HUP0301917A2 - Javított eljárás vízoldható azolvegyületek elżállítására - Google Patents

Javított eljárás vízoldható azolvegyületek elżállítására

Info

Publication number
HUP0301917A2
HUP0301917A2 HU0301917A HUP0301917A HUP0301917A2 HU P0301917 A2 HUP0301917 A2 HU P0301917A2 HU 0301917 A HU0301917 A HU 0301917A HU P0301917 A HUP0301917 A HU P0301917A HU P0301917 A2 HUP0301917 A2 HU P0301917A2
Authority
HU
Hungary
Prior art keywords
general formula
compound
hydroxy
water soluble
defined above
Prior art date
Application number
HU0301917A
Other languages
English (en)
Inventor
Chung-Pin Chen
Timothy Paul Connolly
Laxima Reddy Kolla
John D. Matiskella
Richard H. Mueller
Dejah T. Petsch
Yadagiri Rendri
Original Assignee
Bristol-Myers Squibb Co.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol-Myers Squibb Co. filed Critical Bristol-Myers Squibb Co.
Publication of HUP0301917A2 publication Critical patent/HUP0301917A2/hu
Publication of HUP0301917A3 publication Critical patent/HUP0301917A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having three nitrogen atoms as the only ring hetero atoms
    • C07F9/6518—Five-membered rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preventing Corrosion Or Incrustation Of Metals (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

A találmány tárgya javított eljárás az általános képletű - ahol A egyszekunder vagy tercier hidroxicsoportot tartalmazó triazol fungicidvegyület nem hidroxi része, R és R1 egymástól függetlenül hidrogénatomvagy 1-6 szénatomos alkilcsoport - triazol fungicid vegyületekvízoldható prodrugjainak előállítására, melynek során az egy A-OHképletű vegyületet - egy általános képletű vegyülettel - amelyben R ésR1 jelentése a fentiekben meghatározott, és Pr jelentése jodid-ionforrással rendelkező hidroxi-védőcsoport - reagáltatnak egy inertszerves oldószerben és egy bázis jelenlétében körülbelül 25°C-tól50°C-ig terjedő hőmérsékleten egy általános képletű - amelyben Pr, A,R és R1 jelentése a fentiekben meghatározott - intermedierré, és (b) aPr védőcsoportot a (IV) intermedierből hagyományos módszerekkeleltávolítva egy (I) általános képletű vegyületet kapnak, amelyetkívánt esetben hagyományos módszerekkel, egy gyógyszerészetilegelfogadható sóvá alakítanak. Ó
HU0301917A 2000-11-20 2001-10-18 Proved process for water soluble azole compounds HUP0301917A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25200100P 2000-11-20 2000-11-20
PCT/US2001/032382 WO2002042283A1 (en) 2000-11-20 2001-10-18 Improved process for water soluble azole compounds

Publications (2)

Publication Number Publication Date
HUP0301917A2 true HUP0301917A2 (hu) 2003-09-29
HUP0301917A3 HUP0301917A3 (en) 2005-11-28

Family

ID=22954236

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0301917A HUP0301917A3 (en) 2000-11-20 2001-10-18 Proved process for water soluble azole compounds

Country Status (18)

Country Link
US (1) US6448401B1 (hu)
EP (1) EP1345915B1 (hu)
JP (1) JP4579496B2 (hu)
KR (1) KR100734456B1 (hu)
CN (1) CN1279033C (hu)
AT (1) ATE353079T1 (hu)
AU (2) AU1331702A (hu)
BR (1) BR0115448A (hu)
CA (1) CA2429378C (hu)
CZ (1) CZ20031388A3 (hu)
DE (1) DE60126425T2 (hu)
ES (1) ES2280405T3 (hu)
HU (1) HUP0301917A3 (hu)
IL (2) IL155612A0 (hu)
MX (1) MXPA03004332A (hu)
NO (1) NO20032241D0 (hu)
PL (1) PL361003A1 (hu)
WO (1) WO2002042283A1 (hu)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6362172B2 (en) * 2000-01-20 2002-03-26 Bristol-Myers Squibb Company Water soluble prodrugs of azole compounds
TWI329105B (en) 2002-02-01 2010-08-21 Rigel Pharmaceuticals Inc 2,4-pyrimidinediamine compounds and their uses
KR20120062863A (ko) 2003-07-30 2012-06-14 리겔 파마슈티칼스, 인크. 자가면역 질환의 치료 또는 예방에 사용하기 위한 2,4-피리미딘디아민 화합물
US20060047135A1 (en) * 2004-08-30 2006-03-02 Chadwick Scott T Process for preparing chloromethyl di-tert-butylphosphate
EP2161275A1 (en) 2005-01-19 2010-03-10 Rigel Pharmaceuticals, Inc. Prodrugs of 2,4-pyrimidinediamine compounds and their uses
JO2691B1 (en) * 2005-05-03 2013-03-03 ايساي آر آند دي مانجمنت كو.، ليمتد Monolysine salts for azole compounds
WO2007032263A1 (ja) * 2005-09-13 2007-03-22 Eisai R & D Management Co., Ltd. 安定性が改善されたクロロメチルフォスフェイト誘導体を含む組成物およびその製造方法
CA2632842C (en) * 2005-12-20 2013-06-25 Eisai R & D Management Co., Ltd. Process for preparation of water-soluble azole prodrugs
CN101389333A (zh) 2006-02-22 2009-03-18 卫材R&D管理有限公司 稳定化药物组合物
WO2008108384A1 (ja) 2007-03-06 2008-09-12 Eisai R & D Management Co., Ltd. 安定性が改善されたクロロメチルフォスフェイト誘導体を含む組成物及びその製造方法
FI20070574A0 (fi) * 2007-07-30 2007-07-30 Kuopion Yliopisto Vesiliukoinen propofolin etylideenifosfaatti-aihiolääke
BR112013033239A2 (pt) 2011-06-22 2016-09-06 Vyome Biosciences pró-farmácos de conjugado baseado em atifungicos e antibacterianos
CA3039485A1 (en) * 2016-10-14 2018-04-19 Pulmatrix Operating Company, Inc. Antifungal dry powders

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2111527C (en) 1992-12-24 2000-07-18 Jerzy Golik Phosphonooxymethyl ethers of taxane derivatives
CA2129288C (en) 1993-08-17 2000-05-16 Jerzy Golik Phosphonooxymethyl esters of taxane derivatives
CZ294823B6 (cs) 1993-12-21 2005-03-16 Schering Corporation Fungicidní tetrahydrofurany
SI0741737T1 (en) * 1994-01-24 2000-02-29 Janssen Pharmaceutica N.V. Watersoluble azole antifungals
NZ270418A (en) * 1994-02-07 1997-09-22 Eisai Co Ltd Polycyclic triazole & imidazole derivatives, antifungal compositions
AR002751A1 (es) 1995-06-02 1998-04-29 Schering Corp Antifungicos de tetrahidrofurano, composiciones farmaceuticas que los contienen y el uso de los compuestos para preparar composiciones farmaceuticas utiles para el tratamiento de infecciones fungicas
GB9602080D0 (en) * 1996-02-02 1996-04-03 Pfizer Ltd Pharmaceutical compounds
EP0829478A3 (en) 1996-09-09 1998-03-25 F. Hoffmann-La Roche Ag N-Benzylimidazolium and N-benzyltriazolium derivatives, their preparation and their use as antifungal and antimycotic agents
ATE252590T1 (de) 1998-01-29 2003-11-15 Bristol Myers Squibb Co Phosphorylierte derivate des diaryl 1,3,4 oxadiazolon
US5883097A (en) 1998-04-16 1999-03-16 Schering Corporation Soluble azole antifungal salt
US6265584B1 (en) 1998-05-22 2001-07-24 Bristol-Myers Squibb Company Water soluble prodrugs of azole compounds
US6204257B1 (en) * 1998-08-07 2001-03-20 Universtiy Of Kansas Water soluble prodrugs of hindered alcohols
WO2000030655A1 (en) * 1998-11-20 2000-06-02 Bristol-Myers Squibb Company Water soluble prodrugs of azole compounds
US6362172B2 (en) * 2000-01-20 2002-03-26 Bristol-Myers Squibb Company Water soluble prodrugs of azole compounds

Also Published As

Publication number Publication date
ES2280405T3 (es) 2007-09-16
KR20040020865A (ko) 2004-03-09
HUP0301917A3 (en) 2005-11-28
IL155612A (en) 2010-05-31
BR0115448A (pt) 2004-02-17
IL155612A0 (en) 2003-11-23
NO20032241D0 (no) 2003-05-19
AU1331702A (en) 2002-06-03
EP1345915A4 (en) 2005-08-03
DE60126425T2 (de) 2007-10-18
EP1345915B1 (en) 2007-01-31
CA2429378A1 (en) 2002-05-30
MXPA03004332A (es) 2004-05-04
KR100734456B1 (ko) 2007-07-03
US20020062028A1 (en) 2002-05-23
WO2002042283A1 (en) 2002-05-30
JP2004518640A (ja) 2004-06-24
PL361003A1 (en) 2004-09-20
CN1279033C (zh) 2006-10-11
CA2429378C (en) 2008-03-18
JP4579496B2 (ja) 2010-11-10
ATE353079T1 (de) 2007-02-15
DE60126425D1 (de) 2007-03-22
CN1474817A (zh) 2004-02-11
AU2002213317B2 (en) 2007-03-15
US6448401B1 (en) 2002-09-10
EP1345915A1 (en) 2003-09-24
CZ20031388A3 (cs) 2003-08-13

Similar Documents

Publication Publication Date Title
WO2000061783A3 (en) Process for preparing inhibitors of nucleoside metabolism
HUP0301917A2 (hu) Javított eljárás vízoldható azolvegyületek elżállítására
HUP0204405A2 (en) Water soluble prodrugs of azole compounds
GB0117583D0 (en) Novel compounds
TW200517393A (en) Processes for the preparation of benzoimidazole derivatives
CA2454306A1 (en) Substituted dihydro 3-halo-1h-pyrazole-5-carboxylates their preparation and use
WO2005092895A3 (en) Alpha aryl or heteroaryl methyl beta piperidino propanoic acid compounds as orl1-receptor antagonists
HU9401726D0 (en) 2-piperazinone derivatives and process for producing them
MX2009008858A (es) Derivado de pirazolcarbonitrilo que contiene fluor y el metodo para producirlo y derivado del acido pirazolcarboxilico que contiene fluor obtenido utilizando el derivado de pirazolcarbonitrilo que contiene fluor y el método para producirlo.
JP2002514649A5 (hu)
HUP0302764A2 (hu) Javított eljárás karbapenemszármazékok szintézisére
AU3415599A (en) Benzoheterocyclic distamycin derivatives, process for preparing them, and their use as antitumor agents
NZ332923A (en) Distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents
AU5936901A (en) Process for preparing azacycloalkanoylaminothiazoles
HUP9702399A2 (hu) Eljárás taxol és származékai előállítására
TW200619413A (en) Metal compound, thin film-forming material, and method for producing thin film
AU3285000A (en) 22r-hydroxycholesta-8,14-diene derivatives for the inhibition of meiosis
HU0201262D0 (hu)
ATE247662T1 (de) Indolocarbazolalkaloide aus einer marinen actinomycete
GB9906328D0 (en) 2-Substituted RNA preparation
HUP9901070A2 (hu) Eljárás 1-(3-trialkil-szilil-fenil)-2,2,2-trifluor-metil-etanon-származékok előállítására
IL160982A0 (en) Salts of 20(s)-camptothecin, processes for the preparation thereof and pharmaceutical compositions containing the same
PT1581504E (pt) Processo de preparação de derivados de imidazole substituídos e intermediários utilizados no processo
ES2152860A1 (es) Forma cristalina de la nefazodona y procedimiento para su preparacion.
WO2003018559A3 (en) Intermediates and preparation thereof for the enantioselective synthesis of (20r) homocamptothecins

Legal Events

Date Code Title Description
FA9A Lapse of provisional patent protection due to relinquishment or protection considered relinquished