ATE321067T1 - Neuartige peptidderivate mit thiazolyl-alanin- resten - Google Patents
Neuartige peptidderivate mit thiazolyl-alanin- restenInfo
- Publication number
- ATE321067T1 ATE321067T1 AT97935856T AT97935856T ATE321067T1 AT E321067 T1 ATE321067 T1 AT E321067T1 AT 97935856 T AT97935856 T AT 97935856T AT 97935856 T AT97935856 T AT 97935856T AT E321067 T1 ATE321067 T1 AT E321067T1
- Authority
- AT
- Austria
- Prior art keywords
- thiazolyl
- peptide derivatives
- alanine residue
- novel peptide
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
- C07D207/277—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D207/28—2-Pyrrolidone-5- carboxylic acids; Functional derivatives thereof, e.g. esters, nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/24—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
- C07K5/0825—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp and Glp-amino acid; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Crystallography & Structural Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP22638696 | 1996-08-28 | ||
| JP9052997 | 1997-04-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE321067T1 true ATE321067T1 (de) | 2006-04-15 |
Family
ID=26432009
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT97935856T ATE321067T1 (de) | 1996-08-28 | 1997-08-22 | Neuartige peptidderivate mit thiazolyl-alanin- resten |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP0933379B1 (de) |
| JP (1) | JP3234236B2 (de) |
| KR (1) | KR100318804B1 (de) |
| CN (1) | CN1214040C (de) |
| AT (1) | ATE321067T1 (de) |
| AU (1) | AU713133B2 (de) |
| BR (1) | BR9712081B1 (de) |
| CA (1) | CA2264268C (de) |
| DE (1) | DE69735543T2 (de) |
| DK (1) | DK0933379T3 (de) |
| ES (1) | ES2259805T3 (de) |
| PT (1) | PT933379E (de) |
| TR (1) | TR199900477T2 (de) |
| TW (1) | TW492977B (de) |
| WO (1) | WO1998008867A1 (de) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2642399A (en) | 1998-03-02 | 1999-09-20 | Shionogi & Co., Ltd. | Process for producing 4-thiazolylmethyl derivative |
| WO1999053941A1 (fr) * | 1998-04-15 | 1999-10-28 | Shionogi & Co., Ltd. | Preparations orales contenant des derives de trh |
| JP2002539192A (ja) * | 1999-03-15 | 2002-11-19 | アクシス・ファーマシューティカルズ・インコーポレイテッド | プロテアーゼ阻害剤としての新規な化合物及び組成物 |
| DE60014939T2 (de) | 1999-08-30 | 2006-03-09 | Shionogi & Co., Ltd. | Verfahren für die herstellung von oxo-oxazoline oder alloaminosäuren |
| EP1300155A1 (de) * | 2000-07-11 | 2003-04-09 | Shionogi & Co., Ltd. | Enterische präparation mit physiologisch aktiven peptiden |
| KR20050105290A (ko) * | 2000-08-31 | 2005-11-03 | 시오노기세이야쿠가부시키가이샤 | 파킨슨씨병 치료제 |
| MXPA03005601A (es) | 2000-12-22 | 2004-12-02 | Axys Pharm Inc | Nuevos compuestos y composiciones como inhibidores de catepsina. |
| US7030116B2 (en) | 2000-12-22 | 2006-04-18 | Aventis Pharmaceuticals Inc. | Compounds and compositions as cathepsin inhibitors |
| ES2296962T3 (es) * | 2001-06-27 | 2008-05-01 | Smithkline Beecham Corporation | Pirrolidinas como inhibidores de dipeptidil peptidasa. |
| CN1324008C (zh) | 2001-09-14 | 2007-07-04 | 安万特药物公司 | 作为组织蛋白酶抑制剂的新化合物和组合物 |
| WO2003042197A1 (en) | 2001-11-14 | 2003-05-22 | Aventis Pharmaceuticals Inc. | Oligopeptides and compositions containing them as cathepsin s inhibitors |
