ATE286900T1 - (1,2,4)triazolo(1,5-c)pyrimidin-derivate - Google Patents

(1,2,4)triazolo(1,5-c)pyrimidin-derivate

Info

Publication number
ATE286900T1
ATE286900T1 AT99944771T AT99944771T ATE286900T1 AT E286900 T1 ATE286900 T1 AT E286900T1 AT 99944771 T AT99944771 T AT 99944771T AT 99944771 T AT99944771 T AT 99944771T AT E286900 T1 ATE286900 T1 AT E286900T1
Authority
AT
Austria
Prior art keywords
represent
triazolo
aryl
pyrimidine derivatives
lower alkyl
Prior art date
Application number
AT99944771T
Other languages
English (en)
Inventor
Junichi Shimada
Hironori Imma
Naoto Osakada
Shizuo Shiozaki
Tomoyuki Kanda
Yoshihisa Kuwana
Original Assignee
Kyowa Hakko Kogyo Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kogyo Kk filed Critical Kyowa Hakko Kogyo Kk
Application granted granted Critical
Publication of ATE286900T1 publication Critical patent/ATE286900T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Psychiatry (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT99944771T 1998-09-22 1999-09-22 (1,2,4)triazolo(1,5-c)pyrimidin-derivate ATE286900T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP26717898 1998-09-22
PCT/JP1999/005176 WO2000017201A1 (fr) 1998-09-22 1999-09-22 DERIVES DE [1,2,4]TRIAZOLO[1,5-c]PYRIMIDINE

Publications (1)

Publication Number Publication Date
ATE286900T1 true ATE286900T1 (de) 2005-01-15

Family

ID=17441200

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99944771T ATE286900T1 (de) 1998-09-22 1999-09-22 (1,2,4)triazolo(1,5-c)pyrimidin-derivate

Country Status (15)

Country Link
US (1) US6545000B1 (de)
EP (1) EP1116722B1 (de)
KR (1) KR20010087361A (de)
CN (1) CN1328560A (de)
AT (1) ATE286900T1 (de)
AU (1) AU756144B2 (de)
BR (1) BR9914040A (de)
CA (1) CA2344828A1 (de)
DE (1) DE69923197T2 (de)
EA (1) EA200100265A1 (de)
HU (1) HUP0103921A3 (de)
IL (1) IL142128A0 (de)
NO (1) NO20011417L (de)
NZ (1) NZ510629A (de)
WO (1) WO2000017201A1 (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2002079204A1 (ja) * 2001-03-28 2004-07-22 協和醗酵工業株式会社 8−チアゾリル[1,2,4]トリアゾロ[1,5−c]ピリミジン誘導体
JP5280597B2 (ja) * 2001-03-30 2013-09-04 サンスター技研株式会社 一液加熱硬化型エポキシ樹脂組成物および半導体実装用アンダーフィル材
MXPA04002389A (es) * 2001-09-13 2004-05-31 Schering Corp Combinacion de un antagonista del receptor de adenosian a2a y un antidepresivo o ansiolitico.
AR038366A1 (es) 2001-11-30 2005-01-12 Schering Corp Compuestos de 1,2,4-triazolo [1,5-c] pirimidinas sustituidas, antagonistas del receptor de adenosina a2a, composiciones farmaceuticas, el uso de dichos compuestos para la manufactura de un medicamento para el tratamiento de enfermedades del sistema nervioso central y un kit que comprende combinacion
IL161573A0 (en) * 2001-11-30 2004-09-27 Schering Corp [1,2,4]-TRIAZOLE BICYCLIC ADENOSINE A2a RECEPTOR ANTAGONISTS
PL370980A1 (en) * 2001-12-12 2005-06-13 F.Hoffmann-La Roche Ag Benzothiophenes as adenosine receptor modulators
US6734179B2 (en) * 2001-12-12 2004-05-11 Hoffmann-La Roche Inc. Benzothiazoles
KR20100056569A (ko) 2002-01-28 2010-05-27 교와 핫꼬 기린 가부시키가이샤 운동성 질환에 걸린 환자의 치료 방법
JPWO2003068776A1 (ja) * 2002-02-15 2005-06-02 協和醗酵工業株式会社 [1,2,4]トリアゾロ[1,5−c]ピリミジン誘導体
AU2003272886A1 (en) * 2002-09-24 2004-04-19 Kyowa Hakko Kogyo Co., Ltd. (1,2,4)-TRIAZOLO(1,5-c)PYRIMIDINE DERIVATIVE
EP1615930A2 (de) 2003-04-09 2006-01-18 Biogen Idec MA, Inc. Als a2a-adenosinrezeptor-antagonisten geeignete triazolotriazine und pyrazolotriazine
EP1618109A2 (de) * 2003-04-09 2006-01-25 Biogen Idec MA Inc. Als a2a-adenosinrezeptorantagonisten geeignete triazolo[1,5-c]pyrimidine und pyrazolo[1,5-c]pyrimidine
DE602004018637D1 (de) 2003-04-09 2009-02-05 Biogen Idec Inc A2a-adenosinrezeptorantagonisten
US7674791B2 (en) 2003-04-09 2010-03-09 Biogen Idec Ma Inc. Triazolopyrazines and methods of making and using the same
US8202869B2 (en) 2003-06-10 2012-06-19 Kyowa Hakko Kirin Co., Ltd. Method of treating an anxiety disorder
EP1902716A4 (de) * 2005-06-07 2009-05-13 Kyowa Hakko Kirin Co Ltd Prophylaktisches und/oder therapeutisches mittel für motorische störungen
US7994190B2 (en) 2006-11-01 2011-08-09 Bristol-Myers Squibb Company Modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
TWI473614B (zh) * 2008-05-29 2015-02-21 Kyowa Hakko Kirin Co Ltd Anti-analgesic inhibitors
ES2658892T3 (es) * 2008-07-23 2018-03-12 Kyowa Hakko Kirin Co., Ltd. Agente terapéutico para la migraña
WO2010111626A2 (en) * 2009-03-27 2010-09-30 Takeda Pharmaceutical Company Limited Poly (adp-ribose) polymerase (parp) inhibitors
US11312705B2 (en) * 2017-03-16 2022-04-26 Jiangsu Hengrui Medicine Co., Ltd. Heteroaryl[4,3-C]pyrimidine-5-amine derivative, preparation method therefor, and medical uses thereof
CN117903140A (zh) 2018-02-27 2024-04-19 因赛特公司 作为a2a/a2b抑制剂的咪唑并嘧啶和三唑并嘧啶
CA3100731A1 (en) 2018-05-18 2019-11-21 Incyte Corporation Fused pyrimidine derivatives as a2a / a2b inhibitors
TWI829716B (zh) 2018-07-05 2024-01-21 美商英塞特公司 作為a2a/a2b 抑制劑之稠合吡嗪衍生物
CN110903291B (zh) * 2018-09-14 2021-09-03 江苏恒瑞医药股份有限公司 一种杂芳基并[4,3-c]嘧啶-5-胺类衍生物的盐、盐的晶型及制备方法
TWI829857B (zh) 2019-01-29 2024-01-21 美商英塞特公司 作為a2a / a2b抑制劑之吡唑并吡啶及三唑并吡啶

