ATE309211T1 - Amidino- und guanidino-azetidinone tryptase- inhibitoren - Google Patents

Amidino- und guanidino-azetidinone tryptase- inhibitoren

Info

Publication number
ATE309211T1
ATE309211T1 AT99930402T AT99930402T ATE309211T1 AT E309211 T1 ATE309211 T1 AT E309211T1 AT 99930402 T AT99930402 T AT 99930402T AT 99930402 T AT99930402 T AT 99930402T AT E309211 T1 ATE309211 T1 AT E309211T1
Authority
AT
Austria
Prior art keywords
azetidinone
guanidino
amidino
tryptase inhibitors
tryptase
Prior art date
Application number
AT99930402T
Other languages
English (en)
Inventor
Gregory Bisacchi
William A Slusarchyk
Uwe Treuner
James C Sutton
Robert Zahler
Steven Seiler
David R Kronenthal
Michael E Randazzo
Zhongmin Xu
Zhongping Shi
Mark D Schwinden
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Application granted granted Critical
Publication of ATE309211T1 publication Critical patent/ATE309211T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT99930402T 1998-06-25 1999-06-18 Amidino- und guanidino-azetidinone tryptase- inhibitoren ATE309211T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9063698P 1998-06-25 1998-06-25
PCT/US1999/013811 WO1999067215A1 (en) 1998-06-25 1999-06-18 Amidino and guanidino azetidinone tryptase inhibitors

Publications (1)

Publication Number Publication Date
ATE309211T1 true ATE309211T1 (de) 2005-11-15

Family

ID=22223632

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99930402T ATE309211T1 (de) 1998-06-25 1999-06-18 Amidino- und guanidino-azetidinone tryptase- inhibitoren

Country Status (24)

