ATE263145T1 - Verfahren zur herstellung von n-carbamat- geschütztem beta-aminoepoxid und beta- aminoalkohol - Google Patents

Verfahren zur herstellung von n-carbamat- geschütztem beta-aminoepoxid und beta- aminoalkohol

Info

Publication number
ATE263145T1
ATE263145T1 AT00307521T AT00307521T ATE263145T1 AT E263145 T1 ATE263145 T1 AT E263145T1 AT 00307521 T AT00307521 T AT 00307521T AT 00307521 T AT00307521 T AT 00307521T AT E263145 T1 ATE263145 T1 AT E263145T1
Authority
AT
Austria
Prior art keywords
carbamate
protected beta
aminoepoxide
beta
protected
Prior art date
Application number
AT00307521T
Other languages
English (en)
Inventor
Tomoyuki Onishi
Naoko Hirose
Yasuyuki Otake
Takashi Nakano
Yutaka Honda
Masakazu Nakazawa
Kunisuke Izawa
Original Assignee
Ajinomoto Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ajinomoto Kk filed Critical Ajinomoto Kk
Application granted granted Critical
Publication of ATE263145T1 publication Critical patent/ATE263145T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C269/06—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C269/08—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C07D263/24—Oxygen atoms attached in position 2 with hydrocarbon radicals, substituted by oxygen atoms, attached to other ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/36—Compounds containing oxirane rings with hydrocarbon radicals, substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Epoxy Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT00307521T 1999-08-31 2000-08-31 Verfahren zur herstellung von n-carbamat- geschütztem beta-aminoepoxid und beta- aminoalkohol ATE263145T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP24564599 1999-08-31
JP2000035074 2000-02-14
JP2000082895 2000-03-23
JP2000199234 2000-06-30

Publications (1)

Publication Number Publication Date
ATE263145T1 true ATE263145T1 (de) 2004-04-15

Family

ID=27478006

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00307521T ATE263145T1 (de) 1999-08-31 2000-08-31 Verfahren zur herstellung von n-carbamat- geschütztem beta-aminoepoxid und beta- aminoalkohol

Country Status (7)

Country Link
US (1) US6765100B2 (de)
EP (2) EP1428818A3 (de)
KR (2) KR100708221B1 (de)
AT (1) ATE263145T1 (de)
CA (1) CA2317198A1 (de)
DE (1) DE60009407T2 (de)
ES (1) ES2216828T3 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6764545B2 (en) 2000-12-12 2004-07-20 Ajinomoto Co., Inc. Production method of epoxide crystal
JP2002371044A (ja) * 2001-04-11 2002-12-26 Ajinomoto Co Inc β−アミノ−α−ヒドロキシカルボン酸の製造方法
JP4818124B2 (ja) 2003-12-23 2011-11-16 テイボテク・フアーマシユーチカルズ・リミテツド （３Ｒ，３ａＳ，６ａＲ）−ヘキサヒドロフロ〔２，３−ｂ〕フラン−３−イル（１Ｓ，１Ｒ）−３−〔〔（４−アミノフェニル）スルホニル〕（イソブチル）アミノ〕−１−ベンジル−２−ヒドロキシプロピルカルバマートの製造方法
US7582468B2 (en) * 2005-05-25 2009-09-01 Bristol-Myers Squibb Company Process for preparing (2R,3S)-1,2-epoxy-3-(protected)amino-4-substituted butane and intermediates thereof
JP2007112723A (ja) * 2005-10-18 2007-05-10 Ajinomoto Co Inc アミノクロロヒドリン硫酸塩の製造方法
RS51675B (sr) 2006-11-09 2011-10-31 Tibotec Pharmaceuticals Metode za dobivanje heksahidrofuro[2,3-b]furan-3-ola
WO2008132154A1 (en) 2007-04-27 2008-11-06 Tibotec Pharmaceuticals Ltd. Methods for the preparation of n-isobutyl-n-(2-hydroxy-3-amino-4-phenylbutyl)-p-nitrobenzenesulfonylamide derivatives
CN101795674A (zh) * 2007-06-22 2010-08-04 百时美施贵宝公司 含有阿扎那韦的压片组合物
PL2170292T3 (pl) * 2007-06-22 2014-06-30 Bristol Myers Squibb Holdings Ireland Tabletkowane kompozycje zawierające atazanawir
KR20100033378A (ko) * 2007-06-22 2010-03-29 브리스톨-마이어스 스큅 컴퍼니 아타자나비르를 함유하는 정제 조성물
DE602008005462D1 (de) * 2007-06-22 2011-04-21 Bristol Myers Squibb Co Tablettierte atazanavirhaltige zusammensetzungen
EP2288593A1 (de) * 2008-05-08 2011-03-02 Ranbaxy Laboratories Limited Verfahren zur herstellung von 3,4-epoxy-2-amino-1-substituierten butanderivaten und zwischenprodukte dafür
AR073248A1 (es) 2008-09-01 2010-10-20 Tibotec Pharm Ltd Proceso para la preparacion de (1s, 2r)-3- ((4-aminofenil) sulfonil) ( isobutil) amino)-1- bencil-2- hidroxipropilcarbamato de (3r, 3as,6ar)- hexahidrofuro-(2,3-b) furan-3- ilo (darunavir) y compuestos intermediarios utiles en dicho proceso.
US8921415B2 (en) 2009-01-29 2014-12-30 Mapi Pharma Ltd. Polymorphs of darunavir
PL2528923T3 (pl) 2010-01-28 2015-01-30 Mapi Pharma Ltd Sposób wytwarzania darunawiru i pochodnych darunawiru
WO2013011485A1 (en) 2011-07-20 2013-01-24 Ranbaxy Laboratories Limited Process for the preparation of sulfonamides useful as retroviral protease inhibitors
CN102766074B (zh) * 2012-08-07 2014-05-07 江西东邦药业有限公司 抗艾滋病药物中间体的制备方法
CN103044361B (zh) * 2012-12-30 2014-08-06 江苏八巨药业有限公司 一种（2r,3s）-环氧化氨基苯丁烷的制备方法
CN105461662A (zh) * 2014-08-31 2016-04-06 复旦大学 一种抗hiv药物中间体的手性环氧化合物的合成方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2096528C (en) * 1990-11-19 2005-12-06 Kathryn Lea Reed Retroviral protease inhibitors
EP0532466A3 (en) 1991-09-12 1993-06-16 Ciba-Geigy Ag Derivatives of 5-amino-4-hydroxy-hexanoic acid and their therapeutical use
US5559256A (en) 1992-07-20 1996-09-24 E. R. Squibb & Sons, Inc. Aminediol protease inhibitors
US5481011A (en) * 1994-12-13 1996-01-02 Bristol-Myers Squibb Company Process for preparing N-protected amino acid α-halomethyl ketones and alcohols from N-protected amino acid esters
EP0754669B1 (de) * 1995-02-03 2001-10-31 Kaneka Corporation Verfahren zur herstellung von alpha-haloketonen, alpha-halohydrinen und epoxiden
EP1097919A3 (de) * 1995-11-17 2003-08-06 Ajinomoto Co., Inc. Verfahren zur Herstellung eines 4-Amino-3-oxo-butansäureesters
DE69916030T2 (de) 1998-01-28 2004-08-05 Nippon Kayaku K.K. Verfahren zur herstellung optisch aktiver threo-3-amino-1,2-epoxyverbindungen
EP1151992B1 (de) 1999-01-21 2003-09-17 Kaneka Corporation Methode zur reinigung und abtrennung von (2s,3s)- oder (2r,3s)-halohydrinderivaten
CA2325919C (en) 1999-01-29 2009-07-21 Kaneka Corporation Processes for the preparation of threo-1,2-epoxy-3-amino-4-phenylbutane derivatives
US6605732B1 (en) 1999-05-03 2003-08-12 Aerojet Fine Chemicals Llc Clean, high-yield preparation of S,S and R,S amino acid isosteres

Also Published As

Publication number Publication date
US6765100B2 (en) 2004-07-20
CA2317198A1 (en) 2001-02-28
KR20060116182A (ko) 2006-11-14
EP1428818A3 (de) 2004-11-03
KR100706567B1 (ko) 2007-04-13
US20020072621A1 (en) 2002-06-13
ES2216828T3 (es) 2004-11-01
KR20010067130A (ko) 2001-07-12
DE60009407T2 (de) 2005-03-03
EP1428818A2 (de) 2004-06-16
EP1081133B1 (de) 2004-03-31
DE60009407D1 (de) 2004-05-06
EP1081133A1 (de) 2001-03-07
KR100708221B1 (ko) 2007-04-17

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