IL142128A0 - [1,2,4] triazolo [1,5-c] pyrimidine derivatives - Google Patents
[1,2,4] triazolo [1,5-c] pyrimidine derivativesInfo
- Publication number
- IL142128A0 IL142128A0 IL14212899A IL14212899A IL142128A0 IL 142128 A0 IL142128 A0 IL 142128A0 IL 14212899 A IL14212899 A IL 14212899A IL 14212899 A IL14212899 A IL 14212899A IL 142128 A0 IL142128 A0 IL 142128A0
- Authority
- IL
- Israel
- Prior art keywords
- represent
- triazolo
- aryl
- pyrimidine derivatives
- lower alkyl
- Prior art date
Links
- QLOWGDIISXJREF-UHFFFAOYSA-N [1,2,4]triazolo[1,5-c]pyrimidine Chemical class C1=CN=CN2N=CN=C21 QLOWGDIISXJREF-UHFFFAOYSA-N 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 150000001721 carbon Chemical group 0.000 abstract 2
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- 102000007471 Adenosine A2A receptor Human genes 0.000 abstract 1
- 108010085277 Adenosine A2A receptor Proteins 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- General Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Psychiatry (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP26717898 | 1998-09-22 | ||
| PCT/JP1999/005176 WO2000017201A1 (en) | 1998-09-22 | 1999-09-22 | [1,2,4]TRIAZOLO[1,5-c]PYRIMIDINE DERIVATIVES |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL142128A0 true IL142128A0 (en) | 2002-03-10 |
Family
ID=17441200
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL14212899A IL142128A0 (en) | 1998-09-22 | 1999-09-22 | [1,2,4] triazolo [1,5-c] pyrimidine derivatives |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US6545000B1 (de) |
| EP (1) | EP1116722B1 (de) |
| KR (1) | KR20010087361A (de) |
| CN (1) | CN1328560A (de) |
| AT (1) | ATE286900T1 (de) |
| AU (1) | AU756144B2 (de) |
| BR (1) | BR9914040A (de) |
| CA (1) | CA2344828A1 (de) |
| DE (1) | DE69923197T2 (de) |
| EA (1) | EA200100265A1 (de) |
| HU (1) | HUP0103921A3 (de) |
| IL (1) | IL142128A0 (de) |
| NO (1) | NO20011417L (de) |
| NZ (1) | NZ510629A (de) |
| WO (1) | WO2000017201A1 (de) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002079204A1 (en) * | 2001-03-28 | 2002-10-10 | Kyowa Hakko Kogyo Co., Ltd. | 8-thiazolyl[1,2,4]triazolo[1,5-c]pyrimidine derivative |
| JP5280597B2 (ja) | 2001-03-30 | 2013-09-04 | サンスター技研株式会社 | 一液加熱硬化型エポキシ樹脂組成物および半導体実装用アンダーフィル材 |
| WO2003022283A1 (en) * | 2001-09-13 | 2003-03-20 | Schering Corporation | Combination of an adenosine a2a receptor antagonist and an antidepressant or anxiolytic |
| ES2283625T3 (es) | 2001-11-30 | 2007-11-01 | Schering Corporation | Antagonistas del receptopr a2a de adenosina de (1,2,4)-triazol biciclicos. |
| TW200300686A (en) | 2001-11-30 | 2003-06-16 | Schering Corp | Adenosine A2a receptor antagonists |
| US6734179B2 (en) * | 2001-12-12 | 2004-05-11 | Hoffmann-La Roche Inc. | Benzothiazoles |