Country Link
EP (1) EP1089973B1 (de)
JP (1) JP2002518478A (de)
KR (1) KR20010053173A (de)
CN (1) CN1202081C (de)
AR (1) AR018945A1 (de)
AT (1) ATE309211T1 (de)
AU (1) AU752320B2 (de)
BR (1) BR9911373A (de)
CA (1) CA2336003A1 (de)
DE (1) DE69928257T2 (de)
ES (1) ES2249017T3 (de)
HU (1) HUP0104308A3 (de)
ID (1) ID27137A (de)
IL (1) IL140414A0 (de)
NO (1) NO20006380D0 (de)
NZ (1) NZ507627A (de)
PE (1) PE20000729A1 (de)
PL (1) PL345067A1 (de)
RU (1) RU2211832C2 (de)
TR (1) TR200003859T2 (de)
TW (1) TW548270B (de)
UY (1) UY25580A1 (de)
WO (1) WO1999067215A1 (de)
ZA (1) ZA200006028B (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2308562B1 (de) * 2003-12-25 2015-02-25 Ono Pharmaceutical Co., Ltd. Azetidin-Ringverbindungen und diese enthaltende Arzneimittel
WO2006062110A1 (ja) * 2004-12-06 2006-06-15 Banyu Pharmaceutical Co., Ltd. ピペラジン誘導体
US8772297B2 (en) * 2010-02-17 2014-07-08 Kyoto University TGF-β signal transduction inhibitor
RU2015140600A (ru) * 2013-03-20 2017-04-26 Ф. Хоффманн-Ля Рош Аг Производные мочевины и их применение в качестве ингибиторов белка, связывающего жирные кислоты
WO2014173855A1 (en) 2013-04-22 2014-10-30 Reuter Chemische Apparatebau Kg Process for preparing enantiomerically enriched 3-hydroxymethylpiperidine
EP3036219A4 (de) 2013-06-04 2017-08-23 Temple University Of The Commonwealth System Of Higher Education Neuartige beta-lactame als modulatoren einer glutamataufnahme und verfahren zur verwendung davon
KR101927114B1 (ko) * 2014-02-07 2018-12-10 엑시테라 파마슈티컬스 인코퍼레이티드 치료 화합물 및 조성물
EP3749662A4 (de) 2018-02-07 2021-07-14 Exithera Pharmaceuticals Inc. Therapeutische verbindungen und zusammensetzungen
CN112292376A (zh) * 2018-03-30 2021-01-29 上海美悦生物科技发展有限公司 四元内酰胺类化合物及其药学用途
CN109988098A (zh) * 2019-05-23 2019-07-09 常州工程职业技术学院 一种(r)-n-叔丁氧羰基-3-羟甲基哌啶的合成方法
CN114040908A (zh) * 2019-06-25 2022-02-11 广东东阳光药业有限公司 一种凝血因子XIa抑制剂的晶型及其制备方法
CA3160619A1 (en) 2019-11-08 2021-05-14 Coave Therapeutics Modified adeno-associated virus vectors and delivery thereof into the central nervous system
WO2022096681A1 (en) * 2020-11-06 2022-05-12 Coave Therapeutics Lactam-modified adeno-associated virus vectors
CN116802279A (zh) 2020-11-06 2023-09-22 科亚韦治疗公司 内酰胺修饰的腺相关病毒载体
CN118754827B (zh) * 2024-06-27 2025-03-25 成都普康唯新生物科技有限公司 含保护基的α-甲基鸟氨酸的合成方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5037819A (en) * 1990-06-04 1991-08-06 Bristol-Myers Squibb Company Azetidin-2-one derivatives as serine protease inhibitors
US5250677A (en) * 1990-06-04 1993-10-05 Bristol-Myers Squibb Company Azetidin-2-one derivatives as serine protease inhibitors
US5110812A (en) * 1990-06-04 1992-05-05 Bristol-Myers Squibb Co. Azetidin-2-one derivatives as serine protease inhibitors
US5175283A (en) * 1990-06-04 1992-12-29 Bristol-Myers Squibb Company Azetidin-2-one derivatives as serine protease inhibitors
CA2108584C (en) * 1992-10-27 1998-11-24 James B. Doherty Substituted azetidinones as anti-inflammatory and antidegenerative agents
US5633246A (en) * 1994-11-18 1997-05-27 Schering Corporation Sulfur-substituted azetidinone compounds useful as hypocholesterolemic agents
US5747485A (en) * 1995-04-13 1998-05-05 Merck & Co., Inc. Substituted azetidiones as anti-inflammatory and antidegenerative agents
EP0950046B1 (de) * 1996-09-23 2002-04-10 Naeja Pharmaceutical Inc. 3,4-disubstituierte azetidin-2-on-derivate die als cystein-proteinase regulatoren nuetzlich sind

Also Published As

Publication number Publication date
KR20010053173A (ko) 2001-06-25
ES2249017T3 (es) 2006-03-16
AU4695099A (en) 2000-01-10
BR9911373A (pt) 2001-09-18
UY25580A1 (es) 2001-08-27
DE69928257T2 (de) 2006-08-03
AR018945A1 (es) 2001-12-12
HUP0104308A2 (hu) 2002-04-29
CA2336003A1 (en) 1999-12-29
EP1089973B1 (de) 2005-11-09
EP1089973A4 (de) 2001-12-12
NZ507627A (en) 2003-12-19
WO1999067215A1 (en) 1999-12-29
PL345067A1 (en) 2001-12-03
PE20000729A1 (es) 2000-10-28
AU752320B2 (en) 2002-09-12
JP2002518478A (ja) 2002-06-25
DE69928257D1 (de) 2005-12-15
IL140414A0 (en) 2002-02-10
NO20006380L (no) 2000-12-14
NO20006380D0 (no) 2000-12-14
RU2211832C2 (ru) 2003-09-10
CN1307560A (zh) 2001-08-08
ZA200006028B (en) 2002-09-25
TW548270B (en) 2003-08-21
ID27137A (id) 2001-03-01
CN1202081C (zh) 2005-05-18
EP1089973A1 (de) 2001-04-11
TR200003859T2 (tr) 2001-07-23
HUP0104308A3 (en) 2002-06-28

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