| CA2508487A1 (en) * | 2002-12-04 | 2004-06-17 | Merck & Co., Inc. | Phenylalanine derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes |
| TWI350754B (en) * | 2004-09-09 | 2011-10-21 | Shionogi & Co | A pharmaceutical composition for treating spinocerebellar ataxia |
| JP5196641B2 (ja) * | 2004-09-09 | 2013-05-15 | 塩野義製薬株式会社 | 脊髄小脳変性症治療剤 |
| JP5981719B2 (ja) * | 2009-06-08 | 2016-08-31 | 株式会社カネカ | 光学活性チアゾリルアラニン誘導体およびその塩の製造方法 |
| CN101817870B (zh) * | 2010-04-01 | 2012-04-18 | 济南兆德生物科技有限公司 | 一种促甲状腺素释放激素及其可药用盐的制备方法 |
| WO2024019026A1 (ja) * | 2022-07-20 | 2024-01-25 | 塩野義製薬株式会社 | 生理活性ペプチド含有製剤 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2527723A1 (de) * | 1975-06-21 | 1976-12-30 | Gruenenthal Chemie | Verfahren zur herstellung von dipeptid-derivaten |
| JPS5944308B2 (ja) * | 1976-03-23 | 1984-10-29 | 武田薬品工業株式会社 | ペプタイド |
| JPS62234029A (ja) * | 1985-12-27 | 1987-10-14 | Tanabe Seiyaku Co Ltd | 中枢神経賦活剤 |
| CA2010312C (en) * | 1989-02-21 | 1998-05-12 | Akihiro Yasuda | Peptide derivatives and their pharmaceutical use |
| DK0784629T3 (da) * | 1994-10-05 | 1999-10-25 | Darwin Discovery Ltd | Peptidylforbindelser og deres terapeutiske anvendelse som inhibitorer af metalloproteaser |
-
1997
- 1997-08-22 AU AU38680/97A patent/AU713133B2/en not_active Ceased
- 1997-08-22 JP JP51145998A patent/JP3234236B2/ja not_active Expired - Fee Related
- 1997-08-22 PT PT97935856T patent/PT933379E/pt unknown
- 1997-08-22 EP EP97935856A patent/EP0933379B1/de not_active Expired - Lifetime
- 1997-08-22 WO PCT/JP1997/002917 patent/WO1998008867A1/ja active IP Right Grant
- 1997-08-22 ES ES97935856T patent/ES2259805T3/es not_active Expired - Lifetime
- 1997-08-22 DK DK97935856T patent/DK0933379T3/da active
- 1997-08-22 CA CA002264268A patent/CA2264268C/en not_active Expired - Fee Related
- 1997-08-22 DE DE69735543T patent/DE69735543T2/de not_active Expired - Lifetime
- 1997-08-22 TR TR1999/00477T patent/TR199900477T2/xx unknown
- 1997-08-22 BR BRPI9712081-2A patent/BR9712081B1/pt not_active IP Right Cessation
- 1997-08-22 KR KR1019997001667A patent/KR100318804B1/ko not_active IP Right Cessation
- 1997-08-22 CN CNB971992487A patent/CN1214040C/zh not_active Expired - Fee Related
- 1997-08-22 AT AT97935856T patent/ATE321067T1/de active
- 1997-08-27 TW TW086112314A patent/TW492977B/zh not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| AU3868097A (en) | 1998-03-19 |
| EP0933379A4 (de) | 2001-09-12 |
| EP0933379B1 (de) | 2006-03-22 |
| BR9712081A (pt) | 1999-08-24 |
| TR199900477T2 (xx) | 1999-06-21 |
| CN1235610A (zh) | 1999-11-17 |
| TW492977B (en) | 2002-07-01 |
| EP0933379A1 (de) | 1999-08-04 |
| BR9712081B1 (pt) | 2010-12-14 |
| CN1214040C (zh) | 2005-08-10 |
| AU713133B2 (en) | 1999-11-25 |
| ES2259805T3 (es) | 2006-10-16 |
| KR20000035930A (ko) | 2000-06-26 |
| CA2264268C (en) | 2003-11-11 |
| JP3234236B2 (ja) | 2001-12-04 |
| DE69735543T2 (de) | 2007-03-08 |
| KR100318804B1 (ko) | 2002-01-04 |
| WO1998008867A1 (fr) | 1998-03-05 |
| CA2264268A1 (en) | 1998-03-05 |
| DE69735543D1 (de) | 2006-05-11 |
| DK0933379T3 (da) | 2006-06-26 |
| PT933379E (pt) | 2006-07-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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