| KR100581703B1 (ko) * | 2001-12-12 | 2006-05-22 | 에프. 호프만-라 로슈 아게 | 아데노신 수용체 조절제로서의 벤조티오펜 |
| ES2686123T3 (es) | 2002-01-28 | 2018-10-16 | Kyowa Hakko Kogyo Co., Ltd | Antagonistas del receptor A2A para su uso en el tratamiento de trastornos del movimiento |
| JPWO2003068776A1 (ja) * | 2002-02-15 | 2005-06-02 | 協和醗酵工業株式会社 | ［１，２，４］トリアゾロ［１，５−ｃ］ピリミジン誘導体 |
| AU2003272886A1 (en) * | 2002-09-24 | 2004-04-19 | Kyowa Hakko Kogyo Co., Ltd. | (1,2,4)-TRIAZOLO(1,5-c)PYRIMIDINE DERIVATIVE |
| US7285550B2 (en) | 2003-04-09 | 2007-10-23 | Biogen Idec Ma Inc. | Triazolotriazines and pyrazolotriazines and methods of making and using the same |
| EP1618109A2 (de) * | 2003-04-09 | 2006-01-25 | Biogen Idec MA Inc. | Als a2a-adenosinrezeptorantagonisten geeignete triazolo[1,5-c]pyrimidine und pyrazolo[1,5-c]pyrimidine |
| DE602004018637D1 (de) | 2003-04-09 | 2009-02-05 | Biogen Idec Inc | A2a-adenosinrezeptorantagonisten |
| WO2004092177A1 (en) * | 2003-04-09 | 2004-10-28 | Biogen Idec Ma Inc. | Triazolopyrazines and methods of making and using the same |
| CN1787821A (zh) * | 2003-06-10 | 2006-06-14 | 协和发酵工业株式会社 | 一种治疗焦虑症的方法 |
| EP1902716A4 (de) * | 2005-06-07 | 2009-05-13 | Kyowa Hakko Kirin Co Ltd | Prophylaktisches und/oder therapeutisches mittel für motorische störungen |
| WO2008057855A2 (en) | 2006-11-01 | 2008-05-15 | Bristol-Myers Squibb Company | Heterocyclic compounds as modulators of glucocorticoid receptor, ap-i, and/or np-kappa-b activity |
| TWI473614B (zh) * | 2008-05-29 | 2015-02-21 | Kyowa Hakko Kirin Co Ltd | Anti-analgesic inhibitors |
| JP5599311B2 (ja) * | 2008-07-23 | 2014-10-01 | 協和発酵キリン株式会社 | 片頭痛治療剤 |
| EP2415767B1 (de) * | 2009-03-27 | 2014-09-03 | Takeda Pharmaceutical Company Limited | Poly(ADP-Ribose)Polymerase- (PARP-) Inhibitoren |
| WO2018166493A1 (zh) * | 2017-03-16 | 2018-09-20 | 江苏恒瑞医药股份有限公司 | 杂芳基并[4，3-c]嘧啶-5-胺类衍生物、其制备方法及其在医药上的应用 |
| BR122023024273A2 (pt) | 2018-02-27 | 2024-02-20 | Incyte Corporation | Compostos imidazopirimidinas e triazolopirimidinas, seus usos, método para inibir uma atividade de um receptor de adenosina e composição farmacêutica dos mesmos |
| EP3810610A1 (de) | 2018-05-18 | 2021-04-28 | Incyte Corporation | Kondensierte pyrimidinderivate als a2a/a2b-inhibitoren |
| AU2019297361B2 (en) | 2018-07-05 | 2024-06-27 | Incyte Corporation | Fused pyrazine derivatives as A2A / A2B inhibitors |
| CN110903291B (zh) * | 2018-09-14 | 2021-09-03 | 江苏恒瑞医药股份有限公司 | 一种杂芳基并[4,3-c]嘧啶-5-胺类衍生物的盐、盐的晶型及制备方法 |
| TWI829857B (zh) | 2019-01-29 | 2024-01-21 | 美商英塞特公司 | 作為a2a / a2b抑制劑之吡唑并吡啶及三唑并吡啶 |
| KR20240161147A (ko) | 2022-03-14 | 2024-11-12 | 슬랩 파마슈티컬스 엘엘씨 | 다중 사이클릭 화합물 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4477450A (en) | 1983-03-03 | 1984-10-16 | Riker Laboratories, Inc. | Triazolo [4,3-c]pyrimidines substituted by nitrogen-containing heterocyclic rings |
| US4572910A (en) | 1983-03-03 | 1986-02-25 | Riker Laboratories, Inc. | Triazolo[1,5-c]pyrimidines substituted by nitrogen-containing heterocyclic rings |
| US4483987A (en) | 1983-06-20 | 1984-11-20 | G. D. Searle & Co. | 8-Substituted 7-phenyl-1,2,4-triazolo[2,3-c]pyrimidines-5-amines and amides |
| NZ208996A (en) | 1983-07-28 | 1989-08-29 | American Cyanamid Co | 5-substituted(1,2,4 triazpyrimidin-2-amine derivatives and pharmaceutical compositions |
| GB2244487B (en) * | 1990-05-29 | 1994-02-02 | Ici Plc | Azole derivatives |
| US5356894A (en) | 1990-05-29 | 1994-10-18 | Rodney Peter W | Morpholinyl substituted [1,2,4]-triazolo[1,5-a]triazine as antagonist |
| CA2148502A1 (en) | 1993-09-06 | 1995-03-16 | Fumio Suzuki | Antidepressants |
| CA2284737C (en) | 1997-03-24 | 2007-03-13 | Kyowa Hakko Kogyo Co., Ltd. | [1,2,4]triazolo[1,5-c]pyrimidine derivatives |
-
1999
- 1999-09-22 WO PCT/JP1999/005176 patent/WO2000017201A1/ja not_active Ceased
- 1999-09-22 KR KR1020017003599A patent/KR20010087361A/ko not_active Withdrawn
- 1999-09-22 IL IL14212899A patent/IL142128A0/xx unknown
- 1999-09-22 NZ NZ510629A patent/NZ510629A/xx unknown
- 1999-09-22 HU HU0103921A patent/HUP0103921A3/hu unknown
- 1999-09-22 AU AU57579/99A patent/AU756144B2/en not_active Ceased
- 1999-09-22 EP EP99944771A patent/EP1116722B1/de not_active Expired - Lifetime
- 1999-09-22 CN CN99813569A patent/CN1328560A/zh active Pending
- 1999-09-22 BR BR9914040-3A patent/BR9914040A/pt not_active IP Right Cessation
- 1999-09-22 CA CA002344828A patent/CA2344828A1/en not_active Abandoned
- 1999-09-22 US US09/787,779 patent/US6545000B1/en not_active Expired - Fee Related
- 1999-09-22 DE DE69923197T patent/DE69923197T2/de not_active Expired - Fee Related
- 1999-09-22 AT AT99944771T patent/ATE286900T1/de not_active IP Right Cessation
- 1999-09-22 EA EA200100265A patent/EA200100265A1/ru unknown
-
2001
- 2001-03-20 NO NO20011417A patent/NO20011417L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CN1328560A (zh) | 2001-12-26 |
| WO2000017201A1 (en) | 2000-03-30 |
| EP1116722A4 (de) | 2002-05-29 |
| BR9914040A (pt) | 2002-01-15 |
| HUP0103921A3 (en) | 2002-12-28 |
| DE69923197D1 (de) | 2005-02-17 |
| AU5757999A (en) | 2000-04-10 |
| NO20011417D0 (no) | 2001-03-20 |
| ATE286900T1 (de) | 2005-01-15 |
| EP1116722B1 (de) | 2005-01-12 |
| NO20011417L (no) | 2001-05-21 |
| KR20010087361A (ko) | 2001-09-15 |
| CA2344828A1 (en) | 2000-03-30 |
| EA200100265A1 (ru) | 2001-10-22 |
| NZ510629A (en) | 2003-04-29 |
| EP1116722A1 (de) | 2001-07-18 |
| AU756144B2 (en) | 2003-01-02 |
| DE69923197T2 (de) | 2005-12-29 |
| HUP0103921A2 (hu) | 2002-04-29 |
| US6545000B1 (en) | 2003-04-08 |
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