ATE250620T1 - Verfahren zur herstellung von etoposid - Google Patents
Verfahren zur herstellung von etoposidInfo
- Publication number
- ATE250620T1 ATE250620T1 AT98918330T AT98918330T ATE250620T1 AT E250620 T1 ATE250620 T1 AT E250620T1 AT 98918330 T AT98918330 T AT 98918330T AT 98918330 T AT98918330 T AT 98918330T AT E250620 T1 ATE250620 T1 AT E250620T1
- Authority
- AT
- Austria
- Prior art keywords
- etoposide
- producing
- producing etoposide
- novel
- compound
- Prior art date
Links
- VJJPUSNTGOMMGY-MRVIYFEKSA-N etoposide Chemical compound COC1=C(O)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@@H](O[C@H]3[C@@H]([C@@H](O)[C@@H]4O[C@H](C)OC[C@H]4O3)O)[C@@H]3[C@@H]2C(OC3)=O)=C1 VJJPUSNTGOMMGY-MRVIYFEKSA-N 0.000 title abstract 2
- 229960005420 etoposide Drugs 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 230000001093 anti-cancer Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4829297P | 1997-06-02 | 1997-06-02 | |
| PCT/US1998/007717 WO1998055491A1 (en) | 1997-06-02 | 1998-04-17 | Process for preparing etoposide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE250620T1 true ATE250620T1 (de) | 2003-10-15 |
Family
ID=21953762
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98918330T ATE250620T1 (de) | 1997-06-02 | 1998-04-17 | Verfahren zur herstellung von etoposid |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP0986569B1 (de) |
| JP (1) | JP4698775B2 (de) |
| KR (1) | KR100519498B1 (de) |
| AT (1) | ATE250620T1 (de) |
| AU (1) | AU728986B2 (de) |
| CA (1) | CA2288898A1 (de) |
| DE (1) | DE69818460T2 (de) |
| ES (1) | ES2206917T3 (de) |
| HU (1) | HU228520B1 (de) |
| IL (1) | IL132319A (de) |
| TW (1) | TW491850B (de) |
| WO (1) | WO1998055491A1 (de) |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS59212500A (ja) * | 1983-05-18 | 1984-12-01 | Nippon Kayaku Co Ltd | ４′−デメチル−エピポドフイロトキシン−β−Ｄ−エチリデングルコシドの新規製造法 |
| JPS60246393A (ja) * | 1984-05-22 | 1985-12-06 | Nippon Kayaku Co Ltd | エトポシドの新規製造法 |
| DE3913326A1 (de) * | 1989-04-22 | 1990-11-08 | Behringwerke Ag | Verfahren zur herstellung von etoposiden |
| US5036055A (en) * | 1989-06-07 | 1991-07-30 | Bristol-Myers Company | Acylated derivatives of etoposide |
| JPH02191294A (ja) * | 1989-12-08 | 1990-07-27 | Nippon Kayaku Co Ltd | ４’ ―デメチル―エピポドフィロトキシン―β―Ｄ―エチリデングルコシドのアシル体 |
| FR2658824B1 (fr) * | 1990-02-27 | 1992-07-03 | Pf Medicament | Tris acetyl-2",3",4' ethylidene-4",6" beta-d-glucopyranosides, leur preparation et leur utilisation pour la preparation d'ethylidene beta-d-glucopyranoside de demethyl-4' epipodophyllotoxine. |
| CN1025918C (zh) * | 1990-06-07 | 1994-09-14 | 国家医药管理局上海医药工业研究院 | 抗肿瘤药表鬼臼毒吡喃糖甙的合成新工艺 |
| IT1250692B (it) * | 1991-07-23 | 1995-04-21 | Procedimento per la preparazione di demetilepipodofillotossina- beta-d-glucosidi. | |
| US5459248A (en) * | 1993-11-04 | 1995-10-17 | Bristol-Myers Squibb Company | Process of preparing etoposide phosphate and etoposide |
-
1998
- 1998-04-17 IL IL13231998A patent/IL132319A/xx not_active IP Right Cessation
- 1998-04-17 WO PCT/US1998/007717 patent/WO1998055491A1/en not_active Ceased
- 1998-04-17 JP JP50238999A patent/JP4698775B2/ja not_active Expired - Lifetime
- 1998-04-17 DE DE69818460T patent/DE69818460T2/de not_active Expired - Lifetime
- 1998-04-17 KR KR10-1999-7010912A patent/KR100519498B1/ko not_active Expired - Lifetime
- 1998-04-17 EP EP98918330A patent/EP0986569B1/de not_active Expired - Lifetime
- 1998-04-17 AU AU71276/98A patent/AU728986B2/en not_active Expired
- 1998-04-17 ES ES98918330T patent/ES2206917T3/es not_active Expired - Lifetime
- 1998-04-17 AT AT98918330T patent/ATE250620T1/de active
- 1998-04-17 HU HU0002670A patent/HU228520B1/hu unknown
- 1998-04-17 CA CA002288898A patent/CA2288898A1/en not_active Abandoned
- 1998-05-29 TW TW087108477A patent/TW491850B/zh not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| HUP0002670A2 (hu) | 2000-12-28 |
| IL132319A (en) | 2003-07-06 |
| ES2206917T3 (es) | 2004-05-16 |
| DE69818460T2 (de) | 2004-07-01 |
| IL132319A0 (en) | 2001-03-19 |
| KR20010012942A (ko) | 2001-02-26 |
| JP4698775B2 (ja) | 2011-06-08 |
| EP0986569A4 (de) | 2002-01-09 |
| EP0986569A1 (de) | 2000-03-22 |
| JP2002514223A (ja) | 2002-05-14 |
| HU228520B1 (en) | 2013-03-28 |
| WO1998055491A1 (en) | 1998-12-10 |
| KR100519498B1 (ko) | 2005-10-07 |
| AU728986B2 (en) | 2001-01-25 |
| HK1025576A1 (en) | 2000-11-17 |
| AU7127698A (en) | 1998-12-21 |
| TW491850B (en) | 2002-06-21 |
| CA2288898A1 (en) | 1998-12-10 |
| DE69818460D1 (de) | 2003-10-30 |
| HUP0002670A3 (en) | 2003-05-28 |
| EP0986569B1 (de) | 2003-09-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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