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4477450A (en) 1983-03-03 1984-10-16 Riker Laboratories, Inc. Triazolo [4,3-c]pyrimidines substituted by nitrogen-containing heterocyclic rings
US4572910A (en) 1983-03-03 1986-02-25 Riker Laboratories, Inc. Triazolo[1,5-c]pyrimidines substituted by nitrogen-containing heterocyclic rings
US4483987A (en) 1983-06-20 1984-11-20 G. D. Searle & Co. 8-Substituted 7-phenyl-1,2,4-triazolo[2,3-c]pyrimidines-5-amines and amides
NZ208996A (en) 1983-07-28 1989-08-29 American Cyanamid Co 5-substituted(1,2,4 triazpyrimidin-2-amine derivatives and pharmaceutical compositions
EP0459702A1 (de) 1990-05-29 1991-12-04 Zeneca Limited Azolderivate
US5356894A (en) 1990-05-29 1994-10-18 Rodney Peter W Morpholinyl substituted [1,2,4]-triazolo[1,5-a]triazine as antagonist
CA2148502A1 (en) * 1993-09-06 1995-03-16 Fumio Suzuki Antidepressants
ATE257156T1 (de) 1997-03-24 2004-01-15 Kyowa Hakko Kogyo Kk (1,2,4)triazolo(1,5-c)pyrimidin-derivate

Also Published As

Publication number Publication date
HUP0103921A2 (hu) 2002-04-29
NZ510629A (en) 2003-04-29
EP1116722A1 (de) 2001-07-18
US6545000B1 (en) 2003-04-08
EP1116722B1 (de) 2005-01-12
AU5757999A (en) 2000-04-10
WO2000017201A1 (fr) 2000-03-30
IL142128A0 (en) 2002-03-10
CA2344828A1 (en) 2000-03-30
KR20010087361A (ko) 2001-09-15
DE69923197T2 (de) 2005-12-29
AU756144B2 (en) 2003-01-02
CN1328560A (zh) 2001-12-26
HUP0103921A3 (en) 2002-12-28
NO20011417L (no) 2001-05-21
DE69923197D1 (de) 2005-02-17
BR9914040A (pt) 2002-01-15
EP1116722A4 (de) 2002-05-29
NO20011417D0 (no) 2001-03-20
EA200100265A1 (ru) 2001-10-22

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Legal Events

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