2004-09-20
JP4579496B2 (ja) 2010-11-10
ES2280405T3 (es) 2007-09-16
AU2002213317B2 (en) 2007-03-15
US20020062028A1 (en) 2002-05-23
JP2004518640A (ja) 2004-06-24
CN1474817A (zh) 2004-02-11
MXPA03004332A (es) 2004-05-04
DE60126425T2 (de) 2007-10-18
CA2429378C (en) 2008-03-18
KR100734456B1 (ko) 2007-07-03
NO20032241D0 (no) 2003-05-19

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