DE69818460D1 - Verfahren zur herstellung von etoposid - Google Patents

Verfahren zur herstellung von etoposid

Info

Publication number
DE69818460D1
DE69818460D1 DE69818460T DE69818460T DE69818460D1 DE 69818460 D1 DE69818460 D1 DE 69818460D1 DE 69818460 T DE69818460 T DE 69818460T DE 69818460 T DE69818460 T DE 69818460T DE 69818460 D1 DE69818460 D1 DE 69818460D1
Authority
DE
Germany
Prior art keywords
etoposide
producing
producing etoposide
novel
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69818460T
Other languages
English (en)
Other versions
DE69818460T2 (de
Inventor
Jonathan Silverberg
Purushotham Vemishetti
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Co
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of DE69818460D1 publication Critical patent/DE69818460D1/de
Application granted granted Critical
Publication of DE69818460T2 publication Critical patent/DE69818460T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE69818460T 1997-06-02 1998-04-17 Verfahren zur herstellung von etoposid Expired - Lifetime DE69818460T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US4829297P 1997-06-02 1997-06-02
US48292P 1997-06-02
PCT/US1998/007717 WO1998055491A1 (en) 1997-06-02 1998-04-17 Process for preparing etoposide

Publications (2)

Publication Number Publication Date
DE69818460D1 true DE69818460D1 (de) 2003-10-30
DE69818460T2 DE69818460T2 (de) 2004-07-01

Family

ID=21953762

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69818460T Expired - Lifetime DE69818460T2 (de) 1997-06-02 1998-04-17 Verfahren zur herstellung von etoposid

Country Status (13)

Country Link
EP (1) EP0986569B1 (de)
JP (1) JP4698775B2 (de)
KR (1) KR100519498B1 (de)
AT (1) ATE250620T1 (de)
AU (1) AU728986B2 (de)
CA (1) CA2288898A1 (de)
DE (1) DE69818460T2 (de)
ES (1) ES2206917T3 (de)
HK (1) HK1025576A1 (de)
HU (1) HU228520B1 (de)
IL (1) IL132319A (de)
TW (1) TW491850B (de)
WO (1) WO1998055491A1 (de)

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59212500A (ja) * 1983-05-18 1984-12-01 Nippon Kayaku Co Ltd ４′−デメチル−エピポドフイロトキシン−β−Ｄ−エチリデングルコシドの新規製造法
JPS60246393A (ja) * 1984-05-22 1985-12-06 Nippon Kayaku Co Ltd エトポシドの新規製造法
DE3913326A1 (de) * 1989-04-22 1990-11-08 Behringwerke Ag Verfahren zur herstellung von etoposiden
US5036055A (en) * 1989-06-07 1991-07-30 Bristol-Myers Company Acylated derivatives of etoposide
JPH02191294A (ja) * 1989-12-08 1990-07-27 Nippon Kayaku Co Ltd ４’　―デメチル―エピポドフィロトキシン―β―Ｄ―エチリデングルコシドのアシル体
FR2658824B1 (fr) * 1990-02-27 1992-07-03 Pf Medicament Tris acetyl-2",3",4' ethylidene-4",6" beta-d-glucopyranosides, leur preparation et leur utilisation pour la preparation d'ethylidene beta-d-glucopyranoside de demethyl-4' epipodophyllotoxine.
CN1025918C (zh) * 1990-06-07 1994-09-14 国家医药管理局上海医药工业研究院 抗肿瘤药表鬼臼毒吡喃糖甙的合成新工艺
IT1250692B (it) * 1991-07-23 1995-04-21 Procedimento per la preparazione di demetilepipodofillotossina- beta-d-glucosidi.
US5459248A (en) * 1993-11-04 1995-10-17 Bristol-Myers Squibb Company Process of preparing etoposide phosphate and etoposide

Also Published As

Publication number Publication date
EP0986569A4 (de) 2002-01-09
EP0986569A1 (de) 2000-03-22
JP4698775B2 (ja) 2011-06-08
IL132319A (en) 2003-07-06
AU7127698A (en) 1998-12-21
WO1998055491A1 (en) 1998-12-10
AU728986B2 (en) 2001-01-25
EP0986569B1 (de) 2003-09-24
HU228520B1 (en) 2013-03-28
ES2206917T3 (es) 2004-05-16
HUP0002670A2 (hu) 2000-12-28
IL132319A0 (en) 2001-03-19
ATE250620T1 (de) 2003-10-15
CA2288898A1 (en) 1998-12-10
KR20010012942A (ko) 2001-02-26
TW491850B (en) 2002-06-21
JP2002514223A (ja) 2002-05-14
HK1025576A1 (en) 2000-11-17
KR100519498B1 (ko) 2005-10-07
HUP0002670A3 (en) 2003-05-28
DE69818460T2 (de) 2004-07-01

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition