ATE263145T1 - Verfahren zur herstellung von n-carbamat- geschütztem beta-aminoepoxid und beta- aminoalkohol - Google Patents

Verfahren zur herstellung von n-carbamat- geschütztem beta-aminoepoxid und beta- aminoalkohol

Info

Publication number
ATE263145T1
ATE263145T1 AT00307521T AT00307521T ATE263145T1 AT E263145 T1 ATE263145 T1 AT E263145T1 AT 00307521 T AT00307521 T AT 00307521T AT 00307521 T AT00307521 T AT 00307521T AT E263145 T1 ATE263145 T1 AT E263145T1
Authority
AT
Austria
Prior art keywords
carbamate
protected beta
aminoepoxide
beta
protected
Prior art date
Application number
AT00307521T
Other languages
English (en)
Inventor
Tomoyuki Onishi
Naoko Hirose
Yasuyuki Otake
Takashi Nakano
Yutaka Honda
Masakazu Nakazawa
Kunisuke Izawa
Original Assignee
Ajinomoto Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ajinomoto Kk filed Critical Ajinomoto Kk
Application granted granted Critical
Publication of ATE263145T1 publication Critical patent/ATE263145T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C269/06—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C269/08—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C07D263/24—Oxygen atoms attached in position 2 with hydrocarbon radicals, substituted by oxygen atoms, attached to other ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/36—Compounds containing oxirane rings with hydrocarbon radicals, substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Epoxy Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT00307521T 1999-08-31 2000-08-31 Verfahren zur herstellung von n-carbamat- geschütztem beta-aminoepoxid und beta- aminoalkohol ATE263145T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP24564599 1999-08-31
JP2000035074 2000-02-14
JP2000082895 2000-03-23
JP2000199234 2000-06-30

Publications (1)

Publication Number Publication Date
ATE263145T1 true ATE263145T1 (de) 2004-04-15

Family

ID=27478006

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00307521T ATE263145T1 (de) 1999-08-31 2000-08-31 Verfahren zur herstellung von n-carbamat- geschütztem beta-aminoepoxid und beta- aminoalkohol

Country Status (7)

Country Link
US (1) US6765100B2 (de)
EP (2) EP1428818A3 (de)
KR (2) KR100708221B1 (de)
AT (1) ATE263145T1 (de)
CA (1) CA2317198A1 (de)
DE (1) DE60009407T2 (de)
ES (1) ES2216828T3 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6764545B2 (en) 2000-12-12 2004-07-20 Ajinomoto Co., Inc. Production method of epoxide crystal
JP2002371044A (ja) 2001-04-11 2002-12-26 Ajinomoto Co Inc β−アミノ−α−ヒドロキシカルボン酸の製造方法
US7772411B2 (en) 2003-12-23 2010-08-10 Tibotec Pharmaceuticals Ltd. Process for the preparation of (3R,3aS,6aR)-hexahydrofuro [2,3-b] furan-3-yl (1S,2R)-3[[(4-aminophenyl) sulfonyl] (isobutyl) amino]-1-benzyl-2-hydroxypropylcarbamate
US7582468B2 (en) * 2005-05-25 2009-09-01 Bristol-Myers Squibb Company Process for preparing (2R,3S)-1,2-epoxy-3-(protected)amino-4-substituted butane and intermediates thereof
JP2007112723A (ja) * 2005-10-18 2007-05-10 Ajinomoto Co Inc アミノクロロヒドリン硫酸塩の製造方法
JP5491862B2 (ja) 2006-11-09 2014-05-14 ヤンセン・アールアンドデイ・アイルランド ヘキサヒドロフロ［２，３−ｂ］フラン−３−オールの製造方法
PT2152667E (pt) 2007-04-27 2011-04-06 Tibotec Pharm Ltd Processos para a preparação de derivados de n-isobutil-n- (2-hidroxi-3-amino-4-fenilbutil)-p-nitrobenzenosulfonilamida
DK2170292T3 (da) * 2007-06-22 2014-04-07 Bristol Myers Squibb Holdings Ireland Atazanavirholdige sammensætninger i tabletform
KR20100033378A (ko) * 2007-06-22 2010-03-29 브리스톨-마이어스 스큅 컴퍼니 아타자나비르를 함유하는 정제 조성물
DE602008005462D1 (de) * 2007-06-22 2011-04-21 Bristol Myers Squibb Co Tablettierte atazanavirhaltige zusammensetzungen
DE602008005896D1 (de) * 2007-06-22 2011-05-12 Bristol Myers Squibb Co Tablettierte atazanavirhaltige zusammensetzungen
WO2009136365A1 (en) * 2008-05-08 2009-11-12 Ranbaxy Laboratories Limited Process for the preparation of 3,4-epoxy-2-amino-1-substituted butane derivatives and intermediate compounds thereof
TWI482775B (zh) 2008-09-01 2015-05-01 Tibotec Pharm Ltd 用於製備（３ｒ，３ａｓ，６ａｒ）－六氫呋喃并〔２，３－ｂ〕呋喃－３－基（１ｓ，２ｒ）－３－〔〔（４－胺基苯基）磺醯基〕（異丁基）胺基〕－１－苯甲基－２－羥基丙基胺基甲酸酯之方法
US8921415B2 (en) 2009-01-29 2014-12-30 Mapi Pharma Ltd. Polymorphs of darunavir
ES2516916T3 (es) 2010-01-28 2014-10-31 Mapi Pharma Limited Procedimiento para la preparación de darunavir e intermedios de darunavir
WO2013011485A1 (en) 2011-07-20 2013-01-24 Ranbaxy Laboratories Limited Process for the preparation of sulfonamides useful as retroviral protease inhibitors
CN102766074B (zh) * 2012-08-07 2014-05-07 江西东邦药业有限公司 抗艾滋病药物中间体的制备方法
CN103044361B (zh) * 2012-12-30 2014-08-06 江苏八巨药业有限公司 一种（2r,3s）-环氧化氨基苯丁烷的制备方法
CN105461662A (zh) * 2014-08-31 2016-04-06 复旦大学 一种抗hiv药物中间体的手性环氧化合物的合成方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE196466T1 (de) * 1990-11-19 2000-10-15 Monsanto Co Inhibitoren retroviraler proteasen
EP0532466A3 (en) 1991-09-12 1993-06-16 Ciba-Geigy Ag Derivatives of 5-amino-4-hydroxy-hexanoic acid and their therapeutical use
US5559256A (en) 1992-07-20 1996-09-24 E. R. Squibb & Sons, Inc. Aminediol protease inhibitors
US5481011A (en) * 1994-12-13 1996-01-02 Bristol-Myers Squibb Company Process for preparing N-protected amino acid α-halomethyl ketones and alcohols from N-protected amino acid esters
US5929284A (en) * 1995-02-03 1999-07-27 Kaneka Corporation Processes for producing α-halo ketones, α-halohydrins and epoxides
EP1097919A3 (de) * 1995-11-17 2003-08-06 Ajinomoto Co., Inc. Verfahren zur Herstellung eines 4-Amino-3-oxo-butansäureesters
EP1052257B1 (de) 1998-01-28 2004-03-31 Nippon Kayaku Kabushiki Kaisha Verfahren zur herstellung optisch aktiver threo-3-amino-1,2-epoxyverbindungen
WO2000043357A1 (fr) 1999-01-21 2000-07-27 Kaneka Corporation Procede de purification et d'isolement de derives de (2s, 3s)- ou (2r, 3s)-halohydrine
EP1067125B1 (de) 1999-01-29 2006-07-26 Kaneka Corporation VERFAHREN ZUR HERSTELLUNG VON threo-1,2-EPOXY-3-AMINO-4-PHENYLBUTAN-DERIVATEN
US6605732B1 (en) 1999-05-03 2003-08-12 Aerojet Fine Chemicals Llc Clean, high-yield preparation of S,S and R,S amino acid isosteres

