DE69735543D1 - Neuartige peptidderivate mit thiazolyl-alanin-resten - Google Patents

Neuartige peptidderivate mit thiazolyl-alanin-resten

Info

Publication number
DE69735543D1
DE69735543D1 DE69735543T DE69735543T DE69735543D1 DE 69735543 D1 DE69735543 D1 DE 69735543D1 DE 69735543 T DE69735543 T DE 69735543T DE 69735543 T DE69735543 T DE 69735543T DE 69735543 D1 DE69735543 D1 DE 69735543D1
Authority
DE
Germany
Prior art keywords
thiazole
peptide derivatives
novel peptide
alanine residues
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69735543T
Other languages
English (en)
Other versions
DE69735543T2 (de
Inventor
Tamio Sugawara
Takayoshi Yoshikawa
Yukio Tada
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shionogi and Co Ltd
Original Assignee
Shionogi and Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi and Co Ltd filed Critical Shionogi and Co Ltd
Publication of DE69735543D1 publication Critical patent/DE69735543D1/de
Application granted granted Critical
Publication of DE69735543T2 publication Critical patent/DE69735543T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • C07D207/277—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D207/28—2-Pyrrolidone-5- carboxylic acids; Functional derivatives thereof, e.g. esters, nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/24—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • C07K5/0825—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp and Glp-amino acid; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
DE69735543T 1996-08-28 1997-08-22 Neuartige peptidderivate mit thiazolyl-alanin-resten Expired - Lifetime DE69735543T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP22638696 1996-08-28
JP22638696 1996-08-28
JP9052997 1997-04-09
JP9052997 1997-04-09
PCT/JP1997/002917 WO1998008867A1 (fr) 1996-08-28 1997-08-22 Nouveaux derives de peptides presentant un residu de thiazolyle-alanine

Publications (2)

Publication Number Publication Date
DE69735543D1 true DE69735543D1 (de) 2006-05-11
DE69735543T2 DE69735543T2 (de) 2007-03-08

Family

ID=26432009

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69735543T Expired - Lifetime DE69735543T2 (de) 1996-08-28 1997-08-22 Neuartige peptidderivate mit thiazolyl-alanin-resten

Country Status (15)

Country Link
EP (1) EP0933379B1 (de)
JP (1) JP3234236B2 (de)
KR (1) KR100318804B1 (de)
CN (1) CN1214040C (de)
AT (1) ATE321067T1 (de)
AU (1) AU713133B2 (de)
BR (1) BR9712081B1 (de)
CA (1) CA2264268C (de)
DE (1) DE69735543T2 (de)
DK (1) DK0933379T3 (de)
ES (1) ES2259805T3 (de)
PT (1) PT933379E (de)
TR (1) TR199900477T2 (de)
TW (1) TW492977B (de)
WO (1) WO1998008867A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1069118B1 (de) * 1998-03-02 2004-09-22 Shionogi & Co., Ltd. Verfahren zur herstellung eines 4-thiazolylmethylderivates
WO1999053941A1 (fr) * 1998-04-15 1999-10-28 Shionogi & Co., Ltd. Preparations orales contenant des derives de trh
CA2368148A1 (en) 1999-03-15 2000-09-21 Axys Pharmaceuticals, Inc. Novel compounds and compositions as protease inhibitors
CN1250532C (zh) 1999-08-30 2006-04-12 盐野义制药株式会社 氧代噁唑啉及别氨基酸衍生物的制备方法
WO2002004016A1 (fr) * 2000-07-11 2002-01-17 Shionogi & Co., Ltd. Preparations enteriques contenant des peptides physiologiquement actifs
JP4817281B2 (ja) * 2000-08-31 2011-11-16 塩野義製薬株式会社 パーキンソン病治療剤
US7064123B1 (en) 2000-12-22 2006-06-20 Aventis Pharmaceuticals Inc. Compounds and compositions as cathepsin inhibitors
US7030116B2 (en) 2000-12-22 2006-04-18 Aventis Pharmaceuticals Inc. Compounds and compositions as cathepsin inhibitors
US7196201B2 (en) * 2001-06-27 2007-03-27 Smithkline Beecham Corporation Pyrrolidines as dipeptidyl peptidase inhibitors
IL160819A0 (en) 2001-09-14 2004-08-31 Aventis Pharma Inc Novel compounds and compositions as cathepsin inhibitors
CN1324018C (zh) 2001-11-14 2007-07-04 安万特药物公司 作为组织蛋白酶s抑制剂的寡肽以及含有它们的组合物
EP1578414A4 (de) * 2002-12-04 2007-10-24 Merck & Co Inc Phenylalanin-derivate alsdipeptidyl-peptidase-hemmer zur behandlung oder prävention von diabetes
TWI350754B (en) * 2004-09-09 2011-10-21 Shionogi & Co A pharmaceutical composition for treating spinocerebellar ataxia
JP5196641B2 (ja) * 2004-09-09 2013-05-15 塩野義製薬株式会社 脊髄小脳変性症治療剤
WO2010143409A1 (ja) * 2009-06-08 2010-12-16 株式会社カネカ 光学活性チアゾリルアラニン誘導体およびその塩の製造方法
CN101817870B (zh) * 2010-04-01 2012-04-18 济南兆德生物科技有限公司 一种促甲状腺素释放激素及其可药用盐的制备方法
WO2024019026A1 (ja) * 2022-07-20 2024-01-25 塩野義製薬株式会社 生理活性ペプチド含有製剤

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2527723A1 (de) * 1975-06-21 1976-12-30 Gruenenthal Chemie Verfahren zur herstellung von dipeptid-derivaten
JPS5944308B2 (ja) * 1976-03-23 1984-10-29 武田薬品工業株式会社 ペプタイド
JPS62234029A (ja) * 1985-12-27 1987-10-14 Tanabe Seiyaku Co Ltd 中枢神経賦活剤
JPH0699471B2 (ja) * 1989-02-21 1994-12-07 日本たばこ産業株式会社 新規ペプチド誘導体
DE69509401T2 (de) * 1994-10-05 1999-08-19 Darwin Discovery Ltd. Peptidische verbindungen und deren therapeutische verwendung als metalloproteinase-inhibitoren

Also Published As

Publication number Publication date
CN1214040C (zh) 2005-08-10
CN1235610A (zh) 1999-11-17
EP0933379A4 (de) 2001-09-12
ATE321067T1 (de) 2006-04-15
DK0933379T3 (da) 2006-06-26
AU3868097A (en) 1998-03-19
BR9712081A (pt) 1999-08-24
KR20000035930A (ko) 2000-06-26
EP0933379B1 (de) 2006-03-22
BR9712081B1 (pt) 2010-12-14
PT933379E (pt) 2006-07-31
WO1998008867A1 (fr) 1998-03-05
ES2259805T3 (es) 2006-10-16
CA2264268C (en) 2003-11-11
EP0933379A1 (de) 1999-08-04
KR100318804B1 (ko) 2002-01-04
JP3234236B2 (ja) 2001-12-04
TR199900477T2 (xx) 1999-06-21
TW492977B (en) 2002-07-01
CA2264268A1 (en) 1998-03-05
AU713133B2 (en) 1999-11-25
DE69735543T2 (de) 2007-03-08

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Legal Events

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