IL142128A0 - [1,2,4] triazolo [1,5-c] pyrimidine derivatives - Google Patents
[1,2,4] triazolo [1,5-c] pyrimidine derivativesInfo
- Publication number
- IL142128A0 IL142128A0 IL14212899A IL14212899A IL142128A0 IL 142128 A0 IL142128 A0 IL 142128A0 IL 14212899 A IL14212899 A IL 14212899A IL 14212899 A IL14212899 A IL 14212899A IL 142128 A0 IL142128 A0 IL 142128A0
- Authority
- IL
- Israel
- Prior art keywords
- represent
- triazolo
- aryl
- pyrimidine derivatives
- lower alkyl
- Prior art date
Links
- QLOWGDIISXJREF-UHFFFAOYSA-N [1,2,4]triazolo[1,5-c]pyrimidine Chemical class C1=CN=CN2N=CN=C21 QLOWGDIISXJREF-UHFFFAOYSA-N 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 150000001721 carbon Chemical group 0.000 abstract 2
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- 102000007471 Adenosine A2A receptor Human genes 0.000 abstract 1
- 108010085277 Adenosine A2A receptor Proteins 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- General Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Psychiatry (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP26717898 | 1998-09-22 | ||
| PCT/JP1999/005176 WO2000017201A1 (fr) | 1998-09-22 | 1999-09-22 | DERIVES DE [1,2,4]TRIAZOLO[1,5-c]PYRIMIDINE |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL142128A0 true IL142128A0 (en) | 2002-03-10 |
Family
ID=17441200
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL14212899A IL142128A0 (en) | 1998-09-22 | 1999-09-22 | [1,2,4] triazolo [1,5-c] pyrimidine derivatives |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US6545000B1 (xx) |
| EP (1) | EP1116722B1 (xx) |
| KR (1) | KR20010087361A (xx) |
| CN (1) | CN1328560A (xx) |
| AT (1) | ATE286900T1 (xx) |
| AU (1) | AU756144B2 (xx) |
| BR (1) | BR9914040A (xx) |
| CA (1) | CA2344828A1 (xx) |
| DE (1) | DE69923197T2 (xx) |
| EA (1) | EA200100265A1 (xx) |
| HU (1) | HUP0103921A3 (xx) |
| IL (1) | IL142128A0 (xx) |
| NO (1) | NO20011417L (xx) |
| NZ (1) | NZ510629A (xx) |
| WO (1) | WO2000017201A1 (xx) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPWO2002079204A1 (ja) * | 2001-03-28 | 2004-07-22 | 協和醗酵工業株式会社 | ８−チアゾリル［１，２，４］トリアゾロ［１，５−ｃ］ピリミジン誘導体 |
| JP5280597B2 (ja) * | 2001-03-30 | 2013-09-04 | サンスター技研株式会社 | 一液加熱硬化型エポキシ樹脂組成物および半導体実装用アンダーフィル材 |
| MXPA04002389A (es) * | 2001-09-13 | 2004-05-31 | Schering Corp | Combinacion de un antagonista del receptor de adenosian a2a y un antidepresivo o ansiolitico. |
| AR038366A1 (es) | 2001-11-30 | 2005-01-12 | Schering Corp | Compuestos de 1,2,4-triazolo [1,5-c] pirimidinas sustituidas, antagonistas del receptor de adenosina a2a, composiciones farmaceuticas, el uso de dichos compuestos para la manufactura de un medicamento para el tratamiento de enfermedades del sistema nervioso central y un kit que comprende combinacion |
| IL161573A0 (en) * | 2001-11-30 | 2004-09-27 | Schering Corp | [1,2,4]-TRIAZOLE BICYCLIC ADENOSINE A2a RECEPTOR ANTAGONISTS |
| PL370980A1 (en) * | 2001-12-12 | 2005-06-13 | F.Hoffmann-La Roche Ag | Benzothiophenes as adenosine receptor modulators |
| US6734179B2 (en) * | 2001-12-12 | 2004-05-11 | Hoffmann-La Roche Inc. | Benzothiazoles |
| KR20100056569A (ko) | 2002-01-28 | 2010-05-27 | 교와 핫꼬 기린 가부시키가이샤 | 운동성 질환에 걸린 환자의 치료 방법 |
| JPWO2003068776A1 (ja) * | 2002-02-15 | 2005-06-02 | 協和醗酵工業株式会社 | ［１，２，４］トリアゾロ［１，５−ｃ］ピリミジン誘導体 |
| AU2003272886A1 (en) * | 2002-09-24 | 2004-04-19 | Kyowa Hakko Kogyo Co., Ltd. | (1,2,4)-TRIAZOLO(1,5-c)PYRIMIDINE DERIVATIVE |
| EP1615930A2 (en) | 2003-04-09 | 2006-01-18 | Biogen Idec MA, Inc. | Triazolotriazines and pyrazolotriazines useful as a2a adenosine receptor antagonists |
| EP1618109A2 (en) * | 2003-04-09 | 2006-01-25 | Biogen Idec MA Inc. | Triazolo[1,5-c]pyrimidines and pyrazolo[1,5-c]pyrimidines useful as a2a adenosine receptor antagonists |
| DE602004018637D1 (de) | 2003-04-09 | 2009-02-05 | Biogen Idec Inc | A2a-adenosinrezeptorantagonisten |
| US7674791B2 (en) | 2003-04-09 | 2010-03-09 | Biogen Idec Ma Inc. | Triazolopyrazines and methods of making and using the same |
| US8202869B2 (en) | 2003-06-10 | 2012-06-19 | Kyowa Hakko Kirin Co., Ltd. | Method of treating an anxiety disorder |
| EP1902716A4 (en) * | 2005-06-07 | 2009-05-13 | Kyowa Hakko Kirin Co Ltd | PROPHYLACTIC AND / OR THERAPEUTIC AGENT FOR MOTOR TROUBLESHOOTING |
| US7994190B2 (en) | 2006-11-01 | 2011-08-09 | Bristol-Myers Squibb Company | Modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof |
| TWI473614B (zh) * | 2008-05-29 | 2015-02-21 | Kyowa Hakko Kirin Co Ltd | Anti-analgesic inhibitors |
| ES2658892T3 (es) * | 2008-07-23 | 2018-03-12 | Kyowa Hakko Kirin Co., Ltd. | Agente terapéutico para la migraña |
| WO2010111626A2 (en) * | 2009-03-27 | 2010-09-30 | Takeda Pharmaceutical Company Limited | Poly (adp-ribose) polymerase (parp) inhibitors |
| US11312705B2 (en) * | 2017-03-16 | 2022-04-26 | Jiangsu Hengrui Medicine Co., Ltd. | Heteroaryl[4,3-C]pyrimidine-5-amine derivative, preparation method therefor, and medical uses thereof |
| CN117903140A (zh) | 2018-02-27 | 2024-04-19 | 因赛特公司 | 作为a2a/a2b抑制剂的咪唑并嘧啶和三唑并嘧啶 |
| CA3100731A1 (en) | 2018-05-18 | 2019-11-21 | Incyte Corporation | Fused pyrimidine derivatives as a2a / a2b inhibitors |
| TWI829716B (zh) | 2018-07-05 | 2024-01-21 | 美商英塞特公司 | 作為a2a/a2b 抑制劑之稠合吡嗪衍生物 |
| CN110903291B (zh) * | 2018-09-14 | 2021-09-03 | 江苏恒瑞医药股份有限公司 | 一种杂芳基并[4,3-c]嘧啶-5-胺类衍生物的盐、盐的晶型及制备方法 |
| TWI829857B (zh) | 2019-01-29 | 2024-01-21 | 美商英塞特公司 | 作為a2a / a2b抑制劑之吡唑并吡啶及三唑并吡啶 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4477450A (en) | 1983-03-03 | 1984-10-16 | Riker Laboratories, Inc. | Triazolo [4,3-c]pyrimidines substituted by nitrogen-containing heterocyclic rings |
| US4572910A (en) | 1983-03-03 | 1986-02-25 | Riker Laboratories, Inc. | Triazolo[1,5-c]pyrimidines substituted by nitrogen-containing heterocyclic rings |
| US4483987A (en) | 1983-06-20 | 1984-11-20 | G. D. Searle & Co. | 8-Substituted 7-phenyl-1,2,4-triazolo[2,3-c]pyrimidines-5-amines and amides |
| NZ208996A (en) | 1983-07-28 | 1989-08-29 | American Cyanamid Co | 5-substituted(1,2,4 triazpyrimidin-2-amine derivatives and pharmaceutical compositions |
| EP0459702A1 (en) | 1990-05-29 | 1991-12-04 | Zeneca Limited | Azole Derivatives |
| US5356894A (en) | 1990-05-29 | 1994-10-18 | Rodney Peter W | Morpholinyl substituted [1,2,4]-triazolo[1,5-a]triazine as antagonist |
| CA2148502A1 (en) * | 1993-09-06 | 1995-03-16 | Fumio Suzuki | Antidepressants |
| ATE257156T1 (de) | 1997-03-24 | 2004-01-15 | Kyowa Hakko Kogyo Kk | (1,2,4)triazolo(1,5-c)pyrimidin-derivate |
-
1999
- 1999-09-22 BR BR9914040-3A patent/BR9914040A/pt not_active IP Right Cessation
- 1999-09-22 US US09/787,779 patent/US6545000B1/en not_active Expired - Fee Related
- 1999-09-22 EA EA200100265A patent/EA200100265A1/ru unknown
- 1999-09-22 EP EP99944771A patent/EP1116722B1/en not_active Expired - Lifetime
- 1999-09-22 WO PCT/JP1999/005176 patent/WO2000017201A1/ja active IP Right Grant
- 1999-09-22 IL IL14212899A patent/IL142128A0/xx unknown
- 1999-09-22 AU AU57579/99A patent/AU756144B2/en not_active Ceased
- 1999-09-22 CN CN99813569A patent/CN1328560A/zh active Pending
- 1999-09-22 NZ NZ510629A patent/NZ510629A/xx unknown
- 1999-09-22 AT AT99944771T patent/ATE286900T1/de not_active IP Right Cessation
- 1999-09-22 DE DE69923197T patent/DE69923197T2/de not_active Expired - Fee Related
- 1999-09-22 KR KR1020017003599A patent/KR20010087361A/ko not_active Application Discontinuation
- 1999-09-22 HU HU0103921A patent/HUP0103921A3/hu unknown
- 1999-09-22 CA CA002344828A patent/CA2344828A1/en not_active Abandoned
-
2001
- 2001-03-20 NO NO20011417A patent/NO20011417L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| HUP0103921A2 (hu) | 2002-04-29 |
| NZ510629A (en) | 2003-04-29 |
| EP1116722A1 (en) | 2001-07-18 |
| US6545000B1 (en) | 2003-04-08 |
| EP1116722B1 (en) | 2005-01-12 |
| AU5757999A (en) | 2000-04-10 |
| WO2000017201A1 (fr) | 2000-03-30 |
| CA2344828A1 (en) | 2000-03-30 |
| KR20010087361A (ko) | 2001-09-15 |
| DE69923197T2 (de) | 2005-12-29 |
| AU756144B2 (en) | 2003-01-02 |
| CN1328560A (zh) | 2001-12-26 |
| HUP0103921A3 (en) | 2002-12-28 |
| NO20011417L (no) | 2001-05-21 |
| DE69923197D1 (de) | 2005-02-17 |
| BR9914040A (pt) | 2002-01-15 |
| EP1116722A4 (en) | 2002-05-29 |
| NO20011417D0 (no) | 2001-03-20 |
| ATE286900T1 (de) | 2005-01-15 |
| EA200100265A1 (ru) | 2001-10-22 |
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