Also Published As

Publication number Publication date
KR20060116182A (ko) 2006-11-14
CA2317198A1 (en) 2001-02-28
EP1428818A2 (de) 2004-06-16
DE60009407D1 (de) 2004-05-06
US6765100B2 (en) 2004-07-20
EP1081133B1 (de) 2004-03-31
KR100708221B1 (ko) 2007-04-17
EP1428818A3 (de) 2004-11-03
KR20010067130A (ko) 2001-07-12
ES2216828T3 (es) 2004-11-01
EP1081133A1 (de) 2001-03-07
DE60009407T2 (de) 2005-03-03
KR100706567B1 (ko) 2007-04-13
US20020072621A1 (en) 2002-06-13

Similar Documents

Publication Publication Date Title
ATE263145T1 (de) Verfahren zur herstellung von n-carbamat- geschütztem beta-aminoepoxid und beta- aminoalkohol
WO2000078741A3 (en) Process for extraction and purification of paclitaxel from natural sources
PT1025067E (pt) Processo para a cristalizacao de compostos impedidos estereoquimicamente
RU2006113122A (ru) Ацетоновый сольват диметоксидоцетаксела и способ его получения
ATE417036T1 (de) Verbessertes verfahren zur herstellung von 3- hydroxy-4-hydroxymethyl-pyrrolidin-verbindungen
DK0652219T3 (da) Ny ekstraktionsmetode til udvinding af naturligt forekommende makrolider
DE50206163D1 (de) Verfahren zur herstellung von (meth)acrylsäureestern
BR0108063A (pt) Processo para epoxidação de olefinas
ATE543793T1 (de) Verfahren zur herstellung von benzoesäureestern
ATE445601T1 (de) Verfahren zur herstellung von carvedilol und seinen enantiomeren
ATE374760T1 (de) Verfahren zur herstellung von 4-fluor-1,3- dioxolan-2-on
BR0012641A (pt) Processo para a separação e purificação de uma mistura aquosa a partir dos componentes principais ácido acético e ácido fórmico
ATE312863T1 (de) Verfahren zur reinigung von aldehydverunreinigungen
RU2003119451A (ru) Способ получения 1-(аминометил) циклогексануксусной кислоты
MXPA02011471A (es) Metodo para la purificacion de lactamas.
RU2002120190A (ru) Способ очистки лактамов
DE60005304D1 (de) Methode zur reinigung und abtrennung von (2s,3s)- oder (2r,3s)-halohydrinderivaten
ATE504656T1 (de) Enzymatisches verfahren und verfahren zur enzymatischen herstellung von optisch aktivem cyanhidrin
DE602005013382D1 (de) Feste formen des magnesiumsalzes von (s)-omeprazol und verfahren zu deren herstellung
RU2006110205A (ru) Способ получения бисфенола а
PT992495E (pt) Processo pata obter cloridrato de quinapril e solvatos uteis para isolar e purificar o cloridrato de quinapril
DE60327813D1 (de) Verfahren zu herstellung von lovastatin.
ATE231485T1 (de) Verfahren zur herstellung von arylmalonaten
JPH1036327A (ja) １−（３−メトキシフェニル）エチルアミンの光学活性体の製造方法
DE69926642D1 (de) Verfahren zur herstellung von n-geschützten azetidin-2-carbonsäuren

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties